Motif ID: Sox6_Sox9

Z-value: 0.648

Transcription factors associated with Sox6_Sox9:

Gene SymbolEntrez IDGene Name
Sox6 ENSMUSG00000051910.7 Sox6
Sox9 ENSMUSG00000000567.5 Sox9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox9mm10_v2_chr11_+_112782182_112782248-0.475.9e-03Click!
Sox6mm10_v2_chr7_-_116038734_116038750-0.144.3e-01Click!


Activity profile for motif Sox6_Sox9.

activity profile for motif Sox6_Sox9


Sorted Z-values histogram for motif Sox6_Sox9

Sorted Z-values for motif Sox6_Sox9



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox6_Sox9

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_29528382 6.062 ENSMUST00000049784.9
 Myt1l
myelin transcription factor 1-like
chr11_-_98329641 6.000 ENSMUST00000041685.6
 Neurod2
neurogenic differentiation 2
chr8_-_84773381 3.807 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr18_-_43059418 3.080 ENSMUST00000025377.7
 Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr17_-_79355082 3.077 ENSMUST00000068958.7
 Cdc42ep3
CDC42 effector protein (Rho GTPase binding) 3
chr18_+_37484955 3.034 ENSMUST00000053856.4
 Pcdhb17
protocadherin beta 17
chr17_+_55445550 2.890 ENSMUST00000025000.3
 St6gal2
beta galactoside alpha 2,6 sialyltransferase 2
chr10_-_29144194 2.616 ENSMUST00000070359.2
 Gm9996
predicted gene 9996
chr5_+_3928033 2.388 ENSMUST00000143365.1
 Akap9
A kinase (PRKA) anchor protein (yotiao) 9
chr7_+_96210107 2.365 ENSMUST00000138760.1
 Tenm4
teneurin transmembrane protein 4
chr5_+_66968416 2.270 ENSMUST00000038188.7
 Limch1
LIM and calponin homology domains 1
chr10_+_69534039 2.268 ENSMUST00000182557.1
 Ank3
ankyrin 3, epithelial
chr11_+_67586520 2.260 ENSMUST00000108682.2
 Gas7
growth arrest specific 7
chr1_-_56972437 2.249 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2
chr10_+_29143996 2.224 ENSMUST00000092629.2
 Soga3
SOGA family member 3
chr5_+_66968559 2.222 ENSMUST00000127184.1
 Limch1
LIM and calponin homology domains 1
chr10_-_83534130 2.083 ENSMUST00000020497.7
 Aldh1l2
aldehyde dehydrogenase 1 family, member L2
chr5_+_3928267 2.061 ENSMUST00000044492.8
 Akap9
A kinase (PRKA) anchor protein (yotiao) 9
chr2_+_37516618 1.942 ENSMUST00000065441.6
 Gpr21
G protein-coupled receptor 21
chr5_-_131538687 1.915 ENSMUST00000161374.1
 Auts2
autism susceptibility candidate 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 137 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 6.6 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.3 4.4 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.4 4.1 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.3 3.8 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.8 3.1 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.4 3.1 GO:0034047 regulation of protein phosphatase type 2A activity(GO:0034047)
0.3 3.1 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.2 3.1 GO:0021819 layer formation in cerebral cortex(GO:0021819)
0.1 2.9 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.9 2.8 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.0 2.8 GO:0007019 microtubule depolymerization(GO:0007019)
0.1 2.5 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.6 2.4 GO:0032289 central nervous system myelin formation(GO:0032289) cardiac cell fate specification(GO:0060912)
0.2 2.3 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 2.3 GO:0030041 actin filament polymerization(GO:0030041)
0.0 2.2 GO:0010506 regulation of autophagy(GO:0010506)
0.7 2.1 GO:0042560 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
0.4 2.1 GO:0046684 response to pyrethroid(GO:0046684)
0.0 2.0 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
0.0 2.0 GO:0030705 cytoskeleton-dependent intracellular transport(GO:0030705)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 4.4 GO:0044307 dendritic branch(GO:0044307)
1.0 4.1 GO:0097165 nuclear stress granule(GO:0097165)
0.8 3.1 GO:0043259 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)
0.2 3.1 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 3.1 GO:0005884 actin filament(GO:0005884)
0.0 3.1 GO:0060076 excitatory synapse(GO:0060076)
0.0 2.6 GO:0005871 kinesin complex(GO:0005871)
0.1 2.3 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 2.1 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 1.9 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 1.5 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.2 1.4 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0 1.4 GO:0005923 bicellular tight junction(GO:0005923)
0.1 1.3 GO:0001739 sex chromatin(GO:0001739)
0.0 1.3 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 1.3 GO:0009925 basal plasma membrane(GO:0009925)
0.1 1.2 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 1.2 GO:0016363 nuclear matrix(GO:0016363)
0.0 1.1 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.1 1.0 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 86 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 6.1 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.2 4.9 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.8 4.1 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.1 4.1 GO:0017091 AU-rich element binding(GO:0017091)
0.0 3.4 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.0 3.3 GO:0008017 microtubule binding(GO:0008017)
0.1 3.2 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.4 3.1 GO:0043208 glycosphingolipid binding(GO:0043208)
0.2 3.1 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.1 3.1 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 3.1 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 3.0 GO:0070888 E-box binding(GO:0070888)
0.0 2.7 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 2.6 GO:0003777 microtubule motor activity(GO:0003777)
0.4 2.5 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1 2.5 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.7 2.1 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.1 2.1 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.6 1.9 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.0 1.9 GO:0005267 potassium channel activity(GO:0005267)