Motif ID: Zic4

Z-value: 0.839


Transcription factors associated with Zic4:

Gene SymbolEntrez IDGene Name
Zic4 ENSMUSG00000036972.8 Zic4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zic4mm10_v2_chr9_+_91368811_913688280.222.1e-01Click!


Activity profile for motif Zic4.

activity profile for motif Zic4


Sorted Z-values histogram for motif Zic4

Sorted Z-values for motif Zic4



Network of associatons between targets according to the STRING database.



First level regulatory network of Zic4

PNG image of the network

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Top targets:


Showing 1 to 20 of 183 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_115251839 2.941 ENSMUST00000032462.6
 Timp4
tissue inhibitor of metalloproteinase 4
chr11_-_102946688 2.859 ENSMUST00000057849.5
 C1ql1
complement component 1, q subcomponent-like 1
chr12_-_56535047 2.835 ENSMUST00000178477.2
 Nkx2-1
NK2 homeobox 1
chr6_+_141524379 2.775 ENSMUST00000032362.9
 Slco1c1
solute carrier organic anion transporter family, member 1c1
chr1_+_91179822 2.695 ENSMUST00000097648.4
ENSMUST00000165855.1
 Ramp1

receptor (calcitonin) activity modifying protein 1

chr17_-_71310952 2.403 ENSMUST00000024849.9
 Emilin2
elastin microfibril interfacer 2
chr19_-_57008187 2.285 ENSMUST00000118800.1
ENSMUST00000111584.2
ENSMUST00000122359.1
ENSMUST00000148049.1
 Afap1l2



actin filament associated protein 1-like 2



chr11_+_5861886 2.163 ENSMUST00000102923.3
 Aebp1
AE binding protein 1
chr2_+_147187424 2.008 ENSMUST00000144411.1
 6430503K07Rik
RIKEN cDNA 6430503K07 gene
chr17_+_79051906 1.921 ENSMUST00000040789.4
 Qpct
glutaminyl-peptide cyclotransferase (glutaminyl cyclase)
chr3_-_107986408 1.770 ENSMUST00000012348.2
 Gstm2
glutathione S-transferase, mu 2
chr3_-_107986360 1.746 ENSMUST00000066530.6
 Gstm2
glutathione S-transferase, mu 2
chr2_+_85136355 1.694 ENSMUST00000057019.7
 Aplnr
apelin receptor
chr4_-_64046925 1.692 ENSMUST00000107377.3
 Tnc
tenascin C
chrX_-_49797700 1.675 ENSMUST00000033442.7
ENSMUST00000114891.1
 Igsf1

immunoglobulin superfamily, member 1

chr13_-_95223045 1.596 ENSMUST00000162292.1
 Pde8b
phosphodiesterase 8B
chr11_-_6475992 1.595 ENSMUST00000179343.1
 Purb
purine rich element binding protein B
chr18_-_80713062 1.558 ENSMUST00000170905.1
ENSMUST00000078049.4
 Nfatc1

nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1

chr11_+_121702591 1.525 ENSMUST00000125580.1
 Metrnl
meteorin, glial cell differentiation regulator-like
chr4_-_57143437 1.510 ENSMUST00000095076.3
ENSMUST00000030142.3
 Epb4.1l4b

erythrocyte protein band 4.1-like 4b


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 83 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.8 GO:0046330 positive regulation of JNK cascade(GO:0046330)
0.5 3.5 GO:0070458 detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458)
1.0 2.9 GO:0061743 motor learning(GO:0061743)
0.6 2.9 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.9 2.8 GO:0021759 globus pallidus development(GO:0021759)
0.3 2.8 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.5 2.7 GO:0060050 positive regulation of protein glycosylation(GO:0060050)
0.1 2.6 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742) positive regulation of ERBB signaling pathway(GO:1901186)
0.6 1.9 GO:0018199 peptidyl-glutamine modification(GO:0018199)
0.4 1.7 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.1 1.7 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
0.1 1.7 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.0 1.7 GO:0007369 gastrulation(GO:0007369)
0.5 1.6 GO:0035106 operant conditioning(GO:0035106)
0.5 1.6 GO:0060854 patterning of lymph vessels(GO:0060854)
0.3 1.5 GO:2000507 positive regulation of energy homeostasis(GO:2000507)
0.0 1.5 GO:0060351 cartilage development involved in endochondral bone morphogenesis(GO:0060351)
0.1 1.3 GO:1900452 regulation of long term synaptic depression(GO:1900452)
0.0 1.3 GO:0045580 regulation of T cell differentiation(GO:0045580)
0.1 1.1 GO:0042711 maternal behavior(GO:0042711)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.5 GO:0031012 extracellular matrix(GO:0031012)
0.0 4.2 GO:0005667 transcription factor complex(GO:0005667)
0.0 3.7 GO:0043235 receptor complex(GO:0043235)
0.6 2.9 GO:0044301 climbing fiber(GO:0044301)
0.0 2.3 GO:0005581 collagen trimer(GO:0005581)
0.1 1.7 GO:0005614 interstitial matrix(GO:0005614)
0.1 1.6 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 1.3 GO:0005811 lipid particle(GO:0005811)
0.0 1.2 GO:0031225 anchored component of membrane(GO:0031225)
0.3 1.1 GO:0005594 collagen type IX trimer(GO:0005594)
0.1 1.1 GO:0032593 insulin-responsive compartment(GO:0032593)
0.3 0.8 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.1 0.8 GO:0030057 desmosome(GO:0030057)
0.1 0.8 GO:0031045 dense core granule(GO:0031045)
0.0 0.7 GO:0016592 mediator complex(GO:0016592)
0.1 0.6 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.6 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.6 GO:0032279 asymmetric synapse(GO:0032279)
0.1 0.5 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.5 GO:0005788 endoplasmic reticulum lumen(GO:0005788)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.4 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 3.5 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.2 3.0 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.2 2.9 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.7 2.8 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.2 2.8 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.7 2.7 GO:0097642 calcitonin family receptor activity(GO:0097642)
0.2 2.3 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.3 2.0 GO:0045545 syndecan binding(GO:0045545)
0.1 1.9 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.2 1.7 GO:0034711 inhibin binding(GO:0034711)
0.1 1.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.4 1.6 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.2 1.6 GO:0001224 RNA polymerase II transcription cofactor binding(GO:0001224)
0.0 1.6 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.0 1.5 GO:0005179 hormone activity(GO:0005179)
0.0 1.2 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.3 1.0 GO:0005119 smoothened binding(GO:0005119) hedgehog receptor activity(GO:0008158) hedgehog family protein binding(GO:0097108)
0.3 1.0 GO:0004923 leukemia inhibitory factor receptor activity(GO:0004923) oncostatin-M receptor activity(GO:0004924)
0.1 1.0 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)