Motif ID: Zkscan3

Z-value: 0.358


Transcription factors associated with Zkscan3:

Gene SymbolEntrez IDGene Name
Zkscan3 ENSMUSG00000021327.12 Zkscan3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zkscan3mm10_v2_chr13_-_21402688_21402755-0.559.2e-04Click!


Activity profile for motif Zkscan3.

activity profile for motif Zkscan3


Sorted Z-values histogram for motif Zkscan3

Sorted Z-values for motif Zkscan3



Network of associatons between targets according to the STRING database.



First level regulatory network of Zkscan3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_102365111 1.789 ENSMUST00000006749.9
 Slc4a1
solute carrier family 4 (anion exchanger), member 1
chr8_+_106893616 1.315 ENSMUST00000047629.5
 Cirh1a
cirrhosis, autosomal recessive 1A (human)
chr2_+_104069819 0.995 ENSMUST00000111131.2
ENSMUST00000111132.1
ENSMUST00000129749.1
 Cd59b


CD59b antigen


chr8_-_106893581 0.956 ENSMUST00000176437.1
ENSMUST00000177068.1
ENSMUST00000169312.1
ENSMUST00000176515.1
 Chtf8



CTF8, chromosome transmission fidelity factor 8



chr2_+_104095796 0.840 ENSMUST00000040423.5
ENSMUST00000168176.1
 Cd59a

CD59a antigen

chr8_-_106893515 0.760 ENSMUST00000176090.1
 Chtf8
CTF8, chromosome transmission fidelity factor 8
chr5_-_88675613 0.730 ENSMUST00000113234.1
ENSMUST00000153565.1
 Grsf1

G-rich RNA sequence binding factor 1

chr2_+_31670714 0.683 ENSMUST00000038474.7
ENSMUST00000137156.1
 Exosc2

exosome component 2

chr7_+_101896340 0.619 ENSMUST00000035395.7
ENSMUST00000106973.1
ENSMUST00000144207.1
 Anapc15


anaphase prompoting complex C subunit 15


chr7_-_81345189 0.606 ENSMUST00000080813.4
 Rps17
ribosomal protein S17
chr18_+_61105844 0.604 ENSMUST00000115268.3
 Csf1r
colony stimulating factor 1 receptor
chr5_+_24985840 0.571 ENSMUST00000075081.6
 1500035N22Rik
RIKEN cDNA 1500035N22 gene
chr5_-_73338580 0.562 ENSMUST00000087195.5
 Ociad2
OCIA domain containing 2
chr8_+_33732237 0.549 ENSMUST00000171010.1
 Gtf2e2
general transcription factor II E, polypeptide 2 (beta subunit)
chr19_-_10869757 0.539 ENSMUST00000120524.1
ENSMUST00000025645.7
 Tmem132a

transmembrane protein 132A

chr17_-_35673738 0.521 ENSMUST00000001565.8
 Gtf2h4
general transcription factor II H, polypeptide 4
chr5_-_88675190 0.504 ENSMUST00000133532.1
ENSMUST00000150438.1
 Grsf1

G-rich RNA sequence binding factor 1

chr8_-_116978908 0.502 ENSMUST00000070577.5
 1700030J22Rik
RIKEN cDNA 1700030J22 gene
chr17_-_35673517 0.498 ENSMUST00000162266.1
ENSMUST00000160734.1
ENSMUST00000159852.1
ENSMUST00000160039.1
 Gtf2h4



general transcription factor II H, polypeptide 4



chr6_-_97459279 0.476 ENSMUST00000113359.1
 Frmd4b
FERM domain containing 4B
chr13_+_44730726 0.476 ENSMUST00000173704.1
ENSMUST00000044608.7
ENSMUST00000173367.1
 Jarid2


jumonji, AT rich interactive domain 2


chr3_+_146500071 0.463 ENSMUST00000119130.1
 Gng5
guanine nucleotide binding protein (G protein), gamma 5
chr8_-_105758570 0.461 ENSMUST00000155038.2
ENSMUST00000013294.9
 Gfod2

glucose-fructose oxidoreductase domain containing 2

chr2_+_32646586 0.443 ENSMUST00000009705.7
ENSMUST00000167841.1
 Eng

endoglin

chr2_+_121295437 0.438 ENSMUST00000110639.1
 Map1a
microtubule-associated protein 1 A
chr10_+_80629646 0.437 ENSMUST00000085435.5
 Csnk1g2
casein kinase 1, gamma 2
chr2_-_66634952 0.425 ENSMUST00000100064.2
ENSMUST00000100063.2
 Scn9a

sodium channel, voltage-gated, type IX, alpha

chrX_-_75874536 0.413 ENSMUST00000033547.7
 Pls3
plastin 3 (T-isoform)
chr11_-_88851462 0.391 ENSMUST00000107903.1
 Akap1
A kinase (PRKA) anchor protein 1
chr17_+_46110982 0.355 ENSMUST00000024763.3
ENSMUST00000123646.1
 Mrps18a

mitochondrial ribosomal protein S18A

chr2_+_121171155 0.352 ENSMUST00000110658.1
 Tubgcp4
tubulin, gamma complex associated protein 4
chr1_+_135232045 0.351 ENSMUST00000110798.3
 Gm4204
predicted gene 4204
chr7_+_126759601 0.348 ENSMUST00000050201.4
ENSMUST00000057669.9
 Mapk3

mitogen-activated protein kinase 3

chr2_+_121171204 0.342 ENSMUST00000039541.5
ENSMUST00000110657.1
 Tubgcp4

tubulin, gamma complex associated protein 4

chr11_-_75422586 0.329 ENSMUST00000138661.1
ENSMUST00000000769.7
 Serpinf1

serine (or cysteine) peptidase inhibitor, clade F, member 1

chr14_+_57424054 0.326 ENSMUST00000122063.1
 Ift88
intraflagellar transport 88
chr6_+_125552948 0.326 ENSMUST00000112254.1
ENSMUST00000112253.1
ENSMUST00000001995.7
 Vwf


Von Willebrand factor homolog


chr3_+_146499850 0.325 ENSMUST00000118280.1
 Gng5
guanine nucleotide binding protein (G protein), gamma 5
chr2_-_30194112 0.320 ENSMUST00000113659.1
ENSMUST00000113660.1
 Ccbl1

cysteine conjugate-beta lyase 1

chr19_+_6276725 0.309 ENSMUST00000025684.3
 Ehd1
EH-domain containing 1
chr13_-_38658991 0.299 ENSMUST00000001757.7
 Eef1e1
eukaryotic translation elongation factor 1 epsilon 1
chr2_+_156613664 0.290 ENSMUST00000169464.2
ENSMUST00000109567.3
 Dlgap4

discs, large homolog-associated protein 4 (Drosophila)

chr9_+_114688782 0.279 ENSMUST00000047404.6
 Dync1li1
dynein cytoplasmic 1 light intermediate chain 1
chr13_-_100786402 0.273 ENSMUST00000174038.1
ENSMUST00000091295.7
ENSMUST00000072119.8
 Ccnb1


cyclin B1


chr7_-_27228605 0.238 ENSMUST00000003850.7
 Itpkc
inositol 1,4,5-trisphosphate 3-kinase C
chr11_-_75422524 0.231 ENSMUST00000125982.1
ENSMUST00000137103.1
 Serpinf1

serine (or cysteine) peptidase inhibitor, clade F, member 1

chr8_+_70616816 0.202 ENSMUST00000052437.3
 Lrrc25
leucine rich repeat containing 25
chr8_+_71396853 0.200 ENSMUST00000002473.8
 Babam1
BRISC and BRCA1 A complex member 1
chr8_+_31091593 0.198 ENSMUST00000161713.1
 Dusp26
dual specificity phosphatase 26 (putative)
chr18_-_34651703 0.175 ENSMUST00000025228.5
ENSMUST00000133181.1
 Cdc23

CDC23 cell division cycle 23

chr4_+_139192899 0.168 ENSMUST00000102508.3
ENSMUST00000131912.1
ENSMUST00000102507.3
 Capzb


capping protein (actin filament) muscle Z-line, beta


chr7_-_127020321 0.166 ENSMUST00000032918.2
 Pagr1a
PAXIP1 associated glutamate rich protein 1A
chr4_+_63544747 0.165 ENSMUST00000035301.6
 Atp6v1g1
ATPase, H+ transporting, lysosomal V1 subunit G1
chr13_-_19395728 0.160 ENSMUST00000039694.7
 Stard3nl
STARD3 N-terminal like
chr14_+_51893610 0.150 ENSMUST00000047726.5
ENSMUST00000161888.1
 Slc39a2

