Motif ID: Tcf4_Mesp1

Z-value: 1.994

Transcription factors associated with Tcf4_Mesp1:

Gene SymbolEntrez IDGene Name
Mesp1 ENSMUSG00000030544.5 Mesp1
Tcf4 ENSMUSG00000053477.9 Tcf4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf4mm10_v2_chr18_+_69346143_693462030.502.7e-03Click!


Activity profile for motif Tcf4_Mesp1.

activity profile for motif Tcf4_Mesp1


Sorted Z-values histogram for motif Tcf4_Mesp1

Sorted Z-values for motif Tcf4_Mesp1



Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf4_Mesp1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66831625 16.943 ENSMUST00000164163.1
 Sla
src-like adaptor
chr13_-_57907587 16.045 ENSMUST00000172326.1
 Spock1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1
chr3_+_75557530 14.680 ENSMUST00000161776.1
ENSMUST00000029423.8
 Serpini1

serine (or cysteine) peptidase inhibitor, clade I, member 1

chr5_+_37028329 14.075 ENSMUST00000173836.1
 Jakmip1
janus kinase and microtubule interacting protein 1
chr11_+_113619318 12.495 ENSMUST00000146390.2
ENSMUST00000106630.1
 Sstr2

somatostatin receptor 2

chr13_+_83504032 11.001 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr18_-_42899294 9.993 ENSMUST00000117687.1
 Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr18_-_42899470 9.845 ENSMUST00000120632.1
 Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr16_-_97170707 8.364 ENSMUST00000056102.7
 Dscam
Down syndrome cell adhesion molecule
chr15_+_98634743 8.330 ENSMUST00000003442.7
 Cacnb3
calcium channel, voltage-dependent, beta 3 subunit
chrX_-_73659724 8.230 ENSMUST00000114473.1
ENSMUST00000002087.7
 Pnck

pregnancy upregulated non-ubiquitously expressed CaM kinase

chr12_+_102948843 8.159 ENSMUST00000101099.5
 Unc79
unc-79 homolog (C. elegans)
chr10_+_123264076 7.996 ENSMUST00000050756.7
 Fam19a2
family with sequence similarity 19, member A2
chr7_+_44384803 7.847 ENSMUST00000120262.1
 Syt3
synaptotagmin III
chr5_-_139130159 7.697 ENSMUST00000129851.1
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr7_-_4546567 7.489 ENSMUST00000065957.5
 Syt5
synaptotagmin V
chr11_-_67922136 7.411 ENSMUST00000021288.3
ENSMUST00000108677.1
 Usp43

ubiquitin specific peptidase 43

chr7_+_16310412 7.323 ENSMUST00000136781.1
 Bbc3
BCL2 binding component 3
chr7_+_44384604 7.233 ENSMUST00000130707.1
ENSMUST00000130844.1
 Syt3

synaptotagmin III

chr8_+_3587445 7.101 ENSMUST00000057028.7
ENSMUST00000171962.1
 Camsap3

calmodulin regulated spectrin-associated protein family, member 3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 511 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 24.0 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
2.8 19.8 GO:0034047 regulation of protein phosphatase type 2A activity(GO:0034047)
0.3 15.4 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.3 15.0 GO:0010812 negative regulation of cell-substrate adhesion(GO:0010812)
1.5 13.6 GO:0030432 peristalsis(GO:0030432)
0.3 13.4 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
1.8 12.5 GO:0061502 early endosome to recycling endosome transport(GO:0061502)
0.6 11.7 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
2.8 11.1 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
3.7 11.0 GO:2000111 cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
1.2 10.4 GO:0048149 behavioral response to ethanol(GO:0048149)
0.3 10.0 GO:0008333 endosome to lysosome transport(GO:0008333)
0.1 9.6 GO:0016579 protein deubiquitination(GO:0016579)
0.2 9.4 GO:0034605 cellular response to heat(GO:0034605)
1.7 8.7 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
0.7 8.7 GO:0060081 membrane hyperpolarization(GO:0060081)
1.2 8.5 GO:0061368 behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
2.8 8.4 GO:0060060 post-embryonic retina morphogenesis in camera-type eye(GO:0060060)
0.7 8.2 GO:0032482 Rab protein signal transduction(GO:0032482)
0.3 8.0 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 187 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 38.8 GO:0060076 excitatory synapse(GO:0060076)
0.6 24.5 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
1.2 23.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.2 23.0 GO:0055037 recycling endosome(GO:0055037)
0.2 20.2 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.2 16.4 GO:0043195 terminal bouton(GO:0043195)
0.1 15.1 GO:0097060 synaptic membrane(GO:0097060)
0.2 14.8 GO:0042734 presynaptic membrane(GO:0042734)
0.1 13.7 GO:0019898 extrinsic component of membrane(GO:0019898)
0.4 13.1 GO:0033268 node of Ranvier(GO:0033268)
1.1 10.7 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 10.3 GO:0070382 exocytic vesicle(GO:0070382)
0.4 9.0 GO:0001891 phagocytic cup(GO:0001891)
0.3 8.6 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.3 8.5 GO:0060077 inhibitory synapse(GO:0060077)
0.2 8.3 GO:0031901 early endosome membrane(GO:0031901)
0.1 8.3 GO:0005905 clathrin-coated pit(GO:0005905)
0.6 8.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
1.4 7.1 GO:0036449 microtubule minus-end(GO:0036449)
2.3 7.0 GO:0043512 inhibin A complex(GO:0043512)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 316 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 33.1 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.1 25.0 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
1.7 23.4 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
1.1 20.5 GO:0050811 GABA receptor binding(GO:0050811)
0.6 18.6 GO:0001786 phosphatidylserine binding(GO:0001786)
0.4 18.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.4 14.4 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.7 12.8 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
4.2 12.5 GO:0004994 somatostatin receptor activity(GO:0004994)
0.6 12.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.9 11.9 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 10.5 GO:0101005 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.7 10.4 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.3 9.8 GO:0030215 semaphorin receptor binding(GO:0030215)
0.9 9.6 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.3 9.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.8 9.1 GO:0003680 AT DNA binding(GO:0003680)
2.9 8.8 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.9 8.6 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.3 8.5 GO:0030552 cAMP binding(GO:0030552)