Motif ID: Sox21

Z-value: 0.680


Transcription factors associated with Sox21:

Gene SymbolEntrez IDGene Name
Sox21 ENSMUSG00000061517.7 Sox21

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox21mm10_v2_chr14_-_118237016_1182370350.522.0e-03Click!


Activity profile for motif Sox21.

activity profile for motif Sox21


Sorted Z-values histogram for motif Sox21

Sorted Z-values for motif Sox21



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox21

PNG image of the network

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Top targets:


Showing 1 to 20 of 106 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_-_15403680 8.226 ENSMUST00000079081.6
 Aqp4
aquaporin 4
chr5_-_70842617 4.924 ENSMUST00000031119.1
 Gabrg1
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chr1_-_135167606 3.680 ENSMUST00000027682.8
 Gpr37l1
G protein-coupled receptor 37-like 1
chr11_-_79504078 3.196 ENSMUST00000164465.2
 Omg
oligodendrocyte myelin glycoprotein
chrM_-_14060 3.146 ENSMUST00000082419.1
 mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr2_-_73312701 3.029 ENSMUST00000058615.9
 Cir1
corepressor interacting with RBPJ, 1
chr11_+_32000452 2.685 ENSMUST00000020537.2
ENSMUST00000109409.1
 Nsg2

neuron specific gene family member 2

chr13_-_85127514 2.165 ENSMUST00000179230.1
 Gm4076
predicted gene 4076
chr2_-_147186389 2.147 ENSMUST00000109970.3
ENSMUST00000067075.5
 Nkx2-2

NK2 homeobox 2

chr9_-_79793378 2.100 ENSMUST00000034878.5
 Tmem30a
transmembrane protein 30A
chr5_+_19907502 2.098 ENSMUST00000101558.3
 Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr9_-_79793507 2.052 ENSMUST00000120690.1
 Tmem30a
transmembrane protein 30A
chr12_+_38783503 1.986 ENSMUST00000159334.1
 Etv1
ets variant gene 1
chr8_-_45410539 1.899 ENSMUST00000034056.4
ENSMUST00000167106.1
 Tlr3

toll-like receptor 3

chr10_+_42860776 1.866 ENSMUST00000105494.1
 Scml4
sex comb on midleg-like 4 (Drosophila)
chr8_+_93810832 1.787 ENSMUST00000034198.8
ENSMUST00000125716.1
 Gnao1

guanine nucleotide binding protein, alpha O

chrM_+_14138 1.692 ENSMUST00000082421.1
 mt-Cytb
mitochondrially encoded cytochrome b
chr2_+_136713444 1.667 ENSMUST00000028727.4
ENSMUST00000110098.3
 Snap25

synaptosomal-associated protein 25

chr7_+_28277706 1.656 ENSMUST00000094651.2
 Eid2b
EP300 interacting inhibitor of differentiation 2B
chr1_-_125913101 1.576 ENSMUST00000161361.1
 Lypd1
Ly6/Plaur domain containing 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 8.2 GO:0070295 renal water absorption(GO:0070295)
0.6 5.0 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.2 4.9 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.7 4.2 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.2 4.2 GO:0048268 clathrin coat assembly(GO:0048268)
0.3 3.7 GO:0021940 positive regulation of cerebellar granule cell precursor proliferation(GO:0021940)
0.2 3.6 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.7 2.1 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.1 2.0 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 2.0 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.6 1.9 GO:0045349 regulation of dendritic cell cytokine production(GO:0002730) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.1 1.8 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.3 1.7 GO:0033762 response to glucagon(GO:0033762)
0.1 1.7 GO:0099500 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.1 1.6 GO:0095500 synaptic transmission, cholinergic(GO:0007271) acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.1 1.5 GO:0001504 neurotransmitter uptake(GO:0001504)
0.0 1.4 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.1 1.3 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.2 1.2 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.2 1.2 GO:0003406 retinal pigment epithelium development(GO:0003406)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.4 GO:0009925 basal plasma membrane(GO:0009925)
0.3 4.9 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 4.8 GO:0031225 anchored component of membrane(GO:0031225)
0.1 4.5 GO:0070469 respiratory chain(GO:0070469)
0.7 3.5 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 3.1 GO:0016607 nuclear speck(GO:0016607)
0.0 3.1 GO:0043235 receptor complex(GO:0043235)
0.0 2.3 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 1.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.4 1.7 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.2 1.7 GO:0045275 respiratory chain complex III(GO:0045275)
0.0 1.5 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 1.5 GO:0042734 presynaptic membrane(GO:0042734)
0.1 1.1 GO:0008290 F-actin capping protein complex(GO:0008290)
0.1 1.1 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.9 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.6 GO:0034707 chloride channel complex(GO:0034707)
0.2 0.5 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.2 0.5 GO:0070939 Dsl1p complex(GO:0070939)
0.1 0.4 GO:0030870 Mre11 complex(GO:0030870)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 8.2 GO:0015288 porin activity(GO:0015288)
0.3 4.9 GO:0050811 GABA-A receptor activity(GO:0004890) GABA receptor binding(GO:0050811)
0.1 4.5 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.7 4.2 GO:0032051 clathrin light chain binding(GO:0032051)
0.1 3.7 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.6 3.5 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 3.1 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 3.0 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 1.9 GO:0003725 double-stranded RNA binding(GO:0003725)
0.3 1.8 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.2 1.7 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 1.7 GO:0017075 syntaxin-1 binding(GO:0017075)
0.2 1.6 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.1 1.5 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 1.5 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.3 1.3 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 1.3 GO:0001540 beta-amyloid binding(GO:0001540)
0.2 1.2 GO:0018121 imidazoleglycerol-phosphate synthase activity(GO:0000107) NAD(P)-cysteine ADP-ribosyltransferase activity(GO:0018071) NAD(P)-asparagine ADP-ribosyltransferase activity(GO:0018121) NAD(P)-serine ADP-ribosyltransferase activity(GO:0018127) 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity(GO:0043867) purine deoxyribosyltransferase activity(GO:0044102)
0.4 1.1 GO:0052740 phosphatidylserine 1-acylhydrolase activity(GO:0052739) 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.1 1.1 GO:0015129 lactate transmembrane transporter activity(GO:0015129)