Motif ID: Tlx1

Z-value: 0.991


Transcription factors associated with Tlx1:

Gene SymbolEntrez IDGene Name
Tlx1 ENSMUSG00000025215.9 Tlx1



Activity profile for motif Tlx1.

activity profile for motif Tlx1


Sorted Z-values histogram for motif Tlx1

Sorted Z-values for motif Tlx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Tlx1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_115251839 8.941 ENSMUST00000032462.6
 Timp4
tissue inhibitor of metalloproteinase 4
chr1_+_43730593 7.773 ENSMUST00000027217.8
 1500015O10Rik
RIKEN cDNA 1500015O10 gene
chr7_-_97417730 7.554 ENSMUST00000043077.7
 Thrsp
thyroid hormone responsive
chr11_+_3488275 7.530 ENSMUST00000064265.6
 Pla2g3
phospholipase A2, group III
chr2_-_25470031 7.467 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chr1_+_185454803 6.942 ENSMUST00000061093.6
 Slc30a10
solute carrier family 30, member 10
chr6_+_135362931 6.704 ENSMUST00000032330.9
 Emp1
epithelial membrane protein 1
chr16_+_90831113 6.678 ENSMUST00000037539.7
ENSMUST00000099543.3
 Eva1c

eva-1 homolog C (C. elegans)

chr2_-_164404606 6.071 ENSMUST00000109359.1
ENSMUST00000109358.1
ENSMUST00000103103.3
 Matn4


matrilin 4


chr1_+_172341197 6.020 ENSMUST00000056136.3
 Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
chr18_-_78206408 5.960 ENSMUST00000163367.1
 Slc14a2
solute carrier family 14 (urea transporter), member 2
chr7_+_130936172 5.692 ENSMUST00000006367.7
 Htra1
HtrA serine peptidase 1
chr6_+_55451978 5.471 ENSMUST00000070736.5
ENSMUST00000070756.5
ENSMUST00000166962.1
 Adcyap1r1


adenylate cyclase activating polypeptide 1 receptor 1


chr1_-_162859684 5.323 ENSMUST00000131058.1
 Fmo1
flavin containing monooxygenase 1
chr6_+_55452177 5.184 ENSMUST00000167484.1
 Adcyap1r1
adenylate cyclase activating polypeptide 1 receptor 1
chr12_+_95692212 5.132 ENSMUST00000057324.3
 Flrt2
fibronectin leucine rich transmembrane protein 2
chr5_+_16553488 4.792 ENSMUST00000030683.3
 Hgf
hepatocyte growth factor
chr6_-_24956106 4.689 ENSMUST00000127247.2
 Tmem229a
transmembrane protein 229A
chr1_-_5019342 4.646 ENSMUST00000002533.8
 Rgs20
regulator of G-protein signaling 20
chr1_+_91179822 4.463 ENSMUST00000097648.4
ENSMUST00000165855.1
 Ramp1

receptor (calcitonin) activity modifying protein 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 102 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.7 16.1 GO:1902847 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of tau-protein kinase activity(GO:1902949)
2.6 13.2 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.9 10.7 GO:0060732 positive regulation of inositol phosphate biosynthetic process(GO:0060732)
1.3 9.4 GO:0015840 urea transport(GO:0015840) urea transmembrane transport(GO:0071918)
1.0 7.8 GO:0070314 G1 to G0 transition(GO:0070314)
0.3 7.6 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
1.9 7.5 GO:0019372 lipoxygenase pathway(GO:0019372)
1.5 7.5 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.0 7.4 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.8 6.9 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.4 6.7 GO:0032060 bleb assembly(GO:0032060)
0.6 6.1 GO:0009404 toxin metabolic process(GO:0009404)
0.1 6.1 GO:0048678 response to axon injury(GO:0048678)
2.0 6.0 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.9 5.7 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
0.9 5.1 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
1.0 4.8 GO:1902947 regulation of tau-protein kinase activity(GO:1902947)
0.0 4.7 GO:0051260 protein homooligomerization(GO:0051260)
0.4 4.6 GO:0090244 Wnt signaling pathway involved in somitogenesis(GO:0090244)
0.9 4.5 GO:0060050 positive regulation of protein glycosylation(GO:0060050)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 19.2 GO:0005791 rough endoplasmic reticulum(GO:0005791)
2.3 16.1 GO:0034366 spherical high-density lipoprotein particle(GO:0034366) neurofibrillary tangle(GO:0097418)
0.0 11.1 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 9.4 GO:0005814 centriole(GO:0005814)
0.0 8.2 GO:0030017 sarcomere(GO:0030017)
0.5 6.0 GO:0097449 astrocyte projection(GO:0097449)
0.0 5.8 GO:0005875 microtubule associated complex(GO:0005875)
0.2 4.6 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 4.3 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 3.9 GO:0030863 cortical cytoskeleton(GO:0030863)
0.6 3.1 GO:1990761 growth cone lamellipodium(GO:1990761)
0.0 3.1 GO:0043235 receptor complex(GO:0043235)
0.0 2.9 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 2.7 GO:0034451 centriolar satellite(GO:0034451)
0.0 2.7 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 2.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 2.6 GO:0005930 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 2.6 GO:0055037 recycling endosome(GO:0055037)
0.0 2.6 GO:0016020 membrane(GO:0016020)
0.8 2.4 GO:0005595 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 77 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 16.1 GO:0051787 misfolded protein binding(GO:0051787)
1.0 13.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
2.7 10.7 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
1.6 9.4 GO:0015265 urea channel activity(GO:0015265)
0.1 8.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
1.9 7.5 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.3 6.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.2 6.7 GO:0008748 N-ethylmaleimide reductase activity(GO:0008748) reduced coenzyme F420 dehydrogenase activity(GO:0043738) sulfur oxygenase reductase activity(GO:0043826) malolactic enzyme activity(GO:0043883) epoxyqueuosine reductase activity(GO:0052693)
1.2 6.1 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
2.0 6.0 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.3 6.0 GO:0042056 chemoattractant activity(GO:0042056)
0.1 5.7 GO:0003777 microtubule motor activity(GO:0003777)
0.3 5.1 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.2 4.6 GO:0070016 armadillo repeat domain binding(GO:0070016)
1.1 4.5 GO:0097642 calcitonin family receptor activity(GO:0097642)
0.1 3.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.5 3.7 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.1 3.6 GO:0031593 polyubiquitin binding(GO:0031593)
0.6 3.4 GO:0016453 acetyl-CoA C-acetyltransferase activity(GO:0003985) C-acetyltransferase activity(GO:0016453)
0.8 3.3 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733)