Motif ID: Sox3_Sox10

Z-value: 2.613

Transcription factors associated with Sox3_Sox10:

Gene SymbolEntrez IDGene Name
Sox10 ENSMUSG00000033006.9 Sox10
Sox3 ENSMUSG00000045179.8 Sox3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox10mm10_v2_chr15_-_79164477_79164496-0.484.2e-03Click!
Sox3mm10_v2_chrX_-_60893430_60893440-0.281.2e-01Click!


Activity profile for motif Sox3_Sox10.

activity profile for motif Sox3_Sox10


Sorted Z-values histogram for motif Sox3_Sox10

Sorted Z-values for motif Sox3_Sox10



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox3_Sox10

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_79355082 27.277 ENSMUST00000068958.7
 Cdc42ep3
CDC42 effector protein (Rho GTPase binding) 3
chr11_-_98329641 26.103 ENSMUST00000041685.6
 Neurod2
neurogenic differentiation 2
chrX_-_143933204 24.691 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr8_-_84773381 23.002 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chrX_-_143933089 22.755 ENSMUST00000087313.3
 Dcx
doublecortin
chr18_-_43059418 20.446 ENSMUST00000025377.7
 Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr11_+_67586520 18.698 ENSMUST00000108682.2
 Gas7
growth arrest specific 7
chr18_+_37484955 18.582 ENSMUST00000053856.4
 Pcdhb17
protocadherin beta 17
chr4_-_82705735 17.984 ENSMUST00000155821.1
 Nfib
nuclear factor I/B
chr10_+_29143996 16.550 ENSMUST00000092629.2
 Soga3
SOGA family member 3
chr1_+_34579693 16.532 ENSMUST00000052670.8
 Amer3
APC membrane recruitment 3
chr10_-_29144194 16.494 ENSMUST00000070359.2
 Gm9996
predicted gene 9996
chr13_-_14523178 16.005 ENSMUST00000110516.2
 Hecw1
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
chr2_-_156312470 15.990 ENSMUST00000079125.6
 Scand1
SCAN domain-containing 1
chr9_+_112234257 14.610 ENSMUST00000149308.3
ENSMUST00000144424.2
ENSMUST00000139552.2
 2900079G21Rik


RIKEN cDNA 2900079G21 gene


chr1_+_136131382 13.973 ENSMUST00000075164.4
 Kif21b
kinesin family member 21B
chr11_+_67586675 13.971 ENSMUST00000108680.1
 Gas7
growth arrest specific 7
chr6_+_51432663 12.592 ENSMUST00000005103.5
 Nfe2l3
nuclear factor, erythroid derived 2, like 3
chr5_+_33983437 12.363 ENSMUST00000114384.1
ENSMUST00000094869.5
ENSMUST00000114383.1
 Gm1673


predicted gene 1673


chr10_+_80300997 12.215 ENSMUST00000140828.1
ENSMUST00000138909.1
 Apc2

adenomatosis polyposis coli 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 329 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 68.6 GO:0021819 layer formation in cerebral cortex(GO:0021819)
2.4 38.4 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
2.7 32.1 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.2 28.1 GO:0007018 microtubule-based movement(GO:0007018)
9.3 27.8 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.2 25.8 GO:0030041 actin filament polymerization(GO:0030041)
0.3 22.9 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
1.6 22.3 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
1.2 21.3 GO:0031280 negative regulation of cyclase activity(GO:0031280)
2.9 20.4 GO:0034047 regulation of protein phosphatase type 2A activity(GO:0034047)
0.3 20.3 GO:0001578 microtubule bundle formation(GO:0001578)
0.2 19.9 GO:0010506 regulation of autophagy(GO:0010506)
0.3 18.6 GO:0000045 autophagosome assembly(GO:0000045)
4.5 18.0 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
3.2 15.9 GO:0046684 response to pyrethroid(GO:0046684)
0.8 15.4 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
5.1 15.2 GO:0042560 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
0.1 14.6 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.1 13.8 GO:0048813 dendrite morphogenesis(GO:0048813)
3.4 13.6 GO:1904529 regulation of actin filament binding(GO:1904529) regulation of actin binding(GO:1904616)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 134 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 101.2 GO:0030425 dendrite(GO:0030425)
1.8 44.7 GO:0071565 nBAF complex(GO:0071565)
3.5 34.9 GO:0045298 tubulin complex(GO:0045298)
0.6 27.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.3 25.5 GO:0005884 actin filament(GO:0005884)
0.5 24.9 GO:0031941 filamentous actin(GO:0031941)
2.7 24.4 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.4 24.2 GO:0005871 kinesin complex(GO:0005871)
1.5 24.1 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
1.2 22.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.2 18.4 GO:0043195 terminal bouton(GO:0043195)
0.9 18.0 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.2 16.6 GO:0043198 dendritic shaft(GO:0043198)
4.1 16.3 GO:0044307 dendritic branch(GO:0044307)
0.2 16.1 GO:0042734 presynaptic membrane(GO:0042734)
0.3 14.1 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.2 14.1 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.3 13.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.3 12.0 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.2 12.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 235 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 59.1 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.3 47.9 GO:0008017 microtubule binding(GO:0008017)
1.9 46.4 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
1.8 42.1 GO:0034185 apolipoprotein binding(GO:0034185)
3.5 28.4 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
1.2 28.3 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.4 25.4 GO:0003777 microtubule motor activity(GO:0003777)
0.1 22.5 GO:0003779 actin binding(GO:0003779)
1.0 21.3 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
1.5 20.4 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.8 18.4 GO:0017049 GTP-Rho binding(GO:0017049)
0.4 17.6 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
3.5 17.3 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
1.2 16.4 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.3 15.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.4 15.4 GO:0017091 AU-rich element binding(GO:0017091)
5.1 15.2 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
1.2 15.0 GO:0031005 filamin binding(GO:0031005)
0.1 14.7 GO:0017124 SH3 domain binding(GO:0017124)
0.4 14.6 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)