ISMARA results: arnt2

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for arnt2

Z-value: 4.32

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Transcription factors associated with arnt2

Gene Symbol	Gene ID	Gene Info
arnt2 NCBI UniProt	ENSDARG00000103697	aryl-hydrocarbon receptor nuclear translocator 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
arnt2	dr11_v1_chr7_+_10701770_10701770	0.88	7.0e-32	Click!

Activity profile of arnt2 motif

Sorted Z-values of arnt2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr20_+_35382482 Show fit	93.46	ENSDART00000135284	vsnl1a NCBI UniProt Show fit	visinin-like 1a
chr9_-_44295071 Show fit	92.52	ENSDART00000011837	neurod1 NCBI UniProt Show fit	neuronal differentiation 1
chr13_+_27314795 Show fit	73.90	ENSDART00000128726	eef1a1a NCBI UniProt Show fit	eukaryotic translation elongation factor 1 alpha 1a
chr11_+_7324704 Show fit	62.33	ENSDART00000031937	diras1a NCBI UniProt Show fit	DIRAS family, GTP-binding RAS-like 1a
chr5_-_23429228 Show fit	60.22	ENSDART00000049291	gria3a NCBI UniProt Show fit	glutamate receptor, ionotropic, AMPA 3a
chr5_+_23118470 Show fit	54.80	ENSDART00000149893	nexmifa NCBI UniProt Show fit	neurite extension and migration factor a
chr5_+_32162684 Show fit	54.26	ENSDART00000134472	taok3b NCBI UniProt Show fit	TAO kinase 3b
chr19_+_10396042 Show fit	53.58	ENSDART00000028048 ENSDART00000151735	necap1 NCBI UniProt Show fit	NECAP endocytosis associated 1
chr24_-_11325849 Show fit	52.32	ENSDART00000182485	myrip NCBI UniProt Show fit	myosin VIIA and Rab interacting protein
chr18_+_7345417 Show fit	51.39	ENSDART00000041429	glipr1b NCBI UniProt Show fit	GLI pathogenesis-related 1b

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of arnt2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
6.6	112.2	GO:0098943	neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.3	107.4	GO:0006897	endocytosis(GO:0006897)
2.6	92.5	GO:0045746	negative regulation of Notch signaling pathway(GO:0045746)
26.9	80.7	GO:0099538	synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551) cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
2.7	80.1	GO:0035845	photoreceptor cell outer segment organization(GO:0035845)
8.4	75.4	GO:0048172	regulation of short-term neuronal synaptic plasticity(GO:0048172)
1.0	68.0	GO:0006414	translational elongation(GO:0006414)
12.5	62.3	GO:0061551	trigeminal ganglion development(GO:0061551)
0.7	57.9	GO:0051017	actin filament bundle assembly(GO:0051017)
1.1	56.3	GO:2000649	regulation of sodium ion transmembrane transporter activity(GO:2000649)

Showing 1 to 10 of 225 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
6.4	279.4	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
0.0	277.7	GO:0016020	membrane(GO:0016020)
0.1	133.6	GO:0031226	intrinsic component of plasma membrane(GO:0031226)
0.5	126.7	GO:0030424	axon(GO:0030424)
0.3	125.9	GO:0043005	neuron projection(GO:0043005)
0.4	97.4	GO:0045202	synapse(GO:0045202)
2.2	92.6	GO:0030125	clathrin vesicle coat(GO:0030125)
0.1	90.0	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.5	87.2	GO:0099503	secretory vesicle(GO:0099503)
0.2	73.1	GO:0000139	Golgi membrane(GO:0000139)

Showing 1 to 10 of 89 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	143.3	GO:0005509	calcium ion binding(GO:0005509)
1.5	131.9	GO:0005245	voltage-gated calcium channel activity(GO:0005245)
0.3	104.4	GO:0005096	GTPase activator activity(GO:0005096)
0.9	102.6	GO:0019888	protein phosphatase regulator activity(GO:0019888)
6.1	91.8	GO:0004971	AMPA glutamate receptor activity(GO:0004971)
26.9	80.7	GO:0048403	brain-derived neurotrophic factor binding(GO:0048403) brain-derived neurotrophic factor-activated receptor activity(GO:0060175)
0.2	73.2	GO:0051015	actin filament binding(GO:0051015)
0.8	69.9	GO:0030276	clathrin binding(GO:0030276)
11.3	68.1	GO:0004723	calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
1.5	68.0	GO:0003746	translation elongation factor activity(GO:0003746)

Showing 1 to 10 of 169 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.2	68.1	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
1.3	59.8	SIG CHEMOTAXIS	Genes related to chemotaxis
1.2	30.1	PID EPHA FWDPATHWAY	EPHA forward signaling
0.4	27.2	PID CMYB PATHWAY	C-MYB transcription factor network
0.5	27.1	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
1.2	24.1	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.9	21.1	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.3	20.8	PID TELOMERASE PATHWAY	Regulation of Telomerase
1.2	18.7	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.5	13.7	PID CD40 PATHWAY	CD40/CD40L signaling

Showing 1 to 10 of 27 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.9	92.5	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
4.0	68.1	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.6	45.5	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
1.1	41.4	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins
0.8	36.9	REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	Genes involved in Golgi Associated Vesicle Biogenesis
2.2	33.4	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.8	31.6	REACTOME CIRCADIAN CLOCK	Genes involved in Circadian Clock
0.6	28.8	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.3	28.3	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
2.8	27.6	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling

Showing 1 to 10 of 49 entries

Results for arnt2

Z-value: 4.32

Motif logo

Transcription factors associated with arnt2

Activity-expression correlation:

Activity profile of arnt2 motif

Sorted Z-values of arnt2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of arnt2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: