Motif ID: Tfap4

Z-value: 1.110


Transcription factors associated with Tfap4:

Gene SymbolEntrez IDGene Name
Tfap4 ENSMUSG00000005718.7 Tfap4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap4mm10_v2_chr16_-_4559720_4559747-0.611.9e-04Click!


Activity profile for motif Tfap4.

activity profile for motif Tfap4


Sorted Z-values histogram for motif Tfap4

Sorted Z-values for motif Tfap4



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_91269759 9.931 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr9_-_40346290 7.561 ENSMUST00000121357.1
 Gramd1b
GRAM domain containing 1B
chr15_-_66812593 6.532 ENSMUST00000100572.3
 Sla
src-like adaptor
chr2_+_170731807 6.447 ENSMUST00000029075.4
 Dok5
docking protein 5
chr7_-_97417730 5.812 ENSMUST00000043077.7
 Thrsp
thyroid hormone responsive
chr4_+_119814495 5.776 ENSMUST00000106307.2
 Hivep3
human immunodeficiency virus type I enhancer binding protein 3
chr6_-_58907120 5.158 ENSMUST00000059539.3
 Nap1l5
nucleosome assembly protein 1-like 5
chr18_-_23041641 5.046 ENSMUST00000097651.3
 Nol4
nucleolar protein 4
chr6_-_136171722 4.914 ENSMUST00000053880.6
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr2_+_37516618 4.880 ENSMUST00000065441.6
 Gpr21
G protein-coupled receptor 21
chr4_+_48045144 4.343 ENSMUST00000030025.3
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr3_+_90537242 4.250 ENSMUST00000098911.3
 S100a16
S100 calcium binding protein A16
chr13_+_54949388 4.227 ENSMUST00000026994.7
ENSMUST00000109994.2
 Unc5a

unc-5 homolog A (C. elegans)

chr6_+_90465287 4.117 ENSMUST00000113530.1
 Klf15
Kruppel-like factor 15
chr1_-_79761752 3.961 ENSMUST00000113512.1
ENSMUST00000113513.1
ENSMUST00000113515.1
ENSMUST00000113514.1
ENSMUST00000113510.1
ENSMUST00000113511.1
ENSMUST00000048820.7
 Wdfy1






WD repeat and FYVE domain containing 1






chr8_+_66386292 3.658 ENSMUST00000039540.5
ENSMUST00000110253.2
 March1

membrane-associated ring finger (C3HC4) 1

chr3_-_84220853 3.650 ENSMUST00000154152.1
ENSMUST00000107693.2
ENSMUST00000107695.2
 Trim2


