Motif ID: Stat4_Stat3_Stat5b

Z-value: 1.065

Transcription factors associated with Stat4_Stat3_Stat5b:

Gene SymbolEntrez IDGene Name
Stat3 ENSMUSG00000004040.10 Stat3
Stat4 ENSMUSG00000062939.5 Stat4
Stat5b ENSMUSG00000020919.5 Stat5b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Stat4mm10_v2_chr1_+_51987139_51987151-0.802.1e-08Click!
Stat3mm10_v2_chr11_-_100939540_1009395660.681.3e-05Click!
Stat5bmm10_v2_chr11_-_100822525_100822576-0.183.1e-01Click!


Activity profile for motif Stat4_Stat3_Stat5b.

activity profile for motif Stat4_Stat3_Stat5b


Sorted Z-values histogram for motif Stat4_Stat3_Stat5b

Sorted Z-values for motif Stat4_Stat3_Stat5b



Network of associatons between targets according to the STRING database.



First level regulatory network of Stat4_Stat3_Stat5b

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_64046925 14.232 ENSMUST00000107377.3
 Tnc
tenascin C
chr3_-_80802789 12.805 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chrX_-_61185558 10.129 ENSMUST00000166381.1
 Cdr1
cerebellar degeneration related antigen 1
chr8_-_124569696 6.183 ENSMUST00000063278.6
 Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr17_+_26715644 5.350 ENSMUST00000062519.7
ENSMUST00000144221.1
ENSMUST00000142539.1
ENSMUST00000151681.1
 Crebrf



CREB3 regulatory factor



chr6_-_5496296 4.889 ENSMUST00000019721.4
 Pdk4
pyruvate dehydrogenase kinase, isoenzyme 4
chr11_+_3488275 4.507 ENSMUST00000064265.6
 Pla2g3
phospholipase A2, group III
chr6_+_115134899 4.481 ENSMUST00000009538.5
ENSMUST00000169345.1
 Syn2

synapsin II

chr15_-_54919961 4.257 ENSMUST00000167541.2
ENSMUST00000041591.9
ENSMUST00000173516.1
 Enpp2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr12_+_74297474 4.115 ENSMUST00000072100.3
 Dbpht2
DNA binding protein with his-thr domain
chr1_+_146497614 4.046 ENSMUST00000132847.1
ENSMUST00000166814.1
 Brinp3

bone morphogenetic protein/retinoic acid inducible neural specific 3

chr15_-_37458523 3.943 ENSMUST00000116445.2
 Ncald
neurocalcin delta
chr4_+_148602527 3.851 ENSMUST00000105701.2
ENSMUST00000052060.6
 Masp2

mannan-binding lectin serine peptidase 2

chr1_+_134182404 3.830 ENSMUST00000153856.1
ENSMUST00000082060.3
ENSMUST00000133701.1
ENSMUST00000132873.1
 Chi3l1



chitinase 3-like 1



chr3_-_88000350 3.780 ENSMUST00000090971.5
 Bcan
brevican
chr16_-_23988852 3.640 ENSMUST00000023151.5
 Bcl6
B cell leukemia/lymphoma 6
chr5_+_88886809 3.617 ENSMUST00000148750.1
 Slc4a4
solute carrier family 4 (anion exchanger), member 4
chr15_-_37459327 3.600 ENSMUST00000119730.1
ENSMUST00000120746.1
 Ncald

neurocalcin delta

chr19_-_5797410 3.562 ENSMUST00000173314.1
 Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr12_+_11265867 3.527 ENSMUST00000020931.5
 Smc6
structural maintenance of chromosomes 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 199 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.6 14.2 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.5 11.9 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
2.5 7.6 GO:0008065 establishment of blood-nerve barrier(GO:0008065)
1.1 7.6 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
1.2 7.2 GO:1902847 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of tau-protein kinase activity(GO:1902949)
0.1 7.2 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.1 6.0 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
1.1 5.4 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
1.2 4.9 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
1.6 4.8 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.5 4.7 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
1.1 4.5 GO:0019372 lipoxygenase pathway(GO:0019372)
1.4 4.3 GO:2000569 T-helper 2 cell activation(GO:0035712) positive regulation of T-helper 17 type immune response(GO:2000318) regulation of T-helper 2 cell activation(GO:2000569) positive regulation of T-helper 2 cell activation(GO:2000570)
0.1 3.9 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.9 3.8 GO:0071139 resolution of recombination intermediates(GO:0071139)
0.1 3.7 GO:0021766 hippocampus development(GO:0021766)
1.2 3.6 GO:0043379 memory T cell differentiation(GO:0043379) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.9 3.6 GO:0035063 nuclear speck organization(GO:0035063)
0.2 3.6 GO:0015701 bicarbonate transport(GO:0015701)
0.5 3.5 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 102 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 15.2 GO:0005614 interstitial matrix(GO:0005614)
0.6 12.8 GO:0032279 asymmetric synapse(GO:0032279)
1.0 7.2 GO:0034366 spherical high-density lipoprotein particle(GO:0034366) neurofibrillary tangle(GO:0097418)
0.2 6.1 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 5.1 GO:0005814 centriole(GO:0005814)
0.2 4.8 GO:0030673 axolemma(GO:0030673)
0.2 4.7 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 4.6 GO:0016604 nuclear body(GO:0016604)
0.1 4.0 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 3.7 GO:0072562 blood microparticle(GO:0072562)
0.2 3.6 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
1.2 3.5 GO:0035061 interchromatin granule(GO:0035061)
0.1 3.5 GO:0001772 immunological synapse(GO:0001772)
0.1 3.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 3.4 GO:0042734 presynaptic membrane(GO:0042734)
0.1 2.7 GO:0051233 spindle midzone(GO:0051233)
0.0 2.7 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.7 2.6 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.0 2.6 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 2.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 147 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 14.2 GO:0045545 syndecan binding(GO:0045545)
2.1 12.8 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
1.9 7.6 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.2 7.5 GO:0043014 alpha-tubulin binding(GO:0043014)
0.3 7.2 GO:0051787 misfolded protein binding(GO:0051787)
0.5 6.2 GO:0048018 receptor agonist activity(GO:0048018)
1.2 4.9 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.6 4.8 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 4.5 GO:0004697 protein kinase C activity(GO:0004697)
0.5 3.9 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.2 3.8 GO:0005540 hyaluronic acid binding(GO:0005540)
0.7 3.7 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
1.2 3.6 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.7 3.6 GO:0016972 thiol oxidase activity(GO:0016972)
0.0 3.5 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.3 3.3 GO:0001846 opsonin binding(GO:0001846)
0.3 3.3 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.8 3.2 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.1 3.1 GO:0017091 AU-rich element binding(GO:0017091)
0.3 3.0 GO:0038191 neuropilin binding(GO:0038191)