solute carrier family 39 (zinc transporter), member 2

chr6_-_122856151 0.124 ENSMUST00000042081.8
 C3ar1
complement component 3a receptor 1
chr11_-_100650693 0.110 ENSMUST00000103119.3
 Zfp385c
zinc finger protein 385C
chr5_+_117976761 0.106 ENSMUST00000035579.6
 Fbxo21
F-box protein 21
chr8_-_124897685 0.058 ENSMUST00000098312.2
 Exoc8
exocyst complex component 8
chr1_+_37997975 0.053 ENSMUST00000027252.7
 Eif5b
eukaryotic translation initiation factor 5B
chr18_-_77713978 0.037 ENSMUST00000074653.4
 8030462N17Rik
RIKEN cDNA 8030462N17 gene
chr18_+_82554463 0.016 ENSMUST00000062446.7
ENSMUST00000102812.4
ENSMUST00000075372.5
ENSMUST00000080658.4
ENSMUST00000152071.1
ENSMUST00000114674.3
ENSMUST00000142850.1
ENSMUST00000133193.1
ENSMUST00000123251.1
ENSMUST00000153478.1
ENSMUST00000132369.1
 Mbp










myelin basic protein










chr1_+_58795371 0.008 ENSMUST00000027189.8
 Casp8
caspase 8

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.8 GO:2000258 negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.2 1.7 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.2 0.7 GO:0071033 nuclear retention of pre-mRNA at the site of transcription(GO:0071033) CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043) polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.2 0.6 GO:0038145 macrophage colony-stimulating factor signaling pathway(GO:0038145)
0.1 0.4 GO:0003032 detection of oxygen(GO:0003032)
0.1 0.8 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.1 0.3 GO:0007290 spermatid nucleus elongation(GO:0007290)
0.1 0.7 GO:0051418 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.1 1.2 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.1 0.3 GO:0000189 MAPK import into nucleus(GO:0000189)
0.1 1.8 GO:0015701 response to activity(GO:0014823) bicarbonate transport(GO:0015701) response to arsenic-containing substance(GO:0046685)
0.1 0.3 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
0.1 0.2 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.1 1.0 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.1 0.6 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.1 0.3 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.1 0.5 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.0 0.4 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.0 0.1 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.0 0.2 GO:0051490 negative regulation of filopodium assembly(GO:0051490)
0.0 1.3 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.0 0.6 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.2 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.0 0.4 GO:0048266 behavioral response to pain(GO:0048266)
0.0 0.4 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.0 0.5 GO:0090162 establishment of epithelial cell polarity(GO:0090162)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0034455 t-UTP complex(GO:0034455)
0.3 0.8 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.2 0.7 GO:0005816 spindle pole body(GO:0005816)
0.2 1.7 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.2 0.6 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.2 0.5 GO:0005673 transcription factor TFIIE complex(GO:0005673)
0.1 1.0 GO:0000439 core TFIIH complex(GO:0000439)
0.1 0.3 GO:0020018 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.1 1.0 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.1 0.3 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.1 0.3 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.7 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.3 GO:0060091 kinocilium(GO:0060091)
0.0 0.6 GO:0043203 axon hillock(GO:0043203)
0.0 0.3 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.8 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.4 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 2.0 GO:0014704 intercalated disc(GO:0014704)
0.0 0.4 GO:0030061 mitochondrial crista(GO:0030061)
0.0 1.2 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.2 GO:0070552 BRISC complex(GO:0070552)
0.0 0.3 GO:0031143 pseudopodium(GO:0031143)
0.0 1.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.2 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.2 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0 0.4 GO:0032420 stereocilium(GO:0032420)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.7 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 0.4 GO:0005534 galactose binding(GO:0005534)
0.1 2.0 GO:0001848 complement binding(GO:0001848)
0.1 1.8 GO:0015106 bicarbonate transmembrane transporter activity(GO:0015106)
0.1 0.3 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 0.7 GO:0051011 microtubule minus-end binding(GO:0051011)
0.1 0.2 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.1 0.3 GO:0005113 patched binding(GO:0005113)
0.1 1.0 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.3 GO:0019865 immunoglobulin binding(GO:0019865)
0.0 0.2 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.0 0.4 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.4 GO:0031402 sodium ion binding(GO:0031402)
0.0 0.3 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.5 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.5 GO:0008748 N-ethylmaleimide reductase activity(GO:0008748) reduced coenzyme F420 dehydrogenase activity(GO:0043738) sulfur oxygenase reductase activity(GO:0043826) malolactic enzyme activity(GO:0043883) epoxyqueuosine reductase activity(GO:0052693)
0.0 0.3 GO:0003746 translation elongation factor activity(GO:0003746)