Motif ID: Tbx21

Z-value: 1.554


Transcription factors associated with Tbx21:

Gene SymbolEntrez IDGene Name
Tbx21 ENSMUSG00000001444.2 Tbx21



Activity profile for motif Tbx21.

activity profile for motif Tbx21


Sorted Z-values histogram for motif Tbx21

Sorted Z-values for motif Tbx21



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx21

PNG image of the network

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Top targets:


Showing 1 to 20 of 134 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_170009659 11.478 ENSMUST00000179760.1
 Gm21887
predicted gene, 21887
chr1_-_56969827 11.136 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr1_-_56969864 11.106 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr9_-_112185726 9.337 ENSMUST00000160240.1
ENSMUST00000162065.1
 Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr5_+_98180866 8.953 ENSMUST00000112959.1
 Prdm8
PR domain containing 8
chr11_+_24080664 8.379 ENSMUST00000118955.1
 Bcl11a
B cell CLL/lymphoma 11A (zinc finger protein)
chr18_+_37020097 7.563 ENSMUST00000047614.1
 Pcdha2
protocadherin alpha 2
chr14_+_64588112 7.495 ENSMUST00000181808.1
 A930011O12Rik
RIKEN cDNA A930011O12 gene
chr7_+_45785331 7.000 ENSMUST00000120005.1
ENSMUST00000123585.1
 Lmtk3

lemur tyrosine kinase 3

chr9_-_112185939 6.959 ENSMUST00000070218.5
 Arpp21
cyclic AMP-regulated phosphoprotein, 21
chr3_-_89322883 6.658 ENSMUST00000029673.5
 Efna3
ephrin A3
chr5_-_39644634 6.340 ENSMUST00000053116.6
 Hs3st1
heparan sulfate (glucosamine) 3-O-sulfotransferase 1
chr5_-_39644597 6.094 ENSMUST00000152057.1
 Hs3st1
heparan sulfate (glucosamine) 3-O-sulfotransferase 1
chr15_-_84105662 5.521 ENSMUST00000082365.5
 Sult4a1
sulfotransferase family 4A, member 1
chr7_-_126704816 5.036 ENSMUST00000032949.7
 Coro1a
coronin, actin binding protein 1A
chr9_-_106656081 4.897 ENSMUST00000023959.7
 Grm2
glutamate receptor, metabotropic 2
chr8_+_12984246 4.496 ENSMUST00000110873.3
ENSMUST00000173006.1
ENSMUST00000145067.1
 Mcf2l


mcf.2 transforming sequence-like


chr1_+_62703667 4.480 ENSMUST00000114155.1
ENSMUST00000027112.6
ENSMUST00000063594.6
ENSMUST00000114157.2
 Nrp2



neuropilin 2



chr13_-_100108337 4.468 ENSMUST00000180822.1
 BC001981
cDNA sequence BC001981
chr5_-_138619751 4.339 ENSMUST00000085852.4
ENSMUST00000110905.2
 Zfp68

zinc finger protein 68


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 22.2 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.4 18.8 GO:0034605 cellular response to heat(GO:0034605)
0.6 9.0 GO:0021540 corpus callosum morphogenesis(GO:0021540)
2.9 8.7 GO:0021649 vestibulocochlear nerve morphogenesis(GO:0021648) vestibulocochlear nerve structural organization(GO:0021649) ganglion morphogenesis(GO:0061552) dorsal root ganglion morphogenesis(GO:1904835)
0.6 8.4 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 7.0 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 6.7 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 5.5 GO:0008202 steroid metabolic process(GO:0008202)
0.8 5.0 GO:0032796 uropod organization(GO:0032796)
0.1 4.9 GO:0014047 glutamate secretion(GO:0014047)
0.2 4.5 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.5 4.3 GO:0006561 proline biosynthetic process(GO:0006561)
0.4 4.3 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 4.0 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843)
0.9 3.7 GO:0010040 response to iron(II) ion(GO:0010040) positive regulation of hydrogen peroxide metabolic process(GO:0010726) negative regulation of synaptic transmission, dopaminergic(GO:0032227) negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963) cellular response to copper ion(GO:0071280) regulation of peroxidase activity(GO:2000468)
1.0 2.9 GO:1904742 regulation of telomeric DNA binding(GO:1904742)
0.1 2.9 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 2.9 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.3 2.6 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.2 2.6 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 22.2 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 8.8 GO:0016604 nuclear body(GO:0016604)
0.1 7.8 GO:0035097 histone methyltransferase complex(GO:0035097)
0.0 7.5 GO:0030424 axon(GO:0030424)
0.1 6.7 GO:0031225 anchored component of membrane(GO:0031225)
0.2 5.0 GO:0001891 phagocytic cup(GO:0001891)
0.1 4.9 GO:0042734 presynaptic membrane(GO:0042734)
0.3 4.3 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 4.3 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.9 3.7 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 3.4 GO:0045335 phagocytic vesicle(GO:0045335)
0.4 2.9 GO:0070187 telosome(GO:0070187)
0.1 2.6 GO:0031430 M band(GO:0031430)
0.1 2.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 2.6 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.8 2.5 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.0 2.4 GO:0030133 transport vesicle(GO:0030133)
0.3 2.3 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1 2.2 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 2.2 GO:0008076 voltage-gated potassium channel complex(GO:0008076)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 25.6 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.1 16.3 GO:0005516 calmodulin binding(GO:0005516)
2.1 12.4 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
1.1 9.0 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
1.2 8.7 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.1 8.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 6.7 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 6.2 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.2 5.5 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
0.5 5.0 GO:0032036 myosin heavy chain binding(GO:0032036)
1.0 4.9 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.2 4.5 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
1.1 4.3 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.2 4.3 GO:0031402 sodium ion binding(GO:0031402)
0.1 4.0 GO:0030215 semaphorin receptor binding(GO:0030215)
0.2 3.8 GO:0032794 GTPase activating protein binding(GO:0032794)
0.1 3.8 GO:0019003 GDP binding(GO:0019003)
0.6 3.7 GO:0050544 arachidonic acid binding(GO:0050544)
0.2 2.9 GO:0070182 DNA polymerase binding(GO:0070182)
0.1 2.9 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)