Motif ID: Tlx2

Z-value: 0.962


Transcription factors associated with Tlx2:

Gene SymbolEntrez IDGene Name
Tlx2 ENSMUSG00000068327.3 Tlx2



Activity profile for motif Tlx2.

activity profile for motif Tlx2


Sorted Z-values histogram for motif Tlx2

Sorted Z-values for motif Tlx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tlx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_48662740 7.108 ENSMUST00000122009.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr10_-_103028771 4.018 ENSMUST00000040859.5
 Alx1
ALX homeobox 1
chr10_+_79988584 3.920 ENSMUST00000004784.4
ENSMUST00000105374.1
 Cnn2

calponin 2

chr16_+_91225550 3.010 ENSMUST00000035608.8
 Olig2
oligodendrocyte transcription factor 2
chr3_+_134236483 2.889 ENSMUST00000181904.1
ENSMUST00000053048.9
 Cxxc4

CXXC finger 4

chr12_+_24708984 2.851 ENSMUST00000154588.1
 Rrm2
ribonucleotide reductase M2
chr14_-_48667508 2.632 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
 Otx2



orthodenticle homolog 2 (Drosophila)



chr10_+_94036001 2.614 ENSMUST00000020208.4
 Fgd6
FYVE, RhoGEF and PH domain containing 6
chr11_-_52282564 2.506 ENSMUST00000086844.3
 Tcf7
transcription factor 7, T cell specific
chr5_+_146845071 2.468 ENSMUST00000031646.7
 Rasl11a
RAS-like, family 11, member A
chr3_+_159839729 2.342 ENSMUST00000068952.5
 Wls
wntless homolog (Drosophila)
chr18_-_31949571 2.164 ENSMUST00000064016.5
 Gpr17
G protein-coupled receptor 17
chr7_-_126800354 2.086 ENSMUST00000106348.1
 Aldoa
aldolase A, fructose-bisphosphate
chr7_-_126800036 2.056 ENSMUST00000133514.1
ENSMUST00000151137.1
 Aldoa

aldolase A, fructose-bisphosphate

chr2_-_120154600 2.041 ENSMUST00000028755.7
 Ehd4
EH-domain containing 4
chr11_+_75999912 2.010 ENSMUST00000066408.5
 1700016K19Rik
RIKEN cDNA 1700016K19 gene
chr19_-_28680077 1.918 ENSMUST00000162022.1
ENSMUST00000112612.2
 Glis3

GLIS family zinc finger 3

chr17_+_34263209 1.911 ENSMUST00000040828.5
 H2-Ab1
histocompatibility 2, class II antigen A, beta 1
chr7_-_98309471 1.901 ENSMUST00000033020.7
 Acer3
alkaline ceramidase 3
chr7_+_113766119 1.898 ENSMUST00000084696.4
 Spon1
spondin 1, (f-spondin) extracellular matrix protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 217 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 9.7 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.2 4.6 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.4 4.1 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.4 4.1 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.1 4.1 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.4 3.6 GO:1902715 positive regulation of interferon-gamma secretion(GO:1902715)
1.1 3.4 GO:1903048 regulation of acetylcholine-gated cation channel activity(GO:1903048)
1.0 3.0 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.5 2.9 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.2 2.9 GO:0042178 xenobiotic catabolic process(GO:0042178)
0.1 2.9 GO:0032465 regulation of cytokinesis(GO:0032465)
0.1 2.7 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.3 2.6 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.8 2.5 GO:0071603 endothelial cell-cell adhesion(GO:0071603)
0.3 2.5 GO:0002681 somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153)
0.1 2.5 GO:0045943 positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.2 2.3 GO:0031017 exocrine pancreas development(GO:0031017)
0.2 2.3 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.3 2.2 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.2 2.1 GO:0009404 toxin metabolic process(GO:0009404)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 104 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.0 GO:0005667 transcription factor complex(GO:0005667)
0.1 5.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 5.5 GO:0030426 growth cone(GO:0030426)
0.0 5.0 GO:0032432 actin filament bundle(GO:0032432)
0.9 4.3 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.3 4.1 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 3.5 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.3 3.4 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.3 2.9 GO:0005642 annulate lamellae(GO:0005642)
0.3 2.6 GO:0098533 ATPase dependent transmembrane transport complex(GO:0098533)
0.0 2.6 GO:0016328 lateral plasma membrane(GO:0016328)
0.2 2.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 2.2 GO:0000242 pericentriolar material(GO:0000242)
0.1 2.1 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 2.0 GO:0055038 recycling endosome membrane(GO:0055038)
0.3 1.9 GO:0042613 MHC class II protein complex(GO:0042613)
0.2 1.9 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 1.9 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.2 1.8 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 1.8 GO:0016459 myosin complex(GO:0016459)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 153 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.6 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 4.7 GO:0030165 PDZ domain binding(GO:0030165)
0.9 4.3 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.7 4.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 4.0 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.3 3.6 GO:0019992 diacylglycerol binding(GO:0019992)
0.3 3.4 GO:0004889 acetylcholine-activated cation-selective channel activity(GO:0004889)
0.0 3.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 3.3 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.2 3.0 GO:0017070 U6 snRNA binding(GO:0017070)
0.1 3.0 GO:0071837 HMG box domain binding(GO:0071837)
0.0 2.9 GO:0008013 beta-catenin binding(GO:0008013)
0.2 2.3 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.2 2.2 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 2.2 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.4 2.1 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.3 2.1 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.1 2.1 GO:0070402 NADPH binding(GO:0070402)
0.1 2.0 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.5 1.9 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)