Motif ID: Zbtb4
Z-value: 0.834
Transcription factors associated with Zbtb4:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Zbtb4 | ENSMUSG00000018750.8 | Zbtb4 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Zbtb4 | mm10_v2_chr11_+_69765899_69765925 | 0.76 | 3.5e-07 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 5.0 | GO:2001139 | negative regulation of postsynaptic membrane organization(GO:1901627) negative regulation of dendritic spine maintenance(GO:1902951) negative regulation of phospholipid efflux(GO:1902999) regulation of lipid transport across blood brain barrier(GO:1903000) negative regulation of lipid transport across blood brain barrier(GO:1903001) positive regulation of lipid transport across blood brain barrier(GO:1903002) negative regulation of phospholipid transport(GO:2001139) |
| 0.9 | 2.6 | GO:0030070 | insulin processing(GO:0030070) |
| 0.8 | 5.4 | GO:2001199 | negative regulation of dendritic cell differentiation(GO:2001199) |
| 0.5 | 2.6 | GO:1900170 | negative regulation of glucocorticoid mediated signaling pathway(GO:1900170) |
| 0.5 | 1.9 | GO:0042276 | error-prone translesion synthesis(GO:0042276) |
| 0.5 | 1.9 | GO:0097494 | regulation of vesicle size(GO:0097494) |
| 0.5 | 1.4 | GO:0032430 | positive regulation of phospholipase A2 activity(GO:0032430) activation of meiosis involved in egg activation(GO:0060466) |
| 0.5 | 2.3 | GO:0035093 | spermatogenesis, exchange of chromosomal proteins(GO:0035093) |
| 0.4 | 2.2 | GO:2000325 | regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327) |
| 0.4 | 5.6 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.4 | 1.3 | GO:0072076 | hyaluranon cable assembly(GO:0036118) nephrogenic mesenchyme development(GO:0072076) negative regulation of glomerular mesangial cell proliferation(GO:0072125) negative regulation of glomerulus development(GO:0090194) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106) |
| 0.4 | 1.6 | GO:0033024 | mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025) |
| 0.4 | 1.2 | GO:0048352 | neural plate mediolateral regionalization(GO:0021998) mesoderm structural organization(GO:0048338) paraxial mesoderm structural organization(GO:0048352) |
| 0.4 | 1.2 | GO:0045349 | regulation of dendritic cell cytokine production(GO:0002730) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of interferon-beta biosynthetic process(GO:0045359) |
| 0.3 | 2.1 | GO:2000672 | negative regulation of motor neuron apoptotic process(GO:2000672) |
| 0.3 | 1.3 | GO:1901475 | pyruvate transmembrane transport(GO:1901475) |
| 0.3 | 5.2 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 0.3 | 0.8 | GO:0003219 | cardiac right ventricle formation(GO:0003219) |
| 0.3 | 2.0 | GO:0005513 | detection of calcium ion(GO:0005513) |
| 0.2 | 0.7 | GO:0010636 | positive regulation of mitochondrial fusion(GO:0010636) |
| 0.2 | 1.4 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
| 0.2 | 1.2 | GO:0032804 | negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804) |
| 0.2 | 6.1 | GO:0014912 | negative regulation of smooth muscle cell migration(GO:0014912) |
| 0.2 | 0.6 | GO:0014877 | response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) |
| 0.2 | 0.7 | GO:1900740 | regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740) regulation of membrane tubulation(GO:1903525) |
| 0.2 | 0.7 | GO:0051643 | endoplasmic reticulum localization(GO:0051643) |
| 0.2 | 3.5 | GO:0031115 | negative regulation of microtubule polymerization(GO:0031115) |
| 0.2 | 0.5 | GO:0071895 | odontoblast differentiation(GO:0071895) |
| 0.1 | 1.7 | GO:0031937 | positive regulation of chromatin silencing(GO:0031937) |
| 0.1 | 2.3 | GO:0008209 | androgen metabolic process(GO:0008209) |
| 0.1 | 0.6 | GO:0097116 | gephyrin clustering involved in postsynaptic density assembly(GO:0097116) |
| 0.1 | 0.3 | GO:0015910 | peroxisomal long-chain fatty acid import(GO:0015910) |
| 0.1 | 0.9 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
| 0.1 | 0.5 | GO:0046133 | pyrimidine ribonucleoside catabolic process(GO:0046133) |
| 0.1 | 0.7 | GO:0006004 | fucose metabolic process(GO:0006004) |
| 0.1 | 0.4 | GO:0070345 | negative regulation of fat cell proliferation(GO:0070345) |
| 0.1 | 3.5 | GO:0001919 | regulation of receptor recycling(GO:0001919) |
| 0.1 | 0.4 | GO:0042045 | epithelial fluid transport(GO:0042045) |
| 0.1 | 0.4 | GO:1903553 | positive regulation of extracellular exosome assembly(GO:1903553) |
| 0.1 | 0.3 | GO:0072365 | regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072365) |
| 0.1 | 2.6 | GO:0009214 | cyclic nucleotide catabolic process(GO:0009214) |
| 0.1 | 0.2 | GO:0044268 | multicellular organismal protein metabolic process(GO:0044268) |
| 0.1 | 1.6 | GO:0001913 | T cell mediated cytotoxicity(GO:0001913) |
| 0.1 | 1.5 | GO:0097320 | membrane tubulation(GO:0097320) |
| 0.1 | 1.2 | GO:0006054 | N-acetylneuraminate metabolic process(GO:0006054) |
| 0.1 | 3.9 | GO:0046847 | filopodium assembly(GO:0046847) |
| 0.0 | 0.3 | GO:1903912 | negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:1903912) |
| 0.0 | 0.9 | GO:0001516 | prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457) |
| 0.0 | 0.3 | GO:0019254 | carnitine metabolic process, CoA-linked(GO:0019254) |
| 0.0 | 0.7 | GO:0016926 | protein desumoylation(GO:0016926) |
| 0.0 | 0.9 | GO:0032438 | melanosome organization(GO:0032438) anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
| 0.0 | 0.2 | GO:0010792 | DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) |
| 0.0 | 0.9 | GO:0010763 | positive regulation of fibroblast migration(GO:0010763) |
| 0.0 | 0.3 | GO:0035845 | photoreceptor cell outer segment organization(GO:0035845) |
| 0.0 | 1.0 | GO:0090083 | regulation of inclusion body assembly(GO:0090083) |
| 0.0 | 0.8 | GO:0008053 | mitochondrial fusion(GO:0008053) |
| 0.0 | 0.3 | GO:0051901 | positive regulation of mitochondrial depolarization(GO:0051901) |
| 0.0 | 0.7 | GO:0014887 | muscle hypertrophy in response to stress(GO:0003299) cardiac muscle adaptation(GO:0014887) cardiac muscle hypertrophy in response to stress(GO:0014898) |
| 0.0 | 0.7 | GO:1903779 | regulation of cardiac conduction(GO:1903779) |
| 0.0 | 0.4 | GO:0032733 | positive regulation of interleukin-10 production(GO:0032733) |
| 0.0 | 0.7 | GO:0002076 | osteoblast development(GO:0002076) |
| 0.0 | 0.1 | GO:0031033 | myosin filament organization(GO:0031033) |
| 0.0 | 0.3 | GO:0006824 | cobalt ion transport(GO:0006824) |
| 0.0 | 0.1 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
| 0.0 | 0.4 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.0 | 0.1 | GO:0042138 | meiotic DNA double-strand break formation(GO:0042138) |
| 0.0 | 0.6 | GO:0010960 | magnesium ion homeostasis(GO:0010960) |
| 0.0 | 0.1 | GO:1903546 | receptor localization to nonmotile primary cilium(GO:0097500) protein localization to photoreceptor outer segment(GO:1903546) |
| 0.0 | 0.3 | GO:2000311 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311) |
| 0.0 | 0.3 | GO:0006687 | glycosphingolipid metabolic process(GO:0006687) |
| 0.0 | 0.1 | GO:0050882 | voluntary musculoskeletal movement(GO:0050882) |
| 0.0 | 0.7 | GO:0046513 | ceramide biosynthetic process(GO:0046513) |
| 0.0 | 0.1 | GO:0007168 | receptor guanylyl cyclase signaling pathway(GO:0007168) |
| 0.0 | 0.3 | GO:0045047 | protein targeting to ER(GO:0045047) |
| 0.0 | 0.2 | GO:1902187 | negative regulation of viral release from host cell(GO:1902187) |
| 0.0 | 0.2 | GO:0030157 | pancreatic juice secretion(GO:0030157) |
| 0.0 | 0.1 | GO:0045217 | cell-cell junction maintenance(GO:0045217) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 5.0 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 0.7 | 2.1 | GO:0097058 | CRLF-CLCF1 complex(GO:0097058) |
| 0.5 | 4.9 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.5 | 1.9 | GO:0016035 | zeta DNA polymerase complex(GO:0016035) |
| 0.5 | 3.8 | GO:0035749 | myelin sheath adaxonal region(GO:0035749) |
| 0.4 | 4.0 | GO:0043083 | synaptic cleft(GO:0043083) |
| 0.2 | 0.7 | GO:0042642 | actomyosin, myosin complex part(GO:0042642) |
| 0.2 | 0.8 | GO:0031230 | intrinsic component of cell outer membrane(GO:0031230) integral component of cell outer membrane(GO:0045203) |
| 0.1 | 2.0 | GO:0031045 | dense core granule(GO:0031045) |
| 0.1 | 1.5 | GO:0030122 | AP-2 adaptor complex(GO:0030122) |
| 0.1 | 0.6 | GO:0017059 | serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211) |
| 0.1 | 0.3 | GO:0005787 | signal peptidase complex(GO:0005787) |
| 0.1 | 2.3 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.1 | 0.3 | GO:1902636 | kinociliary basal body(GO:1902636) |
| 0.1 | 0.9 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.1 | 0.9 | GO:0097470 | ribbon synapse(GO:0097470) |
| 0.0 | 0.9 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.0 | 1.4 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 2.7 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 0.7 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.0 | 3.2 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.0 | 0.3 | GO:0016589 | NURF complex(GO:0016589) |
| 0.0 | 0.9 | GO:0051233 | spindle midzone(GO:0051233) |
| 0.0 | 2.2 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 7.1 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.0 | 0.3 | GO:0043203 | axon hillock(GO:0043203) |
| 0.0 | 0.3 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.0 | 0.3 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 0.0 | 1.3 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 1.2 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 0.2 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.0 | 1.4 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.0 | 0.3 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.0 | 0.7 | GO:0014704 | intercalated disc(GO:0014704) |
| 0.0 | 0.4 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.0 | 0.3 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) |
| 0.0 | 0.2 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 0.0 | 0.3 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.0 | 0.1 | GO:0030991 | intraciliary transport particle A(GO:0030991) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 5.0 | GO:0046911 | hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 1.4 | 5.6 | GO:0015349 | thyroid hormone transmembrane transporter activity(GO:0015349) |
| 1.2 | 3.5 | GO:0052658 | inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) |
| 0.6 | 2.6 | GO:0038049 | glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051) |
| 0.6 | 4.0 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.3 | 1.3 | GO:0050833 | pyruvate transmembrane transporter activity(GO:0050833) |
| 0.3 | 1.2 | GO:0004859 | phospholipase inhibitor activity(GO:0004859) phospholipase A2 inhibitor activity(GO:0019834) |
| 0.3 | 1.8 | GO:0005173 | stem cell factor receptor binding(GO:0005173) |
| 0.3 | 2.1 | GO:0005127 | ciliary neurotrophic factor receptor binding(GO:0005127) |
| 0.2 | 1.2 | GO:0003835 | beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835) |
| 0.2 | 0.9 | GO:0004667 | prostaglandin-D synthase activity(GO:0004667) prostaglandin-E synthase activity(GO:0050220) |
| 0.2 | 0.9 | GO:0034481 | chondroitin sulfotransferase activity(GO:0034481) |
| 0.2 | 4.9 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.2 | 1.2 | GO:0098821 | BMP receptor activity(GO:0098821) |
| 0.2 | 0.6 | GO:0004758 | serine C-palmitoyltransferase activity(GO:0004758) |
| 0.2 | 0.7 | GO:0004609 | phosphatidylserine decarboxylase activity(GO:0004609) |
| 0.2 | 0.7 | GO:0042806 | fucose binding(GO:0042806) |
| 0.2 | 2.0 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) cobalt ion binding(GO:0050897) |
| 0.2 | 6.1 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.1 | 0.7 | GO:0008808 | cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572) |
| 0.1 | 0.9 | GO:0046404 | ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) |
| 0.1 | 2.0 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
| 0.1 | 1.3 | GO:0070700 | BMP receptor binding(GO:0070700) |
| 0.1 | 1.6 | GO:0016505 | peptidase activator activity involved in apoptotic process(GO:0016505) |
| 0.1 | 2.2 | GO:0032183 | SUMO binding(GO:0032183) |
| 0.1 | 2.3 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.1 | 0.6 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.1 | 0.3 | GO:0015087 | cobalt ion transmembrane transporter activity(GO:0015087) |
| 0.1 | 0.3 | GO:0004092 | carnitine O-acetyltransferase activity(GO:0004092) |
| 0.1 | 0.6 | GO:0070191 | methionine-R-sulfoxide reductase activity(GO:0070191) |
| 0.1 | 0.6 | GO:0070290 | N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290) |
| 0.1 | 0.5 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.1 | 0.4 | GO:0045545 | syndecan binding(GO:0045545) |
| 0.1 | 0.6 | GO:0001025 | RNA polymerase III transcription factor binding(GO:0001025) |
| 0.1 | 0.4 | GO:0004013 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.1 | 0.2 | GO:0003989 | acetyl-CoA carboxylase activity(GO:0003989) |
| 0.1 | 0.5 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.1 | 0.3 | GO:0005324 | long-chain fatty acid transporter activity(GO:0005324) |
| 0.1 | 1.0 | GO:0008599 | protein phosphatase type 1 regulator activity(GO:0008599) |
| 0.1 | 0.9 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.1 | 1.4 | GO:0043274 | phospholipase binding(GO:0043274) |
| 0.1 | 0.7 | GO:0016929 | SUMO-specific protease activity(GO:0016929) |
| 0.1 | 1.5 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.0 | 2.6 | GO:0004112 | cyclic-nucleotide phosphodiesterase activity(GO:0004112) |
| 0.0 | 1.4 | GO:0042805 | actinin binding(GO:0042805) |
| 0.0 | 0.7 | GO:0043008 | ATP-dependent protein binding(GO:0043008) |
| 0.0 | 5.6 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.0 | 1.1 | GO:0005112 | Notch binding(GO:0005112) |
| 0.0 | 1.1 | GO:0004707 | MAP kinase activity(GO:0004707) |
| 0.0 | 1.9 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 0.7 | GO:0042171 | lysophosphatidic acid acyltransferase activity(GO:0042171) |
| 0.0 | 0.1 | GO:0015183 | L-aspartate transmembrane transporter activity(GO:0015183) |
| 0.0 | 0.2 | GO:0000014 | single-stranded DNA endodeoxyribonuclease activity(GO:0000014) |
| 0.0 | 1.5 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.0 | 0.7 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.0 | 0.1 | GO:0001665 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665) |
| 0.0 | 0.3 | GO:0001222 | transcription corepressor binding(GO:0001222) |
| 0.0 | 1.7 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 1.2 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 0.0 | 0.1 | GO:0015293 | symporter activity(GO:0015293) |
| 0.0 | 0.1 | GO:0017176 | phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176) |
| 0.0 | 0.1 | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) |
| 0.0 | 0.3 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.0 | 0.1 | GO:0046790 | virion binding(GO:0046790) |
| 0.0 | 1.5 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 0.5 | GO:0030145 | manganese ion binding(GO:0030145) |
