Motif ID: Tcf7_Tcf7l2

Z-value: 0.754

Transcription factors associated with Tcf7_Tcf7l2:

Gene SymbolEntrez IDGene Name
Tcf7 ENSMUSG00000000782.9 Tcf7
Tcf7l2 ENSMUSG00000024985.12 Tcf7l2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf7l2mm10_v2_chr19_+_55741884_557419190.144.5e-01Click!
Tcf7mm10_v2_chr11_-_52282564_52282579-0.019.4e-01Click!


Activity profile for motif Tcf7_Tcf7l2.

activity profile for motif Tcf7_Tcf7l2


Sorted Z-values histogram for motif Tcf7_Tcf7l2

Sorted Z-values for motif Tcf7_Tcf7l2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf7_Tcf7l2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_102706356 2.833 ENSMUST00000123759.1
ENSMUST00000111212.1
ENSMUST00000005220.4
 Slc1a2


solute carrier family 1 (glial high affinity glutamate transporter), member 2


chr3_+_76074270 2.356 ENSMUST00000038364.8
 Fstl5
follistatin-like 5
chr14_+_27238018 1.915 ENSMUST00000049206.5
 Arhgef3
Rho guanine nucleotide exchange factor (GEF) 3
chr12_-_41485751 1.716 ENSMUST00000043884.4
 Lrrn3
leucine rich repeat protein 3, neuronal
chr14_+_63436394 1.494 ENSMUST00000121288.1
 Fam167a
family with sequence similarity 167, member A
chr1_+_157458554 1.428 ENSMUST00000046743.4
ENSMUST00000119891.1
 BC026585

cDNA sequence BC026585

chrX_+_166238901 1.280 ENSMUST00000112235.1
 Gpm6b
glycoprotein m6b
chr13_+_65512678 1.243 ENSMUST00000081471.2
 Gm10139
predicted gene 10139
chr1_+_88227005 1.205 ENSMUST00000061013.6
ENSMUST00000113130.1
 Mroh2a

maestro heat-like repeat family member 2A

chr13_-_66851513 1.198 ENSMUST00000169322.1
 Gm17404
predicted gene, 17404
chrX_+_166238923 1.180 ENSMUST00000060210.7
ENSMUST00000112233.1
 Gpm6b

glycoprotein m6b

chr5_-_62765618 1.161 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chrX_+_101532734 1.146 ENSMUST00000118878.1
ENSMUST00000101341.2
ENSMUST00000149274.1
 Taf1


TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor


chr1_-_105659008 1.133 ENSMUST00000070699.8
 Pign
phosphatidylinositol glycan anchor biosynthesis, class N
chr12_+_53248677 1.109 ENSMUST00000101432.2
 Npas3
neuronal PAS domain protein 3
chr9_-_96719549 1.042 ENSMUST00000128269.1
 Zbtb38
zinc finger and BTB domain containing 38
chr2_+_153031852 1.008 ENSMUST00000037235.6
 Xkr7
X Kell blood group precursor related family member 7 homolog
chr12_-_119238794 0.998 ENSMUST00000026360.8
 Itgb8
integrin beta 8
chr15_+_9436028 0.990 ENSMUST00000042360.3
 Capsl
calcyphosine-like
chr11_-_69602741 0.985 ENSMUST00000138694.1
 Atp1b2
ATPase, Na+/K+ transporting, beta 2 polypeptide

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 94 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 2.8 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.4 2.5 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 2.1 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 2.1 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 1.9 GO:0006275 regulation of DNA replication(GO:0006275)
0.0 1.6 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 1.2 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.2 1.1 GO:0030242 pexophagy(GO:0030242)
0.1 1.1 GO:0042711 maternal behavior(GO:0042711)
0.1 1.1 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.0 1.1 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.2 1.0 GO:1903288 regulation of potassium ion import(GO:1903286) positive regulation of potassium ion import(GO:1903288)
0.1 1.0 GO:0070932 histone H3 deacetylation(GO:0070932)
0.0 1.0 GO:0001573 ganglioside metabolic process(GO:0001573)
0.2 0.9 GO:0071449 cellular response to lipid hydroperoxide(GO:0071449)
0.2 0.9 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.1 0.9 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.1 0.9 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.1 0.9 GO:0032060 bleb assembly(GO:0032060)
0.0 0.9 GO:0010107 potassium ion import(GO:0010107)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.1 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 2.8 GO:0030673 axolemma(GO:0030673)
0.0 2.2 GO:0072562 blood microparticle(GO:0072562)
0.0 2.0 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 1.7 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 1.4 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.3 1.3 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 1.3 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.1 1.0 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 1.0 GO:0045120 pronucleus(GO:0045120)
0.0 0.9 GO:0043218 compact myelin(GO:0043218)
0.2 0.8 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 0.8 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 0.7 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.7 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.6 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.6 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 0.5 GO:0044307 dendritic branch(GO:0044307)
0.1 0.5 GO:0036449 microtubule minus-end(GO:0036449)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 2.8 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 2.3 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 2.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 1.9 GO:0008748 N-ethylmaleimide reductase activity(GO:0008748) reduced coenzyme F420 dehydrogenase activity(GO:0043738) sulfur oxygenase reductase activity(GO:0043826) malolactic enzyme activity(GO:0043883) epoxyqueuosine reductase activity(GO:0052693)
0.2 1.7 GO:0008556 sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556)
0.3 1.1 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.0 1.1 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 1.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 1.0 GO:0038191 neuropilin binding(GO:0038191)
0.0 1.0 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.2 0.9 GO:0008808 cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572)
0.1 0.9 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.9 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.9 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.1 0.8 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.1 0.8 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.8 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.8 GO:0042805 actinin binding(GO:0042805)
0.1 0.7 GO:0002054 nucleobase binding(GO:0002054)
0.1 0.7 GO:0043495 protein anchor(GO:0043495)