Motif ID: Tbx5

Z-value: 0.764


Transcription factors associated with Tbx5:

Gene SymbolEntrez IDGene Name
Tbx5 ENSMUSG00000018263.8 Tbx5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tbx5mm10_v2_chr5_+_119834663_119834663-0.163.7e-01Click!


Activity profile for motif Tbx5.

activity profile for motif Tbx5


Sorted Z-values histogram for motif Tbx5

Sorted Z-values for motif Tbx5



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx5

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_75219245 2.610 ENSMUST00000079464.6
 Tuba4a
tubulin, alpha 4A
chr2_-_54085542 2.530 ENSMUST00000100089.2
 Rprm
reprimo, TP53 dependent G2 arrest mediator candidate
chr5_-_22344690 2.435 ENSMUST00000062372.7
ENSMUST00000161356.1
 Reln

reelin

chr3_+_75557530 2.311 ENSMUST00000161776.1
ENSMUST00000029423.8
 Serpini1

serine (or cysteine) peptidase inhibitor, clade I, member 1

chr11_+_98348404 2.192 ENSMUST00000078694.6
 Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr5_+_98180866 1.896 ENSMUST00000112959.1
 Prdm8
PR domain containing 8
chr1_-_138848576 1.730 ENSMUST00000112030.2
 Lhx9
LIM homeobox protein 9
chr19_+_4003334 1.351 ENSMUST00000025806.3
 Doc2g
double C2, gamma
chr11_-_116654245 1.312 ENSMUST00000021166.5
 Cygb
cytoglobin
chr11_-_84068766 1.221 ENSMUST00000018792.5
 Dusp14
dual specificity phosphatase 14
chr10_-_120899067 1.192 ENSMUST00000092143.5
 Msrb3
methionine sulfoxide reductase B3
chr10_+_26229707 1.119 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr6_+_125049952 1.118 ENSMUST00000088294.5
ENSMUST00000032481.7
 Acrbp

proacrosin binding protein

chr8_-_105637403 1.116 ENSMUST00000182046.1
 Gm5914
predicted gene 5914
chr7_-_140082246 1.068 ENSMUST00000166758.2
 Caly
calcyon neuron-specific vesicular protein
chr19_-_46327121 1.044 ENSMUST00000041391.4
ENSMUST00000096029.5
 Psd

pleckstrin and Sec7 domain containing

chr7_-_4546567 1.041 ENSMUST00000065957.5
 Syt5
synaptotagmin V
chr10_-_29535857 1.033 ENSMUST00000092623.3
 Rspo3
R-spondin 3 homolog (Xenopus laevis)
chr4_-_41517326 1.019 ENSMUST00000030152.6
ENSMUST00000095126.4
 1110017D15Rik

RIKEN cDNA 1110017D15 gene

chr8_-_105637350 1.006 ENSMUST00000182863.1
 Gm5914
predicted gene 5914

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 115 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 2.6 GO:0097477 lateral motor column neuron migration(GO:0097477)
0.1 2.4 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 2.3 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.7 2.2 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.0 2.0 GO:0007050 cell cycle arrest(GO:0007050)
0.1 1.9 GO:0021540 corpus callosum morphogenesis(GO:0021540)
0.0 1.9 GO:0014065 phosphatidylinositol 3-kinase signaling(GO:0014065)
0.2 1.8 GO:0098903 regulation of membrane repolarization during action potential(GO:0098903)
0.1 1.8 GO:0097067 negative regulation of erythrocyte differentiation(GO:0045647) cellular response to thyroid hormone stimulus(GO:0097067)
0.3 1.7 GO:0035262 gonad morphogenesis(GO:0035262)
0.3 1.3 GO:0015671 oxygen transport(GO:0015671)
0.1 1.3 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.0 1.3 GO:0006406 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.2 1.2 GO:0030091 protein repair(GO:0030091)
0.0 1.2 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 1.1 GO:0006857 oligopeptide transport(GO:0006857)
0.1 1.1 GO:0048240 sperm capacitation(GO:0048240)
0.0 1.1 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 1.1 GO:0032091 negative regulation of protein binding(GO:0032091)
0.3 1.0 GO:0097623 potassium ion export across plasma membrane(GO:0097623)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 GO:0043204 perikaryon(GO:0043204)
0.0 1.2 GO:0005814 centriole(GO:0005814)
0.1 1.1 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 1.1 GO:0031045 dense core granule(GO:0031045)
0.0 1.1 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 1.0 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 1.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.9 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 0.8 GO:0042629 mast cell granule(GO:0042629)
0.1 0.8 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 0.8 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.8 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 0.7 GO:0002177 manchette(GO:0002177)
0.1 0.7 GO:0033391 chromatoid body(GO:0033391)
0.1 0.6 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.6 GO:0000346 transcription export complex(GO:0000346)
0.0 0.6 GO:0034707 chloride channel complex(GO:0034707)
0.1 0.5 GO:0000836 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.0 0.5 GO:0005801 cis-Golgi network(GO:0005801)
0.1 0.4 GO:0048179 activin receptor complex(GO:0048179)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 85 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.4 2.4 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.7 2.2 GO:0031752 D3 dopamine receptor binding(GO:0031750) D5 dopamine receptor binding(GO:0031752)
0.0 2.1 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 2.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 1.9 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 1.8 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 1.7 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)
0.1 1.4 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.3 1.3 GO:0004096 catalase activity(GO:0004096)
0.3 1.2 GO:0004111 creatine kinase activity(GO:0004111)
0.2 1.2 GO:0070191 methionine-R-sulfoxide reductase activity(GO:0070191)
0.0 1.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.2 1.1 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095)
0.2 1.1 GO:0032051 clathrin light chain binding(GO:0032051)
0.2 1.1 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.1 1.0 GO:0043559 insulin binding(GO:0043559)
0.0 1.0 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 1.0 GO:0005109 frizzled binding(GO:0005109)
0.3 0.9 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)