Project

PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

Navigation
Downloads

Results for atf4a+atf4b

Z-value: 1.34

Motif logo

logo of

Transcription factors associated with atf4a+atf4b

Gene Symbol Gene ID Gene Info
atf4b
ENSDARG00000038141 activating transcription factor 4b
atf4a
ENSDARG00000111939 activating transcription factor 4a
atf4b
ENSDARG00000114163 activating transcription factor 4b
atf4b
ENSDARG00000114542 activating transcription factor 4b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
atf4bdr11_v1_chr3_+_24197934_241979340.449.1e-06Click!
atf4adr11_v1_chr6_+_269204_269204-0.285.6e-03Click!

Activity profile of atf4a+atf4b motif

Sorted Z-values of atf4a+atf4b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_31119548 14.41 ENSDART00000136578
syn1
synapsin I
chr16_+_34523515 14.01 ENSDART00000041007
stmn1b
stathmin 1b
chr3_+_31933893 12.31 ENSDART00000146509
ENSDART00000139644
lin7b
lin-7 homolog B (C. elegans)
chr15_-_24869826 11.66 ENSDART00000127047
tusc5a
tumor suppressor candidate 5a
chr4_+_17279966 11.56 ENSDART00000067005
ENSDART00000137487
bcat1
branched chain amino-acid transaminase 1, cytosolic
chr19_-_9712530 10.65 ENSDART00000134816
slc2a3a
solute carrier family 2 (facilitated glucose transporter), member 3a
chr15_+_29085955 10.24 ENSDART00000156799
si:ch211-137a8.4
si:ch211-137a8.4
chr21_+_30502002 10.03 ENSDART00000043727
slc7a3a
solute carrier family 7 (cationic amino acid transporter, y+ system), member 3a
chr4_+_1600034 9.90 ENSDART00000146779
slc38a2
solute carrier family 38, member 2
chr5_-_55395964 9.90 ENSDART00000145791
prune2
prune homolog 2 (Drosophila)
chr4_+_8797197 9.81 ENSDART00000158671
sult4a1
sulfotransferase family 4A, member 1
chr14_+_28438947 9.44 ENSDART00000006489
acsl4a
acyl-CoA synthetase long chain family member 4a
chr12_+_46960579 8.46 ENSDART00000149032
oat
ornithine aminotransferase
chr7_-_52842605 8.36 ENSDART00000083002
map1aa
microtubule-associated protein 1Aa
chr23_-_27345425 7.79 ENSDART00000022042
ENSDART00000191870
scn8aa
sodium channel, voltage gated, type VIII, alpha subunit a
chr9_-_9228941 7.67 ENSDART00000121665
cbsb
cystathionine-beta-synthase b
chr5_-_32323136 7.44 ENSDART00000110804
hspb15
heat shock protein, alpha-crystallin-related, b15
chr6_+_41255485 7.39 ENSDART00000042683
ENSDART00000186013
cadpsb
Ca2+-dependent activator protein for secretion b
chr7_+_33314925 7.37 ENSDART00000148590
coro2ba
coronin, actin binding protein, 2Ba
chr17_-_45552602 7.18 ENSDART00000154844
ENSDART00000034432
susd4
sushi domain containing 4
chr6_-_11780070 6.94 ENSDART00000151195
march7
membrane-associated ring finger (C3HC4) 7
chr2_-_36932253 6.92 ENSDART00000124217
map1sb
microtubule-associated protein 1Sb
chr5_-_69499486 6.88 ENSDART00000023983
ENSDART00000180293
psat1
phosphoserine aminotransferase 1
chr13_-_24447332 6.82 ENSDART00000043004
slc1a4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr18_-_16179129 6.50 ENSDART00000125353
slc6a15
solute carrier family 6 (neutral amino acid transporter), member 15
chr25_+_7784582 6.32 ENSDART00000155016
dgkzb
diacylglycerol kinase, zeta b
chr19_+_30885258 6.27 ENSDART00000143394
yars
tyrosyl-tRNA synthetase
chr5_-_57528943 6.26 ENSDART00000130320
pisd
phosphatidylserine decarboxylase
chr12_+_34953038 5.98 ENSDART00000187022
ENSDART00000123988
ENSDART00000027034
qki2
QKI, KH domain containing, RNA binding 2
chr21_-_43949208 5.79 ENSDART00000150983
camk2a
calcium/calmodulin-dependent protein kinase II alpha
chr18_+_17493859 5.60 ENSDART00000090754
si:dkey-102f14.5
si:dkey-102f14.5
chr5_-_55395384 5.36 ENSDART00000147298
ENSDART00000082577
prune2
prune homolog 2 (Drosophila)
chr9_+_2574122 5.27 ENSDART00000166326
ENSDART00000191822
CIR1
si:ch73-167c12.2
chr5_+_3501859 5.08 ENSDART00000080486
ywhag1
3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 1
chr20_+_16743056 5.03 ENSDART00000050308
calm1b
calmodulin 1b
chr3_+_33440615 4.93 ENSDART00000146005
gtpbp1
GTP binding protein 1
chr12_-_32066469 4.90 ENSDART00000140685
ENSDART00000062185
rab40b
RAB40B, member RAS oncogene family
chr2_+_35240764 4.82 ENSDART00000015827
tnr
tenascin R (restrictin, janusin)
chr9_-_48214216 4.75 ENSDART00000012938
phgdh
phosphoglycerate dehydrogenase
chr23_-_12014931 4.57 ENSDART00000134652
si:dkey-178k16.1
si:dkey-178k16.1
chr15_-_25392589 4.48 ENSDART00000124205
si:dkey-54n8.4
si:dkey-54n8.4
chr19_-_30447611 4.33 ENSDART00000073705
ENSDART00000048977
ENSDART00000191237
abcf1
ATP-binding cassette, sub-family F (GCN20), member 1
chr19_+_30884706 4.32 ENSDART00000052126
yars
tyrosyl-tRNA synthetase
chr20_-_20610812 4.16 ENSDART00000181870
ppm1ab
protein phosphatase, Mg2+/Mn2+ dependent, 1Ab
chr16_+_40024883 3.93 ENSDART00000110100
hint3
histidine triad nucleotide binding protein 3
chr17_+_12700617 3.85 ENSDART00000191931
stmn4l
stathmin-like 4, like
chr12_+_41697664 3.85 ENSDART00000162302
bnip3
BCL2 interacting protein 3
chr20_-_29418620 3.85 ENSDART00000172634
ryr3
ryanodine receptor 3
chr20_-_20611063 3.79 ENSDART00000063492
ppm1ab
protein phosphatase, Mg2+/Mn2+ dependent, 1Ab
chr3_-_40284744 3.69 ENSDART00000018626
pdap1b
pdgfa associated protein 1b
chr20_-_35246150 3.53 ENSDART00000090549
fzd3a
frizzled class receptor 3a
chr3_-_30152836 3.52 ENSDART00000165920
nucb1
nucleobindin 1
chr3_-_30153242 3.45 ENSDART00000077089
nucb1
nucleobindin 1
chr12_-_46959990 3.44 ENSDART00000084557
lhpp
phospholysine phosphohistidine inorganic pyrophosphate phosphatase
chr20_-_19532531 3.41 ENSDART00000125830
ENSDART00000179566
ENSDART00000184193
eif2b4
BX276101.2
eukaryotic translation initiation factor 2B, subunit 4 delta

chr19_+_30884960 3.37 ENSDART00000140603
ENSDART00000183224
ENSDART00000135484
ENSDART00000139599
yars
tyrosyl-tRNA synthetase
chr22_+_25931782 3.33 ENSDART00000157842
dnaja3b
DnaJ (Hsp40) homolog, subfamily A, member 3B
chr6_+_49551614 3.32 ENSDART00000022581
rab22a
RAB22A, member RAS oncogene family
chr7_-_31830936 3.31 ENSDART00000052514
ENSDART00000129720
cars
cysteinyl-tRNA synthetase
chr6_+_58915889 3.24 ENSDART00000083628
ddit3
DNA-damage-inducible transcript 3
chr24_+_32525146 3.21 ENSDART00000132417
ENSDART00000110185
yme1l1a
YME1-like 1a
chr23_-_18030399 3.17 ENSDART00000136967
pm20d1.1
peptidase M20 domain containing 1, tandem duplicate 1
