Motif ID: Tbx2

Z-value: 0.662


Transcription factors associated with Tbx2:

Gene SymbolEntrez IDGene Name
Tbx2 ENSMUSG00000000093.6 Tbx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tbx2mm10_v2_chr11_+_85832551_85832551-0.671.8e-05Click!


Activity profile for motif Tbx2.

activity profile for motif Tbx2


Sorted Z-values histogram for motif Tbx2

Sorted Z-values for motif Tbx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 118 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_3397189 3.749 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr2_+_124089961 3.356 ENSMUST00000103241.1
 Sema6d
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr2_+_152081529 3.042 ENSMUST00000064061.3
 Scrt2
scratch homolog 2, zinc finger protein (Drosophila)
chr6_+_115134899 2.909 ENSMUST00000009538.5
ENSMUST00000169345.1
 Syn2

synapsin II

chr12_-_41485751 2.750 ENSMUST00000043884.4
 Lrrn3
leucine rich repeat protein 3, neuronal
chr1_+_152954966 2.638 ENSMUST00000043313.8
 Nmnat2
nicotinamide nucleotide adenylyltransferase 2
chr10_+_106470281 2.633 ENSMUST00000029404.9
ENSMUST00000169303.1
 Ppfia2

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

chr5_+_111733924 2.560 ENSMUST00000180627.1
 Gm26897
predicted gene, 26897
chr3_-_158562199 2.463 ENSMUST00000106044.1
 Lrrc7
leucine rich repeat containing 7
chr19_-_46327121 2.446 ENSMUST00000041391.4
ENSMUST00000096029.5
 Psd

pleckstrin and Sec7 domain containing

chr11_-_84068766 2.443 ENSMUST00000018792.5
 Dusp14
dual specificity phosphatase 14
chr9_+_53850243 2.079 ENSMUST00000048485.5
 Sln
sarcolipin
chr4_+_84884418 2.009 ENSMUST00000169371.2
 Cntln
centlein, centrosomal protein
chr3_-_84220853 1.982 ENSMUST00000154152.1
ENSMUST00000107693.2
ENSMUST00000107695.2
 Trim2


tripartite motif-containing 2


chr9_+_48495345 1.939 ENSMUST00000048824.7
 Gm5617
predicted gene 5617
chrX_+_159840463 1.906 ENSMUST00000112451.1
ENSMUST00000112453.2
 Sh3kbp1

SH3-domain kinase binding protein 1

chr16_+_23107413 1.897 ENSMUST00000023599.6
ENSMUST00000168891.1
 Eif4a2

eukaryotic translation initiation factor 4A2

chr1_-_52500679 1.886 ENSMUST00000069792.7
 Nab1
Ngfi-A binding protein 1
chr1_-_105356658 1.871 ENSMUST00000058688.5
ENSMUST00000172299.1
 Rnf152

ring finger protein 152

chr19_-_37207293 1.778 ENSMUST00000132580.1
ENSMUST00000079754.4
ENSMUST00000136286.1
ENSMUST00000126188.1
ENSMUST00000126781.1
 Cpeb3




cytoplasmic polyadenylation element binding protein 3





Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.3 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.1 4.2 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 3.9 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.1 3.4 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.0 3.1 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.1 3.0 GO:2001222 regulation of neuron migration(GO:2001222)
0.0 2.9 GO:0099643 neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
0.9 2.8 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.0 2.8 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.7 2.6 GO:0019355 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process(GO:0034627) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.1 2.4 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 2.2 GO:0003334 keratinocyte development(GO:0003334)
0.7 2.1 GO:1902277 negative regulation of pancreatic amylase secretion(GO:1902277)
0.5 2.1 GO:1901894 regulation of calcium-transporting ATPase activity(GO:1901894)
0.4 2.1 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.1 1.9 GO:0034198 cellular response to amino acid starvation(GO:0034198)
0.0 1.9 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 1.9 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 1.9 GO:0008360 regulation of cell shape(GO:0008360)
0.6 1.8 GO:1900365 positive regulation of mRNA polyadenylation(GO:1900365)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.1 GO:0098793 presynapse(GO:0098793)
0.2 3.9 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 3.0 GO:0005814 centriole(GO:0005814)
0.1 2.9 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 2.8 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 2.8 GO:0031225 anchored component of membrane(GO:0031225)
0.1 2.5 GO:0043194 axon initial segment(GO:0043194)
0.0 2.2 GO:0005770 late endosome(GO:0005770)
0.1 2.1 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 2.1 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 2.1 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 2.0 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.6 1.7 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.1 1.7 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 1.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 1.1 GO:0042581 specific granule(GO:0042581)
0.0 1.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.9 GO:0031430 M band(GO:0031430)
0.3 0.8 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.0 0.8 GO:0032588 trans-Golgi network membrane(GO:0032588)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.0 GO:0030674 protein binding, bridging(GO:0030674)
0.1 4.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.6 3.9 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 3.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 3.4 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 2.8 GO:0030275 LRR domain binding(GO:0030275)
0.7 2.6 GO:0004515 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0 2.5 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 2.4 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 2.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 2.1 GO:0035064 methylated histone binding(GO:0035064)
0.2 2.0 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 1.9 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 1.8 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.2 1.7 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.0 1.5 GO:0017048 Rho GTPase binding(GO:0017048)
0.5 1.4 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.0 1.4 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 1.2 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 1.2 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)