ISMARA results: atf2+atf7a+atf7b

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for atf2+atf7a+atf7b_creb5a+creb5b

Z-value: 2.53

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Transcription factors associated with atf2+atf7a+atf7b_creb5a+creb5b

Gene Symbol	Gene ID	Gene Info
atf7a NCBI UniProt	ENSDARG00000011298	activating transcription factor 7a
atf2 NCBI UniProt	ENSDARG00000023903	activating transcription factor 2
atf7b NCBI UniProt	ENSDARG00000055481	activating transcription factor 7b
atf7b NCBI UniProt	ENSDARG00000114492	activating transcription factor 7b
atf7b NCBI UniProt	ENSDARG00000115171	activating transcription factor 7b
creb5b NCBI UniProt	ENSDARG00000070536	cAMP responsive element binding protein 5b
creb5a NCBI UniProt	ENSDARG00000099002	cAMP responsive element binding protein 5a

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
atf7b	dr11_v1_chr6_-_39631164_39631181	0.75	1.5e-18	Click!
atf2	dr11_v1_chr9_+_2343096_2343172	0.63	1.1e-11	Click!
creb5b	dr11_v1_chr16_-_20707742_20707742	0.59	4.0e-10	Click!
creb5a	dr11_v1_chr19_-_19505167_19505167	0.30	2.9e-03	Click!
atf7a	dr11_v1_chr23_-_27479558_27479558	-0.22	3.0e-02	Click!

Activity profile of atf2+atf7a+atf7b_creb5a+creb5b motif

Sorted Z-values of atf2+atf7a+atf7b_creb5a+creb5b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr16_+_34523515 Show fit	65.64	ENSDART00000041007	stmn1b NCBI UniProt Show fit	stathmin 1b
chr21_-_43606502 Show fit	57.71	ENSDART00000151030	si:ch73-362m14.4 NCBI UniProt Show fit	si:ch73-362m14.4
chr3_-_49566364 Show fit	57.56	ENSDART00000161507	zgc:153426 NCBI UniProt Show fit	zgc:153426
chr24_-_7632187 Show fit	49.95	ENSDART00000041714	atp6v0a1b NCBI UniProt Show fit	ATPase H+ transporting V0 subunit a1b
chr1_-_22861348 Show fit	48.29	ENSDART00000139412	SMIM18 NCBI UniProt Show fit	si:dkey-92j12.6
chr16_-_12173554 Show fit	46.17	ENSDART00000110567 ENSDART00000155935	clstn3 NCBI UniProt Show fit	calsyntenin 3
chr9_+_7548533 Show fit	45.03	ENSDART00000081543	ptprna NCBI UniProt Show fit	protein tyrosine phosphatase, receptor type, Na
chr7_+_40228422 Show fit	41.20	ENSDART00000052222	ptprn2 NCBI UniProt Show fit	protein tyrosine phosphatase, receptor type, N polypeptide 2
chr6_+_27667359 Show fit	40.60	ENSDART00000159624 ENSDART00000049177	rab6ba NCBI UniProt Show fit	RAB6B, member RAS oncogene family a
chr6_+_13920479 Show fit	39.10	ENSDART00000155480	ptprnb NCBI UniProt Show fit	protein tyrosine phosphatase, receptor type, Nb

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of atf2+atf7a+atf7b_creb5a+creb5b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	145.1	GO:0006470	protein dephosphorylation(GO:0006470)
0.2	137.4	GO:0007017	microtubule-based process(GO:0007017)
1.9	92.1	GO:0007019	microtubule depolymerization(GO:0007019)
3.8	57.7	GO:0051127	positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.6	53.6	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	49.6	GO:0006355	regulation of transcription, DNA-templated(GO:0006355)
0.6	47.9	GO:0046839	phospholipid dephosphorylation(GO:0046839)
7.7	46.2	GO:0051965	positive regulation of synapse assembly(GO:0051965)
10.3	41.2	GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
1.2	40.6	GO:0006891	intra-Golgi vesicle-mediated transport(GO:0006891)

Showing 1 to 10 of 145 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	130.9	GO:0043005	neuron projection(GO:0043005)
0.4	117.7	GO:0045211	postsynaptic membrane(GO:0045211)
1.2	109.4	GO:0030141	secretory granule(GO:0030141)
0.2	95.5	GO:0015630	microtubule cytoskeleton(GO:0015630)
1.1	89.3	GO:0005871	kinesin complex(GO:0005871)
0.1	71.0	GO:0005887	integral component of plasma membrane(GO:0005887)
3.6	57.7	GO:0031209	SCAR complex(GO:0031209)
0.3	46.7	GO:0008021	synaptic vesicle(GO:0008021)
0.4	41.2	GO:0005802	trans-Golgi network(GO:0005802)
0.5	34.1	GO:0031902	late endosome membrane(GO:0031902)

Showing 1 to 10 of 62 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	134.3	GO:0001071	nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.6	129.6	GO:0004725	protein tyrosine phosphatase activity(GO:0004725)
0.1	102.3	GO:0005509	calcium ion binding(GO:0005509)
0.3	91.9	GO:0015631	tubulin binding(GO:0015631)
6.4	57.7	GO:0071933	Arp2/3 complex binding(GO:0071933)
0.1	55.0	GO:0003924	GTPase activity(GO:0003924)
1.6	54.3	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1	48.6	GO:0003729	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
1.8	47.9	GO:0042577	lipid phosphatase activity(GO:0042577)
5.4	37.8	GO:0008526	phosphatidylinositol transporter activity(GO:0008526)

Showing 1 to 10 of 106 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	28.5	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.4	18.5	PID IL4 2PATHWAY	IL4-mediated signaling events
0.8	17.0	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
1.0	13.5	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.6	10.9	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.6	10.5	PID VEGFR1 PATHWAY	VEGFR1 specific signals
0.3	8.4	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.5	7.9	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.3	6.8	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
0.7	5.2	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.

Showing 1 to 10 of 18 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	28.7	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.8	18.5	REACTOME G PROTEIN ACTIVATION	Genes involved in G-protein activation
1.7	17.0	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
1.4	16.9	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
0.6	14.4	REACTOME AMYLOIDS	Genes involved in Amyloids
0.1	13.0	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
0.4	12.4	REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN	Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.3	12.1	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.8	10.9	REACTOME AMINE LIGAND BINDING RECEPTORS	Genes involved in Amine ligand-binding receptors
0.2	10.8	REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	Genes involved in Loss of Nlp from mitotic centrosomes

Showing 1 to 10 of 28 entries

Results for atf2+atf7a+atf7b_creb5a+creb5b

Z-value: 2.53

Motif logo

Transcription factors associated with atf2+atf7a+atf7b_creb5a+creb5b

Activity-expression correlation:

Activity profile of atf2+atf7a+atf7b_creb5a+creb5b motif

Sorted Z-values of atf2+atf7a+atf7b_creb5a+creb5b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of atf2+atf7a+atf7b_creb5a+creb5b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: