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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for ddx28+nfatc1+nfatc2b+nfatc3a+nfatc3b+nfatc4

Z-value: 1.50

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Transcription factors associated with ddx28+nfatc1+nfatc2b+nfatc3a+nfatc3b+nfatc4

Gene Symbol Gene ID Gene Info
nfatc1
ENSDARG00000036168 nuclear factor of activated T cells 1
nfatc3b
ENSDARG00000051729 nuclear factor of activated T cells 3b
nfatc4
ENSDARG00000054162 nuclear factor of activated T cells 4
nfatc3a
ENSDARG00000076297 nuclear factor of activated T cells 3a
nfatc2b
ENSDARG00000079972 nuclear factor of activated T cells 2b
ddx28
ENSDARG00000112133 nuclear factor of activated T cells 3a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nfatc1dr11_v1_chr19_+_22216778_222167780.618.1e-11Click!
nfatc3bdr11_v1_chr25_-_36248053_362480530.294.4e-03Click!
nfatc2bdr11_v1_chr6_-_55254786_55254786-0.294.7e-03Click!
nfatc4dr11_v1_chr2_-_37797577_377975770.122.3e-01Click!
nfatc3adr11_v1_chr7_-_34927961_34927961-0.103.6e-01Click!

Activity profile of ddx28+nfatc1+nfatc2b+nfatc3a+nfatc3b+nfatc4 motif

Sorted Z-values of ddx28+nfatc1+nfatc2b+nfatc3a+nfatc3b+nfatc4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_26064480 24.00 ENSDART00000158215
ENSDART00000171206
ENSDART00000171212
ENSDART00000182956
ENSDART00000186779
ldb3b
LIM domain binding 3b
chr2_-_24289641 15.79 ENSDART00000128784
ENSDART00000123565
ENSDART00000141922
ENSDART00000184550
ENSDART00000191469
myh7l
myosin heavy chain 7-like
chr8_-_40464935 13.72 ENSDART00000040013
myl7
myosin, light chain 7, regulatory
chr18_+_26743749 12.19 ENSDART00000145212
alpk3a
alpha-kinase 3a
chr15_-_20933574 12.14 ENSDART00000152648
ENSDART00000152448
ENSDART00000152244
usp2a
ubiquitin specific peptidase 2a
chr6_-_39313027 12.03 ENSDART00000012644
krt4
keratin 4
chr13_+_23157053 11.80 ENSDART00000162359
sorbs1
sorbin and SH3 domain containing 1
chr2_+_42191592 11.52 ENSDART00000144716
cavin4a
caveolae associated protein 4a
chr3_-_32817274 11.08 ENSDART00000142582
mylpfa
myosin light chain, phosphorylatable, fast skeletal muscle a
chr9_-_42989297 9.97 ENSDART00000126871
ttn.2
titin, tandem duplicate 2
chr9_+_6587056 9.55 ENSDART00000193421
fhl2a
four and a half LIM domains 2a
chr16_-_22713152 9.49 ENSDART00000140953
ENSDART00000143836
si:ch211-105c13.3
si:ch211-105c13.3
chr3_-_61181018 9.33 ENSDART00000187970
pvalb4
parvalbumin 4
chr3_-_39152478 9.22 ENSDART00000154550
si:dkeyp-57f11.2
si:dkeyp-57f11.2
chr19_+_5674907 9.05 ENSDART00000042189
pdk2b
pyruvate dehydrogenase kinase, isozyme 2b
chr9_+_6587364 9.04 ENSDART00000122279
fhl2a
four and a half LIM domains 2a
chr1_-_38195012 8.83 ENSDART00000020409
hand2
heart and neural crest derivatives expressed 2
chr6_-_10233538 8.78 ENSDART00000182004
ENSDART00000149237
ENSDART00000148876
xirp2a
xin actin binding repeat containing 2a
chr18_+_26719787 8.77 ENSDART00000141672
alpk3a
alpha-kinase 3a
chr16_+_23397785 8.76 ENSDART00000148961
s100a10b
S100 calcium binding protein A10b
