Motif ID: Zic4
Z-value: 0.839
Transcription factors associated with Zic4:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Zic4 | ENSMUSG00000036972.8 | Zic4 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Zic4 | mm10_v2_chr9_+_91368811_91368828 | 0.22 | 2.1e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.0 | 2.9 | GO:0061743 | motor learning(GO:0061743) |
0.9 | 2.8 | GO:0021759 | globus pallidus development(GO:0021759) |
0.8 | 0.8 | GO:0072554 | blood vessel lumenization(GO:0072554) |
0.6 | 1.9 | GO:0018199 | peptidyl-glutamine modification(GO:0018199) |
0.6 | 2.9 | GO:0051045 | negative regulation of membrane protein ectodomain proteolysis(GO:0051045) |
0.5 | 2.7 | GO:0060050 | positive regulation of protein glycosylation(GO:0060050) |
0.5 | 1.6 | GO:0035106 | operant conditioning(GO:0035106) |
0.5 | 1.6 | GO:0060854 | patterning of lymph vessels(GO:0060854) |
0.5 | 1.0 | GO:0009957 | epidermal cell fate specification(GO:0009957) |
0.5 | 3.5 | GO:0070458 | detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458) |
0.4 | 1.7 | GO:0014012 | peripheral nervous system axon regeneration(GO:0014012) |
0.4 | 0.8 | GO:0045110 | intermediate filament bundle assembly(GO:0045110) |
0.3 | 1.0 | GO:1902358 | sulfate transmembrane transport(GO:1902358) |
0.3 | 1.0 | GO:0038165 | oncostatin-M-mediated signaling pathway(GO:0038165) |
0.3 | 1.5 | GO:2000507 | positive regulation of energy homeostasis(GO:2000507) |
0.3 | 2.8 | GO:0015721 | bile acid and bile salt transport(GO:0015721) |
0.3 | 0.8 | GO:0030070 | insulin processing(GO:0030070) |
0.3 | 0.8 | GO:0051892 | negative regulation of cardioblast differentiation(GO:0051892) dermatome development(GO:0061054) regulation of dermatome development(GO:0061183) canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:0061317) regulation of heart induction(GO:0090381) negative regulation of dopaminergic neuron differentiation(GO:1904339) regulation of cardiac cell fate specification(GO:2000043) |
0.2 | 0.9 | GO:0097374 | sensory neuron axon guidance(GO:0097374) |
0.2 | 0.7 | GO:0045409 | negative regulation of interleukin-6 biosynthetic process(GO:0045409) |
0.2 | 0.6 | GO:0015920 | regulation of phosphatidylcholine catabolic process(GO:0010899) lipopolysaccharide transport(GO:0015920) |
0.2 | 0.8 | GO:0097168 | condensed mesenchymal cell proliferation(GO:0072137) mesenchymal stem cell proliferation(GO:0097168) |
0.2 | 0.7 | GO:0010700 | negative regulation of norepinephrine secretion(GO:0010700) |
0.2 | 0.5 | GO:0097274 | urea homeostasis(GO:0097274) |
0.2 | 0.9 | GO:0002317 | plasma cell differentiation(GO:0002317) negative regulation of amyloid precursor protein biosynthetic process(GO:0042985) |
0.1 | 0.3 | GO:0042939 | glutathione transport(GO:0034635) tripeptide transport(GO:0042939) |
0.1 | 0.4 | GO:0008582 | regulation of synaptic growth at neuromuscular junction(GO:0008582) regulation of sodium:potassium-exchanging ATPase activity(GO:1903406) |
0.1 | 0.9 | GO:0061042 | vascular wound healing(GO:0061042) |
0.1 | 0.6 | GO:0007197 | adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207) |
0.1 | 2.6 | GO:0045742 | positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742) positive regulation of ERBB signaling pathway(GO:1901186) |
0.1 | 0.6 | GO:0006452 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
0.1 | 0.4 | GO:2000048 | negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048) |
0.1 | 1.7 | GO:0032287 | peripheral nervous system myelin maintenance(GO:0032287) |
0.1 | 1.7 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
0.1 | 0.8 | GO:0007213 | G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) |
0.1 | 0.4 | GO:0061428 | positive regulation of oocyte development(GO:0060282) negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428) |
0.1 | 1.1 | GO:0042711 | maternal behavior(GO:0042711) |
0.1 | 0.3 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
0.1 | 0.2 | GO:0072718 | response to cisplatin(GO:0072718) |
0.1 | 0.2 | GO:0070885 | negative regulation of calcineurin-NFAT signaling cascade(GO:0070885) |
0.1 | 0.3 | GO:0021914 | negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914) |
0.1 | 0.3 | GO:2000301 | negative regulation of synaptic vesicle exocytosis(GO:2000301) |
0.1 | 0.6 | GO:0031424 | keratinization(GO:0031424) establishment of skin barrier(GO:0061436) |
0.1 | 0.7 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
0.1 | 0.3 | GO:1902309 | negative regulation of peptidyl-serine dephosphorylation(GO:1902309) |
0.1 | 1.3 | GO:1900452 | regulation of long term synaptic depression(GO:1900452) |
0.1 | 0.2 | GO:0036091 | positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091) |
0.1 | 0.2 | GO:0035907 | dorsal aorta development(GO:0035907) dorsal aorta morphogenesis(GO:0035912) |
0.1 | 0.5 | GO:0007042 | lysosomal lumen acidification(GO:0007042) |
0.1 | 0.1 | GO:0060743 | epithelial cell maturation involved in prostate gland development(GO:0060743) |
0.1 | 0.3 | GO:0002182 | cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248) |
0.0 | 0.4 | GO:0003161 | cardiac conduction system development(GO:0003161) |
0.0 | 0.4 | GO:0070493 | thrombin receptor signaling pathway(GO:0070493) |
0.0 | 0.3 | GO:0006621 | protein retention in ER lumen(GO:0006621) |
0.0 | 0.3 | GO:2001269 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269) |
0.0 | 1.5 | GO:0060351 | cartilage development involved in endochondral bone morphogenesis(GO:0060351) |
0.0 | 0.2 | GO:2001025 | positive regulation of response to drug(GO:2001025) |
0.0 | 1.0 | GO:0035115 | embryonic forelimb morphogenesis(GO:0035115) |
0.0 | 0.3 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
0.0 | 0.5 | GO:0007076 | mitotic chromosome condensation(GO:0007076) |
0.0 | 0.3 | GO:0090074 | negative regulation of protein homodimerization activity(GO:0090074) |
0.0 | 0.5 | GO:0010719 | negative regulation of epithelial to mesenchymal transition(GO:0010719) |
0.0 | 0.9 | GO:0060441 | epithelial tube branching involved in lung morphogenesis(GO:0060441) |
0.0 | 0.2 | GO:0044336 | canonical Wnt signaling pathway involved in negative regulation of apoptotic process(GO:0044336) |
0.0 | 0.3 | GO:0097186 | amelogenesis(GO:0097186) |
0.0 | 3.8 | GO:0046330 | positive regulation of JNK cascade(GO:0046330) |
0.0 | 0.1 | GO:1901678 | iron coordination entity transport(GO:1901678) |
0.0 | 0.2 | GO:0030513 | positive regulation of BMP signaling pathway(GO:0030513) |
0.0 | 0.5 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
0.0 | 0.2 | GO:0044027 | hypermethylation of CpG island(GO:0044027) |
0.0 | 0.2 | GO:1900119 | positive regulation of execution phase of apoptosis(GO:1900119) |
0.0 | 0.5 | GO:0002092 | positive regulation of receptor internalization(GO:0002092) |
0.0 | 0.0 | GO:0060364 | frontal suture morphogenesis(GO:0060364) |
0.0 | 0.3 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
