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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for atf5a+atf5b

Z-value: 1.45

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Transcription factors associated with atf5a+atf5b

Gene Symbol Gene ID Gene Info
atf5a
ENSDARG00000068096 activating transcription factor 5a
atf5b
ENSDARG00000077785 activating transcription factor 5b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
atf5adr11_v1_chr5_-_30418636_304186360.731.1e-16Click!
atf5bdr11_v1_chr15_-_17868870_178688700.171.0e-01Click!

Activity profile of atf5a+atf5b motif

Sorted Z-values of atf5a+atf5b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_21832441 26.64 ENSDART00000151272
ENSDART00000151442
ENSDART00000150168
ENSDART00000148797
ENSDART00000128196
ENSDART00000149259
ENSDART00000052556
ENSDART00000149658
ENSDART00000149639
ENSDART00000148424
mbpa
myelin basic protein a
chr23_-_26521970 21.53 ENSDART00000143712
si:dkey-205h13.1
si:dkey-205h13.1
chr9_+_31282161 20.68 ENSDART00000010774
zic2a
zic family member 2 (odd-paired homolog, Drosophila), a
chr9_+_38962017 19.91 ENSDART00000140436
map2
microtubule-associated protein 2
chr21_+_13908858 18.40 ENSDART00000148199
stxbp1a
syntaxin binding protein 1a
chr16_-_9802998 18.26 ENSDART00000154217
tapbpl
TAP binding protein (tapasin)-like
chr18_+_22793465 17.52 ENSDART00000149685
gnao1a
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a
chr3_+_29714775 17.50 ENSDART00000041388
cacng2a
calcium channel, voltage-dependent, gamma subunit 2a
chr19_+_30662529 17.42 ENSDART00000175662
fam49al
family with sequence similarity 49, member A-like
chr16_-_24518027 17.16 ENSDART00000134120
ENSDART00000143761
cadm4
cell adhesion molecule 4
chr9_-_27648683 17.00 ENSDART00000017292
stxbp5l
syntaxin binding protein 5-like
chr21_-_22115136 16.70 ENSDART00000134715
ENSDART00000089246
ENSDART00000139789
elmod1
ELMO/CED-12 domain containing 1
chr5_-_64213253 16.41 ENSDART00000171711
gpsm1a
G protein signaling modulator 1a
chr24_+_34606966 16.21 ENSDART00000105477
lrrtm2
leucine rich repeat transmembrane neuronal 2
chr17_-_37214196 15.99 ENSDART00000128715
kif3cb
kinesin family member 3Cb
chr3_-_46818001 15.83 ENSDART00000166505
elavl3
ELAV like neuron-specific RNA binding protein 3
chr18_-_38087875 14.92 ENSDART00000111301
luzp2
leucine zipper protein 2
chr18_+_17786548 14.83 ENSDART00000189493
ENSDART00000146133
ZNF423
si:ch211-216l23.1
chr12_+_8373525 14.09 ENSDART00000152180
arid5b
AT-rich interaction domain 5B
chr7_-_28147838 14.09 ENSDART00000158921
lmo1
LIM domain only 1
chr14_+_14225048 13.72 ENSDART00000168749
nlgn3a
neuroligin 3a
chr18_-_38088099 13.52 ENSDART00000146120
luzp2
leucine zipper protein 2
chr3_-_46817838 13.30 ENSDART00000028610
elavl3
ELAV like neuron-specific RNA binding protein 3
chr1_-_5746030 13.27 ENSDART00000150863
nrp2a
neuropilin 2a
chr5_-_33215261 12.62 ENSDART00000097935
ENSDART00000134777
si:dkey-226m8.10
si:dkey-226m8.10
chr13_-_35051897 12.47 ENSDART00000129559
btbd3b
BTB (POZ) domain containing 3b
chr18_+_7283283 12.39 ENSDART00000141493
ANO2 (1 of many)
si:ch73-86n2.1
chr17_-_20711735 11.92 ENSDART00000150056
ank3b
ankyrin 3b
chr1_+_32521469 11.45 ENSDART00000113818
ENSDART00000152580
nlgn4a
neuroligin 4a
chr21_+_13353263 11.44 ENSDART00000114677
si:ch73-62l21.1
si:ch73-62l21.1
chr16_+_29303971 10.94 ENSDART00000087149
hapln2
hyaluronan and proteoglycan link protein 2
chr18_+_22793743 10.64 ENSDART00000150106
gnao1a
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a
chr13_-_23007813 9.70 ENSDART00000057638
hk1
hexokinase 1
chr7_+_36041509 9.69 ENSDART00000162850
irx3a
iroquois homeobox 3a
chr3_-_30123113 9.67 ENSDART00000153562
ppfia3
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr15_+_22267847 9.63 ENSDART00000110665
spa17
sperm autoantigenic protein 17
chr10_-_7386475 9.47 ENSDART00000167963
nrg1
neuregulin 1
chr7_+_25323742 9.34 ENSDART00000110347
cyp26b1
cytochrome P450, family 26, subfamily b, polypeptide 1
chr5_+_25952340 9.33 ENSDART00000147188
trpm3
transient receptor potential cation channel, subfamily M, member 3
chr16_+_10346277 8.83 ENSDART00000081092
si:dkeyp-77h1.4
si:dkeyp-77h1.4
chr13_-_21739142 8.80 ENSDART00000078460
si:dkey-191g9.5
si:dkey-191g9.5
chr18_-_29977431 8.78 ENSDART00000135357
si:ch211-220f16.2
si:ch211-220f16.2
chr3_-_26341959 8.74 ENSDART00000169344
ENSDART00000142878
ENSDART00000087196
zgc:153240
zgc:153240
chr17_-_37054959 8.66 ENSDART00000151921
dnmt3ab
DNA (cytosine-5-)-methyltransferase 3 alpha b
chr13_-_33007781 8.65 ENSDART00000183671
ENSDART00000179859
rbm25a
RNA binding motif protein 25a
chr9_-_35069645 8.48 ENSDART00000122679
ENSDART00000077908
ENSDART00000077894
ENSDART00000125536
appb
amyloid beta (A4) precursor protein b
chr17_+_42027969 8.26 ENSDART00000147563
kiz
kizuna centrosomal protein
chr13_+_28854438 8.20 ENSDART00000193407
ENSDART00000189554
CU639469.1

chr12_-_43435254 8.15 ENSDART00000182723
ptprea
protein tyrosine phosphatase, receptor type, E, a
chr7_+_26138240 8.14 ENSDART00000193750
ENSDART00000184942
nat16
N-acetyltransferase 16
chr14_-_44841503 8.09 ENSDART00000179114
GRXCR1
si:dkey-109l4.6
chr14_+_14224730 7.95 ENSDART00000180112
ENSDART00000184891
ENSDART00000174760
nlgn3a
neuroligin 3a
chr10_-_43718914 7.90 ENSDART00000189277
cetn3
centrin 3
chr4_-_64284924 7.87 ENSDART00000166733
CT956002.2

chr20_+_23676649 7.85 ENSDART00000035239
nek1
NIMA-related kinase 1
chr17_-_37052622 7.71 ENSDART00000186408
dnmt3ab
DNA (cytosine-5-)-methyltransferase 3 alpha b
chr18_+_28988373 7.65 ENSDART00000018685
syt9a
synaptotagmin IXa
chr1_+_16573982 7.64 ENSDART00000166317
mtus1b
microtubule associated tumor suppressor 1b
chr2_-_34555945 7.25 ENSDART00000056671
brinp2
bone morphogenetic protein/retinoic acid inducible neural-specific 2
chr24_+_25069609 7.25 ENSDART00000115165
amer2
APC membrane recruitment protein 2
chr1_+_41498697 7.19 ENSDART00000114230
dtx4
deltex 4, E3 ubiquitin ligase
chr24_-_1341543 7.18 ENSDART00000169341
nrp1a
neuropilin 1a
chr23_-_27607039 7.12 ENSDART00000183639
phf8
PHD finger protein 8
chr21_-_17482465 7.05 ENSDART00000004548
barhl1b
BarH-like homeobox 1b
chr16_+_39159752 6.90 ENSDART00000122081
sybu
syntabulin (syntaxin-interacting)
chr20_-_23026223 6.60 ENSDART00000015755
rasl11b
RAS-like, family 11, member B
chr5_+_58492699 6.51 ENSDART00000181584
FQ378016.1

chr21_-_26691959 6.50 ENSDART00000149702
ENSDART00000149840
bscl2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr15_+_36977208 6.42 ENSDART00000183625
kirrel3l
kirre like nephrin family adhesion molecule 3, like
chr5_+_42467867 6.36 ENSDART00000172028
pimr58
Pim proto-oncogene, serine/threonine kinase, related 58
chr5_-_28679135 6.24 ENSDART00000193585
tnc
tenascin C
chr6_-_52400896 6.22 ENSDART00000187624
mmp24
matrix metallopeptidase 24
chr20_-_26421112 6.17 ENSDART00000183767
ENSDART00000182330
akap12b
A kinase (PRKA) anchor protein 12b
chr17_-_20849879 6.15 ENSDART00000088100
ENSDART00000149630
ank3b
ankyrin 3b
chr3_-_16227490 6.11 ENSDART00000057159
ENSDART00000130611
ENSDART00000012835
cacnb1
calcium channel, voltage-dependent, beta 1 subunit
chr5_-_67911111 5.90 ENSDART00000051833
gsx1
GS homeobox 1
chr20_-_26420939 5.75 ENSDART00000110883
akap12b
A kinase (PRKA) anchor protein 12b
chr16_-_34338537 5.58 ENSDART00000142223
hivep3b
human immunodeficiency virus type I enhancer binding protein 3b
chr16_-_13004166 5.58 ENSDART00000133735
cacng7b
calcium channel, voltage-dependent, gamma subunit 7b
chr3_-_16227683 5.42 ENSDART00000111707
cacnb1
calcium channel, voltage-dependent, beta 1 subunit
chr8_-_37043900 5.35 ENSDART00000139567
renbp
renin binding protein
chr24_-_11309477 5.30 ENSDART00000137257
myrip
myosin VIIA and Rab interacting protein
chr11_+_16152316 5.08 ENSDART00000081054
tada3l
transcriptional adaptor 3 (NGG1 homolog, yeast)-like
chr11_-_44030962 5.00 ENSDART00000171910
FP016005.1

chr16_-_44649053 4.93 ENSDART00000184807
CR925804.2

chr10_-_43568239 4.91 ENSDART00000131731
ENSDART00000097433
ENSDART00000131309
mef2ca
myocyte enhancer factor 2ca
chr11_+_24046179 4.72 ENSDART00000006703
maf1
MAF1 homolog, negative regulator of RNA polymerase III
chr11_-_22916641 4.70 ENSDART00000080201
ENSDART00000154813
mdm4
MDM4, p53 regulator
chr8_-_40251126 4.46 ENSDART00000180435
kdm2ba
lysine (K)-specific demethylase 2Ba
chr9_+_25775816 4.42 ENSDART00000127834
ENSDART00000189994
zeb2a
zinc finger E-box binding homeobox 2a
chr12_+_27024676 4.40 ENSDART00000153104
msl1b
male-specific lethal 1 homolog b (Drosophila)
chr7_-_31321027 4.33 ENSDART00000186878
CR356242.1

chr5_-_48307804 4.22 ENSDART00000182831
ENSDART00000186920
ENSDART00000183585
mef2cb
myocyte enhancer factor 2cb
chr3_+_15358625 4.21 ENSDART00000143280
sh2b1
SH2B adaptor protein 1
chr24_+_9372292 4.18 ENSDART00000082422
ENSDART00000191127
ENSDART00000180510
si:ch211-285f17.1
si:ch211-285f17.1
chr14_-_2209742 4.11 ENSDART00000054889
pcdh2ab5
protocadherin 2 alpha b 5
chr8_+_22289320 3.87 ENSDART00000075126
b3gnt7l
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7, like
chr3_+_15358459 3.78 ENSDART00000141808
sh2b1
SH2B adaptor protein 1
chr16_+_10918252 3.77 ENSDART00000172949
pou2f2a
POU class 2 homeobox 2a
chr19_-_10214264 3.69 ENSDART00000053300
ENSDART00000148225
znf865
zinc finger protein 865
chr7_-_20758825 3.66 ENSDART00000156717
ENSDART00000182629
ENSDART00000179801
chd3
chromodomain helicase DNA binding protein 3
chr17_-_7028418 3.63 ENSDART00000188305
ENSDART00000187895
sash1b
SAM and SH3 domain containing 1b
chr1_+_41498188 3.62 ENSDART00000191934
ENSDART00000146310
dtx4
deltex 4, E3 ubiquitin ligase
chr4_-_8902406 3.62 ENSDART00000192962
mpped1
metallophosphoesterase domain containing 1
chr21_+_33249478 3.58 ENSDART00000169972
si:ch211-151g22.1
si:ch211-151g22.1
chr13_+_41819817 3.36 ENSDART00000185778
CABZ01066611.1

chr1_-_40123943 3.35 ENSDART00000146917
si:ch211-113e8.10
si:ch211-113e8.10
chr4_-_5691257 3.27 ENSDART00000110497
tmem63a
transmembrane protein 63A
chr5_+_45140914 3.24 ENSDART00000172702
smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr1_+_52130213 3.22 ENSDART00000018817
rnf11a
ring finger protein 11a
chr7_-_33881275 3.19 ENSDART00000100102
rxfp3.3a1
relaxin/insulin-like family peptide receptor 3.3a1
chr10_-_15672862 3.11 ENSDART00000109231
mamdc2b
MAM domain containing 2b
chr20_+_27240388 3.05 ENSDART00000123950
si:dkey-85n7.6
si:dkey-85n7.6
chr23_-_35069805 3.04 ENSDART00000087219
BX294434.1