chr14_+_49296052 8.73 ENSDART00000006073
ENSDART00000105346
anxa6
annexin A6
chr11_-_29946640 8.67 ENSDART00000079175
zgc:113276
zgc:113276
chr3_-_20091964 8.56 ENSDART00000029386
ENSDART00000020253
ENSDART00000124326
slc4a1a
solute carrier family 4 (anion exchanger), member 1a (Diego blood group)
chr25_-_28674739 8.44 ENSDART00000067073
lrrc10
leucine rich repeat containing 10
chr7_+_65564163 8.37 ENSDART00000082679
mical2a
microtubule associated monooxygenase, calponin and LIM domain containing 2a
chr22_-_15587360 8.23 ENSDART00000142717
ENSDART00000138978
tpm4a
tropomyosin 4a
chr1_-_38816685 8.17 ENSDART00000075230
asb5b
ankyrin repeat and SOCS box containing 5b
chr7_-_38658411 8.08 ENSDART00000109463
ENSDART00000017155
npsn
nephrosin
chr16_-_12723324 7.98 ENSDART00000131915
sbk3
SH3 domain binding kinase family, member 3
chr16_+_23398369 7.95 ENSDART00000037694
s100a10b
S100 calcium binding protein A10b
chr25_+_14087045 7.79 ENSDART00000155770
actc1c
actin, alpha, cardiac muscle 1c
chr24_+_35975398 7.62 ENSDART00000173058
obscnb
obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF b
chr11_-_11471857 7.59 ENSDART00000030103
krt94
keratin 94
chr3_-_19367081 7.58 ENSDART00000191369
s1pr5a
sphingosine-1-phosphate receptor 5a
chr1_-_41192059 7.58 ENSDART00000084665
ENSDART00000135369
dok7
docking protein 7
chr2_-_20923864 6.83 ENSDART00000006870
ptgs2a
prostaglandin-endoperoxide synthase 2a
chr11_+_13630107 6.81 ENSDART00000172220
si:ch211-1a19.3
si:ch211-1a19.3
chr11_-_30611814 6.67 ENSDART00000089803
slc8a1a
solute carrier family 8 (sodium/calcium exchanger), member 1a
chr7_-_21905851 6.57 ENSDART00000111066
ENSDART00000020288
epoa
erythropoietin a
chr23_+_13814978 6.41 ENSDART00000090864
lmod3
leiomodin 3 (fetal)
chr6_+_60112200 6.31 ENSDART00000008243
prelid3b
PRELI domain containing 3
chr6_-_48094342 6.30 ENSDART00000137458
slc2a1b
solute carrier family 2 (facilitated glucose transporter), member 1b
chr22_-_26353916 6.20 ENSDART00000077958
capn2b
calpain 2, (m/II) large subunit b
chr25_-_32888115 6.19 ENSDART00000087586
c2cd4a
C2 calcium dependent domain containing 4A
chr9_+_35860975 6.06 ENSDART00000134447
rcan1a
regulator of calcineurin 1a
chr22_+_28446557 5.98 ENSDART00000089546
abi3bpb
ABI family, member 3 (NESH) binding protein b
chr22_+_28446365 5.92 ENSDART00000189359
abi3bpb
ABI family, member 3 (NESH) binding protein b
chr11_-_30612166 5.90 ENSDART00000177984
slc8a1a
solute carrier family 8 (sodium/calcium exchanger), member 1a
chr21_-_22928214 5.83 ENSDART00000182760
dub
duboraya
chr20_+_28364742 5.77 ENSDART00000103355
rhov
ras homolog family member V
chr3_+_14463941 5.75 ENSDART00000170927
cnn1b
calponin 1, basic, smooth muscle, b
chr13_+_13681681 5.70 ENSDART00000057825
cfd
complement factor D (adipsin)
chr16_-_35975254 5.66 ENSDART00000167537
eva1ba
eva-1 homolog Ba (C. elegans)
chr9_-_23990416 5.58 ENSDART00000113176
col6a3
collagen, type VI, alpha 3
chr21_+_21621042 5.56 ENSDART00000134907
tgfb1b
transforming growth factor, beta 1b
chr16_+_25245857 5.50 ENSDART00000155220