0.0 | 0.1 | GO:0019065 | receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509) |
0.0 | 1.3 | GO:0045580 | regulation of T cell differentiation(GO:0045580) |
0.0 | 0.3 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
0.0 | 0.2 | GO:0045653 | negative regulation of megakaryocyte differentiation(GO:0045653) |
0.0 | 1.7 | GO:0007369 | gastrulation(GO:0007369) |
0.0 | 0.1 | GO:0007016 | cytoskeletal anchoring at plasma membrane(GO:0007016) |
0.0 | 0.2 | GO:0000186 | activation of MAPKK activity(GO:0000186) |
0.0 | 0.2 | GO:1903861 | regulation of dendrite extension(GO:1903859) positive regulation of dendrite extension(GO:1903861) |
0.0 | 0.4 | GO:0030514 | negative regulation of BMP signaling pathway(GO:0030514) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 2.9 | GO:0044301 | climbing fiber(GO:0044301) |
0.3 | 1.1 | GO:0005594 | collagen type IX trimer(GO:0005594) |
0.3 | 0.8 | GO:1990851 | Wnt-Frizzled-LRP5/6 complex(GO:1990851) |
0.1 | 0.5 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
0.1 | 1.6 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
0.1 | 1.7 | GO:0005614 | interstitial matrix(GO:0005614) |
0.1 | 0.4 | GO:0016035 | zeta DNA polymerase complex(GO:0016035) |
0.1 | 0.4 | GO:0033010 | paranodal junction(GO:0033010) |
0.1 | 0.8 | GO:0030057 | desmosome(GO:0030057) |
0.1 | 1.1 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
0.1 | 0.6 | GO:0005642 | annulate lamellae(GO:0005642) |
0.1 | 0.8 | GO:0031045 | dense core granule(GO:0031045) |
0.0 | 0.6 | GO:0031528 | microvillus membrane(GO:0031528) |
0.0 | 2.3 | GO:0005581 | collagen trimer(GO:0005581) |
0.0 | 0.2 | GO:1990635 | proximal dendrite(GO:1990635) |
0.0 | 0.6 | GO:0032279 | asymmetric synapse(GO:0032279) |
0.0 | 7.5 | GO:0031012 | extracellular matrix(GO:0031012) |
0.0 | 0.3 | GO:0035631 | CD40 receptor complex(GO:0035631) |
0.0 | 1.3 | GO:0005811 | lipid particle(GO:0005811) |
0.0 | 0.7 | GO:0016592 | mediator complex(GO:0016592) |
0.0 | 0.3 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
0.0 | 0.3 | GO:0031430 | M band(GO:0031430) |
0.0 | 0.2 | GO:1902710 | GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711) |
0.0 | 3.7 | GO:0043235 | receptor complex(GO:0043235) |
0.0 | 1.2 | GO:0031225 | anchored component of membrane(GO:0031225) |
0.0 | 0.4 | GO:0097440 | apical dendrite(GO:0097440) |
0.0 | 0.5 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
0.0 | 0.2 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
0.0 | 0.1 | GO:0005916 | fascia adherens(GO:0005916) |
0.0 | 4.2 | GO:0005667 | transcription factor complex(GO:0005667) |
0.0 | 0.1 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.7 | 2.8 | GO:0015349 | thyroid hormone transmembrane transporter activity(GO:0015349) |
0.7 | 2.7 | GO:0097642 | calcitonin family receptor activity(GO:0097642) |
0.4 | 1.6 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
0.3 | 1.0 | GO:0005119 | smoothened binding(GO:0005119) hedgehog receptor activity(GO:0008158) hedgehog family protein binding(GO:0097108) |
0.3 | 2.0 | GO:0045545 | syndecan binding(GO:0045545) |
0.3 | 1.0 | GO:0004923 | leukemia inhibitory factor receptor activity(GO:0004923) oncostatin-M receptor activity(GO:0004924) |
0.3 | 0.8 | GO:0005110 | frizzled-2 binding(GO:0005110) |
0.2 | 3.0 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) |
0.2 | 2.8 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) |
0.2 | 0.7 | GO:0031686 | A1 adenosine receptor binding(GO:0031686) |
