Motif ID: Twist1

Z-value: 0.809


Transcription factors associated with Twist1:

Gene SymbolEntrez IDGene Name
Twist1 ENSMUSG00000035799.5 Twist1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Twist1mm10_v2_chr12_+_33957645_339576710.058.0e-01Click!


Activity profile for motif Twist1.

activity profile for motif Twist1


Sorted Z-values histogram for motif Twist1

Sorted Z-values for motif Twist1



Network of associatons between targets according to the STRING database.



First level regulatory network of Twist1

PNG image of the network

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Top targets:


Showing 1 to 20 of 111 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_172940299 3.765 ENSMUST00000009143.7
 Bmp7
bone morphogenetic protein 7
chr6_-_95718800 2.072 ENSMUST00000079847.5
 Suclg2
succinate-Coenzyme A ligase, GDP-forming, beta subunit
chrX_+_100730178 1.710 ENSMUST00000113744.1
 Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr19_+_25610533 1.615 ENSMUST00000048935.4
 Dmrt3
doublesex and mab-3 related transcription factor 3
chr1_-_119053339 1.589 ENSMUST00000161301.1
ENSMUST00000161451.1
ENSMUST00000162607.1
 Gli2


GLI-Kruppel family member GLI2


chr7_+_4119525 1.550 ENSMUST00000119661.1
ENSMUST00000129423.1
 Ttyh1

tweety homolog 1 (Drosophila)

chr7_+_4119556 1.544 ENSMUST00000079415.5
 Ttyh1
tweety homolog 1 (Drosophila)
chr11_-_59290746 1.516 ENSMUST00000010044.7
 Wnt3a
wingless-related MMTV integration site 3A
chr7_+_45216671 1.460 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr9_+_60794468 1.453 ENSMUST00000050183.6
 Uaca
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr18_+_60911757 1.363 ENSMUST00000040359.5
 Arsi
arylsulfatase i
chr8_-_71381907 1.268 ENSMUST00000002466.8
 Nr2f6
nuclear receptor subfamily 2, group F, member 6
chr5_-_62766153 1.208 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr2_-_180225812 1.169 ENSMUST00000015791.5
 Lama5
laminin, alpha 5
chr2_-_137116624 1.164 ENSMUST00000028735.7
 Jag1
jagged 1
chr9_-_44342332 1.164 ENSMUST00000097558.3
 Hmbs
hydroxymethylbilane synthase
chr8_-_64693027 1.114 ENSMUST00000048967.7
 Cpe
carboxypeptidase E
chr9_-_54661870 1.112 ENSMUST00000034822.5
 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr1_+_74791516 1.103 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr5_+_105519388 1.037 ENSMUST00000067924.6
ENSMUST00000150981.1
 Lrrc8c

leucine rich repeat containing 8 family, member C


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 3.8 GO:0072076 hyaluranon cable assembly(GO:0036118) nephrogenic mesenchyme development(GO:0072076) negative regulation of glomerular mesangial cell proliferation(GO:0072125) negative regulation of glomerulus development(GO:0090194) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.3 2.7 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.6 2.5 GO:0060032 notochord regression(GO:0060032)
0.1 2.3 GO:1902476 chloride transmembrane transport(GO:1902476)
0.2 2.1 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.1 2.1 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.1 1.9 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
0.2 1.7 GO:0090527 actin filament reorganization(GO:0090527)
0.5 1.5 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892) dermatome development(GO:0061054) regulation of dermatome development(GO:0061183) negative regulation of dopaminergic neuron differentiation(GO:1904339) regulation of cardiac cell fate specification(GO:2000043)
0.4 1.5 GO:0051311 spindle assembly involved in female meiosis(GO:0007056) meiotic metaphase plate congression(GO:0051311)
0.3 1.5 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.1 1.5 GO:0030903 notochord development(GO:0030903)
0.1 1.5 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.1 1.3 GO:0050965 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.2 1.2 GO:0072015 ciliary body morphogenesis(GO:0061073) glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.1 1.2 GO:0018065 protein-cofactor linkage(GO:0018065)
0.4 1.1 GO:0030070 insulin processing(GO:0030070)
0.3 1.0 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.3 1.0 GO:2000564 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) CD8-positive, alpha-beta T cell proliferation(GO:0035740) negative regulation of regulatory T cell differentiation(GO:0045590) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564)
0.1 1.0 GO:0000050 urea cycle(GO:0000050) urea metabolic process(GO:0019627)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.3 GO:0031012 extracellular matrix(GO:0031012)
1.0 3.1 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.2 2.5 GO:0097542 ciliary tip(GO:0097542)
0.3 2.1 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0 2.1 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.4 1.5 GO:0043293 apoptosome(GO:0043293)
0.2 1.5 GO:0072687 meiotic spindle(GO:0072687)
0.0 1.5 GO:0005884 actin filament(GO:0005884)
0.5 1.4 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.3 1.2 GO:0043259 laminin-10 complex(GO:0043259)
0.1 1.1 GO:0031045 dense core granule(GO:0031045)
0.3 1.0 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.3 1.0 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.1 0.8 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0 0.8 GO:0002102 podosome(GO:0002102)
0.0 0.8 GO:0031526 brush border membrane(GO:0031526)
0.0 0.7 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.7 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.2 0.6 GO:1990590 ATF1-ATF4 transcription factor complex(GO:1990590)
0.1 0.6 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.2 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.4 3.8 GO:0070700 BMP receptor binding(GO:0070700)
0.0 3.8 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.8 3.1 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.3 2.1 GO:0034943 acyl-CoA ligase activity(GO:0003996) 3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity(GO:0010435) 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity(GO:0018854) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity(GO:0018855) benzoyl acetate-CoA ligase activity(GO:0018856) 2,4-dichlorobenzoate-CoA ligase activity(GO:0018857) pivalate-CoA ligase activity(GO:0034783) cyclopropanecarboxylate-CoA ligase activity(GO:0034793) adipate-CoA ligase activity(GO:0034796) citronellyl-CoA ligase activity(GO:0034823) mentha-1,3-dione-CoA ligase activity(GO:0034841) thiophene-2-carboxylate-CoA ligase activity(GO:0034842) 2,4,4-trimethylpentanoate-CoA ligase activity(GO:0034865) cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034942) trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034943) branched-chain acyl-CoA synthetase (ADP-forming) activity(GO:0043759) aryl-CoA synthetase (ADP-forming) activity(GO:0043762) 3-hydroxypropionyl-CoA synthetase activity(GO:0043955) perillic acid:CoA ligase (ADP-forming) activity(GO:0052685) perillic acid:CoA ligase (AMP-forming) activity(GO:0052686) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity(GO:0052687) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity(GO:0052688) pristanate-CoA ligase activity(GO:0070251) malonyl-CoA synthetase activity(GO:0090409)
0.2 2.1 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.2 1.7 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.5 1.5 GO:0005110 frizzled-2 binding(GO:0005110)
0.1 1.5 GO:0003746 translation elongation factor activity(GO:0003746)
0.2 1.4 GO:0018741 alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902)
0.0 1.4 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 1.3 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.2 1.2 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.0 1.2 GO:0005112 Notch binding(GO:0005112)
0.0 1.2 GO:0005178 integrin binding(GO:0005178)
0.1 1.1 GO:0004185 serine-type carboxypeptidase activity(GO:0004185) cobalt ion binding(GO:0050897)
0.0 1.1 GO:0005109 frizzled binding(GO:0005109)
0.1 1.0 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.1 1.0 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 1.0 GO:0001013 RNA polymerase I regulatory region DNA binding(GO:0001013)