Motif ID: Sox5_Sry

Z-value: 2.015

Transcription factors associated with Sox5_Sry:

Gene SymbolEntrez IDGene Name
Sox5 ENSMUSG00000041540.10 Sox5
Sry ENSMUSG00000069036.3 Sry

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox5mm10_v2_chr6_-_144209558_1442096470.771.3e-07Click!


Activity profile for motif Sox5_Sry.

activity profile for motif Sox5_Sry


Sorted Z-values histogram for motif Sox5_Sry

Sorted Z-values for motif Sox5_Sry



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox5_Sry

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_98329641 38.520 ENSMUST00000041685.6
 Neurod2
neurogenic differentiation 2
chr8_-_84773381 21.426 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr4_-_82505274 20.096 ENSMUST00000050872.8
ENSMUST00000064770.2
 Nfib

nuclear factor I/B

chr5_+_17574268 17.296 ENSMUST00000030568.7
 Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr12_+_29528382 17.097 ENSMUST00000049784.9
 Myt1l
myelin transcription factor 1-like
chr4_-_82505749 17.088 ENSMUST00000107245.2
ENSMUST00000107246.1
 Nfib

nuclear factor I/B

chr4_-_82505707 16.106 ENSMUST00000107248.1
ENSMUST00000107247.1
 Nfib

nuclear factor I/B

chr9_-_49798729 14.655 ENSMUST00000166811.2
 Ncam1
neural cell adhesion molecule 1
chr4_-_129121889 12.822 ENSMUST00000139450.1
ENSMUST00000125931.1
ENSMUST00000116444.2
 Hpca


hippocalcin


chr18_-_43059418 11.325 ENSMUST00000025377.7
 Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr10_+_69706326 10.998 ENSMUST00000182992.1
 Ank3
ankyrin 3, epithelial
chr1_+_19103022 10.679 ENSMUST00000037294.7
 Tfap2d
transcription factor AP-2, delta
chr3_+_95160449 10.608 ENSMUST00000090823.1
ENSMUST00000090821.3
 Sema6c

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C

chr3_+_18054258 10.427 ENSMUST00000026120.6
 Bhlhe22
basic helix-loop-helix family, member e22
chr18_+_69593361 10.389 ENSMUST00000114978.2
ENSMUST00000114977.1
 Tcf4

transcription factor 4

chr18_+_69344503 10.382 ENSMUST00000114985.3
 Tcf4
transcription factor 4
chr3_+_127633134 8.902 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chr1_+_143640664 8.851 ENSMUST00000038252.2
 B3galt2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr9_-_49798905 8.609 ENSMUST00000114476.2
 Ncam1
neural cell adhesion molecule 1
chrX_+_93654863 8.563 ENSMUST00000113933.2
 Pcyt1b
phosphate cytidylyltransferase 1, choline, beta isoform

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 152 entries
Log-likelihood per target Total log-likelihoodTermDescription
14.6 58.5 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
12.8 38.5 GO:2000297 negative regulation of synapse maturation(GO:2000297)
2.9 31.8 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
1.9 27.2 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
7.8 23.3 GO:0001928 regulation of exocyst assembly(GO:0001928)
2.1 20.8 GO:0042118 endothelial cell activation(GO:0042118)
0.5 18.5 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843)
2.5 17.3 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.8 15.0 GO:0021860 pyramidal neuron development(GO:0021860)
4.3 12.8 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.3 11.9 GO:0006376 mRNA splice site selection(GO:0006376)
1.6 11.3 GO:0034047 regulation of protein phosphatase type 2A activity(GO:0034047)
1.7 10.4 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.4 10.3 GO:0030204 chondroitin sulfate metabolic process(GO:0030204)
0.6 8.9 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.3 8.6 GO:0060074 synapse maturation(GO:0060074)
2.1 8.3 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
1.0 8.2 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.1 7.9 GO:0043488 regulation of mRNA stability(GO:0043488)
1.1 7.8 GO:1900194 negative regulation of oocyte maturation(GO:1900194)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 77 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.8 58.5 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.3 35.9 GO:0031225 anchored component of membrane(GO:0031225)
1.6 31.8 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
1.3 12.8 GO:0044327 dendritic spine head(GO:0044327)
0.0 11.6 GO:0005874 microtubule(GO:0005874)
0.6 11.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 9.8 GO:0030054 cell junction(GO:0030054)
0.7 8.8 GO:0042788 polysomal ribosome(GO:0042788)
0.1 8.3 GO:0030425 dendrite(GO:0030425)
0.5 7.3 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.2 7.3 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 6.6 GO:0005802 trans-Golgi network(GO:0005802)
0.0 6.5 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
1.5 6.1 GO:0097165 nuclear stress granule(GO:0097165)
1.5 6.0 GO:0031673 H zone(GO:0031673)
0.0 6.0 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.5 5.6 GO:0005677 chromatin silencing complex(GO:0005677)
1.0 4.9 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 4.9 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 4.5 GO:0016363 nuclear matrix(GO:0016363)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 95 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 51.5 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
1.2 35.8 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.9 34.9 GO:0070888 E-box binding(GO:0070888)
1.3 25.6 GO:0030275 LRR domain binding(GO:0030275)
5.2 20.8 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
2.5 20.2 GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.1 19.3 GO:0008017 microtubule binding(GO:0008017)
0.6 18.5 GO:0030215 semaphorin receptor binding(GO:0030215)
1.6 17.3 GO:0038191 neuropilin binding(GO:0038191)
0.6 15.0 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.4 14.9 GO:0017091 AU-rich element binding(GO:0017091)
0.8 11.3 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.2 10.1 GO:0044824 integrase activity(GO:0008907) T/G mismatch-specific endonuclease activity(GO:0043765) retroviral integrase activity(GO:0044823) retroviral 3' processing activity(GO:0044824)
0.1 9.8 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 9.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 9.2 GO:0051117 ATPase binding(GO:0051117)
1.7 8.6 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
1.2 8.4 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.5 5.9 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 5.9 GO:0061630 ubiquitin protein ligase activity(GO:0061630)