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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for arxa

Z-value: 0.74

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Transcription factors associated with arxa

Gene Symbol Gene ID Gene Info
ENSDARG00000058011 aristaless related homeobox a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
arxadr11_v1_chr24_-_23942722_23942722-0.372.5e-04Click!

Activity profile of arxa motif

Sorted Z-values of arxa motif

Promoter Log-likelihood Transcript Gene Gene Info
chr9_-_9415000 5.43 ENSDART00000146210
si:ch211-214p13.9
chr12_-_35830625 5.36 ENSDART00000180028

chr4_-_9891874 5.16 ENSDART00000067193
adrenomedullin 2a
chr22_+_11775269 4.79 ENSDART00000140272
keratin 96
chr3_-_19368435 3.94 ENSDART00000132987
sphingosine-1-phosphate receptor 5a
chr7_+_6652967 3.84 ENSDART00000102681
purine nucleoside phosphorylase 5a
chr16_+_23799622 3.57 ENSDART00000046922
RAB13, member RAS oncogene family
chr20_-_37813863 3.56 ENSDART00000147529
basic leucine zipper transcription factor, ATF-like 3
chr25_-_21031007 3.56 ENSDART00000138985
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a
chr23_-_33350990 3.31 ENSDART00000144831
si:ch211-226m16.2
chr8_+_25079470 3.24 ENSDART00000000744
synaptophysin-like 2b
chr3_-_29941357 3.19 ENSDART00000147732
ENSDART00000137973
ENSDART00000103523
granulin a
chr16_-_51271962 3.13 ENSDART00000164021
ENSDART00000046420
serpin peptidase inhibitor, clade B (ovalbumin), member 1, like 1
chr12_+_22580579 3.11 ENSDART00000171725
ENSDART00000192290
capping protein (actin filament), gelsolin-like b
chr19_-_5669122 3.08 ENSDART00000112211
si:ch211-264f5.2
chr10_-_43771447 3.04 ENSDART00000052307
arrestin domain containing 3b
chr24_-_29586082 3.02 ENSDART00000136763
vav 3 guanine nucleotide exchange factor a
chr6_-_55399214 2.99 ENSDART00000168367
cathepsin A
chr3_-_26017831 2.85 ENSDART00000179982
heme oxygenase 1a
chr3_+_32118670 2.85 ENSDART00000055287
ENSDART00000111688
zgc:109934
chr11_+_705727 2.83 ENSDART00000165366
TIMP metallopeptidase inhibitor 4, tandem duplicate 2
chr23_-_30041065 2.83 ENSDART00000131209
ENSDART00000127192
coiled-coil domain containing 187
chr22_+_19407531 2.82 ENSDART00000141060
si:dkey-78l4.2
chr20_-_5291012 2.79 ENSDART00000122892
cytochrome P450, family 46, subfamily A, polypeptide 1, tandem duplicate 3
chr13_-_31017960 2.77 ENSDART00000145287
WDFY family member 4
chr17_-_9950911 2.63 ENSDART00000105117
serine palmitoyltransferase, small subunit A
chr23_-_37575030 2.55 ENSDART00000031875
torsin family 1 like 3
chr24_+_19415124 2.55 ENSDART00000186931
sulfatase 1
chr14_-_4145594 2.49 ENSDART00000077348
caspase 3, apoptosis-related cysteine peptidase b
chr2_+_2169337 2.47 ENSDART00000179939
HIG1 hypoxia inducible domain family, member 1A
chr20_+_25225112 2.42 ENSDART00000153088
ENSDART00000127291
ENSDART00000130494
monooxygenase, DBH-like 1
chr21_-_44081540 2.40 ENSDART00000130833

chr6_-_40842768 2.39 ENSDART00000076160
musculoskeletal, embryonic nuclear protein 1a
chr7_-_30677104 2.38 ENSDART00000188360
myosin IE, a
chr8_+_52637507 2.30 ENSDART00000163830
si:dkey-90l8.3
chr12_-_36521767 2.29 ENSDART00000110290
unc-13 homolog D (C. elegans)
chr19_+_2631565 2.28 ENSDART00000171487
family with sequence similarity 126, member A
chr2_-_36918709 2.23 ENSDART00000084876
zgc:153654
chr6_+_36839509 2.21 ENSDART00000190605
ENSDART00000104160
zgc:110788
chr5_-_42083363 2.20 ENSDART00000162596
chemokine (C-X-C motif) ligand 11, duplicate 5
chr14_+_30795559 2.13 ENSDART00000006132
cofilin 1
chr10_+_35358675 2.11 ENSDART00000193263
si:dkey-259j3.5
chr6_+_40922572 2.10 ENSDART00000133599
ENSDART00000002728
ENSDART00000145153
eukaryotic translation initiation factor 4E nuclear import factor 1
chr3_+_29445473 2.08 ENSDART00000020381
GRB2-related adaptor protein 2a
chr18_+_39106722 2.03 ENSDART00000122377
BCL2 like 10
chr25_-_28674739 1.98 ENSDART00000067073
leucine rich repeat containing 10
chr23_+_36460239 1.96 ENSDART00000172441
LIM domain and actin binding 1a
chr21_+_43328685 1.95 ENSDART00000109620
ENSDART00000139668
septin 8a
chr25_+_11008419 1.94 ENSDART00000156589
major histocompatibility complex class I LIA
chr13_+_7049823 1.92 ENSDART00000178997
ENSDART00000161443
ribonuclease T2
chr18_-_46258612 1.87 ENSDART00000153930
si:dkey-244a7.1
chr4_+_20566371 1.82 ENSDART00000127576

chr20_+_29209615 1.81 ENSDART00000062350
katanin p80 subunit B-like 1
chr14_+_901847 1.79 ENSDART00000166991
si:ch73-208h1.2
chr10_+_38610741 1.77 ENSDART00000126444
matrix metallopeptidase 13a
chr3_+_27798094 1.77 ENSDART00000075100
ENSDART00000151437
calcium regulated heat stable protein 1
chr20_-_29864390 1.74 ENSDART00000161834
ENSDART00000132278
ring finger protein 144ab
chr23_-_31969786 1.71 ENSDART00000134550
ORMDL sphingolipid biosynthesis regulator 2
chr5_-_42082730 1.71 ENSDART00000135625
chemokine (C-X-C motif) ligand 11, duplicate 5
chr10_-_3138859 1.70 ENSDART00000190606
ubiquitin-conjugating enzyme E2L 3a
chr12_-_48188928 1.65 ENSDART00000184384
phosphatase domain containing, paladin 1a
chr25_+_30131055 1.65 ENSDART00000152705
apoptosis inhibitor 5
chr10_-_3138403 1.64 ENSDART00000183365
ubiquitin-conjugating enzyme E2L 3a
chr23_+_26733232 1.63 ENSDART00000035080
zgc:158263
chr15_+_41932069 1.62 ENSDART00000143007
si:ch211-191a16.2
chr20_+_19176959 1.60 ENSDART00000163276
ENSDART00000020099
BLK proto-oncogene, Src family tyrosine kinase
chr22_-_5529241 1.55 ENSDART00000157893

chr24_+_29912509 1.55 ENSDART00000168422
ferric-chelate reductase 1b
chr7_+_34620418 1.52 ENSDART00000081338
solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
chr4_-_3353595 1.50 ENSDART00000009076
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
chr4_+_16885854 1.47 ENSDART00000017726
ethanolamine kinase 1
chr11_-_16152400 1.46 ENSDART00000123665
actin related protein 2/3 complex, subunit 4, like
chr14_-_14659023 1.46 ENSDART00000170355
ENSDART00000159888
ENSDART00000172241
NAD(P) dependent steroid dehydrogenase-like
chr20_+_29209767 1.45 ENSDART00000141252
katanin p80 subunit B-like 1
chr9_+_24065855 1.44 ENSDART00000161468
ENSDART00000171577
ENSDART00000172743
ENSDART00000159324
ENSDART00000079689
ENSDART00000023196
ENSDART00000101577
leucine rich repeat (in FLII) interacting protein 1a
chr1_-_57629639 1.43 ENSDART00000158984
zmp:0000001289
chr13_+_24756486 1.40 ENSDART00000137074
collagen, type XVII, alpha 1b
chr7_-_51368681 1.37 ENSDART00000146385
Rho GTPase activating protein 36
chr20_-_40360571 1.33 ENSDART00000144768
sphingomyelin phosphodiesterase, acid-like 3A
chr7_+_19495905 1.32 ENSDART00000125584
ENSDART00000173774
si:ch211-212k18.8
chr13_+_646700 1.32 ENSDART00000006892
tumor protein p53 binding protein, 2a
chr21_+_45223194 1.30 ENSDART00000150902
si:ch73-269m14.3
chr13_+_35339182 1.30 ENSDART00000019323
jagged 1b
chr1_+_47499888 1.27 ENSDART00000027624
STN1, CST complex subunit
chr4_+_5255041 1.27 ENSDART00000137966
coiled-coil domain containing 167
chr18_-_48547564 1.26 ENSDART00000138607
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 1
chr19_+_1688727 1.25 ENSDART00000115136
ENSDART00000166744
DENN/MADD domain containing 3a
chr23_-_16485190 1.25 ENSDART00000155038
si:dkeyp-100a5.4
chr7_-_50410524 1.25 ENSDART00000083346
huntingtin interacting protein K
chr16_-_31351419 1.24 ENSDART00000178298
ENSDART00000018091
maestro heat-like repeat family member 1
chr4_-_9909371 1.22 ENSDART00000102656
si:dkey-22l11.6
chr21_+_13387965 1.22 ENSDART00000134347
zgc:113162
chr16_+_54209504 1.18 ENSDART00000020033
X-ray repair complementing defective repair in Chinese hamster cells 1
chr25_+_13620555 1.18 ENSDART00000163642
si:ch211-172l8.4
chr19_+_43780970 1.17 ENSDART00000063870
ribosomal protein L11
chr14_+_10954345 1.17 ENSDART00000106658
zinc finger, DHHC-type containing 15b
chr2_+_10878406 1.16 ENSDART00000091497
transcription elongation factor A (SII) N-terminal and central domain containing 2
chr9_-_32656656 1.15 ENSDART00000078399
granzyme 3, tandem duplicate 1
chr5_+_32076109 1.14 ENSDART00000051357
ENSDART00000144510
zinc finger, matrin-type 5
chr2_-_55298075 1.14 ENSDART00000186404
ENSDART00000149062
RAB8A, member RAS oncogene family
chr8_+_26059677 1.13 ENSDART00000009178
IMP (inosine 5'-monophosphate) dehydrogenase 2
chr19_+_12237945 1.08 ENSDART00000190034
grainyhead-like transcription factor 2b
chr14_-_33481428 1.07 ENSDART00000147059
ENSDART00000140001
ENSDART00000124242
ENSDART00000164836
ENSDART00000190104
ENSDART00000186833
ENSDART00000180873
lysosomal-associated membrane protein 2
chr18_+_13275735 1.05 ENSDART00000148127
phospholipase C, gamma 2
chr19_-_10810006 1.04 ENSDART00000151157
si:dkey-3n22.9
chr4_-_67980261 1.03 ENSDART00000182305
si:ch211-223k15.1
chr15_+_31590224 1.02 ENSDART00000159634
beta 3-glucosyltransferase a
chr23_-_19225709 1.02 ENSDART00000080099
O-acyl-ADP-ribose deacylase 1
chr13_-_36798204 0.98 ENSDART00000012357
salvador family WW domain containing protein 1
chr3_+_32365811 0.95 ENSDART00000155967
adaptor-related protein complex 2, alpha 1 subunit
chr21_-_15200556 0.95 ENSDART00000141809
splicing factor SWAP
chr14_-_413273 0.94 ENSDART00000163976
ENSDART00000179907
FAT atypical cadherin 4
chr6_+_12527725 0.94 ENSDART00000149328
serine/threonine kinase 24b (STE20 homolog, yeast)
chr5_+_66312359 0.92 ENSDART00000137534
MALT paracaspase 1
chr2_-_9989919 0.91 ENSDART00000180213
ENSDART00000184369
IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast)
chr14_+_34558480 0.91 ENSDART00000075170
pituitary tumor-transforming 1
chr5_+_24156170 0.90 ENSDART00000136570
solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15b
chr2_+_11923615 0.89 ENSDART00000126118
TROVE domain family, member 2
chr20_+_20731633 0.89 ENSDART00000191952
ENSDART00000165224
protein phosphatase 1, regulatory subunit 13Bb
chr1_+_27977297 0.88 ENSDART00000180692
ENSDART00000166819
SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
chr2_-_1622641 0.87 ENSDART00000082143
protein kinase, cAMP-dependent, catalytic, beta b
chr7_+_26173751 0.86 ENSDART00000065131
si:ch211-196f2.7
chr8_-_39822917 0.84 ENSDART00000067843
zgc:162025
chr3_-_58798377 0.83 ENSDART00000161248
si:ch73-281f12.4
chr11_+_26476153 0.81 ENSDART00000103507
un-named sa1614
chr5_-_68074592 0.81 ENSDART00000165052
ENSDART00000018792
sperm associated antigen 7
chr16_-_32013913 0.79 ENSDART00000030282
ENSDART00000138701
glutathione S-transferase kappa 1
chr7_+_19495379 0.79 ENSDART00000180514
si:ch211-212k18.8
chr15_+_23799461 0.79 ENSDART00000154885
si:ch211-167j9.4
chr20_+_25586099 0.78 ENSDART00000063122
ENSDART00000134047
cytochrome P450, family 2, subfamily P, polypeptide 10
chr16_+_19029297 0.78 ENSDART00000115263
ENSDART00000114954
Rap guanine nucleotide exchange factor (GEF) 5b
chr17_+_44697604 0.76 ENSDART00000156625
placental growth factor b
chr22_-_5252005 0.75 ENSDART00000132942
ENSDART00000081801
nicalin
chr25_-_10791437 0.75 ENSDART00000127054