klhl38b
kelch-like family member 38b
chr10_-_43771447 5.27 ENSDART00000052307
arrdc3b
arrestin domain containing 3b
chr11_+_10541258 5.26 ENSDART00000132365
b3gnt5a
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5a
chr9_+_33145522 5.23 ENSDART00000005879
atp5po
ATP synthase peripheral stalk subunit OSCP
chr18_+_26750516 5.22 ENSDART00000110843
alpk3a
alpha-kinase 3a
chr17_+_24848976 5.19 ENSDART00000062917
cx35.4
connexin 35.4
chr14_+_26759332 5.00 ENSDART00000088484
ahnak
AHNAK nucleoprotein
chr7_-_52558495 4.98 ENSDART00000138263
ENSDART00000009938
ENSDART00000174292
ENSDART00000174218
ENSDART00000174335
tcf12
transcription factor 12
chr1_-_58664854 4.94 ENSDART00000109528
adgre5b.3
adhesion G protein-coupled receptor E5b, duplicate 3
chr7_-_52417777 4.94 ENSDART00000110265
myzap
myocardial zonula adherens protein
chr11_-_30601401 4.93 ENSDART00000172244
ENSDART00000046800
slc8a1a
solute carrier family 8 (sodium/calcium exchanger), member 1a
chr4_+_7677318 4.92 ENSDART00000149218
elk3
ELK3, ETS-domain protein
chr6_+_49095646 4.89 ENSDART00000103385
slc25a55a
solute carrier family 25, member 55a
chr20_+_29436601 4.83 ENSDART00000136804
fmn1
formin 1
chr13_-_13754091 4.80 ENSDART00000131255
ky
kyphoscoliosis peptidase
chr2_-_24369087 4.79 ENSDART00000081237
plvapa
plasmalemma vesicle associated protein a
chr12_+_17106117 4.68 ENSDART00000149990
acta2
actin, alpha 2, smooth muscle, aorta
chr20_-_49681850 4.66 ENSDART00000025926
col12a1b
collagen, type XII, alpha 1b
chr9_-_23994225 4.66 ENSDART00000140346
col6a3
collagen, type VI, alpha 3
chr8_+_27743550 4.64 ENSDART00000046004
wnt2bb
wingless-type MMTV integration site family, member 2Bb
chr19_+_18797623 4.50 ENSDART00000166172
ddah2
dimethylarginine dimethylaminohydrolase 2
chr20_+_53577502 4.47 ENSDART00000126983
myh6
myosin, heavy chain 6, cardiac muscle, alpha
chr20_+_46040666 4.47 ENSDART00000060744
si:dkey-7c18.24
si:dkey-7c18.24
chr2_+_4207209 4.46 ENSDART00000157903
ENSDART00000166476
gata6
GATA binding protein 6
chr2_+_38161318 4.43 ENSDART00000044264
mmp14b
matrix metallopeptidase 14b (membrane-inserted)
chr5_+_30179010 4.31 ENSDART00000134624
adamts15a
ADAM metallopeptidase with thrombospondin type 1 motif, 15a
chr13_-_42749916 4.29 ENSDART00000140019
capn2a
calpain 2, (m/II) large subunit a
chr6_-_34220641 4.26 ENSDART00000102391
dmrt2b
doublesex and mab-3 related transcription factor 2b
chr25_+_6122823 4.24 ENSDART00000191824
ENSDART00000067514
rbpms2a
RNA binding protein with multiple splicing 2a
chr16_+_30438041 4.22 ENSDART00000137977
pear1
platelet endothelial aggregation receptor 1
chr16_+_35887868 4.19 ENSDART00000169677
ENSDART00000170772
thrap3a
thyroid hormone receptor associated protein 3a
chr24_+_11334733 4.16 ENSDART00000147552
ENSDART00000143171
si:dkey-12l12.1
si:dkey-12l12.1
chr21_+_2091895 4.13 ENSDART00000161828
si:rp71-1h20.9
si:rp71-1h20.9
chr21_-_17603182 4.04 ENSDART00000020048
ENSDART00000177270
gsna
gelsolin a
chr19_-_38611814 4.01 ENSDART00000151958
col16a1
collagen, type XVI, alpha 1
chr9_+_31752628 3.96 ENSDART00000060054
itgbl1
integrin, beta-like 1
chr23_-_19682971 3.88 ENSDART00000048891
zgc:193598
zgc:193598
chr7_-_30367650 3.87 ENSDART00000075519
aldh1a2
aldehyde dehydrogenase 1 family, member A2
chr7_+_26167420 3.82 ENSDART00000173941
si:ch211-196f2.6
si:ch211-196f2.6
chr22_+_19311411 3.81 ENSDART00000133234
ENSDART00000138284
si:dkey-21e2.16
si:dkey-21e2.16
chr5_-_34997630 3.80 ENSDART00000170684
btf3
basic transcription factor 3
chr13_-_22646134 3.80 ENSDART00000136808
mmrn2a
multimerin 2a
chr6_-_42983843 3.79 ENSDART00000130666
tnfrsf18
tumor necrosis factor receptor superfamily, member 18
chr6_-_49063085 3.75 ENSDART00000156124
si:ch211-105j21.9
si:ch211-105j21.9
chr20_+_6773790 3.75 ENSDART00000169966
igfbp3
insulin-like growth factor binding protein 3
chr6_-_33875919 3.73 ENSDART00000190411
tmem69
transmembrane protein 69
chr13_+_16279890 3.70 ENSDART00000101775
ENSDART00000057948
anxa11a
annexin A11a
chr5_+_37091626 3.65 ENSDART00000161054
tagln2
transgelin 2
chr6_-_49673476 3.54 ENSDART00000112226
apcdd1l
adenomatosis polyposis coli down-regulated 1-like
chr21_+_29077509 3.52 ENSDART00000128561
ecscr
endothelial cell surface expressed chemotaxis and apoptosis regulator
chr16_+_31542645 3.52 ENSDART00000163724
SLA (1 of many)
Src like adaptor
chr7_-_52531252 3.49 ENSDART00000174369
tcf12
transcription factor 12
chr1_-_29658721 3.44 ENSDART00000132063
si:dkey-1h24.6
si:dkey-1h24.6
chr13_+_25410594 3.43 ENSDART00000112092
calhm3
calcium homeostasis modulator 3
chr20_+_31287356 3.40 ENSDART00000007688
slc22a16
solute carrier family 22 (organic cation/carnitine transporter), member 16
chr20_+_38276690 3.38 ENSDART00000061437
ccl38.6
chemokine (C-C motif) ligand 38, duplicate 6
chr6_-_36552844 3.34 ENSDART00000023613
her6
hairy-related 6
chr10_+_26612321 3.32 ENSDART00000134322
fhl1b
four and a half LIM domains 1b
chr11_-_31039533 3.32 ENSDART00000127355
ier2b
immediate early response 2b
chr15_-_34468599 3.29 ENSDART00000192984
meox2a
mesenchyme homeobox 2a
chr25_-_21822426 3.25 ENSDART00000151993
zgc:158222
zgc:158222
chr19_-_33087246 3.23 ENSDART00000052078
klhl38a
kelch-like family member 38a
chr2_-_30182353 3.22 ENSDART00000019149
rpl7
ribosomal protein L7
chr20_+_38285671 3.19 ENSDART00000061432
ccl38a.4
chemokine (C-C motif) ligand 38, duplicate 4
chr23_+_36101185 3.17 ENSDART00000103139
hoxc8a
homeobox C8a
chr8_+_25616946 3.12 ENSDART00000133983
slc38a5a
solute carrier family 38, member 5a
chr6_-_40899618 3.06 ENSDART00000153949
ENSDART00000021969
zgc:172271
zgc:172271
chr20_+_6756247 3.04 ENSDART00000167344
igfbp3
insulin-like growth factor binding protein 3
chr5_-_15851953 3.00 ENSDART00000173101
si:dkey-1k23.3
si:dkey-1k23.3
chr1_-_54425791 2.97 ENSDART00000039911
pkd1a
polycystic kidney disease 1a
chr11_-_18705303 2.96 ENSDART00000059732
id1
inhibitor of DNA binding 1
chr11_-_40165683 2.94 ENSDART00000186510
si:dkey-264d12.4
si:dkey-264d12.4
chr20_+_1996202 2.91 ENSDART00000184143
CABZ01092781.1

chr2_-_25140022 2.87 ENSDART00000134543
nceh1a
