Motif ID: Sp1

Z-value: 1.922


Transcription factors associated with Sp1:

Gene SymbolEntrez IDGene Name
Sp1 ENSMUSG00000001280.6 Sp1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sp1mm10_v2_chr15_+_102406143_1024063800.383.0e-02Click!


Activity profile for motif Sp1.

activity profile for motif Sp1


Sorted Z-values histogram for motif Sp1

Sorted Z-values for motif Sp1



Network of associatons between targets according to the STRING database.



First level regulatory network of Sp1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_25769033 12.838 ENSMUST00000069180.7
 Zcchc24
zinc finger, CCHC domain containing 24
chr2_+_172345565 12.506 ENSMUST00000028995.4
 Fam210b
family with sequence similarity 210, member B
chr11_+_78322965 12.407 ENSMUST00000017534.8
 Aldoc
aldolase C, fructose-bisphosphate
chr8_-_84800024 11.954 ENSMUST00000126806.1
ENSMUST00000076715.6
 Nfix

nuclear factor I/X

chr9_+_80165079 10.408 ENSMUST00000184480.1
 Myo6
myosin VI
chr12_-_100725028 10.113 ENSMUST00000043599.6
 Rps6ka5
ribosomal protein S6 kinase, polypeptide 5
chr4_-_148130678 9.885 ENSMUST00000030862.4
 Draxin
dorsal inhibitory axon guidance protein
chr2_-_73386396 9.875 ENSMUST00000112044.1
ENSMUST00000112043.1
ENSMUST00000076463.5
 Gpr155


G protein-coupled receptor 155


chr3_-_88000350 9.825 ENSMUST00000090971.5
 Bcan
brevican
chr8_-_29219338 9.480 ENSMUST00000168630.2
 Unc5d
unc-5 homolog D (C. elegans)
chr7_-_79149042 9.408 ENSMUST00000032825.8
ENSMUST00000107409.3
 Mfge8

milk fat globule-EGF factor 8 protein

chr9_+_80165013 9.372 ENSMUST00000035889.8
ENSMUST00000113268.1
 Myo6

myosin VI

chr3_+_105452326 9.153 ENSMUST00000098761.3
 Kcnd3
potassium voltage-gated channel, Shal-related family, member 3
chr5_-_109558957 9.119 ENSMUST00000044579.7
 Crlf2
cytokine receptor-like factor 2
chr15_+_81811414 8.849 ENSMUST00000023024.7
 Tef
thyrotroph embryonic factor
chr12_+_12262139 8.774 ENSMUST00000069066.6
ENSMUST00000069005.8
 Fam49a

family with sequence similarity 49, member A

chr9_+_44043384 8.663 ENSMUST00000114840.1
 Thy1
thymus cell antigen 1, theta
chr7_+_57591147 8.435 ENSMUST00000039697.7
 Gabrb3
gamma-aminobutyric acid (GABA) A receptor, subunit beta 3
chr6_+_114131229 8.367 ENSMUST00000032451.7
 Slc6a11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr14_+_21500879 8.344 ENSMUST00000182964.1
 Kat6b
K(lysine) acetyltransferase 6B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 962 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 25.7 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.9 24.5 GO:0030204 chondroitin sulfate metabolic process(GO:0030204)
0.6 23.3 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
1.8 23.1 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
0.7 22.4 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.9 20.1 GO:0071625 vocalization behavior(GO:0071625)
0.4 19.4 GO:0030517 negative regulation of axon extension(GO:0030517)
0.2 19.3 GO:0071805 potassium ion transmembrane transport(GO:0071805)
3.2 19.1 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
3.8 18.8 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441)
1.4 18.2 GO:0071257 cellular response to electrical stimulus(GO:0071257)
1.3 17.8 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.8 17.2 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
2.4 17.0 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.9 15.9 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
2.4 14.5 GO:0014053 negative regulation of gamma-aminobutyric acid secretion(GO:0014053)
0.5 14.1 GO:0006491 N-glycan processing(GO:0006491)
1.4 14.0 GO:0010459 negative regulation of heart rate(GO:0010459)
3.4 13.8 GO:1903288 regulation of potassium ion import(GO:1903286) positive regulation of potassium ion import(GO:1903288)
1.4 13.8 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 264 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 413.9 GO:0016021 integral component of membrane(GO:0016021)
0.3 52.2 GO:0045211 postsynaptic membrane(GO:0045211)
0.2 50.3 GO:0000139 Golgi membrane(GO:0000139)
0.4 43.7 GO:0031225 anchored component of membrane(GO:0031225)
0.4 42.7 GO:0055037 recycling endosome(GO:0055037)
0.3 40.4 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.3 34.3 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
1.4 33.7 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.9 31.4 GO:0032809 neuronal cell body membrane(GO:0032809)
1.0 30.0 GO:0060077 inhibitory synapse(GO:0060077)
0.2 27.0 GO:0030133 transport vesicle(GO:0030133)
0.5 25.4 GO:0045335 phagocytic vesicle(GO:0045335)
0.8 22.0 GO:0048786 presynaptic active zone(GO:0048786)
0.1 20.6 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.7 20.3 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.4 19.7 GO:0005905 clathrin-coated pit(GO:0005905)
0.7 19.5 GO:0043194 axon initial segment(GO:0043194)
1.4 18.0 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.4 17.9 GO:0031901 early endosome membrane(GO:0031901)
1.8 17.5 GO:0044327 dendritic spine head(GO:0044327)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 552 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 53.7 GO:0005096 GTPase activator activity(GO:0005096)
0.3 44.1 GO:0017124 SH3 domain binding(GO:0017124)
1.6 35.9 GO:0034185 apolipoprotein binding(GO:0034185)
0.1 34.9 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.2 26.3 GO:0051015 actin filament binding(GO:0051015)
0.6 26.2 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.2 23.8 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.6 20.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.4 20.8 GO:0005262 calcium channel activity(GO:0005262)
2.2 19.4 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.6 18.3 GO:0001540 beta-amyloid binding(GO:0001540)
0.4 17.8 GO:0045296 cadherin binding(GO:0045296)
0.5 17.4 GO:0017080 sodium channel regulator activity(GO:0017080)
0.5 17.1 GO:0005246 calcium channel regulator activity(GO:0005246)
2.8 16.7 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.8 16.4 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.9 15.6 GO:0004890 GABA-A receptor activity(GO:0004890) GABA receptor activity(GO:0016917)
0.9 15.4 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.4 14.9 GO:0030215 semaphorin receptor binding(GO:0030215)
2.9 14.4 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)