Motif ID: Tbx4

Z-value: 1.158


Transcription factors associated with Tbx4:

Gene SymbolEntrez IDGene Name
Tbx4 ENSMUSG00000000094.6 Tbx4



Activity profile for motif Tbx4.

activity profile for motif Tbx4


Sorted Z-values histogram for motif Tbx4

Sorted Z-values for motif Tbx4



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx4

PNG image of the network

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Top targets:


Showing 1 to 20 of 114 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_134018829 11.520 ENSMUST00000051674.2
 Lin28a
lin-28 homolog A (C. elegans)
chr2_+_164562579 7.465 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2


chr9_-_43239816 7.408 ENSMUST00000034512.5
 Oaf
OAF homolog (Drosophila)
chr10_+_26229707 6.896 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr14_-_70642268 6.725 ENSMUST00000022697.5
 Fgf17
fibroblast growth factor 17
chr6_-_94700137 6.231 ENSMUST00000101126.2
ENSMUST00000032105.4
 Lrig1

leucine-rich repeats and immunoglobulin-like domains 1

chr19_+_20601958 5.064 ENSMUST00000087638.3
 Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
chr7_-_100658394 4.579 ENSMUST00000138830.1
ENSMUST00000107044.3
ENSMUST00000116287.2
 Plekhb1


pleckstrin homology domain containing, family B (evectins) member 1


chr10_-_120899067 4.526 ENSMUST00000092143.5
 Msrb3
methionine sulfoxide reductase B3
chr8_+_45885479 4.326 ENSMUST00000034053.5
 Pdlim3
PDZ and LIM domain 3
chr4_+_117849193 4.317 ENSMUST00000132043.2
ENSMUST00000169990.1
 Slc6a9

solute carrier family 6 (neurotransmitter transporter, glycine), member 9

chr11_-_94507337 4.315 ENSMUST00000040692.8
 Mycbpap
MYCBP associated protein
chr1_+_6730051 4.243 ENSMUST00000043578.6
ENSMUST00000131467.1
ENSMUST00000150761.1
ENSMUST00000151281.1
 St18



suppression of tumorigenicity 18



chr4_+_117849361 4.191 ENSMUST00000163288.1
 Slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr10_-_127341583 4.079 ENSMUST00000026474.3
 Gli1
GLI-Kruppel family member GLI1
chr12_+_3891728 3.881 ENSMUST00000172689.1
ENSMUST00000111186.1
 Dnmt3a

DNA methyltransferase 3A

chr19_+_55894508 3.420 ENSMUST00000142291.1
 Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr7_-_100658364 3.253 ENSMUST00000107043.1
 Plekhb1
pleckstrin homology domain containing, family B (evectins) member 1
chrX_+_100729917 3.029 ENSMUST00000019503.7
 Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr2_-_148045891 3.027 ENSMUST00000109964.1
 Foxa2
forkhead box A2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 11.5 GO:0010587 miRNA catabolic process(GO:0010587)
0.7 9.4 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
2.8 8.5 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.1 6.7 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
2.1 6.2 GO:0032474 otolith morphogenesis(GO:0032474)
0.6 6.1 GO:0090527 actin filament reorganization(GO:0090527)
1.3 5.1 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.9 4.5 GO:0030091 protein repair(GO:0030091)
1.4 4.2 GO:0045014 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594)
0.3 4.2 GO:0097067 negative regulation of erythrocyte differentiation(GO:0045647) cellular response to thyroid hormone stimulus(GO:0097067)
1.0 4.1 GO:0060032 notochord regression(GO:0060032)
0.2 4.1 GO:0045672 positive regulation of osteoclast differentiation(GO:0045672)
0.5 3.9 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.4 3.4 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 3.2 GO:0007519 skeletal muscle tissue development(GO:0007519)
0.1 3.1 GO:0006270 DNA replication initiation(GO:0006270)
0.3 2.9 GO:0071493 cellular response to UV-B(GO:0071493) replicative senescence(GO:0090399)
0.3 2.8 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.3 2.7 GO:0015868 purine ribonucleotide transport(GO:0015868)
0.8 2.5 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 11.5 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 10.4 GO:0005667 transcription factor complex(GO:0005667)
0.2 9.4 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 7.8 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 6.3 GO:0098793 presynapse(GO:0098793)
0.0 6.1 GO:0005884 actin filament(GO:0005884)
0.0 4.3 GO:0030018 Z disc(GO:0030018)
0.3 4.1 GO:0097542 ciliary tip(GO:0097542)
0.2 3.9 GO:0001741 XY body(GO:0001741)
0.4 3.4 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
1.0 2.9 GO:0070557 PCNA-p21 complex(GO:0070557)
0.2 2.5 GO:0005922 connexon complex(GO:0005922)
0.0 2.5 GO:0031985 Golgi cisterna(GO:0031985)
0.4 2.0 GO:1990357 terminal web(GO:1990357)
0.3 1.9 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.1 1.7 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 1.5 GO:0035686 sperm fibrous sheath(GO:0035686)
0.5 1.4 GO:0005787 signal peptidase complex(GO:0005787)
0.0 1.4 GO:0005581 collagen trimer(GO:0005581)
0.1 1.2 GO:0030061 mitochondrial crista(GO:0030061)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 11.5 GO:0035198 miRNA binding(GO:0035198)
0.2 9.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
1.4 8.5 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.0 7.8 GO:0008022 protein C-terminus binding(GO:0008022)
0.1 7.5 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
2.2 6.7 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.1 6.4 GO:0070888 E-box binding(GO:0070888)
0.6 6.1 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.8 5.1 GO:0001758 retinal dehydrogenase activity(GO:0001758) 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.6 4.5 GO:0070191 methionine-R-sulfoxide reductase activity(GO:0070191)
0.2 4.3 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 4.2 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 4.1 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.5 3.9 GO:0051718 DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.1 3.8 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 3.4 GO:0045295 gamma-catenin binding(GO:0045295)
0.2 2.9 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 2.7 GO:0097110 scaffold protein binding(GO:0097110)
0.2 2.5 GO:0005243 gap junction channel activity(GO:0005243)
0.1 2.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)