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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for creb1a+creb1b+crema+cremb

Z-value: 2.37

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Transcription factors associated with creb1a+creb1b+crema+cremb

Gene Symbol Gene ID Gene Info
crema
ENSDARG00000023217 cAMP responsive element modulator a
creb1a
ENSDARG00000053586 cAMP responsive element binding protein 1a
creb1b
ENSDARG00000093420 cAMP responsive element binding protein 1b
cremb
ENSDARG00000102899 cAMP responsive element modulator b
cremb
ENSDARG00000109505 cAMP responsive element modulator b
cremb
ENSDARG00000116064 cAMP responsive element modulator b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
cremadr11_v1_chr2_-_43191465_43191465-0.557.6e-09Click!
crembdr11_v1_chr24_+_31361407_31361407-0.511.9e-07Click!
creb1adr11_v1_chr1_-_33556428_33556428-0.463.8e-06Click!
creb1bdr11_v1_chr9_-_28275600_28275600-0.441.1e-05Click!

Activity profile of creb1a+creb1b+crema+cremb motif

Sorted Z-values of creb1a+creb1b+crema+cremb motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_44926946 8.64 ENSDART00000098567
zgc:154046
zgc:154046
chr8_+_47897734 7.98 ENSDART00000140266
mfn2
mitofusin 2
chr25_-_14398281 7.95 ENSDART00000046934
coq9
coenzyme Q9 homolog (S. cerevisiae)
chr4_-_4834617 7.56 ENSDART00000141539
coa6
cytochrome c oxidase assembly factor 6
chr4_-_4834347 6.85 ENSDART00000141803
coa6
cytochrome c oxidase assembly factor 6
chr4_-_4932619 6.66 ENSDART00000103293
ndufa5
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
chr6_-_54126463 5.94 ENSDART00000161059
tusc2a
tumor suppressor candidate 2a
chr21_-_4250682 5.67 ENSDART00000099389
dnlz
DNL-type zinc finger
chr12_-_25201576 5.38 ENSDART00000077188
cox7a3
cytochrome c oxidase subunit VIIa polypeptide 3
chr7_-_73843720 5.30 ENSDART00000111622
caap1
caspase activity and apoptosis inhibitor 1
chr18_+_808911 5.27 ENSDART00000172518
cox5ab
cytochrome c oxidase subunit Vab
chr4_+_41789497 5.13 ENSDART00000126634
si:dkey-237m9.2
si:dkey-237m9.2
chr4_-_42074960 4.97 ENSDART00000164406
zgc:174696
zgc:174696
chr3_-_8873716 4.90 ENSDART00000171798
znf1150
zinc finger protein 1150
chr4_+_30454496 4.70 ENSDART00000164555
si:dkey-199m13.4
si:dkey-199m13.4
chr5_+_1965296 4.64 ENSDART00000156224
dhx33
DEAH (Asp-Glu-Ala-His) box polypeptide 33
chr4_-_43056627 4.64 ENSDART00000150269
si:dkey-54j5.2
si:dkey-54j5.2
chr25_-_26893006 4.61 ENSDART00000006709
dldh
dihydrolipoamide dehydrogenase
chr11_-_11331052 4.55 ENSDART00000081765
ENSDART00000160247
mrpl4
mitochondrial ribosomal protein L4
chr6_-_49898881 4.52 ENSDART00000150204
atp5f1e
ATP synthase F1 subunit epsilon
chr4_-_69615167 4.43 ENSDART00000171108
si:ch211-120c15.3
si:ch211-120c15.3
chr4_-_30528239 4.43 ENSDART00000169290
znf1052
zinc finger protein 1052
chr4_-_43640507 4.42 ENSDART00000150700
si:dkey-29p23.2
si:dkey-29p23.2
chr4_-_69127091 4.38 ENSDART00000136092
si:ch211-209j12.3
si:ch211-209j12.3
chr4_+_63818718 4.28 ENSDART00000161177
si:dkey-30f3.2
si:dkey-30f3.2
chr4_-_50544015 4.22 ENSDART00000155155
zgc:174704
zgc:174704
chr22_-_17606575 4.21 ENSDART00000183951
gpx4a
glutathione peroxidase 4a
chr4_-_64336954 4.18 ENSDART00000157986
znf1147
zinc finger protein 1147
chr4_-_33405483 4.18 ENSDART00000150625
CT027578.1

chr10_+_28306749 4.16 ENSDART00000142016
ptrh2
peptidyl-tRNA hydrolase 2
chr17_+_12058509 4.14 ENSDART00000150209
tfb2m
transcription factor B2, mitochondrial
chr4_-_61691066 4.14 ENSDART00000159114
znf1129
zinc finger protein 1129
chr4_+_73651452 4.05 ENSDART00000174164
znf989
zinc finger protein 989
chr4_+_56974964 4.04 ENSDART00000158300
znf999
zinc finger protein 999
chr4_-_73561848 4.02 ENSDART00000174210
CU570689.2

chr4_-_64078341 3.87 ENSDART00000162823
znf1106
zinc finger protein 1106
chr20_+_47196506 3.82 ENSDART00000153040
znf975
zinc finger protein 975
chr5_-_3118346 3.82 ENSDART00000167554
hsf5
heat shock transcription factor family member 5
chr4_+_33525559 3.82 ENSDART00000140480
CT027801.1

chr4_-_62466752 3.80 ENSDART00000171569
si:dkey-165b20.3
si:dkey-165b20.3
chr4_-_65037243 3.78 ENSDART00000170059
si:ch211-283l16.1
si:ch211-283l16.1
chr7_-_69429561 3.78 ENSDART00000127351
atxn1l
ataxin 1-like
chr4_-_54969773 3.74 ENSDART00000133535
si:dkey-56m15.6
si:dkey-56m15.6
chr4_-_59159690 3.72 ENSDART00000164706
znf1149
zinc finger protein 1149
chr4_-_30712588 3.72 ENSDART00000142393
si:dkey-16p19.5
si:dkey-16p19.5
chr4_+_34657691 3.71 ENSDART00000158655
AL645691.1

chr3_-_40284744 3.70 ENSDART00000018626
pdap1b
pdgfa associated protein 1b
chr7_+_52949847 3.68 ENSDART00000174216
ENSDART00000174055
ENSDART00000052030
ENSDART00000174240
cdkn2aip
CDKN2A interacting protein
chr4_+_63818212 3.63 ENSDART00000164929
si:dkey-30f3.2
si:dkey-30f3.2
chr18_+_49411417 3.61 ENSDART00000028944
LRFN3
zmp:0000001073
chr15_+_846768 3.56 ENSDART00000155633
ENSDART00000191235
si:dkey-7i4.5
si:dkey-77f5.8
si:dkey-7i4.5
si:dkey-77f5.8
chr4_+_33373100 3.56 ENSDART00000150417
znf1090
zinc finger protein 1090
chr15_+_847077 3.56 ENSDART00000188586
si:dkey-7i4.5
si:dkey-7i4.5
chr4_-_40364889 3.55 ENSDART00000151957
si:dkey-22h13.2
si:dkey-22h13.2
chr2_-_6051836 3.54 ENSDART00000092479
si:ch211-284b7.3
si:ch211-284b7.3
chr3_+_25990052 3.52 ENSDART00000007398
gcat
glycine C-acetyltransferase
chr4_+_52234600 3.45 ENSDART00000191413
si:dkey-16b10.2
si:dkey-16b10.2
chr4_-_73562122 3.45 ENSDART00000174096
CU570689.2

chr4_+_55273988 3.44 ENSDART00000163388
si:dkey-157e10.8
si:dkey-157e10.8
chr4_-_61920018 3.44 ENSDART00000164832
znf1056
zinc finger protein 1056
chr14_+_7377552 3.43 ENSDART00000142158
ENSDART00000141471
hars
histidyl-tRNA synthetase
chr10_-_9346360 3.42 ENSDART00000039536
mrrf
mitochondrial ribosome recycling factor
chr4_-_50158550 3.41 ENSDART00000121664
CR356227.1

chr5_+_67971627 3.41 ENSDART00000144879
mtif3
mitochondrial translational initiation factor 3
chr3_+_4502066 3.40 ENSDART00000088610
rangap1a
RAN GTPase activating protein 1a
chr6_-_10988741 3.40 ENSDART00000090709
coq7
coenzyme Q7 homolog, ubiquinone (yeast)
chr4_+_62262253 3.39 ENSDART00000166022
si:dkeyp-35e5.10
si:dkeyp-35e5.10
chr4_+_68456852 3.39 ENSDART00000165623
znf1146
zinc finger protein 1146
chr12_-_5188413 3.38 ENSDART00000161988
fra10ac1
FRA10A associated CGG repeat 1
chr4_-_32888436 3.38 ENSDART00000176728
BX324003.2

chr4_+_69375564 3.38 ENSDART00000150334
si:dkey-246j6.1
si:dkey-246j6.1
chr4_-_65036768 3.35 ENSDART00000184455
si:ch211-283l16.1
si:ch211-283l16.1
chr4_-_41825115 3.34 ENSDART00000160196
si:dkey-237m9.1
si:dkey-237m9.1
chr3_-_60027255 3.32 ENSDART00000189252
ENSDART00000154684
recql5
RecQ helicase-like 5
chr4_+_61715860 3.31 ENSDART00000170474
znf1082
zinc finger protein 1082
chr4_+_72578191 3.29 ENSDART00000182434
si:cabz01054394.5
si:cabz01054394.5
chr4_+_54798291 3.27 ENSDART00000165113
ENSDART00000109624
si:dkeyp-82b4.6
si:dkeyp-82b4.6
chr4_-_35900331 3.25 ENSDART00000164413
zgc:174653
zgc:174653
chr4_-_38259998 3.25 ENSDART00000172389
znf1093
zinc finger protein 1093
chr8_+_46939391 3.25 ENSDART00000146631
espn
espin
chr4_+_76336061 3.24 ENSDART00000174362
zgc:171673
zgc:171673
chr4_-_57530817 3.22 ENSDART00000158435
zgc:173702
zgc:173702
chr1_-_53714885 3.22 ENSDART00000026409
cct4
chaperonin containing TCP1, subunit 4 (delta)
chr4_-_73548389 3.20 ENSDART00000174327
ENSDART00000150753
ENSDART00000170775
si:ch73-266f23.1
si:ch73-266f23.1
chr4_-_49720964 3.19 ENSDART00000156103
znf1057
zinc finger protein 1057
chr13_-_31370184 3.19 ENSDART00000034829
rrp12
ribosomal RNA processing 12 homolog
chr4_+_69863019 3.18 ENSDART00000168400
znf1117
zinc finger protein 1117
chr10_+_1681518 3.18 ENSDART00000018532
triap1
TP53 regulated inhibitor of apoptosis 1
chr4_+_64147241 3.17 ENSDART00000163509
znf1089
zinc finger protein 1089
chr4_-_64142389 3.17 ENSDART00000172126
BX914205.3

chr4_-_30422325 3.14 ENSDART00000158444
znf1114
zinc finger protein 1114
chr4_+_71735828 3.11 ENSDART00000174867
znf1116
zinc finger protein 1116
chr4_-_43071336 3.11 ENSDART00000150773
znf1072
zinc finger protein 1072
chr4_+_53183373 3.09 ENSDART00000176617
znf1037
zinc finger protein 1037
chr4_-_40364432 3.08 ENSDART00000133544
si:dkey-22h13.2
si:dkey-22h13.2
chr4_+_45504471 3.07 ENSDART00000150399
si:dkey-256i11.2
si:dkey-256i11.2
chr4_+_44577872 3.05 ENSDART00000157214
si:dkey-7j22.2
si:dkey-7j22.2
chr4_-_61651223 3.05 ENSDART00000172688
si:dkey-26i24.1
si:dkey-26i24.1
chr4_-_40536509 3.05 ENSDART00000150835
si:dkey-57c22.1
si:dkey-57c22.1
chr4_-_61650771 3.05 ENSDART00000168593
si:dkey-26i24.1
si:dkey-26i24.1
chr5_+_1089600 3.05 ENSDART00000183128
LO017799.1

chr18_-_6151793 3.03 ENSDART00000122307
gcsha
glycine cleavage system protein H (aminomethyl carrier), a
chr4_+_61865790 3.02 ENSDART00000166793
si:dkey-146c18.5
si:dkey-146c18.5
chr4_-_33331681 3.00 ENSDART00000150319
znf1000
zinc finger protein 1000
chr4_-_63769147 3.00 ENSDART00000189919
znf1098
zinc finger protein 1098
chr4_+_72578548 2.98 ENSDART00000174035
si:cabz01054394.5
si:cabz01054394.5
chr4_+_64577406 2.98 ENSDART00000159754
si:ch211-223a21.4
si:ch211-223a21.4
chr4_+_49506359 2.98 ENSDART00000154478
si:dkey-5i16.5
si:dkey-5i16.5
chr4_+_65139267 2.98 ENSDART00000161450
si:dkey-14o6.4
si:dkey-14o6.4
chr4_+_47385355 2.97 ENSDART00000163413
znf1122
zinc finger protein 1122
chr4_-_49952636 2.97 ENSDART00000157941
si:dkey-156k2.3
si:dkey-156k2.3
chr4_-_49133107 2.96 ENSDART00000150806
znf1146
zinc finger protein 1146
chr4_-_63769637 2.96 ENSDART00000158757
znf1098
zinc finger protein 1098
chr4_+_55593296 2.95 ENSDART00000159365
znf1078
zinc finger protein 1078
chr15_+_25635326 2.93 ENSDART00000135409
ENSDART00000162240
ENSDART00000052645
tsr1
TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
chr4_+_43678985 2.93 ENSDART00000150395
zgc:173705
zgc:173705
chr6_+_15127507 2.93 ENSDART00000063644
dph3
diphthamide biosynthesis 3
chr4_-_72643171 2.92 ENSDART00000130126
CABZ01054394.1

chr20_+_47143900 2.91 ENSDART00000153360
si:dkeyp-104f11.6
si:dkeyp-104f11.6
chr4_+_49073583 2.90 ENSDART00000170022
zgc:173705
zgc:173705
chr4_-_50788075 2.90 ENSDART00000150302
znf1045
zinc finger protein 1045
chr4_-_45301719 2.90 ENSDART00000150282
si:ch211-162i8.2
si:ch211-162i8.2
chr4_+_69190524 2.88 ENSDART00000168009
znf1075
zinc finger protein 1075
chr4_-_39942347 2.88 ENSDART00000124410
znf979
zinc finger protein 979
chr23_-_46034609 2.88 ENSDART00000158712
zgc:65873
zgc:65873
chr4_+_40063572 2.86 ENSDART00000146710
BX649521.1

chr4_-_45433060 2.85 ENSDART00000150524
si:ch211-162i8.4
si:ch211-162i8.4
chr4_+_69409331 2.85 ENSDART00000159440
si:dkey-246j6.3
si:dkey-246j6.3
chr4_-_69917450 2.85 ENSDART00000168915
znf1076
zinc finger protein 1076
chr4_-_55040507 2.85 ENSDART00000161731
si:dkey-56m15.3
si:dkey-56m15.3
chr4_+_41082985 2.84 ENSDART00000164388
si:dkey-16p19.1
si:dkey-16p19.1
chr4_+_59748607 2.83 ENSDART00000108499
znf1068
zinc finger protein 1068
chr4_+_63992019 2.83 ENSDART00000158645
CR790365.2

chr4_-_61419027 2.83 ENSDART00000181567
ENSDART00000187397
ENSDART00000180671
ENSDART00000164053
ENSDART00000187395
znf1021
zinc finger protein 1021
chr4_+_54899568 2.82 ENSDART00000162786
si:dkey-56m15.8
si:dkey-56m15.8
chr4_+_50970601 2.81 ENSDART00000150374
si:dkey-156j15.1
si:dkey-156j15.1
chr19_-_27339670 2.81 ENSDART00000139323
znrd1
zinc ribbon domain containing 1
chr4_-_40536045 2.80 ENSDART00000144513
si:dkey-57c22.1
si:dkey-57c22.1
chr4_-_57416684 2.80 ENSDART00000169434
si:dkey-122c11.7
si:dkey-122c11.7
chr4_+_36906436 2.79 ENSDART00000136773
BX537137.1

chr4_-_70488123 2.79 ENSDART00000169266
si:dkeyp-44b5.5
si:dkeyp-44b5.5
chr15_-_1765098 2.78 ENSDART00000149980
ENSDART00000093074
bud23
BUD23, rRNA methyltransferase and ribosome maturation factor
chr4_-_42171503 2.77 ENSDART00000163798
znf1148
zinc finger protein 1148
chr4_+_52959625 2.75 ENSDART00000158240
si:dkey-201g16.1
si:dkey-201g16.1
chr4_+_41082518 2.75 ENSDART00000151846
si:dkey-16p19.1
si:dkey-16p19.1
chr4_+_69510337 2.74 ENSDART00000165995
znf1025
zinc finger protein 1025
chr4_-_60231222 2.74 ENSDART00000169157
znf1080
zinc finger protein 1080
chr4_-_59057046 2.73 ENSDART00000150249
znf1132
zinc finger protein 1132
chr4_+_64577910 2.73 ENSDART00000128164
si:ch211-223a21.4
si:ch211-223a21.4
chr4_+_49664256 2.73 ENSDART00000155251
znf974
zinc finger protein 974
chr4_+_35876704 2.72 ENSDART00000159084
si:dkey-176f19.7
si:dkey-176f19.7
chr4_+_32566617 2.72 ENSDART00000166485
znf1108
zinc finger protein 1108
chr2_-_33645411 2.72 ENSDART00000114663
b4galt2
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
chr10_-_7913591 2.71 ENSDART00000139661
slc35e4
solute carrier family 35, member E4
chr2_+_935952 2.71 ENSDART00000137477
si:ch211-241e1.5
si:ch211-241e1.5
chr4_-_43280244 2.70 ENSDART00000150762
si:dkeyp-53e4.1
si:dkeyp-53e4.1
chr15_-_31588162 2.70 ENSDART00000153598
hsph1
heat shock 105/110 protein 1
chr4_-_33189070 2.70 ENSDART00000150444
CR759833.1

chr21_+_24536233 2.70 ENSDART00000145448
ENSDART00000109886
ENSDART00000135191
anapc13
anaphase promoting complex subunit 13
chr4_+_41385580 2.69 ENSDART00000152038
znf987
zinc finger protein 987
chr4_+_33462238 2.69 ENSDART00000111083
si:dkey-247i3.1
si:dkey-247i3.1
chr4_-_60356042 2.69 ENSDART00000125171
znf1121
zinc finger protein 1121
chr4_+_35900918 2.68 ENSDART00000162245
znf1088
zinc finger protein 1088
chr4_-_67143082 2.65 ENSDART00000162586
CT573263.1

chr18_+_8917766 2.65 ENSDART00000145226
si:ch211-233h19.2
si:ch211-233h19.2
chr12_-_1406480 2.64 ENSDART00000152308
MED9
si:ch73-105m5.1
chr5_+_26199537 2.63 ENSDART00000144303
zgc:86811
zgc:86811
chr5_+_72194444 2.63 ENSDART00000165436
ddx54
DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
chr14_+_52356897 2.63 ENSDART00000158277
cox18
COX18 cytochrome c oxidase assembly factor
chr4_-_32180155 2.62 ENSDART00000164151
si:dkey-72l17.6
si:dkey-72l17.6
chr22_+_3184500 2.62 ENSDART00000176409
ENSDART00000160604
ftsj3
FtsJ RNA methyltransferase homolog 3
chr4_+_43679421 2.60 ENSDART00000132945
zgc:173705
zgc:173705
chr4_-_30712160 2.60 ENSDART00000141715
si:dkey-16p19.5
si:dkey-16p19.5
chr4_-_44673017 2.59 ENSDART00000156670
si:dkey-7j22.4
si:dkey-7j22.4
chr4_+_64755464 2.57 ENSDART00000129549
znf1018
zinc finger protein 1018
chr4_+_29344957 2.57 ENSDART00000185164
CR847895.1

chr4_+_31450683 2.56 ENSDART00000169303
znf996
zinc finger protein 996
chr4_-_64918854 2.55 ENSDART00000132409
si:ch211-234c11.2
si:ch211-234c11.2
chr4_+_65271779 2.54 ENSDART00000134257
znf1027
zinc finger protein 1027
chr4_+_60001731 2.53 ENSDART00000150615
znf1109
zinc finger protein 1109
chr23_-_43424510 2.52 ENSDART00000055564
rprd1b
regulation of nuclear pre-mRNA domain containing 1B
chr4_-_32179699 2.51 ENSDART00000124106
ENSDART00000158835
si:dkey-72l17.6
si:dkey-72l17.6
chr4_-_30349370 2.50 ENSDART00000161790
znf1047
zinc finger protein 1047
chr4_+_60381608 2.49 ENSDART00000167351
znf1130
zinc finger protein 1130
chr4_-_57994891 2.49 ENSDART00000168657
znf1097
zinc finger protein 1097
chr4_-_45301250 2.48 ENSDART00000181753
si:ch211-162i8.2
si:ch211-162i8.2
chr10_-_26744131 2.48 ENSDART00000020096
ENSDART00000162710
ENSDART00000179853
fgf13b
fibroblast growth factor 13b
chr2_-_45135591 2.46 ENSDART00000014691
ENSDART00000123916
eif4e2
eukaryotic translation initiation factor 4E family member 2
chr15_-_739229 2.46 ENSDART00000153874
si:dkey-7i4.19
si:dkey-7i4.19
chr4_+_29848173 2.45 ENSDART00000150354
znf1121
zinc finger protein 1121
chr4_-_43279775 2.44 ENSDART00000183160
si:dkeyp-53e4.1
si:dkeyp-53e4.1
chr4_+_49016956 2.44 ENSDART00000150289
si:ch211-234c11.2
si:ch211-234c11.2
chr4_+_35993527 2.44 ENSDART00000158190
znf1023
zinc finger protein 1023
chr4_+_59320243 2.42 ENSDART00000150611
znf1084
zinc finger protein 1084
chr4_-_63980140 2.40 ENSDART00000160818
znf1091
zinc finger protein 1091
chr4_-_55178568 2.40 ENSDART00000165288
znf1039
zinc finger protein 1039
chr25_+_17920668 2.38 ENSDART00000093358
borcs5
BLOC-1 related complex subunit 5
chr4_-_52621232 2.37 ENSDART00000124451
si:dkeyp-104f11.6
si:dkeyp-104f11.6
chr4_-_45115963 2.36 ENSDART00000137248
si:dkey-51d8.6
si:dkey-51d8.6
chr4_-_44872722 2.36 ENSDART00000150621
BX649307.1

Network of associatons between targets according to the STRING database.

First level regulatory network of creb1a+creb1b+crema+cremb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 8.6 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
1.2 5.9 GO:0051881 regulation of mitochondrial membrane potential(GO:0051881)
1.1 8.0 GO:0048660 regulation of smooth muscle cell proliferation(GO:0048660) negative regulation of smooth muscle cell proliferation(GO:0048662)
1.0 4.1 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.9 3.7 GO:2000382 positive regulation of mesoderm development(GO:2000382)
0.9 3.4 GO:0032790 ribosome disassembly(GO:0032790)
0.9 17.0 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.8 3.4 GO:0010259 multicellular organism aging(GO:0010259)
0.8 3.0 GO:0019464 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.8 2.3 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.7 2.2 GO:0045579 positive regulation of B cell differentiation(GO:0045579)
0.7 2.8 GO:0036265 RNA (guanine-N7)-methylation(GO:0036265)
0.7 4.6 GO:0045943 positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.6 1.7 GO:0033212 iron assimilation(GO:0033212)
0.5 4.0 GO:0099514 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.5 2.9 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.5 3.3 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.4 3.5 GO:0006566 threonine metabolic process(GO:0006566) threonine catabolic process(GO:0006567)
0.4 8.0 GO:1901663 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.4 5.3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.4 1.9 GO:0090646 mitochondrial tRNA processing(GO:0090646)
0.4 5.3 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.3 1.3 GO:0061668 mitochondrial ribosome assembly(GO:0061668)
0.3 5.7 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.3 2.2 GO:0030262 apoptotic DNA fragmentation(GO:0006309) cellular component disassembly involved in execution phase of apoptosis(GO:0006921) apoptotic nuclear changes(GO:0030262)
0.3 2.4 GO:1902038 positive regulation of hematopoietic stem cell differentiation(GO:1902038)
0.2 2.7 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.2 2.6 GO:0031167 rRNA methylation(GO:0031167)
0.2 4.5 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.2 2.5 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.2 4.6 GO:0045454 cell redox homeostasis(GO:0045454)
0.2 0.5 GO:0071586 CAAX-box protein processing(GO:0071586) CAAX-box protein maturation(GO:0080120)
0.2 0.8 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.2 0.6 GO:0035522 monoubiquitinated protein deubiquitination(GO:0035520) monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.1 3.4 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.1 1.8 GO:0000478 endonucleolytic cleavage involved in rRNA processing(GO:0000478) endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000479)
0.1 0.4 GO:0072526 pyridine nucleotide catabolic process(GO:0019364) NAD catabolic process(GO:0019677) pyridine-containing compound catabolic process(GO:0072526)
0.1 485.2 GO:0006355 regulation of transcription, DNA-templated(GO:0006355)
0.1 6.7 GO:0022904 respiratory electron transport chain(GO:0022904)
0.1 0.4 GO:0006404 RNA import into nucleus(GO:0006404) snRNA import into nucleus(GO:0061015)
0.1 0.5 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.1 0.5 GO:0001765 membrane raft assembly(GO:0001765) plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836)
0.0 2.5 GO:0031124 mRNA 3'-end processing(GO:0031124)
0.0 1.9 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 3.2 GO:0001666 response to hypoxia(GO:0001666)
0.0 1.1 GO:0042255 ribosome assembly(GO:0042255)
0.0 4.2 GO:0006979 response to oxidative stress(GO:0006979)
0.0 4.2 GO:0010942 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
0.0 3.2 GO:0051017 actin filament bundle assembly(GO:0051017)
0.0 2.1 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
0.0 0.2 GO:0006572 tyrosine catabolic process(GO:0006572)
0.0 12.7 GO:0006412 translation(GO:0006412)
0.0 0.5 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 0.1 GO:0048922 posterior lateral line neuromast deposition(GO:0048922)
0.0 0.1 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.0 0.2 GO:0015693 magnesium ion transport(GO:0015693)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.5 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
1.0 3.0 GO:0005960 glycine cleavage complex(GO:0005960)
1.0 4.0 GO:0098574 cytoplasmic side of lysosomal membrane(GO:0098574)
0.5 5.5 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.5 8.0 GO:0031306 intrinsic component of mitochondrial outer membrane(GO:0031306)
0.5 4.6 GO:0001669 acrosomal vesicle(GO:0001669)
0.4 3.4 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.4 5.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.3 3.2 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.3 2.4 GO:0032021 NELF complex(GO:0032021)
0.2 0.9 GO:0070209 ASTRA complex(GO:0070209)
0.2 0.5 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.2 6.9 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.2 6.7 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 2.6 GO:0015030 Cajal body(GO:0015030)
0.1 2.5 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 1.1 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 0.6 GO:0035517 PR-DUB complex(GO:0035517)
0.1 9.0 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 2.3 GO:0044447 axoneme part(GO:0044447)
0.1 68.1 GO:0005739 mitochondrion(GO:0005739)
0.0 2.5 GO:0030426 growth cone(GO:0030426)
0.0 1.7 GO:0031901 early endosome membrane(GO:0031901)
0.0 199.1 GO:0005634 nucleus(GO:0005634)
0.0 1.6 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.9 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.5 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 1.0 GO:0005694 chromosome(GO:0005694)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 8.6 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092)
1.4 4.1 GO:0034246 core DNA-dependent RNA polymerase binding promoter specificity activity(GO:0000996) mitochondrial RNA polymerase binding promoter specificity activity(GO:0034246)
0.9 3.5 GO:0016453 C-acetyltransferase activity(GO:0016453)
0.9 2.6 GO:0016436 rRNA (uridine) methyltransferase activity(GO:0016436)
0.8 4.2 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.6 4.2 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.6 3.5 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.6 1.7 GO:0015086 cadmium ion transmembrane transporter activity(GO:0015086)
0.5 1.6 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.5 1.8 GO:0034511 U3 snoRNA binding(GO:0034511)
0.4 4.5 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.4 1.5 GO:0052905 tRNA (guanine(9)-N(1))-methyltransferase activity(GO:0052905)
0.4 3.3 GO:0009378 four-way junction helicase activity(GO:0009378)
0.4 2.2 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.3 6.7 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.3 2.6 GO:0032977 membrane insertase activity(GO:0032977)
0.3 2.1 GO:0016421 CoA carboxylase activity(GO:0016421)
0.2 2.7 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.2 4.6 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.2 492.2 GO:0001012 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.2 2.6 GO:0004017 adenylate kinase activity(GO:0004017)
0.2 5.3 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 2.5 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.1 5.7 GO:0051087 chaperone binding(GO:0051087)
0.1 0.4 GO:0042781 3'-tRNA processing endoribonuclease activity(GO:0042781)
0.1 3.4 GO:0016875 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.1 1.0 GO:0043035 chromatin insulator sequence binding(GO:0043035)
0.1 0.8 GO:0008174 mRNA methyltransferase activity(GO:0008174)
0.1 2.5 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.1 2.7 GO:0008378 galactosyltransferase activity(GO:0008378)
0.1 2.5 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 0.9 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.1 0.4 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.1 3.4 GO:0043022 ribosome binding(GO:0043022)
0.1 0.8 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 3.4 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 4.4 GO:0003724 RNA helicase activity(GO:0003724)
0.1 4.2 GO:0051082 unfolded protein binding(GO:0051082)
0.0 1.2 GO:0016229 steroid dehydrogenase activity(GO:0016229)
0.0 1.1 GO:0034062 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.0 3.4 GO:0004386 helicase activity(GO:0004386)
0.0 0.2 GO:0016822 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0 0.3 GO:0008410 CoA-transferase activity(GO:0008410)
0.0 6.1 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 2.7 GO:0015297 antiporter activity(GO:0015297)
0.0 0.4 GO:0061608 nuclear import signal receptor activity(GO:0061608)
0.0 0.8 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 8.5 GO:0008289 lipid binding(GO:0008289)
0.0 1.4 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.6 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 1.4 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 3.2 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 1.2 PID RB 1PATHWAY Regulation of retinoblastoma protein

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.2 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.1 2.1 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 6.7 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 1.4 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.1 2.7 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.1 8.0 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 1.9 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 4.0 REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
0.1 1.4 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.1 0.3 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 0.8 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 2.5 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 1.2 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 2.2 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.5 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0 0.4 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA