Motif ID: Tfap2b

Z-value: 0.847


Transcription factors associated with Tfap2b:

Gene SymbolEntrez IDGene Name
Tfap2b ENSMUSG00000025927.7 Tfap2b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap2bmm10_v2_chr1_+_19212054_192121060.364.1e-02Click!


Activity profile for motif Tfap2b.

activity profile for motif Tfap2b


Sorted Z-values histogram for motif Tfap2b

Sorted Z-values for motif Tfap2b



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap2b

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_37824580 5.068 ENSMUST00000063116.9
 Msx1
msh homeobox 1
chr2_+_119742306 3.743 ENSMUST00000028758.7
 Itpka
inositol 1,4,5-trisphosphate 3-kinase A
chr2_-_164404606 2.866 ENSMUST00000109359.1
ENSMUST00000109358.1
ENSMUST00000103103.3
 Matn4


matrilin 4


chr17_+_86963279 2.787 ENSMUST00000139344.1
 Rhoq
ras homolog gene family, member Q
chr17_+_86963077 2.587 ENSMUST00000024956.8
 Rhoq
ras homolog gene family, member Q
chr11_-_102365111 2.269 ENSMUST00000006749.9
 Slc4a1
solute carrier family 4 (anion exchanger), member 1
chr6_-_24956106 2.128 ENSMUST00000127247.2
 Tmem229a
transmembrane protein 229A
chr4_-_57143437 2.050 ENSMUST00000095076.3
ENSMUST00000030142.3
 Epb4.1l4b

erythrocyte protein band 4.1-like 4b

chr10_-_121476248 2.002 ENSMUST00000026902.7
 Rassf3
Ras association (RalGDS/AF-6) domain family member 3
chr4_+_46450892 1.996 ENSMUST00000102926.4
 Anp32b
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr11_+_11115784 1.861 ENSMUST00000056344.4
 Vwc2
von Willebrand factor C domain containing 2
chrX_+_73757069 1.831 ENSMUST00000002079.6
 Plxnb3
plexin B3
chr16_-_38713235 1.800 ENSMUST00000023487.4
 Arhgap31
Rho GTPase activating protein 31
chr9_-_54647199 1.781 ENSMUST00000128163.1
 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr8_-_105943382 1.700 ENSMUST00000038896.7
 Lcat
lecithin cholesterol acyltransferase
chr12_-_76709997 1.671 ENSMUST00000166101.1
 Sptb
spectrin beta, erythrocytic
chr10_-_58675631 1.611 ENSMUST00000003312.4
 Edar
ectodysplasin-A receptor
chr17_-_70849644 1.541 ENSMUST00000134654.1
ENSMUST00000172229.1
ENSMUST00000127719.1
 Tgif1


TGFB-induced factor homeobox 1


chr9_-_57262591 1.485 ENSMUST00000034846.5
 1700017B05Rik
RIKEN cDNA 1700017B05 gene
chr3_-_132950043 1.474 ENSMUST00000117164.1
ENSMUST00000093971.4
ENSMUST00000042729.9
ENSMUST00000042744.9
ENSMUST00000117811.1
 Npnt




nephronectin





Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 118 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.6 GO:0090005 negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
1.7 5.1 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.4 3.7 GO:0006020 inositol metabolic process(GO:0006020)
0.1 2.7 GO:0048678 response to axon injury(GO:0048678)
0.1 2.5 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.1 2.1 GO:0051693 actin filament capping(GO:0051693)
0.1 2.0 GO:0030238 male sex determination(GO:0030238)
0.1 2.0 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.2 1.9 GO:0035092 sperm chromatin condensation(GO:0035092)
0.1 1.9 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.0 1.9 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.5 1.8 GO:0010593 negative regulation of lamellipodium assembly(GO:0010593)
0.0 1.8 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.3 1.7 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372)
0.0 1.7 GO:0034605 cellular response to heat(GO:0034605)
0.2 1.6 GO:0060662 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.4 1.5 GO:0010694 positive regulation of alkaline phosphatase activity(GO:0010694)
0.2 1.5 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601) regulation of wound healing, spreading of epidermal cells(GO:1903689)
0.1 1.5 GO:0010748 negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) positive regulation of fatty acid beta-oxidation(GO:0032000)
0.1 1.5 GO:0048387 nodal signaling pathway(GO:0038092) negative regulation of retinoic acid receptor signaling pathway(GO:0048387)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.1 GO:0005884 actin filament(GO:0005884)
0.0 3.9 GO:0031225 anchored component of membrane(GO:0031225)
0.0 3.3 GO:0072562 blood microparticle(GO:0072562)
0.3 2.8 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 2.6 GO:0005581 collagen trimer(GO:0005581)
0.0 2.3 GO:0030027 lamellipodium(GO:0030027)
0.0 2.1 GO:0043197 dendritic spine(GO:0043197)
0.1 1.9 GO:0005614 interstitial matrix(GO:0005614)
0.0 1.9 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 1.7 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.1 1.7 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.3 1.5 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.1 1.5 GO:0032593 insulin-responsive compartment(GO:0032593)
0.4 1.3 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.0 1.2 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 1.2 GO:0045171 intercellular bridge(GO:0045171)
0.2 1.1 GO:0008091 spectrin(GO:0008091)
0.0 1.1 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.1 1.0 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 0.9 GO:0030173 integral component of Golgi membrane(GO:0030173)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.1 GO:0002039 p53 binding(GO:0002039)
0.0 4.4 GO:0005178 integrin binding(GO:0005178)
0.3 4.2 GO:0005522 profilin binding(GO:0005522)
0.5 3.7 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.2 3.0 GO:0051920 peroxiredoxin activity(GO:0051920)
0.1 2.3 GO:0015106 bicarbonate transmembrane transporter activity(GO:0015106)
0.5 2.0 GO:0045131 pre-mRNA branch point binding(GO:0045131)
0.0 1.9 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.2 1.8 GO:0051022 Rho GDP-dissociation inhibitor binding(GO:0051022)
0.2 1.8 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.4 1.7 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.1 1.7 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 1.7 GO:0032794 GTPase activating protein binding(GO:0032794)
0.1 1.6 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 1.5 GO:0070410 co-SMAD binding(GO:0070410)
0.0 1.5 GO:0043851 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) rRNA (uridine-2'-O-)-methyltransferase activity(GO:0008650) rRNA (adenine-N6-)-methyltransferase activity(GO:0008988) rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383) selenocysteine methyltransferase activity(GO:0016205) rRNA (adenine) methyltransferase activity(GO:0016433) rRNA (cytosine) methyltransferase activity(GO:0016434) rRNA (guanine) methyltransferase activity(GO:0016435) 1-phenanthrol methyltransferase activity(GO:0018707) protein-arginine N5-methyltransferase activity(GO:0019702) dimethylarsinite methyltransferase activity(GO:0034541) 4,5-dihydroxybenzo(a)pyrene methyltransferase activity(GO:0034807) 1-hydroxypyrene methyltransferase activity(GO:0034931) 1-hydroxy-6-methoxypyrene methyltransferase activity(GO:0034933) demethylmenaquinone methyltransferase activity(GO:0043770) cobalt-precorrin-6B C5-methyltransferase activity(GO:0043776) cobalt-precorrin-7 C15-methyltransferase activity(GO:0043777) cobalt-precorrin-5B C1-methyltransferase activity(GO:0043780) cobalt-precorrin-3 C17-methyltransferase activity(GO:0043782) dimethylamine methyltransferase activity(GO:0043791) hydroxyneurosporene-O-methyltransferase activity(GO:0043803) tRNA (adenine-57, 58-N(1)-) methyltransferase activity(GO:0043827) methylamine-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043833) trimethylamine methyltransferase activity(GO:0043834) methanol-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043851) monomethylamine methyltransferase activity(GO:0043852) P-methyltransferase activity(GO:0051994) Se-methyltransferase activity(GO:0051995) 2-phytyl-1,4-naphthoquinone methyltransferase activity(GO:0052624) tRNA (uracil-2'-O-)-methyltransferase activity(GO:0052665) tRNA (cytosine-2'-O-)-methyltransferase activity(GO:0052666) phosphomethylethanolamine N-methyltransferase activity(GO:0052667) tRNA (cytosine-3-)-methyltransferase activity(GO:0052735) rRNA (cytosine-2'-O-)-methyltransferase activity(GO:0070677) rRNA (cytosine-N4-)-methyltransferase activity(GO:0071424) trihydroxyferuloyl spermidine O-methyltransferase activity(GO:0080012)
0.1 1.4 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 1.4 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.1 1.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 1.4 GO:0005109 frizzled binding(GO:0005109)