Motif ID: Tgif2_Tgif2lx1_Tgif2lx2

Z-value: 0.743

Transcription factors associated with Tgif2_Tgif2lx1_Tgif2lx2:

Gene SymbolEntrez IDGene Name
Tgif2 ENSMUSG00000062175.7 Tgif2
Tgif2lx1 ENSMUSG00000061283.4 Tgif2lx1
Tgif2lx2 ENSMUSG00000063242.6 Tgif2lx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tgif2mm10_v2_chr2_+_156840966_156841017-0.441.0e-02Click!


Activity profile for motif Tgif2_Tgif2lx1_Tgif2lx2.

activity profile for motif Tgif2_Tgif2lx1_Tgif2lx2


Sorted Z-values histogram for motif Tgif2_Tgif2lx1_Tgif2lx2

Sorted Z-values for motif Tgif2_Tgif2lx1_Tgif2lx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tgif2_Tgif2lx1_Tgif2lx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 164 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_19103022 5.993 ENSMUST00000037294.7
 Tfap2d
transcription factor AP-2, delta
chr5_-_100159261 4.873 ENSMUST00000139520.1
 Tmem150c
transmembrane protein 150C
chr11_+_98348404 4.798 ENSMUST00000078694.6
 Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr6_-_88875035 4.212 ENSMUST00000145944.1
 Podxl2
podocalyxin-like 2
chr7_+_51621830 3.440 ENSMUST00000032710.5
 Slc17a6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr6_-_88874597 3.046 ENSMUST00000061262.4
ENSMUST00000140455.1
ENSMUST00000145780.1
 Podxl2


podocalyxin-like 2


chr5_-_45857473 3.015 ENSMUST00000016026.7
ENSMUST00000067997.6
ENSMUST00000045586.6
 Lcorl


ligand dependent nuclear receptor corepressor-like


chr2_+_82053222 2.962 ENSMUST00000047527.7
 Zfp804a
zinc finger protein 804A
chr11_+_32000452 2.829 ENSMUST00000020537.2
ENSMUST00000109409.1
 Nsg2

neuron specific gene family member 2

chr13_+_54949388 2.771 ENSMUST00000026994.7
ENSMUST00000109994.2
 Unc5a

unc-5 homolog A (C. elegans)

chr6_+_112273758 2.358 ENSMUST00000032376.5
 Lmcd1
LIM and cysteine-rich domains 1
chr11_+_32000496 2.083 ENSMUST00000093219.3
 Nsg2
neuron specific gene family member 2
chr3_+_102010138 1.929 ENSMUST00000066187.4
 Nhlh2
nescient helix loop helix 2
chr1_-_52727457 1.865 ENSMUST00000156876.1
ENSMUST00000087701.3
 Mfsd6

major facilitator superfamily domain containing 6

chr2_-_168741752 1.857 ENSMUST00000029060.4
 Atp9a
ATPase, class II, type 9A
chr13_-_76385028 1.841 ENSMUST00000099365.1
 Gm10760
predicted gene 10760
chr16_+_7069825 1.805 ENSMUST00000056416.7
 Rbfox1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr11_-_20741447 1.740 ENSMUST00000177543.1
 Aftph
aftiphilin
chr7_+_43562256 1.613 ENSMUST00000107972.1
 Zfp658
zinc finger protein 658
chr2_-_25461094 1.570 ENSMUST00000114261.2
 BC029214
cDNA sequence BC029214

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 7.3 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.1 6.0 GO:0030901 midbrain development(GO:0030901)
0.2 4.9 GO:0048268 clathrin coat assembly(GO:0048268)
1.6 4.8 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.1 3.4 GO:0001504 neurotransmitter uptake(GO:0001504)
0.3 2.8 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.2 2.4 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.1 2.3 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.1 2.1 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 1.9 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.1 1.8 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
0.2 1.7 GO:0007379 segment specification(GO:0007379)
0.2 1.7 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.1 1.6 GO:0051103 DNA ligation involved in DNA repair(GO:0051103)
0.5 1.5 GO:0043201 response to leucine(GO:0043201) cellular response to leucine(GO:0071233)
0.0 1.4 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.4 1.3 GO:0003195 tricuspid valve development(GO:0003175) tricuspid valve morphogenesis(GO:0003186) tricuspid valve formation(GO:0003195) right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.1 1.2 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.2 1.1 GO:1902897 regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.2 1.1 GO:0002591 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) positive regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002591)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.9 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 3.6 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 2.7 GO:0055037 recycling endosome(GO:0055037)
0.1 2.5 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.4 1.7 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.1 1.7 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 1.7 GO:0008023 transcription elongation factor complex(GO:0008023)
0.3 1.6 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.1 1.2 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.1 1.1 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 1.1 GO:0043198 dendritic shaft(GO:0043198)
0.0 0.9 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.8 GO:0097228 sperm principal piece(GO:0097228)
0.1 0.6 GO:0042587 glycogen granule(GO:0042587)
0.1 0.6 GO:0030312 external encapsulating structure(GO:0030312)
0.1 0.6 GO:0042599 lamellar body(GO:0042599)
0.0 0.6 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.5 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 0.5 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.4 GO:0001527 microfibril(GO:0001527)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 4.9 GO:0032051 clathrin light chain binding(GO:0032051)
1.6 4.8 GO:0031752 D3 dopamine receptor binding(GO:0031750) D5 dopamine receptor binding(GO:0031752)
0.0 4.0 GO:0003714 transcription corepressor activity(GO:0003714)
0.2 3.4 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.5 2.8 GO:0005042 netrin receptor activity(GO:0005042)
0.1 2.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 1.9 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.3 1.7 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.2 1.5 GO:0070728 leucine binding(GO:0070728)
0.1 1.2 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.2 1.1 GO:0015440 peptide-transporting ATPase activity(GO:0015440)
0.1 1.1 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 1.1 GO:0051082 unfolded protein binding(GO:0051082)
0.0 1.0 GO:0032947 protein complex scaffold(GO:0032947)
0.1 0.9 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.9 GO:0015297 antiporter activity(GO:0015297)
0.3 0.8 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.1 0.8 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.8 GO:0042605 peptide antigen binding(GO:0042605)
0.0 0.8 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)