Motif ID: Zic3

Z-value: 0.608


Transcription factors associated with Zic3:

Gene SymbolEntrez IDGene Name
Zic3 ENSMUSG00000067860.5 Zic3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zic3mm10_v2_chrX_+_58030622_580306430.241.7e-01Click!


Activity profile for motif Zic3.

activity profile for motif Zic3


Sorted Z-values histogram for motif Zic3

Sorted Z-values for motif Zic3



Network of associatons between targets according to the STRING database.



First level regulatory network of Zic3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_29984219 1.483 ENSMUST00000146092.1
E2f3
E2F transcription factor 3
chr17_+_86963279 1.236 ENSMUST00000139344.1
Rhoq
ras homolog gene family, member Q
chr2_-_170427828 1.214 ENSMUST00000013667.2
ENSMUST00000109152.2
ENSMUST00000068137.4
Bcas1


breast carcinoma amplified sequence 1


chr4_-_53159885 1.082 ENSMUST00000030010.3
Abca1
ATP-binding cassette, sub-family A (ABC1), member 1
chr14_-_103843685 1.081 ENSMUST00000172237.1
Ednrb
endothelin receptor type B
chr11_-_72266596 1.046 ENSMUST00000021161.6
ENSMUST00000140167.1
Slc13a5

solute carrier family 13 (sodium-dependent citrate transporter), member 5

chr7_+_127800604 1.043 ENSMUST00000046863.5
ENSMUST00000106272.1
ENSMUST00000139068.1
Hsd3b7


hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7


chr6_+_63255971 1.021 ENSMUST00000159561.1
ENSMUST00000095852.3
Grid2

glutamate receptor, ionotropic, delta 2

chr7_-_100656953 1.002 ENSMUST00000107046.1
ENSMUST00000107045.1
ENSMUST00000139708.1
Plekhb1


pleckstrin homology domain containing, family B (evectins) member 1


chr7_+_88278085 0.917 ENSMUST00000032779.5
ENSMUST00000128791.1
Ctsc

cathepsin C

chr1_+_166254095 0.910 ENSMUST00000111416.1
Ildr2
immunoglobulin-like domain containing receptor 2
chr2_-_160872985 0.859 ENSMUST00000109460.1
ENSMUST00000127201.1
Zhx3

zinc fingers and homeoboxes 3

chrY_-_1286563 0.852 ENSMUST00000091190.5
Ddx3y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr2_-_39190687 0.847 ENSMUST00000142872.1
ENSMUST00000038874.5
Scai

suppressor of cancer cell invasion

chr7_+_73391160 0.815 ENSMUST00000128471.1
Rgma
RGM domain family, member A
chrX_+_56454871 0.784 ENSMUST00000039374.2
ENSMUST00000101553.2
Ddx26b

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B

chr5_+_137758133 0.765 ENSMUST00000141733.1
ENSMUST00000110985.1
Tsc22d4

TSC22 domain family, member 4

chr15_-_94404258 0.706 ENSMUST00000035342.4
ENSMUST00000155907.1
Adamts20

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20

chr10_+_39732364 0.695 ENSMUST00000164763.1
Rev3l
REV3-like, catalytic subunit of DNA polymerase zeta RAD54 like (S. cerevisiae)
chr12_+_3806513 0.689 ENSMUST00000172719.1
Dnmt3a
DNA methyltransferase 3A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 111 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.8 GO:0090005 negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
0.4 1.7 GO:0055099 response to high density lipoprotein particle(GO:0055099)
0.3 1.5 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.2 1.3 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.1 1.3 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.1 1.2 GO:0015697 quaternary ammonium group transport(GO:0015697)
0.4 1.1 GO:0014826 vein smooth muscle contraction(GO:0014826)
0.0 1.1 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.3 1.0 GO:0006842 tricarboxylic acid transport(GO:0006842) succinate transport(GO:0015744) citrate transport(GO:0015746)
0.1 1.0 GO:0060134 prepulse inhibition(GO:0060134)
0.0 1.0 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.2 0.9 GO:0016340 calcium-dependent cell-matrix adhesion(GO:0016340)
0.2 0.9 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.1 0.9 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.0 0.9 GO:0001913 T cell mediated cytotoxicity(GO:0001913)
0.1 0.8 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.0 0.8 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.2 0.7 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021) glutamate secretion, neurotransmission(GO:0061535)
0.1 0.7 GO:0060178 regulation of exocyst localization(GO:0060178)
0.1 0.7 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 GO:0098878 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.1 1.1 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.1 0.9 GO:0016011 dystroglycan complex(GO:0016011)
0.2 0.7 GO:0097165 nuclear stress granule(GO:0097165)
0.2 0.7 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.7 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.7 GO:0001741 XY body(GO:0001741)
0.0 0.6 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.6 GO:0031941 filamentous actin(GO:0031941)
0.1 0.5 GO:0000796 condensin complex(GO:0000796)
0.0 0.5 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 0.4 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.0 0.4 GO:0098536 deuterosome(GO:0098536)
0.0 0.4 GO:0046930 pore complex(GO:0046930)
0.0 0.4 GO:0097542 ciliary tip(GO:0097542)
0.1 0.3 GO:0043511 inhibin complex(GO:0043511)
0.1 0.3 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.1 0.3 GO:0035189 Rb-E2F complex(GO:0035189)
0.0 0.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.3 GO:0005614 interstitial matrix(GO:0005614)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 80 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.8 GO:0005522 profilin binding(GO:0005522)
0.2 1.3 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.2 1.3 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.1 1.3 GO:0015026 coreceptor activity(GO:0015026)
0.1 1.2 GO:0005234 extracellular-glutamate-gated ion channel activity(GO:0005234)
0.4 1.1 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188)
0.4 1.1 GO:0004962 endothelin receptor activity(GO:0004962)
0.3 1.0 GO:0017153 sodium:dicarboxylate symporter activity(GO:0017153)
0.1 1.0 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 1.0 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 0.9 GO:0051718 DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.1 0.9 GO:0016505 peptidase activator activity involved in apoptotic process(GO:0016505)
0.1 0.9 GO:0051393 alpha-actinin binding(GO:0051393)
0.0 0.8 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.8 GO:0031490 chromatin DNA binding(GO:0031490)
0.2 0.7 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.7 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.2 0.6 GO:0008504 monoamine transmembrane transporter activity(GO:0008504)
0.1 0.6 GO:0045545 syndecan binding(GO:0045545)
0.1 0.6 GO:0005138 interleukin-6 receptor binding(GO:0005138)