ISMARA results: cux2b

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for cux2b

Z-value: 1.31

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Transcription factors associated with cux2b

Gene Symbol	Gene ID	Gene Info
cux2b NCBI UniProt	ENSDARG00000086345	cut-like homeobox 2b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
cux2b	dr11_v1_chr8_-_4097722_4097722	-0.35	4.9e-04	Click!

Activity profile of cux2b motif

Sorted Z-values of cux2b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr25_+_31264155 Show fit	16.94	ENSDART00000012256	tnni2a.3 NCBI UniProt Show fit	troponin I type 2a (skeletal, fast), tandem duplicate 3
chr3_-_61205711 Show fit	16.32	ENSDART00000055062	pvalb1 NCBI UniProt Show fit	parvalbumin 1
chr25_+_29160102 Show fit	14.99	ENSDART00000162854	pkmb NCBI UniProt Show fit	pyruvate kinase M1/2b
chr5_-_71705191 Show fit	14.12	ENSDART00000187767	ak1 NCBI UniProt Show fit	adenylate kinase 1
chr11_-_18253111 Show fit	13.76	ENSDART00000125984	mustn1b NCBI UniProt Show fit	musculoskeletal, embryonic nuclear protein 1b
chr25_+_31267268 Show fit	13.09	ENSDART00000181239	tnni2a.3 NCBI UniProt Show fit	troponin I type 2a (skeletal, fast), tandem duplicate 3
chr11_+_11200550 Show fit	13.02	ENSDART00000181339 ENSDART00000187116	myom2a NCBI UniProt Show fit	myomesin 2a
chr24_+_38301080 Show fit	12.38	ENSDART00000105672	mybpc2b NCBI UniProt Show fit	myosin binding protein C, fast type b
chr2_-_15324837 Show fit	11.97	ENSDART00000015655	tecrl2b NCBI UniProt Show fit	trans-2,3-enoyl-CoA reductase-like 2b
chr13_+_50375800 Show fit	11.93	ENSDART00000099537	cox5b2 NCBI UniProt Show fit	cytochrome c oxidase subunit Vb 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of cux2b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	30.0	GO:0003009	skeletal muscle contraction(GO:0003009)
0.4	20.0	GO:0000038	very long-chain fatty acid metabolic process(GO:0000038)
0.1	18.1	GO:0060537	muscle tissue development(GO:0060537)
1.0	17.5	GO:0007339	binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
1.7	17.1	GO:0070836	membrane raft assembly(GO:0001765) plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836)
0.3	17.1	GO:0006414	translational elongation(GO:0006414)
0.5	16.8	GO:0002377	immunoglobulin production(GO:0002377)
0.3	15.8	GO:0006096	glycolytic process(GO:0006096)
2.0	14.1	GO:0009136	ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180)
2.8	13.8	GO:0035988	chondrocyte proliferation(GO:0035988)

Showing 1 to 10 of 254 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	63.0	GO:0005576	extracellular region(GO:0005576)
0.7	30.0	GO:0005861	troponin complex(GO:0005861)
0.1	28.6	GO:0031012	extracellular matrix(GO:0031012)
0.1	26.1	GO:0005840	ribosome(GO:0005840)
0.2	18.7	GO:0030018	Z disc(GO:0030018)
0.0	17.9	GO:0005739	mitochondrion(GO:0005739)
0.4	17.1	GO:0044853	caveola(GO:0005901) plasma membrane raft(GO:0044853)
4.1	16.5	GO:0008290	F-actin capping protein complex(GO:0008290)
0.6	13.0	GO:0031430	M band(GO:0031430)
0.1	12.7	GO:0009897	external side of plasma membrane(GO:0009897)

Showing 1 to 10 of 90 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	31.1	GO:0003735	structural constituent of ribosome(GO:0003735)
0.1	29.6	GO:0051015	actin filament binding(GO:0051015)
1.6	17.5	GO:0035804	structural constituent of egg coat(GO:0035804)
0.4	17.1	GO:0003746	translation elongation factor activity(GO:0003746)
0.1	16.7	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.1	15.7	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.5	15.1	GO:0015002	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
2.5	15.0	GO:0004743	pyruvate kinase activity(GO:0004743)
0.0	14.8	GO:0004674	protein serine/threonine kinase activity(GO:0004674)
0.0	14.5	GO:0005509	calcium ion binding(GO:0005509)

Showing 1 to 10 of 184 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	15.6	NABA COLLAGENS	Genes encoding collagen proteins
0.4	14.5	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.2	13.7	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3	12.1	PID PLK1 PATHWAY	PLK1 signaling events
0.1	9.2	PID P73PATHWAY	p73 transcription factor network
0.4	8.8	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.0	5.7	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.4	4.7	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.1	3.7	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.0	3.4	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins

Showing 1 to 10 of 38 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	15.6	REACTOME EXTRACELLULAR MATRIX ORGANIZATION	Genes involved in Extracellular matrix organization
0.7	14.1	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.2	12.1	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2	11.7	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.3	8.3	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.3	6.0	REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS	Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.3	5.8	REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX	Genes involved in CDC6 association with the ORC:origin complex
0.1	5.2	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression
0.3	4.7	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
0.1	4.4	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events

Showing 1 to 10 of 67 entries

Results for cux2b

Z-value: 1.31

Motif logo

Transcription factors associated with cux2b

Activity-expression correlation:

Activity profile of cux2b motif

Sorted Z-values of cux2b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of cux2b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: