Motif ID: Stat6

Z-value: 0.920


Transcription factors associated with Stat6:

Gene SymbolEntrez IDGene Name
Stat6 ENSMUSG00000002147.12 Stat6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Stat6mm10_v2_chr10_+_127642975_1276430340.493.8e-03Click!


Activity profile for motif Stat6.

activity profile for motif Stat6


Sorted Z-values histogram for motif Stat6

Sorted Z-values for motif Stat6



Network of associatons between targets according to the STRING database.



First level regulatory network of Stat6

PNG image of the network

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Top targets:


Showing 1 to 20 of 146 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_-_15403680 6.321 ENSMUST00000079081.6
 Aqp4
aquaporin 4
chr1_+_146497614 5.999 ENSMUST00000132847.1
ENSMUST00000166814.1
 Brinp3

bone morphogenetic protein/retinoic acid inducible neural specific 3

chr4_+_136143497 5.897 ENSMUST00000008016.2
 Id3
inhibitor of DNA binding 3
chr7_+_107567445 4.047 ENSMUST00000120990.1
 Olfml1
olfactomedin-like 1
chr2_-_147186389 3.648 ENSMUST00000109970.3
ENSMUST00000067075.5
 Nkx2-2

NK2 homeobox 2

chr1_+_146495621 3.505 ENSMUST00000074622.4
 Brinp3
bone morphogenetic protein/retinoic acid inducible neural specific 3
chr11_-_55419898 3.415 ENSMUST00000108858.1
ENSMUST00000141530.1
 Sparc

secreted acidic cysteine rich glycoprotein

chr18_+_50053282 3.188 ENSMUST00000148159.2
 Tnfaip8
tumor necrosis factor, alpha-induced protein 8
chr15_+_32920723 3.147 ENSMUST00000022871.5
 Sdc2
syndecan 2
chr9_+_44066993 2.745 ENSMUST00000034508.7
 Usp2
ubiquitin specific peptidase 2
chr6_+_66896397 2.646 ENSMUST00000043148.6
ENSMUST00000114228.1
ENSMUST00000114227.1
ENSMUST00000114226.1
ENSMUST00000114225.1
ENSMUST00000114224.1
 Gng12





guanine nucleotide binding protein (G protein), gamma 12





chr10_+_97479470 2.591 ENSMUST00000105287.3
 Dcn
decorin
chr11_+_101245996 2.563 ENSMUST00000129680.1
 Ramp2
receptor (calcitonin) activity modifying protein 2
chr2_-_125723387 2.547 ENSMUST00000042246.7
 Shc4
SHC (Src homology 2 domain containing) family, member 4
chr6_-_125313844 2.392 ENSMUST00000032489.7
 Ltbr
lymphotoxin B receptor
chr1_-_120121030 2.362 ENSMUST00000027634.6
 Dbi
diazepam binding inhibitor
chr9_+_44067072 2.219 ENSMUST00000177054.1
 Usp2
ubiquitin specific peptidase 2
chr1_+_59516264 2.214 ENSMUST00000114243.1
 Gm973
predicted gene 973
chr2_-_51972990 2.166 ENSMUST00000145481.1
ENSMUST00000112705.2
 Nmi

N-myc (and STAT) interactor

chr13_+_43785107 2.150 ENSMUST00000015540.2
 Cd83
CD83 antigen

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.5 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.2 6.6 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
1.3 6.3 GO:0070295 renal water absorption(GO:0070295)
0.3 5.3 GO:0048642 negative regulation of skeletal muscle tissue development(GO:0048642)
1.2 3.6 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.1 3.2 GO:0050830 defense response to Gram-positive bacterium(GO:0050830)
0.0 3.1 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
0.3 2.8 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.4 2.6 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.3 2.6 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.1 2.5 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
0.5 2.4 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.2 2.4 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.7 2.2 GO:1902524 negative regulation of interferon-alpha production(GO:0032687) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) negative regulation of interferon-beta biosynthetic process(GO:0045358) positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.1 2.2 GO:1903077 negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.4 2.1 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
0.1 1.9 GO:0001921 positive regulation of receptor recycling(GO:0001921)
0.6 1.7 GO:0086017 renin secretion into blood stream(GO:0002001) cell communication by chemical coupling(GO:0010643) Purkinje myocyte action potential(GO:0086017) regulation of renin secretion into blood stream(GO:1900133)
0.1 1.7 GO:0051127 positive regulation of actin nucleation(GO:0051127)
0.4 1.6 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.4 GO:0005813 centrosome(GO:0005813)
0.1 6.3 GO:0009925 basal plasma membrane(GO:0009925)
0.1 4.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.9 3.4 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.2 2.8 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 2.6 GO:0098644 complex of collagen trimers(GO:0098644)
0.1 2.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 2.2 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.9 GO:0031985 Golgi cisterna(GO:0031985)
0.1 1.7 GO:0005922 connexon complex(GO:0005922)
0.4 1.6 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 1.4 GO:0000776 kinetochore(GO:0000776)
0.1 1.3 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.2 1.1 GO:1990131 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.1 0.8 GO:0042825 TAP complex(GO:0042825)
0.0 0.8 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.8 GO:0016459 myosin complex(GO:0016459)
0.0 0.7 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.0 0.7 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.7 GO:0005788 endoplasmic reticulum lumen(GO:0005788)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 6.3 GO:0015288 porin activity(GO:0015288)
0.1 6.0 GO:0050840 extracellular matrix binding(GO:0050840)
0.5 4.7 GO:0042301 phosphate ion binding(GO:0042301)
0.1 4.6 GO:0005504 fatty acid binding(GO:0005504)
0.1 4.6 GO:0030332 cyclin binding(GO:0030332)
0.1 3.4 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 3.4 GO:0051015 actin filament binding(GO:0051015)
0.1 3.2 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.5 2.8 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 2.6 GO:0015026 coreceptor activity(GO:0015026)
0.0 2.5 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.6 2.4 GO:0030156 benzodiazepine receptor binding(GO:0030156)
0.1 2.4 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.3 2.2 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.3 1.7 GO:0071253 connexin binding(GO:0071253)
0.4 1.6 GO:0036468 aromatic-L-amino-acid decarboxylase activity(GO:0004058) L-dopa decarboxylase activity(GO:0036468)
0.2 1.6 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.2 1.6 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 1.6 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 1.5 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)