Motif ID: Vsx1_Uncx_Prrx2_Shox2_Noto

Z-value: 0.957

Transcription factors associated with Vsx1_Uncx_Prrx2_Shox2_Noto:

Gene SymbolEntrez IDGene Name
Noto ENSMUSG00000068302.7 Noto
Prrx2 ENSMUSG00000039476.7 Prrx2
Shox2 ENSMUSG00000027833.10 Shox2
Uncx ENSMUSG00000029546.11 Uncx
Vsx1 ENSMUSG00000033080.8 Vsx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Shox2mm10_v2_chr3_-_66981279_669813180.663.5e-05Click!
Prrx2mm10_v2_chr2_+_30834972_308349720.592.9e-04Click!
Uncxmm10_v2_chr5_+_139543889_1395439040.575.1e-04Click!


Activity profile for motif Vsx1_Uncx_Prrx2_Shox2_Noto.

activity profile for motif Vsx1_Uncx_Prrx2_Shox2_Noto


Sorted Z-values histogram for motif Vsx1_Uncx_Prrx2_Shox2_Noto

Sorted Z-values for motif Vsx1_Uncx_Prrx2_Shox2_Noto



Network of associatons between targets according to the STRING database.



First level regulatory network of Vsx1_Uncx_Prrx2_Shox2_Noto

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_48665098 24.120 ENSMUST00000118578.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr2_-_168767136 15.006 ENSMUST00000029061.5
ENSMUST00000103074.1
 Sall4

sal-like 4 (Drosophila)

chr5_+_139543889 14.265 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr2_-_168767029 14.051 ENSMUST00000075044.3
 Sall4
sal-like 4 (Drosophila)
chr13_-_53473074 13.501 ENSMUST00000021922.8
 Msx2
msh homeobox 2
chr17_+_34592248 12.561 ENSMUST00000038149.6
 Pbx2
pre B cell leukemia homeobox 2
chr3_+_159839729 12.379 ENSMUST00000068952.5
 Wls
wntless homolog (Drosophila)
chr7_-_49636847 10.091 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr10_-_45470201 9.893 ENSMUST00000079390.6
 Lin28b
lin-28 homolog B (C. elegans)
chr8_-_61902669 9.516 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein

chr3_+_125404292 8.649 ENSMUST00000144344.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr13_-_102905740 8.615 ENSMUST00000167462.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr3_+_125404072 8.524 ENSMUST00000173932.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr13_-_102906046 8.072 ENSMUST00000171791.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr3_-_154328634 7.423 ENSMUST00000167744.1
 Lhx8
LIM homeobox protein 8
chr3_+_55782500 7.331 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr7_-_37773555 6.307 ENSMUST00000176534.1
 Zfp536
zinc finger protein 536
chr9_+_119063429 6.262 ENSMUST00000141185.1
ENSMUST00000126251.1
ENSMUST00000136561.1
 Vill


villin-like


chr13_+_89540636 6.177 ENSMUST00000022108.7
 Hapln1
hyaluronan and proteoglycan link protein 1
chr9_+_72806874 5.572 ENSMUST00000055535.8
 Prtg
protogenin homolog (Gallus gallus)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 158 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 29.1 GO:0001833 inner cell mass cell proliferation(GO:0001833)
6.6 26.5 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
1.8 14.3 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
4.5 13.5 GO:0048818 embryonic nail plate morphogenesis(GO:0035880) positive regulation of hair follicle maturation(GO:0048818) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364)
1.6 12.6 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
1.0 12.4 GO:0031017 exocrine pancreas development(GO:0031017)
0.6 10.1 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
1.1 9.9 GO:0010587 miRNA catabolic process(GO:0010587)
0.6 9.9 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.7 9.5 GO:0071803 positive regulation of podosome assembly(GO:0071803)
2.8 8.5 GO:0048389 BMP signaling pathway involved in heart induction(GO:0003130) endodermal-mesodermal cell signaling(GO:0003133) endodermal-mesodermal cell signaling involved in heart induction(GO:0003134) intermediate mesoderm development(GO:0048389) regulation of transcription from RNA polymerase II promoter involved in kidney development(GO:0060994) pattern specification involved in mesonephros development(GO:0061227) regulation of hepatocyte differentiation(GO:0070366) comma-shaped body morphogenesis(GO:0072049) S-shaped body morphogenesis(GO:0072050) anterior/posterior pattern specification involved in kidney development(GO:0072098) negative regulation of glomerular mesangial cell proliferation(GO:0072125) ureter urothelium development(GO:0072190) negative regulation of glomerulus development(GO:0090194) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.1 8.1 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.2 7.0 GO:0006270 DNA replication initiation(GO:0006270)
0.5 6.8 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
1.1 6.4 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.1 6.3 GO:0051693 actin filament capping(GO:0051693)
0.0 5.7 GO:0007067 mitotic nuclear division(GO:0007067)
1.3 5.2 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.1 5.2 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.2 5.0 GO:0009954 proximal/distal pattern formation(GO:0009954)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 29.0 GO:0000792 heterochromatin(GO:0000792)
0.1 28.7 GO:0005667 transcription factor complex(GO:0005667)
0.4 12.4 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 11.3 GO:0030427 site of polarized growth(GO:0030427)
0.4 9.5 GO:0002102 podosome(GO:0002102)
0.0 7.5 GO:0005759 mitochondrial matrix(GO:0005759)
1.2 7.4 GO:0001674 female germ cell nucleus(GO:0001674)
0.2 6.7 GO:0032809 neuronal cell body membrane(GO:0032809)
0.2 5.2 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.4 3.9 GO:0005915 zonula adherens(GO:0005915)
0.0 3.9 GO:0000776 kinetochore(GO:0000776)
0.6 3.7 GO:0000444 MIS12/MIND type complex(GO:0000444)
1.2 3.6 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.1 3.6 GO:0001750 photoreceptor outer segment(GO:0001750)
0.7 3.4 GO:0033093 Weibel-Palade body(GO:0033093)
0.7 3.4 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 3.1 GO:0016607 nuclear speck(GO:0016607)
0.6 3.0 GO:0031523 Myb complex(GO:0031523)
0.0 2.9 GO:0043198 dendritic shaft(GO:0043198)
0.2 2.8 GO:0042555 MCM complex(GO:0042555)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 105 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 52.6 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.1 27.7 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 18.5 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
2.3 16.0 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
1.6 15.9 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.1 15.4 GO:0000287 magnesium ion binding(GO:0000287)
0.0 12.8 GO:0003779 actin binding(GO:0003779)
1.8 12.6 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.7 10.5 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.9 8.5 GO:0039706 co-receptor binding(GO:0039706)
0.2 8.1 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.4 6.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 5.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.4 5.2 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.5 4.9 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 4.8 GO:0008134 transcription factor binding(GO:0008134)
0.4 4.5 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 4.4 GO:0016749 N-succinyltransferase activity(GO:0016749)
0.3 3.9 GO:0070097 delta-catenin binding(GO:0070097)
0.2 3.8 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)