chr21_+_944715 3.10 ENSDART00000144766
nars
asparaginyl-tRNA synthetase
chr6_+_37754763 3.07 ENSDART00000110770
herc2
HECT and RLD domain containing E3 ubiquitin protein ligase 2
chr6_-_37422841 3.07 ENSDART00000138351
cth
cystathionase (cystathionine gamma-lyase)
chr6_-_31233696 3.07 ENSDART00000079173
lepr
leptin receptor
chr12_-_35386910 3.06 ENSDART00000153453
camk2g1
calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1
chr8_+_42917515 3.01 ENSDART00000021715
slc23a2
solute carrier family 23 (ascorbic acid transporter), member 2
chr6_+_23809501 3.01 ENSDART00000168701
glulb
glutamate-ammonia ligase (glutamine synthase) b
chr13_-_25548733 2.96 ENSDART00000168099
ENSDART00000135788
ENSDART00000077655
mcmbp
minichromosome maintenance complex binding protein
chr10_-_31104983 2.94 ENSDART00000186941
pknox2
pbx/knotted 1 homeobox 2
chr12_+_27129659 2.79 ENSDART00000076161
hoxb5b
homeobox B5b
chr12_-_13205572 2.78 ENSDART00000152670
pelo
pelota mRNA surveillance and ribosome rescue factor
chr12_+_30789611 2.77 ENSDART00000181501
aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr16_-_20006270 2.75 ENSDART00000079155
hdac9b
histone deacetylase 9b
chr20_+_37794633 2.74 ENSDART00000022060
atf3
activating transcription factor 3
chr7_-_35036770 2.64 ENSDART00000123174
galr1b
galanin receptor 1b
chr5_-_57652168 2.52 ENSDART00000166245
gb:eh456644
expressed sequence EH456644
chr2_+_7849890 2.30 ENSDART00000114241
si:ch211-38m6.6
si:ch211-38m6.6
chr25_+_28893615 2.28 ENSDART00000156994
ENSDART00000075151
amn1
antagonist of mitotic exit network 1 homolog (S. cerevisiae)
chr2_-_37059966 2.25 ENSDART00000137967
diras1b
DIRAS family, GTP-binding RAS-like 1b
chr13_+_4225173 2.22 ENSDART00000058242
ENSDART00000143456
mea1
male-enhanced antigen 1
chr18_-_18667416 2.15 ENSDART00000100401
ENSDART00000136544
aars
alanyl-tRNA synthetase
chr12_-_48374728 2.12 ENSDART00000153403
ENSDART00000188117
dnajb12b
DnaJ (Hsp40) homolog, subfamily B, member 12b
chr15_-_23908779 2.12 ENSDART00000088808
usp32
ubiquitin specific peptidase 32
chr15_-_2754056 2.12 ENSDART00000129380
ppp5c
protein phosphatase 5, catalytic subunit
chr23_+_35504824 2.11 ENSDART00000082647
ENSDART00000159218
acp1
acid phosphatase 1
chr12_+_30788912 2.06 ENSDART00000160422
aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr7_-_30272871 2.05 ENSDART00000099586
zgc:162945
zgc:162945
chr20_+_28266892 2.04 ENSDART00000103330
chac1
ChaC, cation transport regulator homolog 1 (E. coli)
chr8_-_46386024 2.03 ENSDART00000136602
ENSDART00000060919
ENSDART00000137472
qars
glutaminyl-tRNA synthetase
chr14_-_30945515 2.00 ENSDART00000161540
si:zfos-80g12.1
si:zfos-80g12.1
chr2_+_1001560 1.93 ENSDART00000134656
cacna1eb
calcium channel, voltage-dependent, R type, alpha 1E subunit b
chr15_-_42283830 1.92 ENSDART00000015979
farsb
phenylalanyl-tRNA synthetase, beta subunit
chr12_-_13205854 1.91 ENSDART00000077829
pelo
pelota mRNA surveillance and ribosome rescue factor
chr2_-_28671139 1.87 ENSDART00000165272
ENSDART00000164657
dhcr7
7-dehydrocholesterol reductase
chr3_+_15394428 1.86 ENSDART00000133168
atxn2l
ataxin 2-like
chr20_-_18915376 1.85 ENSDART00000063725
xkr6b
XK, Kell blood group complex subunit-related family, member 6b
chr3_+_25907266 1.81 ENSDART00000170324
ENSDART00000192633
tom1
target of myb1 membrane trafficking protein
chr15_-_17870090 1.80 ENSDART00000155066
atf5b
activating transcription factor 5b
chr2_+_16597011 1.79 ENSDART00000160641
ENSDART00000125413
xrn1
5'-3' exoribonuclease 1
chr8_-_31384607 1.78 ENSDART00000164134
ENSDART00000024872
creb3l3l
cAMP responsive element binding protein 3-like 3 like
chr25_-_21894317 1.76 ENSDART00000089642
fbxo31
F-box protein 31
chr12_+_13205955 1.75 ENSDART00000092906
ppp1cab
protein phosphatase 1, catalytic subunit, alpha isozyme b
chr25_+_26923193 1.64 ENSDART00000187364
grm8b
glutamate receptor, metabotropic 8b
chr10_+_10210455 1.61 ENSDART00000144214
sh2d3ca
SH2 domain containing 3Ca
chr24_-_37484123 1.56 ENSDART00000111623
cluap1
clusterin associated protein 1
chr5_-_43935460 1.55 ENSDART00000166152
ENSDART00000188969
si:ch211-204c21.1
si:ch211-204c21.1
chr15_+_24737599 1.47 ENSDART00000078024
crk
v-crk avian sarcoma virus CT10 oncogene homolog
chr24_-_38644937 1.47 ENSDART00000170194
slc6a16b
solute carrier family 6, member 16b
chr16_+_10429770 1.46 ENSDART00000173132
vars
valyl-tRNA synthetase
chr15_+_45994123 1.44 ENSDART00000124704
lrfn1
leucine rich repeat and fibronectin type III domain containing 1
chr7_+_39664055 1.44 ENSDART00000146171
zgc:158564
zgc:158564
chr16_+_4839078 1.43 ENSDART00000150111
ibtk
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr3_+_13879446 1.31 ENSDART00000164767
farsa
phenylalanyl-tRNA synthetase, alpha subunit
chr20_+_28803977 1.28 ENSDART00000153351
ENSDART00000038149
fntb
farnesyltransferase, CAAX box, beta
chr14_-_47882706 1.22 ENSDART00000188772
rapgef2
Rap guanine nucleotide exchange factor (GEF) 2
chr4_+_16784553 1.17 ENSDART00000134054
si:dkey-13i19.8
si:dkey-13i19.8
chr8_+_54202554 1.17 ENSDART00000020569
creld1b
cysteine-rich with EGF-like domains 1b
chr14_-_23801389 1.17 ENSDART00000054264
nr3c1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr3_+_40856095 1.16 ENSDART00000143207
mmd2a
monocyte to macrophage differentiation-associated 2a
chr20_-_14680897 1.11 ENSDART00000063857
ENSDART00000161314
scrn2
secernin 2
chr20_-_32007209 1.09 ENSDART00000021575
adgb
androglobin
chr14_-_1454413 1.07 ENSDART00000185403
ENSDART00000191357
pmt
phosphoethanolamine methyltransferase
chr16_+_4838808 1.07 ENSDART00000179363
ibtk
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr16_-_31351419 1.06 ENSDART00000178298
ENSDART00000018091
mroh1
maestro heat-like repeat family member 1
chr7_+_38090515 1.00 ENSDART00000131387
cebpg
CCAAT/enhancer binding protein (C/EBP), gamma
chr8_+_7778770 0.98 ENSDART00000171325
tfe3a
transcription factor binding to IGHM enhancer 3a
chr2_-_32486080 0.97 ENSDART00000110821
ttc19
tetratricopeptide repeat domain 19
chr23_-_43718067 0.97 ENSDART00000015777
abce1
ATP-binding cassette, sub-family E (OABP), member 1
chr22_-_20720427 0.97 ENSDART00000105532
oaz1a
ornithine decarboxylase antizyme 1a
chr13_+_22317216 0.95 ENSDART00000110794
usp54a
ubiquitin specific peptidase 54a
chr1_+_37312580 0.93 ENSDART00000171340
fam193a
family with sequence similarity 193, member A
chr18_+_27926839 0.92 ENSDART00000191835
hipk3b
homeodomain interacting protein kinase 3b
chr16_-_36093776 0.89 ENSDART00000159134
OSCP1
organic solute carrier partner 1
chr14_+_7892383 0.86 ENSDART00000063837
ube2d2
ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)
chr3_-_15889508 0.84 ENSDART00000148363
cramp1
cramped chromatin regulator homolog 1
chr15_-_33495048 0.83 ENSDART00000159882
stard13b
StAR-related lipid transfer (START) domain containing 13b
chr14_-_1454045 0.82 ENSDART00000161460
pmt
phosphoethanolamine methyltransferase
chr8_+_46386601 0.81 ENSDART00000129661
ENSDART00000084081
ogg1
8-oxoguanine DNA glycosylase
chr18_-_2727764 0.80 ENSDART00000160841
ARHGEF17
si:ch211-248g20.5
chr12_+_17603528 0.80 ENSDART00000111565
pms2
PMS1 homolog 2, mismatch repair system component
chr14_-_38809561 0.79 ENSDART00000159159
sil1
SIL1 nucleotide exchange factor
chr23_-_36441693 0.76 ENSDART00000024354
csad
cysteine sulfinic acid decarboxylase
chr14_+_7892021 0.73 ENSDART00000161307
ube2d2
ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)
chr22_+_38276024 0.73 ENSDART00000143792
rcor3
REST corepressor 3
chr16_-_42770064 0.64 ENSDART00000112879
slc4a7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr4_-_17642168 0.64 ENSDART00000007030
klhl42
kelch-like family, member 42
chr5_-_43935119 0.60 ENSDART00000142271
si:ch211-204c21.1
si:ch211-204c21.1
chr16_+_41826584 0.46 ENSDART00000147523
si:dkey-199f5.6
si:dkey-199f5.6
chr12_-_17602958 0.45 ENSDART00000134690
ENSDART00000028090
eif2ak1
eukaryotic translation initiation factor 2-alpha kinase 1
chr24_+_20536056 0.43 ENSDART00000082082
gars
glycyl-tRNA synthetase
chr3_+_19216567 0.39 ENSDART00000134433
il12rb2l
interleukin 12 receptor, beta 2a, like
chr13_-_9300299 0.37 ENSDART00000144142
HTRA2 (1 of many)
si:dkey-33c12.12
chr15_-_23908605 0.37 ENSDART00000185578
usp32
ubiquitin specific peptidase 32
chr19_-_8812891 0.34 ENSDART00000151134
ENSDART00000025385
ENSDART00000180291
cers2a
ceramide synthase 2a
chr4_+_12113105 0.33 ENSDART00000182399
tmem178b
transmembrane protein 178B
chr18_-_16922905 0.32 ENSDART00000187165
wee1
WEE1 G2 checkpoint kinase
chr17_-_50220228 0.26 ENSDART00000058707
jdp2a
Jun dimerization protein 2a
chr9_+_747612 0.26 ENSDART00000181004
insig2
insulin induced gene 2
chr22_-_24284447 0.26 ENSDART00000149894
si:ch211-117l17.4
si:ch211-117l17.4
chr15_-_24960730 0.19 ENSDART00000109990
ENSDART00000186706
abhd15a
abhydrolase domain containing 15a
chr12_+_17154655 0.13 ENSDART00000028003
ankrd22
ankyrin repeat domain 22
chr15_-_5780593 0.13 ENSDART00000163555
ENSDART00000082388
chchd2
coiled-coil-helix-coiled-coil-helix domain containing 2
chr3_+_1107102 0.11 ENSDART00000092690
srebf2
sterol regulatory element binding transcription factor 2
chr12_+_6065661 0.06 ENSDART00000142418
sgms1
sphingomyelin synthase 1
chr25_-_6389713 0.02 ENSDART00000083539
sin3aa
SIN3 transcription regulator family member Aa

Network of associatons between targets according to the STRING database.

First level regulatory network of atf4a+atf4b

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 11.6 GO:0006564 L-serine biosynthetic process(GO:0006564)
2.9 11.6 GO:0009098 leucine biosynthetic process(GO:0009098)
2.6 7.7 GO:0031335 regulation of sulfur amino acid metabolic process(GO:0031335) regulation of homocysteine metabolic process(GO:0050666)
2.5 12.3 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
2.4 7.2 GO:0006957 complement activation, alternative pathway(GO:0006957) regulation of protein activation cascade(GO:2000257)
1.9 7.8 GO:0007638 mechanosensory behavior(GO:0007638)
1.7 10.0 GO:0090467 L-arginine import(GO:0043091) amino acid import across plasma membrane(GO:0089718) arginine import(GO:0090467) L-arginine import across plasma membrane(GO:0097638) L-arginine transport(GO:1902023) L-arginine import into cell(GO:1902765) amino acid import into cell(GO:1902837) L-arginine transmembrane transport(GO:1903400) arginine transmembrane transport(GO:1903826)
1.6 6.5 GO:0015803 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
1.6 9.4 GO:1900744 regulation of p38MAPK cascade(GO:1900744)
1.5 13.3 GO:0055129 proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
1.4 15.3 GO:0006798 polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798)
1.2 4.7 GO:0032790 ribosome disassembly(GO:0032790)
1.1 3.2 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
1.0 3.0 GO:0019852 L-ascorbic acid transport(GO:0015882) L-ascorbic acid metabolic process(GO:0019852)
1.0 9.9 GO:0006868 glutamine transport(GO:0006868)
0.8 3.2 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway(GO:2001244)
0.8 3.2 GO:2000275 regulation of oxidative phosphorylation uncoupler activity(GO:2000275)
0.8 3.1 GO:0019344 homoserine metabolic process(GO:0009092) cysteine biosynthetic process via cystathionine(GO:0019343) cysteine biosynthetic process(GO:0019344) transsulfuration(GO:0019346)
0.7 33.1 GO:0007019 microtubule depolymerization(GO:0007019)
0.6 7.4 GO:1990504 dense core granule exocytosis(GO:1990504)
0.5 6.3 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.4 2.2 GO:0061551 trigeminal ganglion development(GO:0061551)
0.4 3.0 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.4 3.8 GO:0097345 mitochondrial outer membrane permeabilization(GO:0097345)
0.4 2.1 GO:0071218 response to misfolded protein(GO:0051788) cellular response to misfolded protein(GO:0071218)
0.4 9.8 GO:0051923 sulfation(GO:0051923)
0.3 8.0 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.3 5.6 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.3 1.3 GO:0018343 protein farnesylation(GO:0018343)
0.3 1.9 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.3 1.2 GO:0071387 cellular response to cortisol stimulus(GO:0071387)
0.3 6.3 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.3 3.5 GO:0021754 facial nucleus development(GO:0021754)
0.2 2.8 GO:0010002 cardioblast differentiation(GO:0010002)
0.2 2.0 GO:0006751 glutathione catabolic process(GO:0006751)
0.2 1.9 GO:0070782 phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.2 1.0 GO:0097033 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.2 6.0 GO:0014866 skeletal myofibril assembly(GO:0014866)
0.1 3.3 GO:0009408 response to heat(GO:0009408)
0.1 8.9 GO:0003146 heart jogging(GO:0003146)
0.1 1.8 GO:0016075 rRNA catabolic process(GO:0016075)
0.1 14.4 GO:0099643 neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
0.1 2.2 GO:0045807 positive regulation of endocytosis(GO:0045807)
0.1 3.2 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.1 3.8 GO:0051209 release of sequestered calcium ion into cytosol(GO:0051209)
0.1 3.1 GO:0003323 type B pancreatic cell development(GO:0003323)
0.1 0.4 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
0.1 0.3 GO:0036315 response to sterol(GO:0036314) cellular response to sterol(GO:0036315) SREBP-SCAP complex retention in endoplasmic reticulum(GO:0036316) regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.1 1.9 GO:0042446 hormone biosynthetic process(GO:0042446)
0.1 2.7 GO:0060319 primitive erythrocyte differentiation(GO:0060319)
0.1 1.0 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.1 1.6 GO:0033138 positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.1 1.6 GO:0045879 negative regulation of smoothened signaling pathway(GO:0045879)
0.1 0.8 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.1 4.6 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.1 1.0 GO:0006596 polyamine biosynthetic process(GO:0006596)
0.1 0.6 GO:1990798 pancreas regeneration(GO:1990798)
0.1 1.5 GO:0007520 myoblast fusion(GO:0007520)
0.1 3.0 GO:0007062 sister chromatid cohesion(GO:0007062)
0.1 0.3 GO:0031063 regulation of histone deacetylation(GO:0031063)
0.1 1.0 GO:0033753 ribosomal subunit export from nucleus(GO:0000054) ribosome localization(GO:0033750) establishment of ribosome localization(GO:0033753) rRNA-containing ribonucleoprotein complex export from nucleus(GO:0071428)
0.1 1.6 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.0 1.6 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0 1.2 GO:0019835 cytolysis(GO:0019835)
0.0 3.9 GO:0006413 translational initiation(GO:0006413)
0.0 4.3 GO:0072659 protein localization to plasma membrane(GO:0072659) protein localization to cell periphery(GO:1990778)
0.0 1.8 GO:0006414 translational elongation(GO:0006414)
0.0 0.6 GO:0015701 bicarbonate transport(GO:0015701)
0.0 1.9 GO:0070509 calcium ion import(GO:0070509)
0.0 2.7 GO:0009615 response to virus(GO:0009615)
0.0 2.6 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 15.7 GO:0007420 brain development(GO:0007420)
0.0 1.8 GO:0006073 glycogen metabolic process(GO:0005977) cellular glucan metabolic process(GO:0006073) glucan metabolic process(GO:0044042)
0.0 0.9 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.0 0.7 GO:0016575 histone deacetylation(GO:0016575)
0.0 0.7 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.0 0.8 GO:0048741 myotube cell development(GO:0014904) skeletal muscle fiber development(GO:0048741)
0.0 4.8 GO:0050767 regulation of neurogenesis(GO:0050767)
0.0 0.1 GO:0010885 regulation of cholesterol storage(GO:0010885)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 12.3 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.5 3.8 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.3 1.3 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.3 20.0 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.2 5.1 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.2 9.4 GO:0005811 lipid particle(GO:0005811)
0.2 7.4 GO:0098978 glutamatergic synapse(GO:0098978)
0.2 3.0 GO:0042555 MCM complex(GO:0042555)
0.1 6.3 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.1 15.3 GO:0043025 neuronal cell body(GO:0043025)
0.1 7.0 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 1.6 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 0.3 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 0.8 GO:0032300 mismatch repair complex(GO:0032300)
0.1 1.9 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 3.5 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 4.9 GO:0008021 synaptic vesicle(GO:0008021)
0.0 1.0 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 1.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 3.5 GO:0043235 receptor complex(GO:0043235)
0.0 2.9 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 3.3 GO:0005769 early endosome(GO:0005769)
0.0 3.2 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 17.3 GO:0043005 neuron projection(GO:0043005)
0.0 0.9 GO:0016605 PML body(GO:0016605)
0.0 2.0 GO:0005802 trans-Golgi network(GO:0005802)
0.0 1.9 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 18.9 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 14.2 GO:0005739 mitochondrion(GO:0005739)
0.0 0.6 GO:0016323 basolateral plasma membrane(GO:0016323)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 12.3 GO:0097016 L27 domain binding(GO:0097016)
2.9 11.6 GO:0004084 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
1.5 7.7 GO:0004122 cystathionine beta-synthase activity(GO:0004122)
1.4 10.0 GO:0015189 L-lysine transmembrane transporter activity(GO:0015189)
1.4 15.3 GO:0004309 exopolyphosphatase activity(GO:0004309)
1.3 6.5 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
1.0 4.8 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.9 3.4 GO:0004427 inorganic diphosphatase activity(GO:0004427) protein histidine phosphatase activity(GO:0101006)
0.9 9.4 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.8 9.9 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.8 3.2 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.8 3.8 GO:0048763 ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
0.6 15.3 GO:0008483 transaminase activity(GO:0008483)
0.5 2.0 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.4 1.8 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.4 2.6 GO:0004966 galanin receptor activity(GO:0004966)
0.4 3.0 GO:0016211 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.4 2.1 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.4 3.2 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.3 1.3 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.3 3.2 GO:0004046 aminoacylase activity(GO:0004046)
0.3 6.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.2 1.0 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.2 1.6 GO:0001642 group III metabotropic glutamate receptor activity(GO:0001642)
0.2 1.1 GO:0070004 cysteine-type exopeptidase activity(GO:0070004)
0.2 5.1 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.2 0.8 GO:0000702 oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.2 2.7 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.2 8.9 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.2 2.7 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.1 2.1 GO:0030544 Hsp70 protein binding(GO:0030544)
0.1 11.8 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 9.8 GO:0008146 sulfotransferase activity(GO:0008146)
0.1 4.5 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 1.8 GO:0035497 cAMP response element binding(GO:0035497)
0.1 1.0 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.1 33.1 GO:0015631 tubulin binding(GO:0015631)
0.1 4.5 GO:0017124 SH3 domain binding(GO:0017124)
0.1 3.3 GO:0031072 heat shock protein binding(GO:0031072)
0.1 1.9 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.1 4.7 GO:0051287 NAD binding(GO:0051287)
0.1 2.7 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 2.2 GO:0019003 GDP binding(GO:0019003)
0.0 0.6 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.4 GO:0030332 cyclin binding(GO:0030332)
0.0 4.7 GO:0004519 endonuclease activity(GO:0004519)
0.0 1.1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 1.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 3.5 GO:0019955 cytokine binding(GO:0019955)
0.0 18.4 GO:0003779 actin binding(GO:0003779)
0.0 0.2 GO:0034338 short-chain carboxylesterase activity(GO:0034338)
0.0 1.9 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.3 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 3.2 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 5.6 GO:0003924 GTPase activity(GO:0003924)
0.0 2.8 GO:0015293 symporter activity(GO:0015293)
0.0 0.6 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 1.2 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 4.0 GO:0016887 ATPase activity(GO:0016887)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.8 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 6.3 PID HNF3A PATHWAY FOXA1 transcription factor network
0.2 1.5 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.2 11.6 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 6.0 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 2.1 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.1 3.8 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 3.1 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.0 1.6 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 2.5 PID BCR 5PATHWAY BCR signaling pathway
0.0 1.2 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 2.1 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.0 0.3 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.8 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.8 PID RHOA REG PATHWAY Regulation of RhoA activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 14.4 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
2.5 24.9 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
2.5 9.9 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
2.5 9.8 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
1.9 5.8 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.9 25.3 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.6 11.6 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.6 13.3 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.4 3.2 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.3 1.6 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.2 3.8 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.2 1.5 REACTOME ARMS MEDIATED ACTIVATION Genes involved in ARMS-mediated activation
0.1 1.8 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.1 1.6 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 1.9 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 0.8 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.1 3.0 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 1.2 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.3 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.8 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.6 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides