Motif ID: Tgif1_Meis3

Z-value: 3.649

Transcription factors associated with Tgif1_Meis3:

Gene SymbolEntrez IDGene Name
Meis3 ENSMUSG00000041420.12 Meis3
Tgif1 ENSMUSG00000047407.11 Tgif1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tgif1mm10_v2_chr17_-_70853482_70853546-0.921.8e-14Click!
Meis3mm10_v2_chr7_+_16175085_161751390.749.0e-07Click!


Activity profile for motif Tgif1_Meis3.

activity profile for motif Tgif1_Meis3


Sorted Z-values histogram for motif Tgif1_Meis3

Sorted Z-values for motif Tgif1_Meis3



Network of associatons between targets according to the STRING database.



First level regulatory network of Tgif1_Meis3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_64046925 31.434 ENSMUST00000107377.3
 Tnc
tenascin C
chr1_-_132542934 29.695 ENSMUST00000086521.4
 Cntn2
contactin 2
chr7_+_49246131 27.555 ENSMUST00000064395.6
 Nav2
neuron navigator 2
chr8_-_84800024 21.192 ENSMUST00000126806.1
ENSMUST00000076715.6
 Nfix

nuclear factor I/X

chr15_-_66831625 20.419 ENSMUST00000164163.1
 Sla
src-like adaptor
chr8_+_57455898 18.774 ENSMUST00000034023.3
 Scrg1
scrapie responsive gene 1
chr6_-_88874045 18.652 ENSMUST00000038409.5
 Podxl2
podocalyxin-like 2
chr15_-_58076456 18.220 ENSMUST00000070143.6
ENSMUST00000110168.1
 Zhx1

zinc fingers and homeoboxes 1

chr4_-_82705735 17.720 ENSMUST00000155821.1
 Nfib
nuclear factor I/B
chr15_-_66801577 17.311 ENSMUST00000168589.1
 Sla
src-like adaptor
chr7_-_97417730 16.522 ENSMUST00000043077.7
 Thrsp
thyroid hormone responsive
chr15_+_18818895 16.105 ENSMUST00000166873.2
 Cdh10
cadherin 10
chr3_+_26331150 15.805 ENSMUST00000099182.2
 A830092H15Rik
RIKEN cDNA A830092H15 gene
chr12_-_24493656 15.341 ENSMUST00000073088.2
 Gm16372
predicted pseudogene 16372
chr19_+_23758819 15.154 ENSMUST00000025830.7
 Apba1
amyloid beta (A4) precursor protein binding, family A, member 1
chr15_+_82256023 14.300 ENSMUST00000143238.1
 1500009C09Rik
RIKEN cDNA 1500009C09 gene
chr1_+_194619815 14.161 ENSMUST00000027952.5
 Plxna2
plexin A2
chr3_-_116968969 13.730 ENSMUST00000143611.1
ENSMUST00000040097.7
 Palmd

palmdelphin

chr4_+_102254993 13.655 ENSMUST00000106908.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr10_+_111164794 13.006 ENSMUST00000105275.1
ENSMUST00000095310.1
 Osbpl8

oxysterol binding protein-like 8


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 561 entries
Log-likelihood per target Total log-likelihoodTermDescription
10.1 40.2 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
2.6 38.3 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.8 34.6 GO:0006376 mRNA splice site selection(GO:0006376)
7.9 31.4 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
1.6 30.5 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
4.3 30.2 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
7.4 29.7 GO:0031133 regulation of axon diameter(GO:0031133)
2.9 28.7 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
2.1 27.6 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.9 26.8 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
1.5 25.2 GO:0021860 pyramidal neuron development(GO:0021860)
0.6 24.7 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843)
2.1 24.6 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
1.8 23.4 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
1.6 20.9 GO:0045332 phospholipid translocation(GO:0045332)
4.4 17.7 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
5.9 17.6 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
5.6 16.7 GO:0016191 synaptic vesicle uncoating(GO:0016191) regulation of endosome organization(GO:1904978) positive regulation of endosome organization(GO:1904980)
1.2 16.2 GO:0000042 protein targeting to Golgi(GO:0000042)
0.2 15.9 GO:0007612 learning(GO:0007612)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 205 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 120.9 GO:0016021 integral component of membrane(GO:0016021)
0.4 93.4 GO:0045211 postsynaptic membrane(GO:0045211)
4.0 64.8 GO:0005614 interstitial matrix(GO:0005614)
0.1 58.1 GO:0005768 endosome(GO:0005768)
1.4 45.5 GO:0033268 node of Ranvier(GO:0033268)
1.2 44.2 GO:0090544 BAF-type complex(GO:0090544)
1.5 38.5 GO:0030132 clathrin coat of coated pit(GO:0030132)
0.3 35.3 GO:0043197 dendritic spine(GO:0043197)
0.5 27.7 GO:0098878 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.2 24.7 GO:0005802 trans-Golgi network(GO:0005802)
1.1 24.4 GO:0000930 gamma-tubulin complex(GO:0000930)
0.2 24.3 GO:0055037 recycling endosome(GO:0055037)
1.1 23.0 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 21.5 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.4 19.3 GO:0042734 presynaptic membrane(GO:0042734)
0.2 18.2 GO:0060076 excitatory synapse(GO:0060076)
1.4 17.3 GO:0016342 catenin complex(GO:0016342)
1.0 16.1 GO:0043205 fibril(GO:0043205)
1.3 14.2 GO:0002116 semaphorin receptor complex(GO:0002116)
0.7 14.0 GO:0000159 protein phosphatase type 2A complex(GO:0000159)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 363 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 63.7 GO:0003714 transcription corepressor activity(GO:0003714)
1.2 47.6 GO:0030552 cAMP binding(GO:0030552)
0.3 32.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
5.2 31.5 GO:0045545 syndecan binding(GO:0045545)
0.2 30.8 GO:0017137 Rab GTPase binding(GO:0017137)
0.5 26.5 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
1.2 26.0 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.6 25.0 GO:0001540 beta-amyloid binding(GO:0001540)
2.5 22.1 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.2 20.8 GO:0008201 heparin binding(GO:0008201)
0.7 20.0 GO:0030215 semaphorin receptor binding(GO:0030215)
0.8 18.4 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.9 17.7 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 16.8 GO:0017124 SH3 domain binding(GO:0017124)
0.1 16.8 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
2.3 16.3 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
4.0 16.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.5 15.3 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.3 15.3 GO:0043621 protein self-association(GO:0043621)
0.6 15.2 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)