Motif ID: Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

Z-value: 1.141

Transcription factors associated with Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2:

Gene SymbolEntrez IDGene Name
Bhlhe41 ENSMUSG00000030256.5 Bhlhe41
Srebf1 ENSMUSG00000020538.9 Srebf1
Srebf2 ENSMUSG00000022463.7 Srebf2
Tfeb ENSMUSG00000023990.12 Tfeb
Usf1 ENSMUSG00000026641.7 Usf1
Usf2 ENSMUSG00000058239.7 Usf2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfebmm10_v2_chr17_+_47737030_477371070.762.5e-07Click!
Srebf1mm10_v2_chr11_-_60210410_602104650.722.2e-06Click!
Usf2mm10_v2_chr7_-_30956742_309568030.567.6e-04Click!
Srebf2mm10_v2_chr15_+_82147238_821472750.559.2e-04Click!
Usf1mm10_v2_chr1_+_171411305_171411337-0.086.8e-01Click!


Activity profile for motif Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2.

activity profile for motif Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2


Sorted Z-values histogram for motif Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

Sorted Z-values for motif Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_89773221 14.101 ENSMUST00000038450.1
 4632404H12Rik
RIKEN cDNA 4632404H12 gene
chr6_+_90462562 10.922 ENSMUST00000032174.5
 Klf15
Kruppel-like factor 15
chr4_-_148038769 10.504 ENSMUST00000030879.5
ENSMUST00000137724.1
 Clcn6

chloride channel 6

chr16_-_45158624 9.378 ENSMUST00000180636.1
 Slc35a5
solute carrier family 35, member A5
chr16_-_45158566 9.022 ENSMUST00000181177.1
 Slc35a5
solute carrier family 35, member A5
chr8_+_13159135 8.980 ENSMUST00000033824.6
 Lamp1
lysosomal-associated membrane protein 1
chr16_-_45158453 8.878 ENSMUST00000181750.1
 Slc35a5
solute carrier family 35, member A5
chr16_-_45158650 8.640 ENSMUST00000023344.3
 Slc35a5
solute carrier family 35, member A5
chr17_-_66077022 8.213 ENSMUST00000150766.1
ENSMUST00000038116.5
 Ankrd12

ankyrin repeat domain 12

chr16_-_45158183 8.063 ENSMUST00000114600.1
 Slc35a5
solute carrier family 35, member A5
chr15_+_66577536 7.976 ENSMUST00000048188.8
 Phf20l1
PHD finger protein 20-like 1
chr7_+_35802593 7.386 ENSMUST00000052454.2
 E130304I02Rik
RIKEN cDNA E130304I02 gene
chr12_-_84450944 7.268 ENSMUST00000085192.5
 Aldh6a1
aldehyde dehydrogenase family 6, subfamily A1
chr14_+_34819811 6.999 ENSMUST00000043349.5
 Grid1
glutamate receptor, ionotropic, delta 1
chr15_-_3995708 6.782 ENSMUST00000046633.8
 AW549877
expressed sequence AW549877
chr8_-_46294592 6.742 ENSMUST00000058636.7
 Helt
helt bHLH transcription factor
chr11_-_116199040 6.646 ENSMUST00000066587.5
 Acox1
acyl-Coenzyme A oxidase 1, palmitoyl
chrX_+_166344692 6.622 ENSMUST00000112223.1
ENSMUST00000112224.1
ENSMUST00000112229.2
ENSMUST00000112228.1
ENSMUST00000112227.2
ENSMUST00000112226.2
 Gpm6b





glycoprotein m6b





chr4_+_127077374 6.323 ENSMUST00000046751.6
ENSMUST00000094713.3
 Zmym6

zinc finger, MYM-type 6

chr11_-_116198701 6.064 ENSMUST00000072948.4
 Acox1
acyl-Coenzyme A oxidase 1, palmitoyl

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 341 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 47.4 GO:0008643 carbohydrate transport(GO:0008643)
4.5 13.6 GO:1901254 positive regulation of intracellular transport of viral material(GO:1901254)
0.3 13.6 GO:0036465 synaptic vesicle recycling(GO:0036465)
3.2 12.7 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.8 11.0 GO:0072010 renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.4 10.7 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
1.2 9.7 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
1.4 9.6 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
3.0 9.0 GO:0043323 positive regulation of natural killer cell degranulation(GO:0043323)
0.5 8.6 GO:0097352 autophagosome maturation(GO:0097352)
2.1 8.5 GO:0016340 calcium-dependent cell-matrix adhesion(GO:0016340)
0.3 8.3 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.1 8.1 GO:0043473 pigmentation(GO:0043473)
1.5 7.6 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.2 7.6 GO:0051703 social behavior(GO:0035176) intraspecies interaction between organisms(GO:0051703)
2.4 7.3 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.5 7.2 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
1.8 7.1 GO:0035434 copper ion transmembrane transport(GO:0035434)
2.3 6.8 GO:0043379 memory T cell differentiation(GO:0043379)
0.3 6.5 GO:0010738 regulation of protein kinase A signaling(GO:0010738)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 158 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 65.2 GO:0016021 integral component of membrane(GO:0016021)
0.2 47.0 GO:0000139 Golgi membrane(GO:0000139)
4.5 13.6 GO:0042025 viral replication complex(GO:0019034) host cell nucleus(GO:0042025) host cell nuclear part(GO:0044094)
0.2 12.1 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 10.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
2.5 10.1 GO:0031084 BLOC-2 complex(GO:0031084)
3.0 9.0 GO:0044194 cytolytic granule(GO:0044194)
0.6 8.5 GO:0043196 varicosity(GO:0043196)
0.1 8.2 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 7.9 GO:0045211 postsynaptic membrane(GO:0045211)
1.1 7.5 GO:0033263 CORVET complex(GO:0033263)
0.8 6.9 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.2 6.3 GO:0035861 site of double-strand break(GO:0035861)
0.9 6.0 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.2 6.0 GO:0097440 apical dendrite(GO:0097440)
1.2 5.8 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 5.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 5.4 GO:0031225 anchored component of membrane(GO:0031225)
0.6 5.2 GO:0000813 ESCRT I complex(GO:0000813)
0.6 5.1 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 245 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 44.7 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.6 16.0 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
2.1 12.7 GO:0016401 palmitoyl-CoA oxidase activity(GO:0016401)
2.5 12.6 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.1 10.4 GO:0005262 calcium channel activity(GO:0005262)
0.0 10.4 GO:0005096 GTPase activator activity(GO:0005096)
0.2 9.5 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.6 9.1 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 9.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.3 8.7 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.1 8.5 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.5 8.3 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
1.3 8.1 GO:0043426 MRF binding(GO:0043426)
0.1 8.0 GO:0008565 protein transporter activity(GO:0008565)
0.1 7.8 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.3 7.3 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.3 7.0 GO:0005234 extracellular-glutamate-gated ion channel activity(GO:0005234)
0.1 6.5 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.3 6.3 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.1 6.2 GO:0003727 single-stranded RNA binding(GO:0003727)