0.2 | 2.9 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
0.2 | 0.6 | GO:0001875 | lipopolysaccharide receptor activity(GO:0001875) |
0.2 | 2.3 | GO:0030296 | protein tyrosine kinase activator activity(GO:0030296) |
0.2 | 1.7 | GO:0034711 | inhibin binding(GO:0034711) |
0.2 | 0.4 | GO:0034739 | histone deacetylase activity (H4-K16 specific)(GO:0034739) |
0.2 | 1.6 | GO:0001224 | RNA polymerase II transcription cofactor binding(GO:0001224) |
0.1 | 1.9 | GO:0016755 | transferase activity, transferring amino-acyl groups(GO:0016755) |
0.1 | 0.4 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
0.1 | 3.5 | GO:1900750 | glutathione binding(GO:0043295) oligopeptide binding(GO:1900750) |
0.1 | 0.6 | GO:0016907 | G-protein coupled acetylcholine receptor activity(GO:0016907) |
0.1 | 0.3 | GO:0015562 | efflux transmembrane transporter activity(GO:0015562) oligopeptide transmembrane transporter activity(GO:0035673) |
0.1 | 1.0 | GO:0008271 | secondary active sulfate transmembrane transporter activity(GO:0008271) |
0.1 | 0.3 | GO:0015183 | L-aspartate transmembrane transporter activity(GO:0015183) |
0.1 | 0.3 | GO:0046923 | ER retention sequence binding(GO:0046923) |
0.1 | 1.7 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
0.1 | 4.4 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
0.1 | 0.3 | GO:0008273 | calcium, potassium:sodium antiporter activity(GO:0008273) |
0.1 | 0.2 | GO:0035939 | microsatellite binding(GO:0035939) |
0.1 | 0.8 | GO:0019215 | intermediate filament binding(GO:0019215) |
0.0 | 0.6 | GO:0017070 | U6 snRNA binding(GO:0017070) |
0.0 | 0.4 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
0.0 | 0.3 | GO:0050815 | phosphoserine binding(GO:0050815) |
0.0 | 0.7 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
0.0 | 0.5 | GO:0035612 | AP-2 adaptor complex binding(GO:0035612) |
0.0 | 1.6 | GO:0004120 | calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715) |
0.0 | 0.3 | GO:0048273 | mitogen-activated protein kinase p38 binding(GO:0048273) |
0.0 | 0.8 | GO:0005112 | Notch binding(GO:0005112) |
0.0 | 1.5 | GO:0005179 | hormone activity(GO:0005179) |
0.0 | 0.3 | GO:0043023 | GTPase inhibitor activity(GO:0005095) ribosomal large subunit binding(GO:0043023) |
0.0 | 0.9 | GO:0001540 | beta-amyloid binding(GO:0001540) |
0.0 | 0.2 | GO:0051718 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718) |
0.0 | 0.4 | GO:0008432 | JUN kinase binding(GO:0008432) |
0.0 | 0.5 | GO:0030506 | ankyrin binding(GO:0030506) |
0.0 | 0.8 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
0.0 | 0.4 | GO:0030552 | cAMP binding(GO:0030552) |
0.0 | 0.5 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
0.0 | 1.2 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
0.0 | 0.2 | GO:0043008 | ATP-dependent protein binding(GO:0043008) |
0.0 | 0.2 | GO:0005375 | copper ion transmembrane transporter activity(GO:0005375) |
0.0 | 0.2 | GO:0017166 | vinculin binding(GO:0017166) |
0.0 | 0.6 | GO:0008748 | N-ethylmaleimide reductase activity(GO:0008748) reduced coenzyme F420 dehydrogenase activity(GO:0043738) sulfur oxygenase reductase activity(GO:0043826) malolactic enzyme activity(GO:0043883) epoxyqueuosine reductase activity(GO:0052693) |
0.0 | 0.2 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
0.0 | 0.6 | GO:0045296 | cadherin binding(GO:0045296) |
0.0 | 0.7 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
0.0 | 0.1 | GO:0016917 | GABA receptor activity(GO:0016917) |