ISMARA results: atf3+jdp2b

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for atf3+jdp2b

Z-value: 1.93

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Transcription factors associated with atf3+jdp2b

Gene Symbol	Gene ID	Gene Info
atf3 NCBI UniProt	ENSDARG00000007823	activating transcription factor 3
jdp2b NCBI UniProt	ENSDARG00000020133	Jun dimerization protein 2b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
atf3	dr11_v1_chr20_+_37794633_37794633	0.31	2.3e-03	Click!
jdp2b	dr11_v1_chr20_+_46586678_46586692	0.26	1.2e-02	Click!

Activity profile of atf3+jdp2b motif

Sorted Z-values of atf3+jdp2b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr6_+_112579 Show fit	23.89	ENSDART00000034505	ap1m2 NCBI UniProt Show fit	adaptor-related protein complex 1, mu 2 subunit
chr10_+_20256454 Show fit	23.86	ENSDART00000111097	TCIM (1 of many) NCBI UniProt Show fit	transcriptional and immune response regulator
chr23_-_44723102 Show fit	21.82	ENSDART00000129138	mogat3a NCBI UniProt Show fit	monoacylglycerol O-acyltransferase 3a
chr5_+_29831235 Show fit	20.91	ENSDART00000109660	f11r.1 NCBI UniProt Show fit	F11 receptor, tandem duplicate 1
chr18_-_5598958 Show fit	19.83	ENSDART00000161538	cyp1a NCBI UniProt Show fit	cytochrome P450, family 1, subfamily A
chr5_+_57658898 Show fit	18.58	ENSDART00000074268 ENSDART00000124568	zgc:153929 NCBI UniProt Show fit	zgc:153929
chr24_-_26328721 Show fit	18.52	ENSDART00000125468	apodb NCBI UniProt Show fit	apolipoprotein Db
chr14_+_21106444 Show fit	16.97	ENSDART00000075744 ENSDART00000132363	aldob NCBI UniProt Show fit	aldolase b, fructose-bisphosphate
chr5_-_29531948 Show fit	16.48	ENSDART00000098360	arrdc1a NCBI UniProt Show fit	arrestin domain containing 1a
chr17_-_2039511 Show fit	15.73	ENSDART00000160223	spint1a NCBI UniProt Show fit	serine peptidase inhibitor, Kunitz type 1 a

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of atf3+jdp2b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	32.0	GO:0030168	platelet activation(GO:0030168)
0.1	30.8	GO:0016567	protein ubiquitination(GO:0016567)
0.8	30.5	GO:0030199	collagen fibril organization(GO:0030199)
3.0	30.0	GO:0006450	regulation of translational fidelity(GO:0006450)
0.0	25.2	GO:0006508	proteolysis(GO:0006508)
1.6	24.7	GO:0090559	regulation of membrane permeability(GO:0090559)
0.4	23.1	GO:0006892	post-Golgi vesicle-mediated transport(GO:0006892)
0.1	22.3	GO:0006412	translation(GO:0006412)
0.7	21.8	GO:0019432	triglyceride biosynthetic process(GO:0019432)
3.0	21.0	GO:0031444	slow-twitch skeletal muscle fiber contraction(GO:0031444)

Showing 1 to 10 of 362 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	65.0	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.0	43.5	GO:0005615	extracellular space(GO:0005615)
0.3	37.7	GO:0005840	ribosome(GO:0005840)
0.3	32.1	GO:0005581	collagen trimer(GO:0005581)
0.3	30.9	GO:0005923	bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.3	28.9	GO:0042579	peroxisome(GO:0005777) microbody(GO:0042579)
0.4	25.7	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.1	25.6	GO:0005730	nucleolus(GO:0005730)
0.4	23.9	GO:0031901	early endosome membrane(GO:0031901)
0.2	23.4	GO:0016459	myosin complex(GO:0016459)

Showing 1 to 10 of 159 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	69.8	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.3	61.0	GO:0003735	structural constituent of ribosome(GO:0003735)
0.3	34.9	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.3	28.6	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.3	28.3	GO:0003724	RNA helicase activity(GO:0003724)
0.6	27.2	GO:0000049	tRNA binding(GO:0000049)
0.2	25.6	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.4	24.6	GO:0015020	glucuronosyltransferase activity(GO:0015020)
0.1	23.4	GO:0061630	ubiquitin protein ligase activity(GO:0061630)
1.0	22.7	GO:0035615	clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)

Showing 1 to 10 of 243 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	43.4	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
1.4	42.0	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.4	20.5	PID P53 REGULATION PATHWAY	p53 pathway
0.5	15.4	PID WNT NONCANONICAL PATHWAY	Noncanonical Wnt signaling pathway
0.4	11.9	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.1	11.9	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.4	10.5	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.2	9.9	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network
0.3	9.0	PID ATR PATHWAY	ATR signaling pathway
0.3	8.5	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms

Showing 1 to 10 of 56 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	46.5	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
1.2	26.9	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
2.2	24.6	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.7	24.2	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
1.9	20.8	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.6	17.5	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.6	15.0	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.7	13.5	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
0.5	11.4	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.2	11.2	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation

Showing 1 to 10 of 86 entries

Results for atf3+jdp2b

Z-value: 1.93

Motif logo

Transcription factors associated with atf3+jdp2b

Activity-expression correlation:

Activity profile of atf3+jdp2b motif

Sorted Z-values of atf3+jdp2b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of atf3+jdp2b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: