Motif ID: Tfap2a

Z-value: 1.369


Transcription factors associated with Tfap2a:

Gene SymbolEntrez IDGene Name
Tfap2a ENSMUSG00000021359.9 Tfap2a

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap2amm10_v2_chr13_-_40733768_40733836-0.512.6e-03Click!


Activity profile for motif Tfap2a.

activity profile for motif Tfap2a


Sorted Z-values histogram for motif Tfap2a

Sorted Z-values for motif Tfap2a



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap2a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_64046925 9.849 ENSMUST00000107377.3
 Tnc
tenascin C
chr17_+_69969073 6.421 ENSMUST00000133983.1
 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr11_+_78322965 6.279 ENSMUST00000017534.8
 Aldoc
aldolase C, fructose-bisphosphate
chr9_+_26733728 5.861 ENSMUST00000160899.1
ENSMUST00000161431.1
ENSMUST00000159799.1
 B3gat1


beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)


chr1_+_159737510 5.687 ENSMUST00000111669.3
 Tnr
tenascin R
chr13_-_110280103 5.569 ENSMUST00000167824.1
 Rab3c
RAB3C, member RAS oncogene family
chr17_+_69969217 5.385 ENSMUST00000060072.5
 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr10_+_100015817 5.367 ENSMUST00000130190.1
ENSMUST00000020129.7
 Kitl

kit ligand

chr4_-_148287927 5.261 ENSMUST00000047720.8
 Ptchd2
patched domain containing 2
chr11_-_118909487 5.247 ENSMUST00000117731.1
ENSMUST00000106278.2
ENSMUST00000120061.1
ENSMUST00000017576.4
 Rbfox3



RNA binding protein, fox-1 homolog (C. elegans) 3



chr13_+_54949388 5.120 ENSMUST00000026994.7
ENSMUST00000109994.2
 Unc5a

unc-5 homolog A (C. elegans)

chr11_-_102897123 4.916 ENSMUST00000067444.3
 Gfap
glial fibrillary acidic protein
chr5_+_117841839 4.907 ENSMUST00000142742.2
 Nos1
nitric oxide synthase 1, neuronal
chr17_+_69969387 4.781 ENSMUST00000146730.1
 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr2_+_91945703 4.692 ENSMUST00000178895.1
 Gm9821
predicted gene 9821
chr5_-_146585239 4.459 ENSMUST00000036211.6
 Gpr12
G-protein coupled receptor 12
chr10_+_81575306 4.359 ENSMUST00000146916.1
 Tle2
transducin-like enhancer of split 2, homolog of Drosophila E(spl)
chr11_-_116110211 4.298 ENSMUST00000106441.1
ENSMUST00000021120.5
 Trim47

tripartite motif-containing 47

chr14_-_29721835 4.277 ENSMUST00000022567.7
 Cacna2d3
calcium channel, voltage-dependent, alpha2/delta subunit 3
chr4_-_20778527 4.047 ENSMUST00000119374.1
 Nkain3
Na+/K+ transporting ATPase interacting 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 243 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 16.6 GO:0070842 aggresome assembly(GO:0070842)
0.7 14.1 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
2.5 10.1 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
1.3 9.1 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
1.6 8.0 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)
1.4 7.0 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441)
0.3 6.4 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.2 6.4 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.6 6.3 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
1.9 5.7 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.1 5.5 GO:0002028 regulation of sodium ion transport(GO:0002028)
1.3 5.4 GO:0033024 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.8 5.3 GO:0032811 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of epinephrine secretion(GO:0032811)
0.0 5.3 GO:0008203 cholesterol metabolic process(GO:0008203)
0.2 5.2 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.6 5.1 GO:0033564 anterior/posterior axon guidance(GO:0033564)
1.6 4.8 GO:0060060 post-embryonic retina morphogenesis in camera-type eye(GO:0060060)
0.7 4.4 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.3 4.4 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.4 4.3 GO:0010459 negative regulation of heart rate(GO:0010459)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 103 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 18.3 GO:0045211 postsynaptic membrane(GO:0045211)
0.2 11.3 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.6 9.8 GO:0005614 interstitial matrix(GO:0005614)
0.0 8.4 GO:0030426 growth cone(GO:0030426)
2.0 8.0 GO:0097450 astrocyte end-foot(GO:0097450)
0.2 7.4 GO:0032809 neuronal cell body membrane(GO:0032809)
0.5 7.0 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.3 6.5 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
1.9 5.7 GO:0072534 perineuronal net(GO:0072534)
0.1 5.6 GO:0032420 stereocilium(GO:0032420)
0.1 5.5 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.2 5.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
1.1 5.3 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.0 5.3 GO:0030424 axon(GO:0030424)
0.1 5.0 GO:0031225 anchored component of membrane(GO:0031225)
0.2 4.4 GO:0060077 inhibitory synapse(GO:0060077)
0.0 4.4 GO:0000139 Golgi membrane(GO:0000139)
0.4 4.2 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.2 3.6 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 3.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 177 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 14.1 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
1.9 11.2 GO:0045545 syndecan binding(GO:0045545)
0.1 8.4 GO:0017137 Rab GTPase binding(GO:0017137)
0.8 7.0 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) calcium-independent phospholipase A2 activity(GO:0047499)
1.0 6.3 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.6 5.7 GO:0046625 sphingolipid binding(GO:0046625)
0.0 5.7 GO:0003714 transcription corepressor activity(GO:0003714)
0.2 5.6 GO:0031489 myosin V binding(GO:0031489)
0.9 5.4 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 5.4 GO:0050681 androgen receptor binding(GO:0050681)
0.9 5.3 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 5.3 GO:0030695 GTPase regulator activity(GO:0030695)
0.9 5.1 GO:0005042 netrin receptor activity(GO:0005042)
1.6 4.9 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.1 4.8 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.1 4.7 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.1 4.6 GO:0050699 WW domain binding(GO:0050699)
0.5 4.5 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.1 4.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.6 4.3 GO:0004351 glutamate decarboxylase activity(GO:0004351)