tripartite motif-containing 2


chr2_-_52335134 3.634 ENSMUST00000075301.3
 Neb
nebulin
chr15_-_102722120 3.629 ENSMUST00000171838.1
 Calcoco1
calcium binding and coiled coil domain 1
chr15_-_102722150 3.582 ENSMUST00000023818.3
 Calcoco1
calcium binding and coiled coil domain 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 121 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.2 GO:0048709 oligodendrocyte differentiation(GO:0048709)
0.1 7.6 GO:0051592 response to calcium ion(GO:0051592)
0.4 6.5 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.6 6.4 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.2 5.8 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
1.1 5.7 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 5.6 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 5.2 GO:0006334 nucleosome assembly(GO:0006334)
0.8 4.9 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
1.1 4.4 GO:0001920 negative regulation of receptor recycling(GO:0001920)
1.4 4.3 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
0.0 4.3 GO:0030518 intracellular steroid hormone receptor signaling pathway(GO:0030518)
0.5 4.2 GO:0033564 anterior/posterior axon guidance(GO:0033564)
1.0 4.0 GO:0034145 positive regulation of toll-like receptor 4 signaling pathway(GO:0034145)
0.2 3.7 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0 3.7 GO:0043523 regulation of neuron apoptotic process(GO:0043523)
0.1 3.6 GO:0045214 sarcomere organization(GO:0045214)
0.1 3.3 GO:0071625 vocalization behavior(GO:0071625)
0.1 3.3 GO:0021799 cerebral cortex radially oriented cell migration(GO:0021799)
0.1 3.2 GO:0032728 positive regulation of interferon-beta production(GO:0032728)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 12.4 GO:0005768 endosome(GO:0005768)
0.0 11.6 GO:0005730 nucleolus(GO:0005730)
0.0 8.0 GO:0000790 nuclear chromatin(GO:0000790)
0.0 6.0 GO:0005802 trans-Golgi network(GO:0005802)
0.1 5.6 GO:0000785 chromatin(GO:0000785)
0.1 5.2 GO:0005776 autophagosome(GO:0005776)
0.4 4.9 GO:0043083 synaptic cleft(GO:0043083)
0.1 4.2 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 3.7 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.2 3.6 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 3.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.2 3.1 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.2 3.0 GO:0042405 nuclear inclusion body(GO:0042405)
0.1 3.0 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.7 2.8 GO:1990795 lateral part of cell(GO:0097574) basolateral part of cell(GO:1990794) rod bipolar cell terminal bouton(GO:1990795)
0.9 2.7 GO:0097512 cardiac myofibril(GO:0097512)
0.3 2.7 GO:0005883 neurofilament(GO:0005883)
0.3 2.5 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.1 2.2 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 2.2 GO:0030667 secretory granule membrane(GO:0030667)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 7.2 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 6.9 GO:0005158 insulin receptor binding(GO:0005158)
0.3 6.6 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.2 5.7 GO:0034945 dihydrolipoamide branched chain acyltransferase activity(GO:0004147) palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity(GO:0008951) serine O-acyltransferase activity(GO:0016412) O-succinyltransferase activity(GO:0016750) sinapoyltransferase activity(GO:0016752) O-sinapoyltransferase activity(GO:0016753) peptidyl-lysine N6-myristoyltransferase activity(GO:0018030) peptidyl-lysine N6-palmitoyltransferase activity(GO:0018031) benzoyl acetate-CoA thiolase activity(GO:0018711) 3-hydroxybutyryl-CoA thiolase activity(GO:0018712) 3-ketopimelyl-CoA thiolase activity(GO:0018713) N-palmitoyltransferase activity(GO:0019105) acyl-CoA N-acyltransferase activity(GO:0019186) protein-cysteine S-myristoyltransferase activity(GO:0019705) glucosaminyl-phosphotidylinositol O-acyltransferase activity(GO:0032216) ergosterol O-acyltransferase activity(GO:0034737) lanosterol O-acyltransferase activity(GO:0034738) naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity(GO:0034848) 2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity(GO:0034851) 2-methylhexanoyl-CoA C-acetyltransferase activity(GO:0034915) butyryl-CoA 2-C-propionyltransferase activity(GO:0034919) 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity(GO:0034945) L-2-aminoadipate N-acetyltransferase activity(GO:0043741) keto acid formate lyase activity(GO:0043806) azetidine-2-carboxylic acid acetyltransferase activity(GO:0046941) peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0052858) acetyl-CoA:L-lysine N6-acetyltransferase(GO:0090595)
1.6 4.9 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.5 4.9 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.5 4.4 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.3 4.3 GO:0001223 transcription coactivator binding(GO:0001223)
0.7 4.2 GO:0005042 netrin receptor activity(GO:0005042)
0.2 3.7 GO:0042287 MHC protein binding(GO:0042287)
0.1 3.6 GO:0050681 androgen receptor binding(GO:0050681)
0.0 3.4 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.3 3.0 GO:0034046 poly(G) binding(GO:0034046)
0.0 2.9 GO:0016209 antioxidant activity(GO:0016209)
0.4 2.8 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 2.8 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.3 2.7 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 2.7 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.0 2.6 GO:0004376 alpha-1,2-mannosyltransferase activity(GO:0000026) glycolipid mannosyltransferase activity(GO:0004376)
0.4 2.4 GO:0009374 biotin binding(GO:0009374)