chr20_+_11731039 0.75 ENSDART00000152215
ENSDART00000152585
si:ch211-155o21.3
chr11_-_21528056 0.75 ENSDART00000181626
SLIT-ROBO Rho GTPase activating protein 2
chr20_+_29209926 0.75 ENSDART00000152949
ENSDART00000153016
katanin p80 subunit B-like 1
chr7_-_5375214 0.74 ENSDART00000033316
VANGL planar cell polarity protein 2
chr17_-_16422654 0.70 ENSDART00000150149
tyrosyl-DNA phosphodiesterase 1
chr8_+_28695914 0.70 ENSDART00000033386
osteoclast stimulatory transmembrane protein
chr18_-_43884044 0.68 ENSDART00000087382
DEAD (Asp-Glu-Ala-Asp) box helicase 6
chr18_+_35128685 0.68 ENSDART00000151579
si:ch211-195m9.3
chr2_+_9990491 0.68 ENSDART00000011906
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3b
chr14_-_7137808 0.68 ENSDART00000054803
tRNA phosphotransferase 1
chr22_+_19366866 0.68 ENSDART00000137301
si:dkey-21e2.12
chr20_+_27240388 0.67 ENSDART00000123950
si:dkey-85n7.6
chr6_+_24420523 0.66 ENSDART00000185461
transforming growth factor, beta receptor III
chr5_-_11809710 0.66 ENSDART00000186998
ENSDART00000181363
ENSDART00000180681
neurofibromin 2a (merlin)
chr11_-_39118882 0.66 ENSDART00000113185
ENSDART00000156526
adaptor-related protein complex 5, beta 1 subunit
chr20_-_9095105 0.66 ENSDART00000140792
OMA1 zinc metallopeptidase
chr11_-_41853874 0.65 ENSDART00000002556
MRT4 homolog, ribosome maturation factor
chr6_-_7720332 0.63 ENSDART00000135945
ribosomal protein SA
chr9_+_43799829 0.63 ENSDART00000186240
ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)
chr10_+_11261576 0.61 ENSDART00000155333
hydroxysteroid dehydrogenase like 2
chr23_+_11347313 0.59 ENSDART00000135406
cell adhesion molecule L1-like a
chr6_-_40884453 0.57 ENSDART00000017968
ENSDART00000154100
sirtuin 4
chr17_+_43032529 0.57 ENSDART00000055611
ENSDART00000154863
iron-sulfur cluster assembly 2
chr10_-_2788668 0.57 ENSDART00000131749
ENSDART00000124356
ENSDART00000085031
ash2 (absent, small, or homeotic)-like (Drosophila)
chr24_-_37640705 0.56 ENSDART00000066583
zgc:112496
chr5_-_7199998 0.55 ENSDART00000167316

chr22_-_8725768 0.55 ENSDART00000189873
ENSDART00000181819
si:ch73-27e22.1
si:ch73-27e22.8
chr16_-_54971277 0.54 ENSDART00000113358
WD and tetratricopeptide repeats 1
chr23_+_4709607 0.54 ENSDART00000166503
ENSDART00000158752
ENSDART00000163860
ENSDART00000172739
Raf-1 proto-oncogene, serine/threonine kinase a
Raf-1 proto-oncogene, serine/threonine kinase a
chr6_+_8598428 0.52 ENSDART00000032118
ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast)
chr5_-_69649044 0.51 ENSDART00000011192
ENSDART00000170885
eukaryotic translation initiation factor 2B, subunit 1 alpha
chr19_+_42955280 0.50 ENSDART00000141225
fatty acid binding protein 3, muscle and heart
chr6_+_49551614 0.50 ENSDART00000022581
RAB22A, member RAS oncogene family
chr4_+_51551318 0.50 ENSDART00000190283
si:dkey-165e24.1
chr11_+_16153207 0.49 ENSDART00000192356
transcriptional adaptor 3 (NGG1 homolog, yeast)-like
chr15_-_38129845 0.48 ENSDART00000057095
si:dkey-24p1.1
chr16_+_13818743 0.48 ENSDART00000090191
folliculin
chr4_-_1801519 0.46 ENSDART00000188604
ENSDART00000135749
nudix (nucleoside diphosphate linked moiety X)-type motif 4b
chr4_+_59845617 0.45 ENSDART00000167626
ENSDART00000123157
si:dkey-196n19.2
chr2_-_26596794 0.45 ENSDART00000134685
ENSDART00000056787
zgc:113691
chr1_+_44127292 0.44 ENSDART00000160542
calcium binding protein 2a
chr20_+_20731052 0.44 ENSDART00000047662
protein phosphatase 1, regulatory subunit 13Bb
chr5_-_16472719 0.44 ENSDART00000162071
piwi-like RNA-mediated gene silencing 2
chr9_-_11676491 0.43 ENSDART00000022358
zinc finger CCCH-type containing 15
chr18_+_7073130 0.43 ENSDART00000101216
ENSDART00000148947
si:dkey-88e18.2
chr21_+_43172506 0.43 ENSDART00000121725
zinc finger, CCHC domain containing 10
chr25_-_13319112 0.43 ENSDART00000179885
si:ch211-194m7.8
chr22_-_35330532 0.41 ENSDART00000172654

chr10_-_11261565 0.41 ENSDART00000146727
polypyrimidine tract binding protein 3
chr1_+_47165842 0.41 ENSDART00000053152
ENSDART00000167051
carbonyl reductase 1
chr21_-_45188233 0.40 ENSDART00000130880
si:ch73-269m14.2
chr6_-_40922971 0.40 ENSDART00000155363
SFI1 centrin binding protein
chr7_+_21272833 0.38 ENSDART00000052942
serine (or cysteine) peptidase inhibitor, clade H, member 2
chr8_+_49065348 0.38 ENSDART00000032277
DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
chr22_+_15633013 0.37 ENSDART00000188095
ENSDART00000048763

chr25_+_7241084 0.37 ENSDART00000190501
ENSDART00000190588
high mobility group 20A
chr11_+_45436703 0.36 ENSDART00000168295
ENSDART00000173293
son of sevenless homolog 1 (Drosophila)
chr4_+_72723304 0.36 ENSDART00000186791
ENSDART00000158902
ENSDART00000191925
RAB3A interacting protein (rabin3)
chr4_-_69428110 0.36 ENSDART00000160607
si:ch211-145h19.3
chr24_+_37640626 0.35 ENSDART00000008047
WD repeat domain 24
chr1_-_31171242 0.35 ENSDART00000190294
potassium voltage-gated channel, KQT-like subfamily, member 5b
chr24_-_7995960 0.35 ENSDART00000186594
biogenesis of lysosomal organelles complex-1, subunit 5, muted
chr12_-_4185554 0.34 ENSDART00000152313
si:dkey-32n7.7
chr12_+_2381213 0.33 ENSDART00000188007

chr20_-_43663494 0.32 ENSDART00000144564

chr5_+_66433287 0.31 ENSDART00000170757
kinetochore associated 1

Network of associatons between targets according to the STRING database.

First level regulatory network of arxa

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.7 GO:0048210 Golgi vesicle fusion to target membrane(GO:0048210)
1.0 2.9 GO:0007585 respiratory gaseous exchange(GO:0007585) regulation of respiratory gaseous exchange(GO:0043576)
0.8 2.4 GO:0042420 octopamine biosynthetic process(GO:0006589) dopamine catabolic process(GO:0042420) norepinephrine biosynthetic process(GO:0042421) octopamine metabolic process(GO:0046333)
0.7 2.1 GO:0030043 actin filament fragmentation(GO:0030043)
0.5 1.6 GO:0070228 B cell apoptotic process(GO:0001783) regulation of B cell apoptotic process(GO:0002902) regulation of lymphocyte apoptotic process(GO:0070228)
0.5 2.5 GO:0071763 nuclear membrane organization(GO:0071763)
0.5 2.4 GO:0035988 chondrocyte proliferation(GO:0035988)
0.5 2.8 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.4 1.7 GO:2000303 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) negative regulation of ceramide biosynthetic process(GO:1900060) regulation of membrane lipid metabolic process(GO:1905038) regulation of ceramide biosynthetic process(GO:2000303)
0.4 2.5 GO:0097250 mitochondrial respiratory chain supercomplex assembly(GO:0097250)
0.4 3.2 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.4 1.9 GO:0000012 single strand break repair(GO:0000012)
0.3 2.5 GO:2000290 smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910) regulation of myotome development(GO:2000290)
0.3 0.9 GO:1990575 mitochondrial ornithine transport(GO:0000066) mitochondrial L-ornithine transmembrane transport(GO:1990575)
0.3 3.3 GO:0006032 chitin catabolic process(GO:0006032)
0.3 2.8 GO:0006707 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.2 2.0 GO:0010522 regulation of calcium ion transport into cytosol(GO:0010522) regulation of release of sequestered calcium ion into cytosol(GO:0051279)
0.2 3.8 GO:0030183 B cell differentiation(GO:0030183)
0.2 1.0 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.2 2.0 GO:0061026 cardiac muscle tissue regeneration(GO:0061026)
0.2 0.8 GO:1900145 nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)
0.1 0.7 GO:2001223 negative regulation of neuron migration(GO:2001223)
0.1 0.7 GO:0008591 regulation of Wnt signaling pathway, calcium modulating pathway(GO:0008591)
0.1 0.8 GO:0097065 anterior head development(GO:0097065)
0.1 2.5 GO:0030216 keratinocyte differentiation(GO:0030216)
0.1 1.5 GO:0097369 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.1 0.5 GO:0045922 regulation of fatty acid biosynthetic process(GO:0042304) negative regulation of fatty acid metabolic process(GO:0045922)
0.1 1.3 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.1 3.1 GO:0051014 actin filament severing(GO:0051014)
0.1 1.9 GO:0016075 rRNA catabolic process(GO:0016075)
0.1 1.3 GO:0051898 negative regulation of protein kinase B signaling(GO:0051898)
0.1 1.1 GO:0006177 GMP biosynthetic process(GO:0006177) GMP metabolic process(GO:0046037)
0.1 0.4 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.1 3.9 GO:0071219 cellular response to molecule of bacterial origin(GO:0071219) cellular response to lipopolysaccharide(GO:0071222)
0.1 1.2 GO:0016188 synaptic vesicle maturation(GO:0016188)
0.1 1.1 GO:0006622 protein targeting to lysosome(GO:0006622)
0.1 0.5 GO:1901906 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.1 1.3 GO:0060325 face morphogenesis(GO:0060325)
0.1 0.7 GO:0034063 stress granule assembly(GO:0034063)
0.1 1.3 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.1 1.1 GO:0060561 apoptotic process involved in morphogenesis(GO:0060561)
0.1 0.7 GO:1990845 adaptive thermogenesis(GO:1990845)
0.1 0.6 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.1 1.5 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.1 1.8 GO:0048246 macrophage chemotaxis(GO:0048246)
0.1 0.8 GO:0060753 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.1 0.7 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.1 2.4 GO:0003094 glomerular filtration(GO:0003094)
0.1 2.2 GO:0050821 protein stabilization(GO:0050821)
0.1 0.6 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.1 1.2 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
0.0 4.3 GO:0006672 ceramide metabolic process(GO:0006672)
0.0 0.7 GO:0090481 pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.0 3.7 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 0.9 GO:0010737 protein kinase A signaling(GO:0010737)
0.0 0.9 GO:2000816 negative regulation of sister chromatid segregation(GO:0033046) negative regulation of mitotic sister chromatid segregation(GO:0033048) negative regulation of mitotic sister chromatid separation(GO:2000816)
0.0 2.3 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 1.5 GO:0001878 response to yeast(GO:0001878)
0.0 0.5 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 0.9 GO:0051092 positive regulation of NF-kappaB transcription factor activity(GO:0051092)
0.0 5.7 GO:0000209 protein polyubiquitination(GO:0000209)
0.0 1.1 GO:0009395 phospholipid catabolic process(GO:0009395)
0.0 0.6 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.3 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.0 0.7 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.2 GO:0098789 mRNA cleavage involved in mRNA processing(GO:0098787) pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.0 1.0 GO:0009950 dorsal/ventral axis specification(GO:0009950)
0.0 7.3 GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway(GO:0007188)
0.0 2.0 GO:0051017 actin filament bundle assembly(GO:0051017)
0.0 0.5 GO:0016233 telomere capping(GO:0016233)
0.0 0.6 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 0.7 GO:0043967 histone H4 acetylation(GO:0043967)
0.0 2.6 GO:0006413 translational initiation(GO:0006413)
0.0 1.2 GO:0043488 regulation of mRNA stability(GO:0043488)
0.0 0.8 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 1.8 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.0 0.6 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.0 1.3 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.0 0.8 GO:0042738 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.0 0.2 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0 0.2 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 0.7 GO:0001837 epithelial to mesenchymal transition(GO:0001837)
0.0 0.2 GO:0006415 translational termination(GO:0006415)
0.0 0.8 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 0.4 GO:0002181 cytoplasmic translation(GO:0002181)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 5.4 GO:0019815 B cell receptor complex(GO:0019815)
0.6 1.9 GO:0005775 vacuolar lumen(GO:0005775) lysosomal lumen(GO:0043202)
0.4 4.3 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.4 1.3 GO:1990879 CST complex(GO:1990879)
0.4 1.1 GO:0031166 integral component of vacuolar membrane(GO:0031166) intrinsic component of vacuolar membrane(GO:0031310)
0.4 3.6 GO:0032593 insulin-responsive compartment(GO:0032593)
0.3 0.9 GO:0034457 Mpp10 complex(GO:0034457)
0.2 1.5 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.1 1.0 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 0.4 GO:0070319 Golgi to plasma membrane transport vesicle(GO:0070319)
0.1 2.0 GO:0030667 secretory granule membrane(GO:0030667)
0.1 0.4 GO:1990923 PET complex(GO:1990923)
0.1 0.5 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.1 0.7 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 3.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 2.0 GO:0005940 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 1.1 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 1.1 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 2.5 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 4.8 GO:0005882 intermediate filament(GO:0005882)
0.0 0.7 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 3.1 GO:0001726 ruffle(GO:0001726)
0.0 0.7 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.0 0.6 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.7 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 1.9 GO:0031228 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 1.8 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.2 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.3 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 0.7 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.3 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.2 GO:0005675 holo TFIIH complex(GO:0005675)
0.0 1.2 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 2.0 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.2 GO:1990246 uniplex complex(GO:1990246)
0.0 0.5 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 4.7 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 1.9 GO:0016459 myosin complex(GO:0016459)
0.0 1.1 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.2 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.6 GO:0022626 cytosolic ribosome(GO:0022626) cytosolic small ribosomal subunit(GO:0022627)
0.0 3.5 GO:0015629 actin cytoskeleton(GO:0015629)
0.0 0.2 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 2.0 GO:0030017 sarcomere(GO:0030017)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0004500 dopamine beta-monooxygenase activity(GO:0004500)
0.6 1.9 GO:0033897 ribonuclease T2 activity(GO:0033897)
0.6 3.0 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.5 1.6 GO:0001729 ceramide kinase activity(GO:0001729)
0.5 3.9 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.5 2.8 GO:0033781 cholesterol 24-hydroxylase activity(GO:0033781)
0.4 3.8 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.4 2.6 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.4 3.9 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.3 1.9 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.3 3.3 GO:0004568 chitinase activity(GO:0004568)
0.3 3.6 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.2 0.7 GO:0070259 tyrosyl-DNA phosphodiesterase activity(GO:0070259)
0.2 2.8 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.2 1.1 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.2 0.9 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.2 1.5 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.1 2.6 GO:0002039 p53 binding(GO:0002039)
0.1 1.5 GO:0015386 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.1 1.5 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.1 2.5 GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153)
0.1 2.5 GO:0019894 kinesin binding(GO:0019894)
0.1 1.3 GO:0043047 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.1 0.7 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.1 0.9 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.1 1.3 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 0.5 GO:0008486 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.1 1.3 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1 4.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 3.2 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 1.3 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.8 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.1 0.7 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.1 0.4 GO:0034584 piRNA binding(GO:0034584)
0.0 1.1 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 1.6 GO:0051020 GTPase binding(GO:0051020)
0.0 0.9 GO:0030515 snoRNA binding(GO:0030515)
0.0 1.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 1.0 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.6 GO:0070403 NAD+ binding(GO:0070403)
0.0 1.9 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 5.2 GO:0005179 hormone activity(GO:0005179)
0.0 0.3 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0 3.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.1 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.0 1.2 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.6 GO:0043236 laminin binding(GO:0043236)
0.0 2.6 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 1.2 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.2 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 5.7 GO:0051015 actin filament binding(GO:0051015)
0.0 0.6 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.4 GO:0005112 Notch binding(GO:0005112)
0.0 0.2 GO:0043515 kinetochore binding(GO:0043515)
0.0 1.8 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.2 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 2.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.2 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 1.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 1.1 GO:0003724 RNA helicase activity(GO:0003724)
0.0 2.0 GO:0060090 binding, bridging(GO:0060090)
0.0 0.7 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 1.0 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.0 0.7 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 0.8 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.0 2.4 GO:0046982 protein heterodimerization activity(GO:0046982)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.4 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.2 2.8 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 3.1 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 1.0 PID ARF 3PATHWAY Arf1 pathway
0.0 1.4 PID EPO PATHWAY EPO signaling pathway
0.0 5.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.9 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.2 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 1.2 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.6 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.1 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.1 1.5 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.1 1.0 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.1 1.2 REACTOME RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway
0.1 1.1 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 3.0 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 1.5 REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.1 2.6 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 1.5 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.0 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.7 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.9 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.0 0.7 REACTOME DOUBLE STRAND BREAK REPAIR Genes involved in Double-Strand Break Repair
0.0 0.7 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 1.5 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.2 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 1.1 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.1 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 1.8 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 1.4 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.2 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.2 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.2 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs