Motif ID: Zic2

Z-value: 0.580


Transcription factors associated with Zic2:

Gene SymbolEntrez IDGene Name
Zic2 ENSMUSG00000061524.8 Zic2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zic2mm10_v2_chr14_+_122475397_1224754350.345.5e-02Click!


Activity profile for motif Zic2.

activity profile for motif Zic2


Sorted Z-values histogram for motif Zic2

Sorted Z-values for motif Zic2



Network of associatons between targets according to the STRING database.



First level regulatory network of Zic2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_19699008 3.496 ENSMUST00000174355.1
ENSMUST00000172983.1
ENSMUST00000174710.1
ENSMUST00000167646.2
ENSMUST00000003066.9
ENSMUST00000174064.1
 Apoe





apolipoprotein E





chr7_-_19698206 1.820 ENSMUST00000172808.1
ENSMUST00000174191.1
 Apoe

apolipoprotein E

chr7_-_19698383 1.693 ENSMUST00000173739.1
 Apoe
apolipoprotein E
chr6_-_115251839 1.536 ENSMUST00000032462.6
 Timp4
tissue inhibitor of metalloproteinase 4
chr14_+_27039001 1.519 ENSMUST00000035336.3
 Il17rd
interleukin 17 receptor D
chr8_+_80494032 1.373 ENSMUST00000063359.6
 Gypa
glycophorin A
chr7_+_117380937 1.254 ENSMUST00000032892.5
 Xylt1
xylosyltransferase 1
chr10_+_125966214 1.210 ENSMUST00000074807.6
 Lrig3
leucine-rich repeats and immunoglobulin-like domains 3
chr2_-_122611238 1.188 ENSMUST00000028624.8
 Gatm
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr14_+_19751257 1.162 ENSMUST00000022340.3
 Nid2
nidogen 2
chr5_-_70842617 1.153 ENSMUST00000031119.1
 Gabrg1
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chr4_-_41503046 1.131 ENSMUST00000054920.4
 AI464131
expressed sequence AI464131
chr1_+_9547948 1.086 ENSMUST00000144177.1
 Adhfe1
alcohol dehydrogenase, iron containing, 1
chr4_+_42240639 1.079 ENSMUST00000117202.2
 Gm10600
predicted gene 10600
chr15_-_8710409 1.071 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr11_+_63128973 1.039 ENSMUST00000108702.1
 Pmp22
peripheral myelin protein 22
chr16_-_10313940 1.026 ENSMUST00000078357.4
 Emp2
epithelial membrane protein 2
chr11_-_68386974 1.020 ENSMUST00000135141.1
 Ntn1
netrin 1
chr12_-_56536895 0.971 ENSMUST00000001536.8
 Nkx2-1
NK2 homeobox 1
chr5_-_92278155 0.916 ENSMUST00000159345.1
ENSMUST00000113102.3
 Naaa

N-acylethanolamine acid amidase


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 189 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 7.0 GO:2001139 negative regulation of postsynaptic membrane organization(GO:1901627) negative regulation of dendritic spine maintenance(GO:1902951) negative regulation of phospholipid efflux(GO:1902999) regulation of lipid transport across blood brain barrier(GO:1903000) negative regulation of lipid transport across blood brain barrier(GO:1903001) positive regulation of lipid transport across blood brain barrier(GO:1903002) negative regulation of phospholipid transport(GO:2001139)
0.1 2.2 GO:0032060 bleb assembly(GO:0032060)
0.1 1.7 GO:0090005 negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
0.3 1.5 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.3 1.4 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.2 1.4 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.1 1.4 GO:0061032 visceral serous pericardium development(GO:0061032)
0.1 1.4 GO:0042178 xenobiotic catabolic process(GO:0042178)
0.1 1.3 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.4 1.2 GO:0032474 otolith morphogenesis(GO:0032474)
0.4 1.2 GO:0006601 creatine biosynthetic process(GO:0006601)
0.1 1.2 GO:0005980 polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.0 1.2 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.3 1.1 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.1 1.1 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0 1.1 GO:0046677 response to antibiotic(GO:0046677)
0.0 1.1 GO:0001658 branching involved in ureteric bud morphogenesis(GO:0001658)
0.3 1.0 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
0.3 1.0 GO:0021759 globus pallidus development(GO:0021759)
0.2 1.0 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 7.0 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.0 3.4 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 3.3 GO:0000139 Golgi membrane(GO:0000139)
0.0 3.2 GO:0005604 basement membrane(GO:0005604)
0.0 3.2 GO:0016324 apical plasma membrane(GO:0016324)
0.0 1.7 GO:0005643 nuclear pore(GO:0005643)
0.0 1.7 GO:0005884 actin filament(GO:0005884)
0.0 1.5 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 1.3 GO:0072562 blood microparticle(GO:0072562)
0.1 1.2 GO:0043205 fibril(GO:0043205)
0.1 1.2 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.2 1.0 GO:0032127 dense core granule membrane(GO:0032127)
0.1 1.0 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 1.0 GO:0043218 compact myelin(GO:0043218)
0.3 0.9 GO:0097543 ciliary inversin compartment(GO:0097543)
0.0 0.9 GO:0005581 collagen trimer(GO:0005581)
0.3 0.8 GO:0018444 translation release factor complex(GO:0018444)
0.2 0.7 GO:0043259 laminin-10 complex(GO:0043259)
0.1 0.7 GO:0044301 climbing fiber(GO:0044301)
0.1 0.7 GO:0046930 pore complex(GO:0046930)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 134 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 7.0 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.1 1.7 GO:0005522 profilin binding(GO:0005522)
0.1 1.6 GO:0044653 trehalase activity(GO:0015927) dextrin alpha-glucosidase activity(GO:0044653) starch alpha-glucosidase activity(GO:0044654) beta-glucanase activity(GO:0052736) beta-6-sulfate-N-acetylglucosaminidase activity(GO:0052769) glucan endo-1,4-beta-glucosidase activity(GO:0052859)
0.0 1.6 GO:0051015 actin filament binding(GO:0051015)
0.5 1.5 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.1 1.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 1.4 GO:0017166 vinculin binding(GO:0017166)
0.1 1.4 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 1.4 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.4 1.3 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.1 1.3 GO:0008517 folic acid transporter activity(GO:0008517) water channel activity(GO:0015250)
0.2 1.2 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.1 1.2 GO:0050811 GABA-A receptor activity(GO:0004890) GABA receptor binding(GO:0050811)
0.0 1.2 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
0.2 1.1 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.1 1.1 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.1 1.1 GO:0070402 NADPH binding(GO:0070402)
0.0 1.1 GO:0020037 heme binding(GO:0020037)
0.0 1.1 GO:0003697 single-stranded DNA binding(GO:0003697)
0.2 1.0 GO:0004667 prostaglandin-D synthase activity(GO:0004667)