neutral cholesterol ester hydrolase 1a
chr22_-_28653074 2.86 ENSDART00000154717
col8a1b
collagen, type VIII, alpha 1b
chr18_+_13309862 2.83 ENSDART00000131555
si:ch211-260p9.3
si:ch211-260p9.3
chr13_-_18835254 2.81 ENSDART00000147579
ENSDART00000146795
lzts2a
leucine zipper, putative tumor suppressor 2a
chr6_-_52675630 2.81 ENSDART00000083830
sdc4
syndecan 4
chr1_+_51475094 2.79 ENSDART00000146352
meis1a
Meis homeobox 1 a
chr15_-_17618800 2.78 ENSDART00000157185
adamts15b
ADAM metallopeptidase with thrombospondin type 1 motif, 15b
chr2_+_10914023 2.78 ENSDART00000146546
mrpl37
mitochondrial ribosomal protein L37
chr15_-_25518084 2.77 ENSDART00000158594
hif1al
hypoxia-inducible factor 1, alpha subunit, like
chr8_-_45834825 2.77 ENSDART00000132965
ogdha
oxoglutarate (alpha-ketoglutarate) dehydrogenase a (lipoamide)
chr23_+_44049509 2.77 ENSDART00000102003
txk
TXK tyrosine kinase
chr11_-_34628789 2.77 ENSDART00000192433
mapkapk3
mitogen-activated protein kinase-activated protein kinase 3
chr7_+_44445595 2.76 ENSDART00000108766
cdh5
cadherin 5
chr14_+_46028003 2.76 ENSDART00000113469
nocta
nocturnin a
chr6_-_50204262 2.75 ENSDART00000163648
raly
RALY heterogeneous nuclear ribonucleoprotein
chr16_+_40301056 2.74 ENSDART00000058578
rspo3
R-spondin 3
chr13_-_39947335 2.72 ENSDART00000056996
sfrp5
secreted frizzled-related protein 5
chr2_-_48196092 2.72 ENSDART00000139944
snorc
secondary ossification center associated regulator of chondrocyte maturation
chr14_-_4120636 2.68 ENSDART00000059230
irf2
interferon regulatory factor 2
chr11_-_10643091 2.66 ENSDART00000192314
mcf2l2
MCF.2 cell line derived transforming sequence-like 2
chr16_+_20910186 2.66 ENSDART00000046766
hoxa10b
homeobox A10b
chr8_+_17078692 2.65 ENSDART00000023206
plk2b
polo-like kinase 2b (Drosophila)
chr3_-_10677890 2.63 ENSDART00000155382
ENSDART00000171319
si:ch1073-144j5.2
si:ch1073-144j5.2
chr12_+_16281312 2.63 ENSDART00000152500
ppp1r3cb
protein phosphatase 1, regulatory subunit 3Cb
chr14_-_33454595 2.61 ENSDART00000109615
ENSDART00000173267
ENSDART00000185737
ENSDART00000190989
tmem255a
transmembrane protein 255A
chr5_-_44496553 2.59 ENSDART00000178081
gas1a
growth arrest-specific 1a
chr4_-_13502549 2.56 ENSDART00000140366
si:ch211-266a5.12
si:ch211-266a5.12
chr14_+_30568961 2.56 ENSDART00000184303
mrpl11
mitochondrial ribosomal protein L11
chr7_+_30051880 2.54 ENSDART00000075609
pstpip1b
proline-serine-threonine phosphatase interacting protein 1b
chr17_+_27456804 2.54 ENSDART00000017756
ENSDART00000181461
ENSDART00000180178
ctsl.1
cathepsin L.1
chr10_-_7892192 2.53 ENSDART00000145480
smtna
smoothelin a
chr13_+_35690023 2.53 ENSDART00000128865
ENSDART00000130050
psme4a
proteasome activator subunit 4a
chr10_+_42159471 2.53 ENSDART00000122160
CR925773.1

chr8_-_38403018 2.52 ENSDART00000134100
sorbs3
sorbin and SH3 domain containing 3
chr21_-_43131752 2.52 ENSDART00000024137
p4ha2
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide 2
chr23_-_764135 2.51 ENSDART00000010248
ENSDART00000183978
mitfb
microphthalmia-associated transcription factor b
chr22_-_10470663 2.51 ENSDART00000143352
omd
osteomodulin
chr20_-_13660600 2.50 ENSDART00000063826
TAGAP
si:ch211-122h15.4
chr17_-_25382367 2.49 ENSDART00000162306
ENSDART00000165282
lck
LCK proto-oncogene, Src family tyrosine kinase
chr8_+_40628926 2.48 ENSDART00000163598
dusp2
dual specificity phosphatase 2
chr8_-_50132860 2.46 ENSDART00000149964
antxr1a
anthrax toxin receptor 1a
chr10_+_8437930 2.45 ENSDART00000074553
pptc7b
PTC7 protein phosphatase homolog b
chr14_+_6182346 2.44 ENSDART00000075525
si:ch73-22a13.3
si:ch73-22a13.3
chr25_-_12635371 2.43 ENSDART00000162463
zcchc14
zinc finger, CCHC domain containing 14
chr9_+_13985567 2.43 ENSDART00000102296
cd28
CD28 molecule
chr20_+_38279523 2.38 ENSDART00000061311
ccl38a.5
chemokine (C-C motif) ligand 38, duplicate 5
chr8_-_19342111 2.35 ENSDART00000138881
rgl1
ral guanine nucleotide dissociation stimulator-like 1
chr6_+_48978202 2.30 ENSDART00000150023
slc16a1a
solute carrier family 16 (monocarboxylate transporter), member 1a
chr19_-_35596207 2.30 ENSDART00000136811
col8a2
collagen, type VIII, alpha 2
chr6_+_52263236 2.29 ENSDART00000144174
esyt1b
extended synaptotagmin-like protein 1b
chr12_+_20627505 2.26 ENSDART00000074384
stx4
syntaxin 4
chr16_-_28091597 2.26 ENSDART00000166595
CR626941.1

chr1_-_44484 2.26 ENSDART00000171547
ENSDART00000164075
ENSDART00000168091
tmem39a
transmembrane protein 39A
chr10_+_8767541 2.24 ENSDART00000170272
itga1
integrin, alpha 1
chr3_-_34076807 2.21 ENSDART00000150964
ighv7-1
immunoglobulin heavy variable 7-1
chr20_-_13660767 2.20 ENSDART00000127654
TAGAP
si:ch211-122h15.4
chr15_-_21852963 2.18 ENSDART00000153581
ENSDART00000155588
ENSDART00000079399
laynb
layilin b
chr22_+_18884971 2.18 ENSDART00000186332
fstl3
follistatin-like 3 (secreted glycoprotein)
chr16_-_17541890 2.18 ENSDART00000131328
clcn1b
chloride channel, voltage-sensitive 1b
chr5_+_33498253 2.17 ENSDART00000140993
ms4a17c.2
membrane-spanning 4-domains, subfamily A, member 17c.2
chr22_+_5752257 2.17 ENSDART00000143052
cox14
COX14 cytochrome c oxidase assembly factor
chr9_-_8454060 2.14 ENSDART00000110158
irs2b
insulin receptor substrate 2b
chr23_-_14825450 2.13 ENSDART00000188009
sla2
Src-like-adaptor 2
chr8_-_32803227 2.12 ENSDART00000110079
zgc:194839
zgc:194839
chr21_-_27213166 2.12 ENSDART00000146959
mark2a
MAP/microtubule affinity-regulating kinase 2a
chr3_-_11322732 2.11 ENSDART00000161957
AL935044.2

chr25_+_6451038 2.10 ENSDART00000009971
snx33
sorting nexin 33
chr4_-_9722568 2.09 ENSDART00000067190
tspan9b
tetraspanin 9b
chr8_-_19904124 2.08 ENSDART00000129193
trabd2b
TraB domain containing 2B
chr21_+_30746348 2.06 ENSDART00000050172
trpc2b
transient receptor potential cation channel, subfamily C, member 2b
chr4_+_76764315 2.05 ENSDART00000075598
ms4a17a.12
membrane-spanning 4-domains, subfamily A, member 17A.12
chr9_+_13682133 2.03 ENSDART00000175639
mpp4a
membrane protein, palmitoylated 4a (MAGUK p55 subfamily member 4)

Network of associatons between targets according to the STRING database.

