Motif ID: Spdef

Z-value: 0.548


Transcription factors associated with Spdef:

Gene SymbolEntrez IDGene Name
Spdef ENSMUSG00000024215.7 Spdef

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Spdefmm10_v2_chr17_-_27728889_277289560.029.0e-01Click!


Activity profile for motif Spdef.

activity profile for motif Spdef


Sorted Z-values histogram for motif Spdef

Sorted Z-values for motif Spdef



Network of associatons between targets according to the STRING database.



First level regulatory network of Spdef

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_34861200 2.192 ENSMUST00000165033.1
 Egr1
early growth response 1
chr14_+_54936456 2.132 ENSMUST00000037814.6
 Cmtm5
CKLF-like MARVEL transmembrane domain containing 5
chr14_+_54254124 1.810 ENSMUST00000180359.1
 Abhd4
abhydrolase domain containing 4
chr15_-_37458523 1.578 ENSMUST00000116445.2
 Ncald
neurocalcin delta
chr3_+_27938638 1.565 ENSMUST00000120834.1
 Pld1
phospholipase D1
chr4_+_3678108 1.548 ENSMUST00000041377.6
ENSMUST00000103010.3
 Lyn

Yamaguchi sarcoma viral (v-yes-1) oncogene homolog

chr11_+_78176711 1.528 ENSMUST00000098545.5
 Tlcd1
TLC domain containing 1
chr10_-_58675631 1.518 ENSMUST00000003312.4
 Edar
ectodysplasin-A receptor
chr8_-_124569696 1.315 ENSMUST00000063278.6
 Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr14_-_70207637 1.292 ENSMUST00000022682.5
 Sorbs3
sorbin and SH3 domain containing 3
chr2_+_129592818 1.238 ENSMUST00000153491.1
ENSMUST00000161620.1
ENSMUST00000179001.1
 Sirpa


signal-regulatory protein alpha


chr11_-_55419898 1.216 ENSMUST00000108858.1
ENSMUST00000141530.1
 Sparc

secreted acidic cysteine rich glycoprotein

chr6_+_4003926 1.183 ENSMUST00000031670.8
 Gng11
guanine nucleotide binding protein (G protein), gamma 11
chr3_+_37639945 1.167 ENSMUST00000108109.1
ENSMUST00000038569.1
 Spry1

sprouty homolog 1 (Drosophila)

chr6_+_63255971 1.141 ENSMUST00000159561.1
ENSMUST00000095852.3
 Grid2

glutamate receptor, ionotropic, delta 2

chr3_+_37639985 1.115 ENSMUST00000108107.1
 Spry1
sprouty homolog 1 (Drosophila)
chr3_+_135825788 1.102 ENSMUST00000167390.1
 Slc39a8
solute carrier family 39 (metal ion transporter), member 8
chr9_+_80165079 1.056 ENSMUST00000184480.1
 Myo6
myosin VI
chr9_+_80165013 1.020 ENSMUST00000035889.8
ENSMUST00000113268.1
 Myo6

myosin VI

chr2_+_129592914 0.990 ENSMUST00000103203.1
 Sirpa
signal-regulatory protein alpha

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 118 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 3.6 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.1 2.4 GO:0006910 phagocytosis, recognition(GO:0006910)
0.7 2.2 GO:0072223 metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.2 2.1 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.2 1.8 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.1 1.8 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 1.8 GO:0019915 lipid storage(GO:0019915)
0.2 1.6 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.0 1.6 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.5 1.5 GO:0002765 immune response-inhibiting signal transduction(GO:0002765) positive regulation of dendritic cell apoptotic process(GO:2000670)
0.5 1.5 GO:0035696 monocyte extravasation(GO:0035696) regulation of monocyte extravasation(GO:2000437)
0.2 1.5 GO:0060662 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.1 1.4 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.0 1.3 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
0.0 1.3 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.1 1.2 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.0 1.2 GO:0031529 ruffle organization(GO:0031529)
0.4 1.1 GO:0002447 eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil degranulation(GO:0043308) regulation of eosinophil activation(GO:1902566)
0.1 1.1 GO:0035330 regulation of hippo signaling(GO:0035330)
0.1 1.1 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 2.1 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.1 1.8 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 1.8 GO:0005811 lipid particle(GO:0005811)
0.0 1.7 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 1.6 GO:0031985 Golgi cisterna(GO:0031985)
0.5 1.5 GO:0034666 integrin alpha2-beta1 complex(GO:0034666)
0.0 1.5 GO:0072562 blood microparticle(GO:0072562)
0.3 1.2 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.2 1.2 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.2 1.1 GO:0000322 storage vacuole(GO:0000322)
0.0 1.1 GO:0098878 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.3 1.0 GO:0097543 ciliary inversin compartment(GO:0097543)
0.0 1.0 GO:0032420 stereocilium(GO:0032420)
0.2 0.9 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.1 0.9 GO:0030027 lamellipodium(GO:0030027)
0.0 0.9 GO:0002102 podosome(GO:0002102)
0.0 0.8 GO:0031526 brush border membrane(GO:0031526)
0.1 0.7 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.1 0.7 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 83 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.6 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 2.4 GO:0003774 motor activity(GO:0003774)
0.1 2.2 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.1 2.2 GO:0045309 protein phosphorylated amino acid binding(GO:0045309)
0.1 2.0 GO:0017166 vinculin binding(GO:0017166)
0.1 1.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 1.8 GO:0052771 coenzyme F390-A hydrolase activity(GO:0052770) coenzyme F390-G hydrolase activity(GO:0052771)
0.0 1.8 GO:0005125 cytokine activity(GO:0005125)
0.1 1.7 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.2 1.6 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.1 1.6 GO:0043014 alpha-tubulin binding(GO:0043014)
0.5 1.5 GO:0005128 erythropoietin receptor binding(GO:0005128)
0.1 1.5 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.4 1.3 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.0 1.2 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.3 1.1 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.0 1.1 GO:0005234 extracellular-glutamate-gated ion channel activity(GO:0005234)
0.0 1.1 GO:0005518 collagen binding(GO:0005518)
0.3 0.9 GO:0048039 ubiquinone binding(GO:0048039)
0.1 0.9 GO:0048038 quinone binding(GO:0048038)