Motif ID: Tcf21_Msc

Z-value: 1.219

Transcription factors associated with Tcf21_Msc:

Gene SymbolEntrez IDGene Name
Msc ENSMUSG00000025930.5 Msc
Tcf21 ENSMUSG00000045680.7 Tcf21



Activity profile for motif Tcf21_Msc.

activity profile for motif Tcf21_Msc


Sorted Z-values histogram for motif Tcf21_Msc

Sorted Z-values for motif Tcf21_Msc



Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf21_Msc

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_122611238 12.004 ENSMUST00000028624.8
 Gatm
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chrX_-_106485214 9.144 ENSMUST00000039447.7
 Fndc3c1
fibronectin type III domain containing 3C1
chrX_-_106485367 8.145 ENSMUST00000140707.1
 Fndc3c1
fibronectin type III domain containing 3C1
chr13_-_71963713 5.080 ENSMUST00000077337.8
 Irx1
Iroquois related homeobox 1 (Drosophila)
chr3_+_90537242 5.034 ENSMUST00000098911.3
 S100a16
S100 calcium binding protein A16
chr3_+_14863495 4.664 ENSMUST00000029076.4
 Car3
carbonic anhydrase 3
chr18_+_73863672 3.983 ENSMUST00000134847.1
 Mro
maestro
chr15_+_78926720 3.932 ENSMUST00000089377.5
 Lgals1
lectin, galactose binding, soluble 1
chr12_-_72664759 3.895 ENSMUST00000021512.9
 Dhrs7
dehydrogenase/reductase (SDR family) member 7
chr18_+_50051702 3.823 ENSMUST00000134348.1
ENSMUST00000153873.2
 Tnfaip8

tumor necrosis factor, alpha-induced protein 8

chr3_+_90537306 3.789 ENSMUST00000107335.1
 S100a16
S100 calcium binding protein A16
chrX_+_71663665 3.763 ENSMUST00000070449.5
 Gpr50
G-protein-coupled receptor 50
chr8_-_122432924 3.736 ENSMUST00000017604.8
 Cyba
cytochrome b-245, alpha polypeptide
chr11_-_4118778 3.696 ENSMUST00000003681.7
 Sec14l2
SEC14-like 2 (S. cerevisiae)
chr12_+_109459843 3.619 ENSMUST00000173812.1
 Dlk1
delta-like 1 homolog (Drosophila)
chr18_+_4994600 3.589 ENSMUST00000140448.1
 Svil
supervillin
chr16_+_91269759 3.368 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr6_+_107529717 3.154 ENSMUST00000049285.8
 Lrrn1
leucine rich repeat protein 1, neuronal
chr5_+_12383156 3.074 ENSMUST00000030868.6
 Sema3d
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
chr15_-_102004305 3.073 ENSMUST00000023952.8
 Krt8
keratin 8

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 213 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.0 12.0 GO:0006601 creatine biosynthetic process(GO:0006601)
0.1 7.9 GO:0051592 response to calcium ion(GO:0051592)
0.2 7.0 GO:0006730 one-carbon metabolic process(GO:0006730)
0.6 5.7 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.5 4.2 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.3 4.1 GO:0090205 positive regulation of cholesterol biosynthetic process(GO:0045542) positive regulation of cholesterol metabolic process(GO:0090205)
0.1 4.0 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
0.1 4.0 GO:0048709 oligodendrocyte differentiation(GO:0048709)
0.8 3.9 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.2 3.8 GO:0007202 activation of phospholipase C activity(GO:0007202)
1.2 3.7 GO:0033860 regulation of NAD(P)H oxidase activity(GO:0033860)
0.1 3.5 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.1 3.4 GO:0032611 interleukin-1 beta production(GO:0032611)
0.3 3.3 GO:0090527 actin filament reorganization(GO:0090527)
0.8 3.1 GO:0051599 response to hydrostatic pressure(GO:0051599)
1.0 3.0 GO:2000564 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) CD8-positive, alpha-beta T cell proliferation(GO:0035740) negative regulation of regulatory T cell differentiation(GO:0045590) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564)
0.1 3.0 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.1 3.0 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.3 2.9 GO:0042572 retinol metabolic process(GO:0042572)
0.7 2.8 GO:0043987 histone H3-S10 phosphorylation(GO:0043987)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 101 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.9 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 10.0 GO:0005615 extracellular space(GO:0005615)
0.0 9.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 4.5 GO:0009897 external side of plasma membrane(GO:0009897)
0.9 3.7 GO:0043020 NADPH oxidase complex(GO:0043020)
0.3 3.7 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 3.2 GO:0043034 costamere(GO:0043034)
0.0 3.1 GO:0017053 transcriptional repressor complex(GO:0017053)
0.7 2.8 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.7 2.8 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.4 2.8 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 2.8 GO:0072562 blood microparticle(GO:0072562)
0.4 2.7 GO:0016011 dystroglycan complex(GO:0016011)
0.2 2.7 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.2 2.5 GO:0005614 interstitial matrix(GO:0005614)
0.0 2.5 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 2.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 2.2 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 2.2 GO:0031526 brush border membrane(GO:0031526)
0.4 2.1 GO:0001651 dense fibrillar component(GO:0001651) box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 149 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 13.6 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
0.0 8.8 GO:0005509 calcium ion binding(GO:0005509)
0.2 7.2 GO:0050840 extracellular matrix binding(GO:0050840)
0.5 6.6 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 5.4 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 5.0 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.9 4.5 GO:0001069 regulatory region RNA binding(GO:0001069)
0.2 4.0 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 4.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.3 3.9 GO:0005534 galactose binding(GO:0005534)
0.6 3.9 GO:0045703 pinocarveol dehydrogenase activity(GO:0018446) chloral hydrate dehydrogenase activity(GO:0018447) hydroxymethylmethylsilanediol oxidase activity(GO:0018448) 1-phenylethanol dehydrogenase activity(GO:0018449) myrtenol dehydrogenase activity(GO:0018450) cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene dehydrogenase activity(GO:0034522) 3-hydroxy-4-methyloctanoyl-CoA dehydrogenase activity(GO:0034582) 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA dehydrogenase activity(GO:0034778) cis-9,10-dihydroanthracene-9,10-diol dehydrogenase activity(GO:0034817) citronellol dehydrogenase activity(GO:0034821) naphthyl-2-hydroxymethyl-succinyl-CoA dehydrogenase activity(GO:0034847) 2,4,4-trimethyl-1-pentanol dehydrogenase activity(GO:0034863) 2,4,4-trimethyl-3-hydroxypentanoyl-CoA dehydrogenase activity(GO:0034868) 1-hydroxy-4,4-dimethylpentan-3-one dehydrogenase activity(GO:0034871) endosulfan diol dehydrogenase activity(GO:0034891) endosulfan hydroxyether dehydrogenase activity(GO:0034901) 3-hydroxy-2-methylhexanoyl-CoA dehydrogenase activity(GO:0034918) 3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA dehydrogenase activity(GO:0034944) versicolorin reductase activity(GO:0042469) ketoreductase activity(GO:0045703)
1.3 3.8 GO:0008502 melatonin receptor activity(GO:0008502)
0.9 3.7 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.2 3.3 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 3.2 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 3.2 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.3 3.1 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.3 3.1 GO:0038191 neuropilin binding(GO:0038191)
0.0 3.0 GO:0005539 glycosaminoglycan binding(GO:0005539)
0.4 2.9 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)