Motif ID: Tcf7l1

Z-value: 1.247


Transcription factors associated with Tcf7l1:

Gene SymbolEntrez IDGene Name
Tcf7l1 ENSMUSG00000055799.7 Tcf7l1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf7l1mm10_v2_chr6_-_72788952_727890610.638.3e-05Click!


Activity profile for motif Tcf7l1.

activity profile for motif Tcf7l1


Sorted Z-values histogram for motif Tcf7l1

Sorted Z-values for motif Tcf7l1



Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf7l1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_180889660 10.759 ENSMUST00000137629.1
 Gm14342
predicted gene 14342
chr17_-_70851189 7.205 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr7_-_49636847 6.682 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr3_+_131110350 6.471 ENSMUST00000066849.6
ENSMUST00000106341.2
ENSMUST00000029611.7
 Lef1


lymphoid enhancer binding factor 1


chrX_+_6415736 5.661 ENSMUST00000143641.3
 Shroom4
shroom family member 4
chr1_-_183147461 5.375 ENSMUST00000171366.1
 Disp1
dispatched homolog 1 (Drosophila)
chr14_+_27039001 5.222 ENSMUST00000035336.3
 Il17rd
interleukin 17 receptor D
chr6_+_17065129 5.055 ENSMUST00000115467.4
ENSMUST00000154266.2
ENSMUST00000076654.7
 Tes


testis derived transcript


chr14_-_98169542 4.983 ENSMUST00000069334.7
ENSMUST00000071533.6
 Dach1

dachshund 1 (Drosophila)

chr2_+_174760619 4.801 ENSMUST00000029030.2
 Edn3
endothelin 3
chr11_+_108920800 4.669 ENSMUST00000140821.1
 Axin2
axin2
chr5_-_134946917 4.484 ENSMUST00000051401.2
 Cldn4
claudin 4
chr10_+_79988584 4.419 ENSMUST00000004784.4
ENSMUST00000105374.1
 Cnn2

calponin 2

chr6_-_148944750 4.334 ENSMUST00000111562.1
ENSMUST00000081956.5
 Fam60a

family with sequence similarity 60, member A

chr10_-_61979073 4.109 ENSMUST00000105453.1
ENSMUST00000105452.2
ENSMUST00000105454.2
 Col13a1


collagen, type XIII, alpha 1


chr2_-_69586021 4.066 ENSMUST00000100051.2
ENSMUST00000092551.4
ENSMUST00000080953.5
 Lrp2


low density lipoprotein receptor-related protein 2


chr7_-_144939823 4.066 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chrX_-_48034842 4.038 ENSMUST00000039026.7
 Apln
apelin
chr2_+_173022360 4.013 ENSMUST00000173997.1
 Rbm38
RNA binding motif protein 38
chr12_-_16800674 3.869 ENSMUST00000162112.1
 Greb1
gene regulated by estrogen in breast cancer protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 115 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 7.8 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.5 7.7 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.4 7.1 GO:0048617 embryonic foregut morphogenesis(GO:0048617)
0.6 6.8 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.4 6.7 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
2.2 6.5 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.5 5.4 GO:0060539 diaphragm development(GO:0060539)
1.7 5.0 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.1 5.0 GO:0071300 cellular response to retinoic acid(GO:0071300)
1.6 4.8 GO:0003100 regulation of systemic arterial blood pressure by endothelin(GO:0003100) vein smooth muscle contraction(GO:0014826)
1.2 4.8 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.1 4.7 GO:0007601 visual perception(GO:0007601)
0.0 4.6 GO:0007015 actin filament organization(GO:0007015)
0.5 4.5 GO:0061436 establishment of skin barrier(GO:0061436)
0.3 4.4 GO:0050765 negative regulation of phagocytosis(GO:0050765)
0.6 4.1 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.4 4.1 GO:0045056 transcytosis(GO:0045056)
0.6 4.0 GO:0051461 positive regulation of heat generation(GO:0031652) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
1.2 3.7 GO:0060217 hemangioblast cell differentiation(GO:0060217)
0.1 3.6 GO:0071347 cellular response to interleukin-1(GO:0071347)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 19.0 GO:0005667 transcription factor complex(GO:0005667)
0.8 8.3 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.1 7.9 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 5.9 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.4 5.7 GO:0016460 myosin II complex(GO:0016460)
0.5 5.1 GO:0001739 sex chromatin(GO:0001739)
1.2 4.8 GO:0043259 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)
0.2 4.6 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.2 4.5 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.2 4.3 GO:0016580 Sin3 complex(GO:0016580)
0.1 4.1 GO:0031526 brush border membrane(GO:0031526)
0.1 3.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
1.2 3.7 GO:0033193 Lsd1/2 complex(GO:0033193)
0.2 3.6 GO:0071564 npBAF complex(GO:0071564)
0.0 3.0 GO:0005581 collagen trimer(GO:0005581)
0.5 2.9 GO:0044530 supraspliceosomal complex(GO:0044530)
0.1 2.8 GO:0001772 immunological synapse(GO:0001772)
0.5 2.7 GO:0044294 dendritic growth cone(GO:0044294)
0.5 2.5 GO:0008623 CHRAC(GO:0008623)
0.3 2.4 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 85 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.5 GO:0003682 chromatin binding(GO:0003682)
0.4 8.8 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.4 7.8 GO:0070411 I-SMAD binding(GO:0070411)
0.4 7.2 GO:0070410 co-SMAD binding(GO:0070410)
0.1 6.8 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.1 6.8 GO:0001047 core promoter binding(GO:0001047)
1.1 6.5 GO:0030284 estrogen receptor activity(GO:0030284)
0.1 6.4 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.4 6.3 GO:0015197 peptide transporter activity(GO:0015197)
0.2 5.5 GO:0071889 14-3-3 protein binding(GO:0071889)
1.7 5.2 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 5.2 GO:0051015 actin filament binding(GO:0051015)
1.7 5.0 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.2 5.0 GO:0070064 proline-rich region binding(GO:0070064)
0.6 4.8 GO:0043208 glycosphingolipid binding(GO:0043208)
1.6 4.7 GO:0005118 sevenless binding(GO:0005118)
0.0 4.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.8 4.1 GO:0030492 hemoglobin binding(GO:0030492)
0.0 4.0 GO:0000287 magnesium ion binding(GO:0000287)
0.0 3.9 GO:0061630 ubiquitin protein ligase activity(GO:0061630)