chr21_-_38031038 3.04 ENSDART00000179483
ENSDART00000076238
rbm41
RNA binding motif protein 41
chr11_-_25324534 3.03 ENSDART00000158598
si:ch211-232b12.5
si:ch211-232b12.5
chr14_+_8127893 2.98 ENSDART00000169091
psd2
pleckstrin and Sec7 domain containing 2
chr3_+_45758760 2.86 ENSDART00000076007
gper1
G protein-coupled estrogen receptor 1
chr18_+_17786710 2.80 ENSDART00000190203
ENSDART00000187095
ENSDART00000083296
ZNF423
si:ch211-216l23.1
chr17_-_29902187 2.79 ENSDART00000009104
esrrb
estrogen-related receptor beta
chr25_-_16832705 2.79 ENSDART00000171336
ENSDART00000189396
dyrk4
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chr25_-_27729046 2.77 ENSDART00000131437
zgc:153935
zgc:153935
chr22_-_30935510 2.75 ENSDART00000133335
si:dkey-49n23.1
si:dkey-49n23.1
chr14_+_31496543 2.72 ENSDART00000170683
phf6
PHD finger protein 6
chr25_-_32751982 2.70 ENSDART00000012862
isl2a
ISL LIM homeobox 2a
chr11_-_37880492 2.68 ENSDART00000102868
etnk2
ethanolamine kinase 2
chr4_+_5180650 2.61 ENSDART00000067390
fgf6b
fibroblast growth factor 6b
chr18_-_23875370 2.60 ENSDART00000130163
nr2f2
nuclear receptor subfamily 2, group F, member 2
chr10_-_34889053 2.57 ENSDART00000136966
ccdc169
coiled-coil domain containing 169
chr11_+_26476153 2.48 ENSDART00000103507
unm_sa1614
un-named sa1614
chr20_+_27194833 2.48 ENSDART00000150072
si:dkey-85n7.8
si:dkey-85n7.8
chr14_-_10387377 2.45 ENSDART00000145118
commd5
COMM domain containing 5
chr7_+_60359347 2.33 ENSDART00000145201
ENSDART00000039827
ppp1r14bb
protein phosphatase 1, regulatory (inhibitor) subunit 14Bb
chr16_+_10422836 2.33 ENSDART00000161568
ino80e
INO80 complex subunit E
chr6_-_42971184 2.27 ENSDART00000014552
arl8ba
ADP-ribosylation factor-like 8Ba
chr25_+_20694177 2.23 ENSDART00000073648
kxd1
KxDL motif containing 1
chr13_+_30874153 2.20 ENSDART00000112380
ENSDART00000189016
ENSDART00000134809
ercc6
excision repair cross-complementation group 6
chr7_-_52153105 2.16 ENSDART00000174378
CT737190.1

chr19_-_3931917 2.09 ENSDART00000162532
map7d1b
MAP7 domain containing 1b
chr5_-_19052184 2.07 ENSDART00000133330
fam214b
family with sequence similarity 214, member B
chr10_-_44981295 2.01 ENSDART00000166528
purbb
purine-rich element binding protein Bb
chr17_-_21793113 2.01 ENSDART00000104612
hmx3a
H6 family homeobox 3a
chr16_-_24135508 2.00 ENSDART00000171819
ENSDART00000103176
bcam
basal cell adhesion molecule (Lutheran blood group)
chr4_+_15954293 1.95 ENSDART00000132695
si:dkey-117n7.4
si:dkey-117n7.4
chr3_-_50118140 1.93 ENSDART00000131913
hgs
hepatocyte growth factor-regulated tyrosine kinase substrate
chr23_-_25779995 1.90 ENSDART00000110670
si:dkey-21c19.3
si:dkey-21c19.3
chr5_-_24812715 1.88 ENSDART00000140042
ENSDART00000137128
ENSDART00000182415
ENSDART00000190898
ap1b1
adaptor-related protein complex 1, beta 1 subunit
chr18_-_50152689 1.85 ENSDART00000006078
loxl1
lysyl oxidase-like 1
chr3_-_26787430 1.85 ENSDART00000087047
rab40c
RAB40c, member RAS oncogene family
chr5_-_38107741 1.75 ENSDART00000156853
si:ch211-284e13.14
si:ch211-284e13.14
chr1_-_27014872 1.73 ENSDART00000147414
ENSDART00000134032
ENSDART00000192087
ENSDART00000189111
ENSDART00000187348
ENSDART00000187248
cntln
centlein, centrosomal protein
chr19_-_35596207 1.73 ENSDART00000136811
col8a2
collagen, type VIII, alpha 2
chr1_+_23784905 1.72 ENSDART00000171951
ENSDART00000188521
ENSDART00000183029
ENSDART00000187183
slit2
slit homolog 2 (Drosophila)
chr5_-_65921536 1.68 ENSDART00000108729
adamtsl2
ADAMTS-like 2
chr4_+_4079418 1.68 ENSDART00000028016
waslb
Wiskott-Aldrich syndrome-like b
chr23_-_27692717 1.68 ENSDART00000053878
ENSDART00000145028
IKZF4
si:dkey-166n8.9
chr4_+_9536860 1.67 ENSDART00000130083
lsm8
LSM8 homolog, U6 small nuclear RNA associated
chr6_+_36807861 1.67 ENSDART00000161708
si:ch73-29l19.1
si:ch73-29l19.1
chr13_+_23214100 1.65 ENSDART00000163393
sorbs1
sorbin and SH3 domain containing 1
chr24_+_25919809 1.63 ENSDART00000006615
map3k15
mitogen-activated protein kinase kinase kinase 15
chr8_+_18010568 1.55 ENSDART00000121984
ssbp3b
single stranded DNA binding protein 3b
chr17_+_38476300 1.54 ENSDART00000123298
stard9
StAR-related lipid transfer (START) domain containing 9
chr3_+_17456428 1.54 ENSDART00000090676
ENSDART00000182082
si:ch211-210g13.5
si:ch211-210g13.5
chr7_+_20019125 1.49 ENSDART00000186391
bcl6b
B-cell CLL/lymphoma 6, member B
chr18_+_22174630 1.47 ENSDART00000089549
ripor1
RHO family interacting cell polarization regulator 1
chr15_-_39963009 1.44 ENSDART00000157388
lypc
ly6 domain containing, pigment cell
chr5_-_40178092 1.37 ENSDART00000146664
wdfy3
WD repeat and FYVE domain containing 3
chr11_-_16152105 1.29 ENSDART00000081062
arpc4l
actin related protein 2/3 complex, subunit 4, like
chr18_+_34362608 1.26 ENSDART00000131478
kcnab1a
potassium voltage-gated channel, shaker-related subfamily, beta member 1 a
chr12_-_31995840 1.26 ENSDART00000112881
grin2cb
glutamate receptor, ionotropic, N-methyl D-aspartate 2Cb
chr24_+_10310577 1.23 ENSDART00000141718
otulina
OTU deubiquitinase with linear linkage specificity a
chr1_+_16574312 1.22 ENSDART00000187067
mtus1b
microtubule associated tumor suppressor 1b
chr9_+_30720048 1.12 ENSDART00000146115
klf12b
Kruppel-like factor 12b
chr24_-_17400143 1.10 ENSDART00000134947
cul1b
cullin 1b
chr17_+_25432449 1.08 ENSDART00000150195
srrm1
serine/arginine repetitive matrix 1
chr24_-_24796583 1.06 ENSDART00000144791
ENSDART00000146570
pde7a
phosphodiesterase 7A
chr3_-_37476278 1.02 ENSDART00000083442
si:ch211-278a6.1
si:ch211-278a6.1
chr6_+_37308716 0.89 ENSDART00000085498
ptger3
prostaglandin E receptor 3 (subtype EP3)
chr8_-_14067517 0.79 ENSDART00000140948
dedd
death effector domain containing
chr25_-_27541288 0.79 ENSDART00000187245
spam1
sperm adhesion molecule 1
chr4_-_16333944 0.76 ENSDART00000079523
epyc
epiphycan
chr12_+_35046704 0.73 ENSDART00000105523
ENSDART00000149946
timm23a
translocase of inner mitochondrial membrane 23 homolog a (yeast)
chr4_-_16334362 0.72 ENSDART00000101461
epyc
epiphycan
chr3_+_15776446 0.71 ENSDART00000146651
znf652
zinc finger protein 652
chr4_-_12104421 0.68 ENSDART00000139561
mrps33
mitochondrial ribosomal protein S33
chr16_-_29146624 0.66 ENSDART00000159814
ENSDART00000009826
mef2d
myocyte enhancer factor 2d
chr14_-_24110251 0.64 ENSDART00000079226
cpeb4a
cytoplasmic polyadenylation element binding protein 4a
chr12_+_18744610 0.61 ENSDART00000153456
mkl1b
megakaryoblastic leukemia (translocation) 1b
chr14_+_5385855 0.54 ENSDART00000031508
lbx2
ladybird homeobox 2
chr13_+_18520738 0.53 ENSDART00000113952
tlr4al
toll-like receptor 4a, like
chr1_+_54835131 0.51 ENSDART00000145070
si:ch211-196h16.4
si:ch211-196h16.4
chr14_-_44841335 0.48 ENSDART00000173011
GRXCR1
si:dkey-109l4.6
chr1_+_24557414 0.45 ENSDART00000076519
dctpp1
dCTP pyrophosphatase 1
chr8_-_7474997 0.44 ENSDART00000146555
gata1b
GATA binding protein 1b
chr10_-_39055620 0.40 ENSDART00000187437
igsf5a
immunoglobulin superfamily, member 5a
chr14_-_26425416 0.40 ENSDART00000088690
lman2
lectin, mannose-binding 2
chr22_+_36656680 0.34 ENSDART00000134031
ENSDART00000056169
b3gnt7
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7
chr3_-_26222381 0.33 ENSDART00000103746
mapk3
mitogen-activated protein kinase 3
chr9_-_41401564 0.32 ENSDART00000059628
nab1b
NGFI-A binding protein 1b (EGR1 binding protein 1)
chr14_-_24110062 0.30 ENSDART00000177062
cpeb4a
cytoplasmic polyadenylation element binding protein 4a

Network of associatons between targets according to the STRING database.

First level regulatory network of atf5a+atf5b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 11.9 GO:1904969 bleb assembly(GO:0032060) slow muscle cell migration(GO:1904969)
3.4 20.7 GO:0021846 cell proliferation in forebrain(GO:0021846)
3.2 9.5 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171) Schwann cell migration(GO:0036135) cardiac neuron differentiation(GO:0060945) cardiac neuron development(GO:0060959)
3.1 9.3 GO:0035992 tendon formation(GO:0035992)
2.9 17.2 GO:0003232 bulbus arteriosus development(GO:0003232)
2.4 7.1 GO:0061187 regulation of chromatin silencing at rDNA(GO:0061187) negative regulation of chromatin silencing at rDNA(GO:0061188)
2.1 6.2 GO:0008582 regulation of synaptic growth at neuromuscular junction(GO:0008582) axon regeneration at neuromuscular junction(GO:0014814) positive regulation of synaptic growth at neuromuscular junction(GO:0045887)
2.0 21.7 GO:0097104 presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105)
1.7 6.9 GO:0060074 synapse maturation(GO:0060074)
1.7 18.3 GO:0019883 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
1.6 4.9 GO:0036076 ligamentous ossification(GO:0036076)
1.6 9.3 GO:0050951 detection of temperature stimulus(GO:0016048) sensory perception of temperature stimulus(GO:0050951)
1.4 7.2 GO:0007508 larval development(GO:0002164) larval heart development(GO:0007508) angiogenesis involved in wound healing(GO:0060055)
1.4 14.1 GO:0060612 adipose tissue development(GO:0060612)
1.4 23.1 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
1.0 2.9 GO:0060845 lymphatic endothelial cell fate commitment(GO:0060838) venous endothelial cell differentiation(GO:0060843) venous endothelial cell fate commitment(GO:0060845)
1.0 2.9 GO:1903430 negative regulation of cell maturation(GO:1903430)
0.9 6.5 GO:0034389 lipid particle organization(GO:0034389)
0.9 5.4 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)
0.7 7.3 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.7 28.2 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.6 9.7 GO:0001678 cellular glucose homeostasis(GO:0001678)
0.6 4.4 GO:0090243 fibroblast growth factor receptor signaling pathway involved in somitogenesis(GO:0090243)
0.6 1.7 GO:0007414 axonal defasciculation(GO:0007414)
0.5 3.2 GO:0031507 heterochromatin assembly(GO:0031507)
0.5 16.4 GO:0006305 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.5 10.9 GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030947)
0.5 17.0 GO:0050708 regulation of protein secretion(GO:0050708)
0.4 11.5 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.4 4.4 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.4 4.7 GO:0071157 negative regulation of cell cycle arrest(GO:0071157)
0.4 18.4 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.4 7.3 GO:0007398 ectoderm development(GO:0007398)
0.3 1.3 GO:1902260 negative regulation of potassium ion transmembrane transporter activity(GO:1901017) negative regulation of potassium ion transmembrane transport(GO:1901380) negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817) negative regulation of cation channel activity(GO:2001258)
0.3 2.2 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.3 1.9 GO:1904375 regulation of protein localization to plasma membrane(GO:1903076) regulation of protein localization to cell periphery(GO:1904375)
0.3 1.7 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.3 6.4 GO:0039022 pronephric duct development(GO:0039022) nephric duct development(GO:0072176)
0.3 6.6 GO:0048382 mesendoderm development(GO:0048382)
0.3 2.7 GO:0048845 venous blood vessel morphogenesis(GO:0048845)
0.3 19.9 GO:0001578 microtubule bundle formation(GO:0001578)
0.3 5.1 GO:0043967 histone H4 acetylation(GO:0043967)
0.2 7.6 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.2 0.9 GO:0044058 regulation of digestive system process(GO:0044058)
0.2 13.5 GO:0048813 dendrite morphogenesis(GO:0048813)
0.2 11.8 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.2 1.2 GO:1990108 protein linear deubiquitination(GO:1990108)
0.2 6.2 GO:0030574 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.1 0.4 GO:0009211 pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211)
0.1 2.2 GO:0032418 lysosome localization(GO:0032418)
0.1 9.6 GO:0003341 cilium movement(GO:0003341)
0.1 4.5 GO:0006482 protein demethylation(GO:0006482) protein dealkylation(GO:0008214)
0.1 1.9 GO:0016926 protein desumoylation(GO:0016926)
0.1 1.7 GO:0051127 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.1 16.4 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.1 1.6 GO:0000186 activation of MAPKK activity(GO:0000186)
0.1 0.5 GO:1904105 positive regulation of convergent extension involved in gastrulation(GO:1904105)
0.1 25.6 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.1 1.3 GO:0060079 excitatory postsynaptic potential(GO:0060079)
0.1 9.7 GO:0099643 neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
0.1 17.3 GO:0007018 microtubule-based movement(GO:0007018)
0.1 8.7 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 35.1 GO:0050767 regulation of neurogenesis(GO:0050767)
0.1 8.3 GO:0007051 spindle organization(GO:0007051)
0.1 3.0 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 0.7 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.1 0.8 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.0 0.1 GO:0070314 G1 to G0 transition(GO:0070314)
0.0 2.5 GO:0055013 cardiac muscle cell development(GO:0055013)
0.0 2.8 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.0 0.8 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.0 0.7 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 1.1 GO:0038061 NIK/NF-kappaB signaling(GO:0038061)
0.0 7.4 GO:0030833 regulation of actin filament polymerization(GO:0030833)
0.0 2.5 GO:0006119 oxidative phosphorylation(GO:0006119)
0.0 2.3 GO:0006338 chromatin remodeling(GO:0006338)
0.0 3.2 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 6.9 GO:0007059 chromosome segregation(GO:0007059)
0.0 2.6 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.0 1.5 GO:0048017 phosphatidylinositol-mediated signaling(GO:0048015) inositol lipid-mediated signaling(GO:0048017)
0.0 0.5 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.0 0.3 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 4.2 GO:0048706 embryonic skeletal system development(GO:0048706)
0.0 4.7 GO:0000398 RNA splicing, via transesterification reactions(GO:0000375) RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 1.7 GO:0031018 endocrine pancreas development(GO:0031018)
0.0 6.4 GO:0046777 protein autophosphorylation(GO:0046777)
0.0 13.1 GO:0007417 central nervous system development(GO:0007417)
0.0 0.3 GO:0097324 melanocyte migration(GO:0097324)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 12.6 GO:0016586 RSC complex(GO:0016586)
1.5 26.6 GO:0043209 myelin sheath(GO:0043209)
0.6 7.6 GO:0031045 dense core granule(GO:0031045)
0.6 5.1 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.6 4.4 GO:0072487 MSL complex(GO:0072487)
0.5 23.1 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.4 2.9 GO:0032591 dendritic spine membrane(GO:0032591)
0.4 26.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 19.2 GO:0030141 secretory granule(GO:0030141)
0.2 17.5 GO:0005871 kinesin complex(GO:0005871)
0.2 17.0 GO:0031201 SNARE complex(GO:0031201)
0.2 6.9 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.2 2.2 GO:0031083 BLOC-1 complex(GO:0031083)
0.2 1.7 GO:0005688 U6 snRNP(GO:0005688)
0.1 2.3 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.1 3.0 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.1 9.7 GO:0048786 presynaptic active zone(GO:0048786)
0.1 9.6 GO:0031514 motile cilium(GO:0031514)
0.1 1.2 GO:0071797 LUBAC complex(GO:0071797)
0.1 2.5 GO:0045277 respiratory chain complex IV(GO:0045277)
0.1 8.5 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 1.3 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 3.2 GO:0016514 SWI/SNF complex(GO:0016514)
0.1 1.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 3.7 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 1.9 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 19.9 GO:0005874 microtubule(GO:0005874)
0.1 3.0 GO:0032587 ruffle membrane(GO:0032587)
0.1 9.0 GO:0005802 trans-Golgi network(GO:0005802)
0.1 25.7 GO:0005815 microtubule organizing center(GO:0005815)
0.1 7.3 GO:0043025 neuronal cell body(GO:0043025)
0.1 0.7 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0 6.5 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 2.3 GO:0005819 spindle(GO:0005819)
0.0 0.2 GO:0060171 stereocilium membrane(GO:0060171)
0.0 5.5 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 16.1 GO:0009986 cell surface(GO:0009986)
0.0 8.5 GO:0031012 extracellular matrix(GO:0031012)
0.0 1.1 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 3.2 GO:0005730 nucleolus(GO:0005730)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.6 28.2 GO:0031852 mu-type opioid receptor binding(GO:0031852) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
3.1 9.3 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
1.8 7.1 GO:0035575 histone demethylase activity (H4-K20 specific)(GO:0035575)
1.8 26.6 GO:0019911 structural constituent of myelin sheath(GO:0019911)
1.6 9.7 GO:0008865 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) glucose binding(GO:0005536) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
1.5 18.1 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
1.3 8.0 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
1.3 16.4 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
1.0 17.0 GO:0045159 myosin II binding(GO:0045159)
0.8 21.7 GO:0042043 neurexin family protein binding(GO:0042043)
0.8 21.5 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.8 9.5 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.8 3.0 GO:0030626 U12 snRNA binding(GO:0030626)
0.6 25.3 GO:0017075 syntaxin-1 binding(GO:0017075)
0.4 12.6 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.4 31.6 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.4 11.9 GO:0051018 protein kinase A binding(GO:0051018)
0.4 2.9 GO:0001972 retinoic acid binding(GO:0001972)
0.3 2.9 GO:0030284 estrogen receptor activity(GO:0030284)
0.3 2.0 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.3 2.3 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.2 9.8 GO:0042826 histone deacetylase binding(GO:0042826)
0.2 6.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 7.6 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 17.5 GO:0003777 microtubule motor activity(GO:0003777)
0.1 7.3 GO:0008013 beta-catenin binding(GO:0008013)
0.1 12.5 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.1 0.5 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.1 0.7 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.1 1.9 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.1 32.2 GO:0008017 microtubule binding(GO:0008017)
0.1 1.7 GO:0048495 Roundabout binding(GO:0048495)
0.1 14.1 GO:0003713 transcription coactivator activity(GO:0003713)
0.1 4.5 GO:0032452 histone demethylase activity(GO:0032452)
0.1 34.8 GO:0030695 GTPase regulator activity(GO:0030695)
0.1 2.6 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 0.9 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.1 2.5 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 5.4 GO:0008094 DNA-dependent ATPase activity(GO:0008094)
0.1 3.2 GO:0019957 C-C chemokine binding(GO:0019957)
0.1 2.1 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 2.8 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 0.4 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.1 1.6 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 1.3 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.1 9.6 GO:0005516 calmodulin binding(GO:0005516)
0.1 13.3 GO:0042802 identical protein binding(GO:0042802)
0.1 0.8 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.1 1.3 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.0 1.5 GO:0004629 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.0 8.4 GO:0030414 peptidase inhibitor activity(GO:0030414)
0.0 2.8 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 10.7 GO:0003682 chromatin binding(GO:0003682)
0.0 0.4 GO:0005537 mannose binding(GO:0005537)
0.0 4.6 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.3 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 1.8 GO:0003678 DNA helicase activity(GO:0003678)
0.0 1.6 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 7.4 GO:0003924 GTPase activity(GO:0003924)
0.0 8.8 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0 1.5 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 1.1 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 1.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 23.1 GO:0001159 core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0 2.3 GO:0005525 GTP binding(GO:0005525)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 9.5 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.7 7.9 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.4 6.2 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.4 12.4 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.3 14.2 PID LKB1 PATHWAY LKB1 signaling events
0.2 9.7 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.2 4.8 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 8.3 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 4.7 PID P53 REGULATION PATHWAY p53 pathway
0.1 1.7 PID GLYPICAN 1PATHWAY Glypican 1 network
0.1 1.9 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 7.3 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.6 PID INSULIN PATHWAY Insulin Pathway
0.0 5.8 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.7 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.8 PID P73PATHWAY p73 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 9.5 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.9 6.2 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.7 8.0 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.5 2.9 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.5 10.8 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.4 9.3 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.2 9.7 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.2 2.7 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.2 0.9 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.2 1.9 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.2 6.2 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 1.7 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 6.2 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 2.8 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.6 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 2.2 REACTOME RNA POL I TRANSCRIPTION INITIATION Genes involved in RNA Polymerase I Transcription Initiation
0.1 1.9 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.1 1.7 REACTOME EXTRACELLULAR MATRIX ORGANIZATION Genes involved in Extracellular matrix organization
0.1 0.3 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 1.1 REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.0 0.7 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 1.1 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events