Motif ID: Vsx2_Dlx3

Z-value: 1.166

Transcription factors associated with Vsx2_Dlx3:

Gene SymbolEntrez IDGene Name
Dlx3 ENSMUSG00000001510.7 Dlx3
Vsx2 ENSMUSG00000021239.6 Vsx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Vsx2mm10_v2_chr12_+_84569762_845698400.354.5e-02Click!


Activity profile for motif Vsx2_Dlx3.

activity profile for motif Vsx2_Dlx3


Sorted Z-values histogram for motif Vsx2_Dlx3

Sorted Z-values for motif Vsx2_Dlx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Vsx2_Dlx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 131 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_139543889 29.631 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr6_-_23248264 24.073 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr2_-_168767136 15.129 ENSMUST00000029061.5
ENSMUST00000103074.1
 Sall4

sal-like 4 (Drosophila)

chr2_-_168767029 11.264 ENSMUST00000075044.3
 Sall4
sal-like 4 (Drosophila)
chr3_-_154328634 10.720 ENSMUST00000167744.1
 Lhx8
LIM homeobox protein 8
chr12_-_56535047 6.844 ENSMUST00000178477.2
 Nkx2-1
NK2 homeobox 1
chr3_+_159839729 6.511 ENSMUST00000068952.5
 Wls
wntless homolog (Drosophila)
chr14_-_48662740 6.101 ENSMUST00000122009.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr17_-_70853482 5.411 ENSMUST00000118283.1
 Tgif1
TGFB-induced factor homeobox 1
chr10_+_128337761 4.593 ENSMUST00000005826.7
 Cs
citrate synthase
chr7_-_49636847 4.544 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr9_-_79977782 4.525 ENSMUST00000093811.4
 Filip1
filamin A interacting protein 1
chr5_-_98566762 3.934 ENSMUST00000086912.4
 1700010H22Rik
RIKEN cDNA 1700010H22 gene
chr3_-_49757257 3.701 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr3_-_116253467 3.664 ENSMUST00000090473.5
 Gpr88
G-protein coupled receptor 88
chr3_+_55782500 3.662 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr9_+_119063429 3.134 ENSMUST00000141185.1
ENSMUST00000126251.1
ENSMUST00000136561.1
 Vill


villin-like


chr14_-_12345847 3.130 ENSMUST00000022262.4
 Fezf2
Fez family zinc finger 2
chr17_+_43952999 2.698 ENSMUST00000177857.1
 Rcan2
regulator of calcineurin 2
chr12_+_109545390 2.666 ENSMUST00000146701.1
 Meg3
maternally expressed 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.7 29.6 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
4.5 27.2 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.5 26.4 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 10.7 GO:0008585 female gonad development(GO:0008585)
2.3 6.8 GO:0021759 globus pallidus development(GO:0021759)
0.5 6.5 GO:0031017 exocrine pancreas development(GO:0031017)
0.4 6.2 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
1.5 6.1 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.3 4.6 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.3 4.5 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.2 3.7 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.6 3.3 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.2 3.3 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.4 3.1 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.1 3.1 GO:0051693 actin filament capping(GO:0051693)
0.1 2.7 GO:0008340 determination of adult lifespan(GO:0008340)
0.8 2.4 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.1 2.2 GO:0097352 autophagosome maturation(GO:0097352)
0.1 2.2 GO:0009409 response to cold(GO:0009409)
0.0 2.1 GO:0072661 protein targeting to plasma membrane(GO:0072661)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 26.4 GO:0000792 heterochromatin(GO:0000792)
1.8 10.7 GO:0001674 female germ cell nucleus(GO:0001674)
0.2 6.5 GO:0032590 dendrite membrane(GO:0032590)
0.0 4.6 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 2.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 2.3 GO:0016460 myosin II complex(GO:0016460)
0.2 2.0 GO:0061700 GATOR2 complex(GO:0061700)
0.1 2.0 GO:0002102 podosome(GO:0002102)
0.1 1.8 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.3 1.7 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.3 1.7 GO:0061689 paranodal junction(GO:0033010) tricellular tight junction(GO:0061689)
0.0 1.5 GO:0030131 clathrin adaptor complex(GO:0030131)
0.2 1.4 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.1 1.4 GO:0033655 host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655)
0.1 1.1 GO:0060091 kinocilium(GO:0060091)
0.1 1.0 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 1.0 GO:0070469 respiratory chain(GO:0070469)
0.2 0.9 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.1 0.9 GO:0045252 dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
0.1 0.8 GO:0042824 MHC class I peptide loading complex(GO:0042824)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 68.9 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.1 20.5 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.6 6.8 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.7 6.5 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.2 5.4 GO:0070410 co-SMAD binding(GO:0070410)
0.0 5.4 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.8 4.6 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.6 3.3 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.2 2.4 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 2.4 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 2.4 GO:0000287 magnesium ion binding(GO:0000287)
0.0 2.3 GO:0035254 glutamate receptor binding(GO:0035254)
0.2 2.2 GO:0070700 BMP receptor binding(GO:0070700)
0.3 2.0 GO:0070728 leucine binding(GO:0070728)
0.1 1.9 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.2 1.7 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 1.7 GO:0004774 succinate-CoA ligase activity(GO:0004774)
0.1 1.6 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 1.4 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 1.4 GO:0005537 mannose binding(GO:0005537)