Motif ID: Sox2

Z-value: 3.704


Transcription factors associated with Sox2:

Gene SymbolEntrez IDGene Name
Sox2 ENSMUSG00000074637.4 Sox2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox2mm10_v2_chr3_+_34649987_34650005-0.654.6e-05Click!


Activity profile for motif Sox2.

activity profile for motif Sox2


Sorted Z-values histogram for motif Sox2

Sorted Z-values for motif Sox2



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_143933204 24.432 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chrX_-_143933089 24.284 ENSMUST00000087313.3
 Dcx
doublecortin
chr17_-_79355082 23.950 ENSMUST00000068958.7
 Cdc42ep3
CDC42 effector protein (Rho GTPase binding) 3
chr11_-_98329641 22.323 ENSMUST00000041685.6
 Neurod2
neurogenic differentiation 2
chr10_+_29143996 20.762 ENSMUST00000092629.2
 Soga3
SOGA family member 3
chr10_+_80300997 20.090 ENSMUST00000140828.1
ENSMUST00000138909.1
 Apc2

adenomatosis polyposis coli 2

chr1_+_136131382 18.026 ENSMUST00000075164.4
 Kif21b
kinesin family member 21B
chr10_-_29144194 17.952 ENSMUST00000070359.2
 Gm9996
predicted gene 9996
chr10_-_84440591 13.942 ENSMUST00000020220.8
 Nuak1
NUAK family, SNF1-like kinase, 1
chr8_-_33747724 13.042 ENSMUST00000179364.1
 Smim18
small integral membrane protein 18
chr4_-_129121889 12.742 ENSMUST00000139450.1
ENSMUST00000125931.1
ENSMUST00000116444.2
 Hpca


hippocalcin


chr1_+_34579693 12.052 ENSMUST00000052670.8
 Amer3
APC membrane recruitment 3
chr8_-_69184177 11.995 ENSMUST00000185176.1
 Lzts1
leucine zipper, putative tumor suppressor 1
chr8_+_45507768 11.689 ENSMUST00000067065.7
ENSMUST00000098788.3
ENSMUST00000067107.7
ENSMUST00000171337.2
ENSMUST00000138049.1
ENSMUST00000141039.1
 Sorbs2





sorbin and SH3 domain containing 2





chr7_+_99466004 11.367 ENSMUST00000037359.2
 Klhl35
kelch-like 35
chr4_+_43406435 11.331 ENSMUST00000098106.2
ENSMUST00000139198.1
 Rusc2

RUN and SH3 domain containing 2

chr5_-_22344690 11.291 ENSMUST00000062372.7
ENSMUST00000161356.1
 Reln

reelin

chr1_-_12991109 11.083 ENSMUST00000115403.2
ENSMUST00000115402.1
 Slco5a1

solute carrier organic anion transporter family, member 5A1

chr7_-_74013676 11.060 ENSMUST00000026896.4
 St8sia2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr11_+_58948890 11.020 ENSMUST00000078267.3
 Hist3h2ba
histone cluster 3, H2ba

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 397 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.4 78.4 GO:0021819 layer formation in cerebral cortex(GO:0021819)
2.2 35.2 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
2.4 28.9 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
2.4 26.9 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.4 26.3 GO:0000045 autophagosome assembly(GO:0000045)
1.6 26.1 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
7.8 23.5 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.6 22.8 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 22.8 GO:0007018 microtubule-based movement(GO:0007018)
0.6 21.1 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
4.2 20.8 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.9 18.8 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.5 18.0 GO:0050919 negative chemotaxis(GO:0050919)
0.2 17.8 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
0.9 17.5 GO:0086036 regulation of cardiac muscle cell membrane potential(GO:0086036)
3.5 17.3 GO:0046684 response to pyrethroid(GO:0046684)
1.8 16.5 GO:0035881 amacrine cell differentiation(GO:0035881)
0.5 15.8 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
1.7 15.6 GO:0035507 regulation of myosin-light-chain-phosphatase activity(GO:0035507)
1.1 14.4 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 167 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 77.4 GO:0005874 microtubule(GO:0005874)
1.8 44.6 GO:0071565 nBAF complex(GO:0071565)
0.4 33.7 GO:0043198 dendritic shaft(GO:0043198)
3.1 31.4 GO:0045298 tubulin complex(GO:0045298)
1.3 26.9 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
1.2 26.7 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
2.2 22.3 GO:0044327 dendritic spine head(GO:0044327)
2.5 22.2 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.4 22.0 GO:0034704 calcium channel complex(GO:0034704)
0.3 21.3 GO:0005871 kinesin complex(GO:0005871)
2.3 20.8 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.4 19.9 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.2 19.6 GO:0005923 bicellular tight junction(GO:0005923)
1.5 19.4 GO:0016342 catenin complex(GO:0016342)
0.4 18.1 GO:0044295 axonal growth cone(GO:0044295)
1.1 17.3 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
2.4 17.1 GO:0031933 telomeric heterochromatin(GO:0031933)
0.4 16.3 GO:0031941 filamentous actin(GO:0031941)
0.4 15.1 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 14.9 GO:0005802 trans-Golgi network(GO:0005802)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 256 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 66.0 GO:0008270 zinc ion binding(GO:0008270)
0.0 54.6 GO:0044822 poly(A) RNA binding(GO:0044822)
0.1 54.1 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.3 49.2 GO:0008017 microtubule binding(GO:0008017)
2.0 48.7 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
1.1 34.4 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
1.7 31.3 GO:0034185 apolipoprotein binding(GO:0034185)
3.5 27.8 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.8 27.5 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.4 26.2 GO:0003777 microtubule motor activity(GO:0003777)
0.3 24.5 GO:0033613 activating transcription factor binding(GO:0033613)
0.6 21.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.3 19.9 GO:0061733 peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.2 19.6 GO:0017124 SH3 domain binding(GO:0017124)
0.0 18.5 GO:0005509 calcium ion binding(GO:0005509)
0.4 18.0 GO:0070888 E-box binding(GO:0070888)
2.5 17.4 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.8 17.4 GO:0001784 phosphotyrosine binding(GO:0001784)
0.5 17.4 GO:0004364 glutathione transferase activity(GO:0004364)
0.8 17.3 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)