Motif ID: Tfap2e

Z-value: 0.742


Transcription factors associated with Tfap2e:

Gene SymbolEntrez IDGene Name
Tfap2e ENSMUSG00000042477.7 Tfap2e

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap2emm10_v2_chr4_-_126736236_126736245-0.493.4e-03Click!


Activity profile for motif Tfap2e.

activity profile for motif Tfap2e


Sorted Z-values histogram for motif Tfap2e

Sorted Z-values for motif Tfap2e



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap2e

PNG image of the network

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Top targets:


Showing 1 to 20 of 59 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_102897123 8.252 ENSMUST00000067444.3
 Gfap
glial fibrillary acidic protein
chr2_+_91945703 6.267 ENSMUST00000178895.1
 Gm9821
predicted gene 9821
chr11_-_102897146 6.078 ENSMUST00000077902.4
 Gfap
glial fibrillary acidic protein
chr8_+_94152607 3.773 ENSMUST00000034211.8
 Mt3
metallothionein 3
chr1_+_159737510 3.295 ENSMUST00000111669.3
 Tnr
tenascin R
chr2_+_102658640 2.607 ENSMUST00000080210.3
 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr13_-_101768154 2.510 ENSMUST00000055518.6
 Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr6_-_137649211 2.032 ENSMUST00000134630.1
ENSMUST00000058210.6
ENSMUST00000111878.1
 Eps8


epidermal growth factor receptor pathway substrate 8


chr17_+_37046555 1.696 ENSMUST00000172789.1
 Gabbr1
gamma-aminobutyric acid (GABA) B receptor, 1
chr1_-_125913101 1.510 ENSMUST00000161361.1
 Lypd1
Ly6/Plaur domain containing 1
chr8_+_41239718 1.507 ENSMUST00000045218.7
 Pcm1
pericentriolar material 1
chr13_+_54949388 1.343 ENSMUST00000026994.7
ENSMUST00000109994.2
 Unc5a

unc-5 homolog A (C. elegans)

chr5_-_34187670 1.309 ENSMUST00000042701.6
ENSMUST00000119171.1
 Mxd4

Max dimerization protein 4

chr15_-_102524615 1.223 ENSMUST00000023814.7
 Npff
neuropeptide FF-amide peptide precursor
chr9_+_25252439 1.094 ENSMUST00000115272.2
ENSMUST00000165594.2
 Sept7

septin 7

chr6_+_108213086 1.056 ENSMUST00000032192.6
 Itpr1
inositol 1,4,5-trisphosphate receptor 1
chr7_-_19629355 1.046 ENSMUST00000049912.8
ENSMUST00000094762.3
ENSMUST00000098754.4
 Relb


avian reticuloendotheliosis viral (v-rel) oncogene related B


chr16_+_93832121 1.041 ENSMUST00000044068.6
 Morc3
microrchidia 3
chr8_+_107293463 1.010 ENSMUST00000169453.1
 Nfat5
nuclear factor of activated T cells 5
chr3_-_113630068 1.006 ENSMUST00000092154.3
ENSMUST00000106536.1
ENSMUST00000106535.1
 Rnpc3


RNA-binding region (RNP1, RRM) containing 3



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 14.3 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)
1.3 3.8 GO:0097212 lysosomal membrane organization(GO:0097212)
0.4 3.7 GO:0010459 negative regulation of heart rate(GO:0010459)
1.1 3.3 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.4 2.6 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.5 2.0 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.1 1.9 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.2 1.7 GO:0032811 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of epinephrine secretion(GO:0032811)
0.4 1.5 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.1 1.5 GO:0007271 synaptic transmission, cholinergic(GO:0007271)
0.2 1.3 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.2 1.1 GO:0042045 epithelial fluid transport(GO:0042045)
0.1 1.1 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.1 1.1 GO:0031268 pseudopodium organization(GO:0031268)
0.2 1.0 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.1 1.0 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.1 1.0 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.0 1.0 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.0 1.0 GO:0006862 nucleotide transport(GO:0006862)
0.2 0.9 GO:1900095 regulation of dosage compensation by inactivation of X chromosome(GO:1900095)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.6 14.3 GO:0097450 astrocyte end-foot(GO:0097450)
0.0 3.8 GO:0008021 synaptic vesicle(GO:0008021)
1.1 3.3 GO:0072534 perineuronal net(GO:0072534)
0.1 3.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 2.6 GO:0030673 axolemma(GO:0030673)
0.1 2.0 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.3 1.7 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1 1.5 GO:0000242 pericentriolar material(GO:0000242)
0.0 1.5 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.3 GO:0032589 neuron projection membrane(GO:0032589) neuronal cell body membrane(GO:0032809)
0.4 1.1 GO:0005940 septin ring(GO:0005940)
0.4 1.1 GO:0031088 platelet dense granule membrane(GO:0031088)
0.2 1.0 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 1.0 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 1.0 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 1.0 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 0.9 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.2 0.8 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.1 0.8 GO:0034464 BBSome(GO:0034464)
0.0 0.8 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 14.3 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.2 3.3 GO:0046625 sphingolipid binding(GO:0046625)
0.7 2.6 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.6 2.5 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.0 2.0 GO:0035591 signaling adaptor activity(GO:0035591)
0.3 1.7 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 1.7 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.2 1.5 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.1 1.4 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.2 1.3 GO:0005042 netrin receptor activity(GO:0005042)
0.1 1.2 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.4 1.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 1.1 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.1 1.0 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.1 1.0 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.2 0.8 GO:0097016 L27 domain binding(GO:0097016)
0.1 0.8 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.7 GO:0008748 N-ethylmaleimide reductase activity(GO:0008748) reduced coenzyme F420 dehydrogenase activity(GO:0043738) sulfur oxygenase reductase activity(GO:0043826) malolactic enzyme activity(GO:0043883) epoxyqueuosine reductase activity(GO:0052693)
0.1 0.6 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 0.6 GO:0005227 calcium activated cation channel activity(GO:0005227)