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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for clocka+clockb+npas2
Z-value: 1.88
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Transcription factors associated with clocka+clockb+npas2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| clocka | dr11_v1_chr20_+_22067337_22067337 | -0.66 | 5.7e-13 | Click! |
| clockb | dr11_v1_chr1_+_19434198_19434198 | -0.49 | 4.9e-07 | Click! |
| npas2 | dr11_v1_chr5_+_22791686_22791686 | -0.37 | 2.6e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of clocka+clockb+npas2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 71.5 | GO:0042254 | ribosome biogenesis(GO:0042254) |
| 0.2 | 58.9 | GO:0006412 | translation(GO:0006412) peptide biosynthetic process(GO:0043043) |
| 5.8 | 34.9 | GO:0003272 | endocardial cushion formation(GO:0003272) |
| 0.4 | 33.1 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 0.9 | 31.3 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.4 | 23.4 | GO:0006414 | translational elongation(GO:0006414) |
| 0.7 | 22.8 | GO:0072310 | glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310) |
| 0.2 | 22.0 | GO:0019722 | calcium-mediated signaling(GO:0019722) |
| 0.1 | 19.4 | GO:0046777 | protein autophosphorylation(GO:0046777) |
| 2.7 | 18.9 | GO:0045901 | positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 96.7 | GO:0005730 | nucleolus(GO:0005730) |
| 1.0 | 64.1 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 2.2 | 34.9 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.0 | 33.1 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 29.3 | GO:0015629 | actin cytoskeleton(GO:0015629) |
| 0.0 | 28.6 | GO:0005739 | mitochondrion(GO:0005739) |
| 1.8 | 22.1 | GO:0000808 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.3 | 20.4 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.1 | 17.6 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.0 | 16.3 | GO:0005576 | extracellular region(GO:0005576) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 48.4 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.9 | 42.3 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.4 | 28.7 | GO:0003724 | RNA helicase activity(GO:0003724) |
| 0.6 | 28.2 | GO:0019843 | rRNA binding(GO:0019843) |
| 0.2 | 27.6 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.2 | 27.5 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.5 | 22.3 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 0.0 | 20.0 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 2.3 | 16.3 | GO:0016426 | tRNA (adenine) methyltransferase activity(GO:0016426) |
| 0.0 | 16.1 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 11.8 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 11.2 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 10.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 9.5 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.2 | 8.1 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.4 | 8.0 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.2 | 7.8 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.2 | 7.4 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.2 | 6.8 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.4 | 6.7 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 71.7 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 1.7 | 23.3 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 1.4 | 22.1 | REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 0.7 | 21.6 | REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.3 | 11.8 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 0.2 | 11.8 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.4 | 11.4 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.5 | 11.3 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.6 | 10.6 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.6 | 9.1 | REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |