Motif ID: Sp2

Z-value: 0.721


Transcription factors associated with Sp2:

Gene SymbolEntrez IDGene Name
Sp2 ENSMUSG00000018678.6 Sp2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sp2mm10_v2_chr11_-_96968655_96968673-0.105.8e-01Click!


Activity profile for motif Sp2.

activity profile for motif Sp2


Sorted Z-values histogram for motif Sp2

Sorted Z-values for motif Sp2



Network of associatons between targets according to the STRING database.



First level regulatory network of Sp2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_87948666 9.602 ENSMUST00000005019.5
 Crabp2
cellular retinoic acid binding protein II
chr12_+_112644828 3.201 ENSMUST00000021728.4
ENSMUST00000109755.3
 Siva1

SIVA1, apoptosis-inducing factor

chr1_+_72824482 2.482 ENSMUST00000047328.4
 Igfbp2
insulin-like growth factor binding protein 2
chrX_-_133688978 2.371 ENSMUST00000149154.1
ENSMUST00000167944.1
 Pcdh19

protocadherin 19

chr1_+_131962941 2.301 ENSMUST00000177943.1
 Slc45a3
solute carrier family 45, member 3
chr17_+_23679363 2.249 ENSMUST00000024699.2
 Cldn6
claudin 6
chr7_-_110061319 2.143 ENSMUST00000098110.2
 AA474408
expressed sequence AA474408
chr2_-_92370999 2.125 ENSMUST00000176810.1
ENSMUST00000090582.4
 Gyltl1b

glycosyltransferase-like 1B

chr2_-_120154600 1.946 ENSMUST00000028755.7
 Ehd4
EH-domain containing 4
chr2_-_92371039 1.890 ENSMUST00000068586.6
 Gyltl1b
glycosyltransferase-like 1B
chrX_-_48034842 1.881 ENSMUST00000039026.7
 Apln
apelin
chr10_-_103028771 1.809 ENSMUST00000040859.5
 Alx1
ALX homeobox 1
chr2_+_38339258 1.806 ENSMUST00000143783.2
 Lhx2
LIM homeobox protein 2
chr10_+_128194446 1.756 ENSMUST00000044776.6
 Gls2
glutaminase 2 (liver, mitochondrial)
chr6_-_82774448 1.749 ENSMUST00000000642.4
 Hk2
hexokinase 2
chr10_-_103029043 1.729 ENSMUST00000167156.2
 Alx1
ALX homeobox 1
chr2_-_92370968 1.727 ENSMUST00000176774.1
 Gyltl1b
glycosyltransferase-like 1B
chr4_-_117133953 1.695 ENSMUST00000076859.5
 Plk3
polo-like kinase 3
chr4_+_3938888 1.623 ENSMUST00000121110.1
ENSMUST00000108386.1
ENSMUST00000149544.1
 Chchd7


coiled-coil-helix-coiled-coil-helix domain containing 7


chr10_-_128565827 1.556 ENSMUST00000131728.1
ENSMUST00000026425.6
 Pa2g4

proliferation-associated 2G4


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 207 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 10.7 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.4 5.7 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.1 3.5 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.2 3.0 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.1 2.7 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.2 2.5 GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901030)
0.2 2.5 GO:0002227 innate immune response in mucosa(GO:0002227)
0.0 2.4 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.8 2.3 GO:0015772 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.0 2.2 GO:0043966 histone H3 acetylation(GO:0043966)
0.3 2.1 GO:0045989 positive regulation of striated muscle contraction(GO:0045989)
0.7 2.0 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.2 2.0 GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.6 1.9 GO:0000087 mitotic M phase(GO:0000087)
0.3 1.9 GO:0031652 positive regulation of heat generation(GO:0031652)
0.2 1.9 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.1 1.9 GO:0006907 pinocytosis(GO:0006907)
0.4 1.8 GO:0006543 glutamine catabolic process(GO:0006543)
0.2 1.8 GO:0045199 maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.6 1.7 GO:1901228 positive regulation of transcription from RNA polymerase II promoter involved in heart development(GO:1901228)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 105 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 3.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 3.1 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 2.5 GO:0005840 ribosome(GO:0005840)
0.2 2.1 GO:0034709 methylosome(GO:0034709)
0.1 2.1 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 1.9 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 1.8 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 1.8 GO:0045120 pronucleus(GO:0045120)
0.1 1.8 GO:0002102 podosome(GO:0002102)
0.0 1.8 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.2 1.7 GO:0034719 SMN-Sm protein complex(GO:0034719)
0.0 1.6 GO:0055038 recycling endosome membrane(GO:0055038)
0.5 1.5 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.3 1.5 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.0 1.5 GO:0000502 proteasome complex(GO:0000502)
0.0 1.5 GO:0072562 blood microparticle(GO:0072562)
0.0 1.5 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.2 1.4 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 1.4 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 147 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 9.6 GO:0019841 retinol binding(GO:0019841)
0.0 8.7 GO:0003735 structural constituent of ribosome(GO:0003735)
1.1 5.7 GO:0018121 imidazoleglycerol-phosphate synthase activity(GO:0000107) NAD(P)-cysteine ADP-ribosyltransferase activity(GO:0018071) NAD(P)-asparagine ADP-ribosyltransferase activity(GO:0018121) NAD(P)-serine ADP-ribosyltransferase activity(GO:0018127) 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity(GO:0043867) purine deoxyribosyltransferase activity(GO:0044102)
0.1 4.6 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 4.4 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987)
0.0 3.6 GO:0002039 p53 binding(GO:0002039)
0.0 3.5 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 3.0 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 2.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.3 2.5 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.8 2.3 GO:0008515 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.1 2.0 GO:0001848 complement binding(GO:0001848)
0.1 2.0 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.2 1.9 GO:0001618 virus receptor activity(GO:0001618)
0.2 1.9 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.1 1.9 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.4 1.8 GO:0004359 glutaminase activity(GO:0004359)
0.1 1.8 GO:0070410 co-SMAD binding(GO:0070410)
0.1 1.8 GO:0003746 translation elongation factor activity(GO:0003746)
0.3 1.7 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)