Motif ID: Spic

Z-value: 0.786


Transcription factors associated with Spic:

Gene SymbolEntrez IDGene Name
Spic ENSMUSG00000004359.10 Spic

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Spicmm10_v2_chr10_-_88683021_88683025-0.373.6e-02Click!


Activity profile for motif Spic.

activity profile for motif Spic


Sorted Z-values histogram for motif Spic

Sorted Z-values for motif Spic



Network of associatons between targets according to the STRING database.



First level regulatory network of Spic

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_32276400 6.803 ENSMUST00000020531.2
 Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr19_+_53529100 3.258 ENSMUST00000038287.6
 Dusp5
dual specificity phosphatase 5
chr2_+_120463566 2.793 ENSMUST00000028749.7
ENSMUST00000110721.1
 Capn3

calpain 3

chr19_-_41896132 2.360 ENSMUST00000038677.3
 Rrp12
ribosomal RNA processing 12 homolog (S. cerevisiae)
chr11_+_120948480 2.241 ENSMUST00000070653.6
 Slc16a3
solute carrier family 16 (monocarboxylic acid transporters), member 3
chr13_-_53473074 1.998 ENSMUST00000021922.8
 Msx2
msh homeobox 2
chr17_+_29360923 1.928 ENSMUST00000024810.6
 Fgd2
FYVE, RhoGEF and PH domain containing 2
chr12_+_112760652 1.893 ENSMUST00000063888.3
 Pld4
phospholipase D family, member 4
chr6_-_136941694 1.798 ENSMUST00000032344.5
 Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr12_-_80260356 1.743 ENSMUST00000021554.8
 Actn1
actinin, alpha 1
chr4_+_130913264 1.732 ENSMUST00000156225.1
ENSMUST00000156742.1
 Laptm5

lysosomal-associated protein transmembrane 5

chr9_-_114781986 1.676 ENSMUST00000035009.8
ENSMUST00000084867.7
 Cmtm7

CKLF-like MARVEL transmembrane domain containing 7

chr7_+_28982832 1.627 ENSMUST00000085835.6
 Map4k1
mitogen-activated protein kinase kinase kinase kinase 1
chr4_-_133874682 1.594 ENSMUST00000168974.2
 Rps6ka1
ribosomal protein S6 kinase polypeptide 1
chr6_+_48684570 1.571 ENSMUST00000067506.7
ENSMUST00000119575.1
ENSMUST00000114527.2
ENSMUST00000121957.1
ENSMUST00000090070.5
 Gimap4




GTPase, IMAP family member 4




chr5_-_138171248 1.558 ENSMUST00000153867.1
 Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr12_-_80260091 1.546 ENSMUST00000167327.1
 Actn1
actinin, alpha 1
chr4_+_130913120 1.524 ENSMUST00000151698.1
 Laptm5
lysosomal-associated protein transmembrane 5
chr7_+_43607169 1.507 ENSMUST00000120935.1
ENSMUST00000127765.1
ENSMUST00000032661.7
 Zfp819


zinc finger protein 819


chr5_-_138170992 1.507 ENSMUST00000139983.1
 Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 159 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 6.8 GO:0015671 oxygen transport(GO:0015671)
0.0 6.2 GO:0000375 RNA splicing, via transesterification reactions(GO:0000375)
0.4 5.0 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 5.0 GO:0006412 translation(GO:0006412)
0.8 4.1 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.7 3.9 GO:0032796 uropod organization(GO:0032796)
0.4 3.3 GO:0051639 actin filament network formation(GO:0051639)
0.0 3.3 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.9 2.8 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
0.6 2.4 GO:0002309 T cell proliferation involved in immune response(GO:0002309)
0.1 2.3 GO:0001706 endoderm formation(GO:0001706)
0.6 2.2 GO:0002337 B-1a B cell differentiation(GO:0002337)
0.1 2.2 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.7 2.0 GO:0048818 embryonic nail plate morphogenesis(GO:0035880) positive regulation of hair follicle maturation(GO:0048818) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364)
0.1 2.0 GO:0006270 DNA replication initiation(GO:0006270)
0.3 1.9 GO:0045656 negative regulation of monocyte differentiation(GO:0045656)
0.2 1.9 GO:1990173 protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) protein localization to nucleoplasm(GO:1990173)
0.2 1.9 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.0 1.9 GO:0032543 mitochondrial translation(GO:0032543)
0.2 1.6 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 6.8 GO:0005833 hemoglobin complex(GO:0005833)
0.4 5.4 GO:0042555 MCM complex(GO:0042555)
0.1 5.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 4.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 4.5 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.2 3.9 GO:0001891 phagocytic cup(GO:0001891)
0.4 3.8 GO:0030008 TRAPP complex(GO:0030008)
0.8 3.3 GO:0032127 dense core granule membrane(GO:0032127)
0.0 2.5 GO:0072562 blood microparticle(GO:0072562)
0.0 2.0 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 2.0 GO:0030315 T-tubule(GO:0030315)
0.2 1.9 GO:0031595 nuclear proteasome complex(GO:0031595)
0.2 1.9 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.1 1.8 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.2 1.4 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.3 1.3 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 1.2 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 1.2 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.3 1.1 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.1 1.1 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 114 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.9 GO:0003735 structural constituent of ribosome(GO:0003735)
1.4 6.8 GO:0005344 oxygen transporter activity(GO:0005344)
0.1 5.0 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.6 4.1 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.4 3.9 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 3.9 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.2 3.3 GO:0017166 vinculin binding(GO:0017166)
0.1 3.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.3 2.8 GO:0031432 titin binding(GO:0031432)
0.2 2.8 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.0 2.8 GO:0019843 rRNA binding(GO:0019843)
0.1 2.2 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.3 1.9 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.1 1.9 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 1.9 GO:0005125 cytokine activity(GO:0005125)
0.4 1.8 GO:0019864 IgG binding(GO:0019864)
0.1 1.6 GO:0035014 phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.1 1.6 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 1.6 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 1.4 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)