Motif ID: Tfap2c

Z-value: 0.630


Transcription factors associated with Tfap2c:

Gene SymbolEntrez IDGene Name
Tfap2c ENSMUSG00000028640.5 Tfap2c

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap2cmm10_v2_chr2_+_172550761_172550782-0.308.5e-02Click!


Activity profile for motif Tfap2c.

activity profile for motif Tfap2c


Sorted Z-values histogram for motif Tfap2c

Sorted Z-values for motif Tfap2c



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap2c

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_4505493 2.211 ENSMUST00000031668.8
 Col1a2
collagen, type I, alpha 2
chr8_+_70493156 2.097 ENSMUST00000008032.7
 Crlf1
cytokine receptor-like factor 1
chr6_+_4504814 1.944 ENSMUST00000141483.1
 Col1a2
collagen, type I, alpha 2
chr11_+_85832551 1.362 ENSMUST00000000095.6
 Tbx2
T-box 2
chr14_+_119138415 0.956 ENSMUST00000065904.3
 Hs6st3
heparan sulfate 6-O-sulfotransferase 3
chr11_-_106715251 0.831 ENSMUST00000080853.4
ENSMUST00000183610.1
ENSMUST00000103069.3
ENSMUST00000106796.2
 Pecam1



platelet/endothelial cell adhesion molecule 1



chr9_+_89909775 0.822 ENSMUST00000034912.4
ENSMUST00000034909.4
 Rasgrf1

RAS protein-specific guanine nucleotide-releasing factor 1

chr6_+_88198656 0.801 ENSMUST00000015197.7
 Gata2
GATA binding protein 2
chr12_+_109459843 0.801 ENSMUST00000173812.1
 Dlk1
delta-like 1 homolog (Drosophila)
chr1_-_184883218 0.792 ENSMUST00000048308.5
 C130074G19Rik
RIKEN cDNA C130074G19 gene
chr7_+_99535652 0.690 ENSMUST00000032995.8
ENSMUST00000162404.1
 Arrb1

arrestin, beta 1

chr12_-_76709997 0.685 ENSMUST00000166101.1
 Sptb
spectrin beta, erythrocytic
chr11_+_67455339 0.685 ENSMUST00000108681.1
 Gas7
growth arrest specific 7
chr2_-_32353247 0.650 ENSMUST00000078352.5
ENSMUST00000113352.2
ENSMUST00000113365.1
 Dnm1


dynamin 1


chr8_+_122282117 0.640 ENSMUST00000054052.8
 Zfpm1
zinc finger protein, multitype 1
chr6_+_21985903 0.632 ENSMUST00000137437.1
ENSMUST00000115383.2
 Cped1

cadherin-like and PC-esterase domain containing 1

chr15_+_100761741 0.615 ENSMUST00000023776.6
 Slc4a8
solute carrier family 4 (anion exchanger), member 8
chrX_+_94234594 0.615 ENSMUST00000153900.1
 Klhl15
kelch-like 15
chr19_+_5068077 0.603 ENSMUST00000070630.6
 Cd248
CD248 antigen, endosialin
chr7_-_29518566 0.602 ENSMUST00000181975.1
 Sipa1l3
signal-induced proliferation-associated 1 like 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 86 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.3 GO:0043589 skin morphogenesis(GO:0043589)
0.3 2.1 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.5 1.4 GO:0007521 muscle cell fate determination(GO:0007521) mammary placode formation(GO:0060596)
0.2 1.0 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 0.9 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.3 0.8 GO:0021837 motogenic signaling involved in postnatal olfactory bulb interneuron migration(GO:0021837) positive regulation of mitotic cell cycle DNA replication(GO:1903465)
0.2 0.8 GO:0050904 diapedesis(GO:0050904)
0.1 0.8 GO:0042178 xenobiotic catabolic process(GO:0042178)
0.0 0.8 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.2 0.7 GO:0010725 regulation of primitive erythrocyte differentiation(GO:0010725)
0.2 0.7 GO:0097309 cap1 mRNA methylation(GO:0097309)
0.2 0.7 GO:1904177 regulation of adipose tissue development(GO:1904177)
0.1 0.7 GO:0034393 positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.1 0.7 GO:1903423 positive regulation of synaptic vesicle recycling(GO:1903423)
0.0 0.7 GO:0033014 porphyrin-containing compound biosynthetic process(GO:0006779) tetrapyrrole biosynthetic process(GO:0033014)
0.3 0.6 GO:0090202 transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
0.1 0.6 GO:0060032 notochord regression(GO:0060032)
0.1 0.6 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.0 0.6 GO:0060033 anatomical structure regression(GO:0060033)
0.0 0.6 GO:0015701 bicarbonate transport(GO:0015701)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 4.2 GO:0005584 collagen type I trimer(GO:0005584)
0.7 2.1 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.2 0.8 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 0.8 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 0.7 GO:0008091 spectrin(GO:0008091)
0.1 0.7 GO:0005638 lamin filament(GO:0005638)
0.0 0.7 GO:0043196 varicosity(GO:0043196)
0.0 0.7 GO:0031143 pseudopodium(GO:0031143)
0.1 0.6 GO:0061689 tricellular tight junction(GO:0061689)
0.1 0.6 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.6 GO:0097542 ciliary tip(GO:0097542)
0.0 0.6 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.6 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.6 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 0.5 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 0.4 GO:0044194 cytolytic granule(GO:0044194)
0.0 0.4 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 0.3 GO:0032426 stereocilium tip(GO:0032426)
0.0 0.3 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.2 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 2.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.3 2.1 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 1.0 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
0.0 1.0 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.2 0.8 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.1 0.8 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 0.8 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.1 0.8 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.0 0.8 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.2 0.7 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.2 0.7 GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483)
0.0 0.7 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.7 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 0.6 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.6 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.1 0.5 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.1 0.5 GO:1990188 euchromatin binding(GO:1990188)
0.0 0.5 GO:0070402 NADPH binding(GO:0070402)
0.0 0.5 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)