Motif ID: Sox18_Sox12

Z-value: 0.531

Transcription factors associated with Sox18_Sox12:

Gene SymbolEntrez IDGene Name
Sox12 ENSMUSG00000051817.8 Sox12
Sox18 ENSMUSG00000046470.5 Sox18

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox18mm10_v2_chr2_-_181671622_181671645-0.134.6e-01Click!
Sox12mm10_v2_chr2_-_152398046_1523980760.115.2e-01Click!


Activity profile for motif Sox18_Sox12.

activity profile for motif Sox18_Sox12


Sorted Z-values histogram for motif Sox18_Sox12

Sorted Z-values for motif Sox18_Sox12



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox18_Sox12

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_113934679 1.267 ENSMUST00000101044.2
 Atp2b2
ATPase, Ca++ transporting, plasma membrane 2
chr18_-_74961252 1.131 ENSMUST00000066532.4
 Lipg
lipase, endothelial
chr9_-_60511003 0.877 ENSMUST00000098660.3
 Thsd4
thrombospondin, type I, domain containing 4
chr11_-_11970540 0.869 ENSMUST00000109653.1
 Grb10
growth factor receptor bound protein 10
chr14_+_62837679 0.848 ENSMUST00000014691.8
 Wdfy2
WD repeat and FYVE domain containing 2
chr16_-_91618986 0.793 ENSMUST00000143058.1
ENSMUST00000049244.8
ENSMUST00000169982.1
ENSMUST00000133731.1
 Dnajc28



DnaJ (Hsp40) homolog, subfamily C, member 28



chr7_+_24271568 0.754 ENSMUST00000032696.6
 Zfp93
zinc finger protein 93
chr16_-_23520579 0.679 ENSMUST00000089883.5
 Masp1
mannan-binding lectin serine peptidase 1
chr1_-_133921393 0.650 ENSMUST00000048432.5
 Prelp
proline arginine-rich end leucine-rich repeat
chr9_-_79718720 0.626 ENSMUST00000121227.1
 Col12a1
collagen, type XII, alpha 1
chr9_-_79718518 0.626 ENSMUST00000071750.6
 Col12a1
collagen, type XII, alpha 1
chr11_-_62392605 0.606 ENSMUST00000151498.2
ENSMUST00000159069.1
 Ncor1

nuclear receptor co-repressor 1

chr14_+_116925379 0.577 ENSMUST00000088483.3
 Gpc6
glypican 6
chr9_-_79718631 0.567 ENSMUST00000180083.1
 Col12a1
collagen, type XII, alpha 1
chr7_+_75643223 0.563 ENSMUST00000137959.1
 Akap13
A kinase (PRKA) anchor protein 13
chr5_+_92809372 0.544 ENSMUST00000113054.2
 Shroom3
shroom family member 3
chr18_-_88927447 0.535 ENSMUST00000147313.1
 Socs6
suppressor of cytokine signaling 6
chr19_-_34527396 0.530 ENSMUST00000049572.8
ENSMUST00000178114.1
 Lipa

lysosomal acid lipase A

chr14_-_100149764 0.504 ENSMUST00000097079.4
 Klf12
Kruppel-like factor 12
chr2_+_25180737 0.485 ENSMUST00000104999.2
 Nrarp
Notch-regulated ankyrin repeat protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 83 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.3 GO:0048840 otolith development(GO:0048840)
0.4 1.1 GO:0010986 positive regulation of lipoprotein particle clearance(GO:0010986)
0.1 0.9 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 0.9 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.1 0.8 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.1 0.8 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.1 0.8 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.8 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 0.8 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.0 0.8 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.2 0.6 GO:0072362 regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072362)
0.0 0.5 GO:0014807 regulation of somitogenesis(GO:0014807)
0.0 0.5 GO:0048873 homeostasis of number of cells within a tissue(GO:0048873)
0.0 0.5 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 0.4 GO:0045075 interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.0 0.4 GO:0006958 complement activation, classical pathway(GO:0006958)
0.1 0.3 GO:0050929 corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260)
0.1 0.3 GO:0071492 cellular response to UV-A(GO:0071492)
0.1 0.3 GO:0033326 cerebrospinal fluid secretion(GO:0033326)
0.1 0.3 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 1.8 GO:0005595 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
0.0 1.3 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 0.9 GO:0001527 microfibril(GO:0001527)
0.0 0.9 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 0.8 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.8 GO:0030673 axolemma(GO:0030673)
0.0 0.7 GO:0016459 myosin complex(GO:0016459)
0.0 0.6 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.5 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.5 GO:0001772 immunological synapse(GO:0001772)
0.0 0.4 GO:0005581 collagen trimer(GO:0005581)
0.1 0.3 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.3 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.3 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.3 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 0.2 GO:0031673 H zone(GO:0031673)
0.0 0.2 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.2 GO:0043259 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)
0.0 0.2 GO:0070187 telosome(GO:0070187)
0.0 0.2 GO:0042612 MHC class I protein complex(GO:0042612)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.3 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.3 1.1 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.0 1.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.9 GO:0001784 phosphotyrosine binding(GO:0001784)
0.2 0.8 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.8 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.7 GO:0030507 spectrin binding(GO:0030507)
0.1 0.6 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.1 0.4 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 0.4 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.4 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 0.3 GO:0008384 IkappaB kinase activity(GO:0008384)
0.1 0.3 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 0.3 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.3 GO:0043237 laminin-1 binding(GO:0043237)
0.0 0.3 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.0 0.3 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.3 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.3 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.3 GO:0009982 pseudouridine synthase activity(GO:0009982)