First level regulatory network of ddx28+nfatc1+nfatc2b+nfatc3a+nfatc3b+nfatc4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 18.2 GO:0055014 atrial cardiac muscle cell development(GO:0055014)
2.2 8.7 GO:0001778 plasma membrane repair(GO:0001778) chondrocyte differentiation involved in endochondral bone morphogenesis(GO:0003413) growth plate cartilage chondrocyte differentiation(GO:0003418)
1.9 5.8 GO:0061341 non-canonical Wnt signaling pathway involved in heart development(GO:0061341)
1.9 5.8 GO:0071896 protein localization to adherens junction(GO:0071896)
1.7 6.8 GO:0019371 cyclooxygenase pathway(GO:0019371)
1.6 4.7 GO:0090131 mesenchyme migration(GO:0090131)
1.4 8.4 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
1.4 2.7 GO:0061031 endodermal digestive tract morphogenesis(GO:0061031)
1.3 5.2 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
1.3 3.8 GO:0002727 response to tumor cell(GO:0002347) natural killer cell cytokine production(GO:0002370) immune response to tumor cell(GO:0002418) natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell cytokine production(GO:0002727) positive regulation of natural killer cell cytokine production(GO:0002729) positive regulation of response to biotic stimulus(GO:0002833) regulation of response to tumor cell(GO:0002834) positive regulation of response to tumor cell(GO:0002836) regulation of immune response to tumor cell(GO:0002837) positive regulation of immune response to tumor cell(GO:0002839) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860) positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
1.2 7.2 GO:0071908 determination of intestine left/right asymmetry(GO:0071908)
1.2 4.6 GO:0061010 gall bladder development(GO:0061010)
1.1 5.7 GO:0051145 smooth muscle cell differentiation(GO:0051145)
1.1 3.4 GO:0015695 organic cation transport(GO:0015695)
1.1 4.5 GO:0045429 regulation of nitric oxide biosynthetic process(GO:0045428) positive regulation of nitric oxide biosynthetic process(GO:0045429) positive regulation of reactive oxygen species biosynthetic process(GO:1903428) positive regulation of nitric oxide metabolic process(GO:1904407)
1.0 3.9 GO:0061113 pancreas morphogenesis(GO:0061113)
1.0 19.2 GO:0098703 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.9 6.6 GO:0048823 nucleate erythrocyte development(GO:0048823)
0.9 10.0 GO:0048769 sarcomerogenesis(GO:0048769)
0.9 4.5 GO:0043011 myeloid dendritic cell activation(GO:0001773) myeloid dendritic cell differentiation(GO:0043011)
0.8 3.1 GO:1902024 L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024)
0.7 3.0 GO:0032965 regulation of collagen metabolic process(GO:0010712) regulation of collagen biosynthetic process(GO:0032965) regulation of multicellular organismal metabolic process(GO:0044246)
0.7 6.4 GO:0051694 skeletal muscle thin filament assembly(GO:0030240) pointed-end actin filament capping(GO:0051694)
0.7 2.8 GO:0036445 neuronal stem cell division(GO:0036445) somatic stem cell division(GO:0048103)
0.7 2.8 GO:0009826 unidimensional cell growth(GO:0009826)
0.7 2.7 GO:0060829 negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060829)
0.6 8.4 GO:0061026 cardiac muscle tissue regeneration(GO:0061026)
0.6 2.5 GO:0033301 cell cycle comprising mitosis without cytokinesis(GO:0033301)
0.6 6.8 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.6 1.8 GO:0045579 positive regulation of B cell differentiation(GO:0045579)
0.6 1.7 GO:0006043 glucosamine metabolic process(GO:0006041) glucosamine catabolic process(GO:0006043)
0.6 3.3 GO:0030908 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)
0.5 4.4 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.5 4.9 GO:0015813 acidic amino acid transport(GO:0015800) aspartate transport(GO:0015810) L-glutamate transport(GO:0015813) malate-aspartate shuttle(GO:0043490)
0.5 1.4 GO:1900158 negative regulation of chondrocyte differentiation(GO:0032331) negative regulation of cartilage development(GO:0061037) negative regulation of chondrocyte development(GO:0061182) regulation of bone mineralization involved in bone maturation(GO:1900157) negative regulation of bone mineralization involved in bone maturation(GO:1900158) negative regulation of bone development(GO:1903011)
0.5 2.8 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.5 0.9 GO:1901232 regulation of convergent extension involved in axis elongation(GO:1901232) positive regulation of epiboly involved in gastrulation with mouth forming second(GO:1904088)
0.4 1.7 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.4 2.5 GO:0035093 spermatid nucleus differentiation(GO:0007289) sperm chromatin condensation(GO:0035092) spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.4 1.7 GO:0015871 choline transport(GO:0015871)
0.4 9.5 GO:1990798 pancreas regeneration(GO:1990798)
0.4 25.5 GO:0010842 retina layer formation(GO:0010842)
0.4 1.6 GO:0014909 smooth muscle cell migration(GO:0014909)
0.4 5.6 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.4 8.6 GO:0015701 bicarbonate transport(GO:0015701)
0.4 3.3 GO:0021794 thalamus development(GO:0021794)
0.4 2.8 GO:0051013 microtubule severing(GO:0051013)
0.3 1.7 GO:0097066 response to thyroid hormone(GO:0097066)
0.3 1.6 GO:0071763 nuclear membrane organization(GO:0071763)
0.3 2.3 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.3 3.5 GO:0035479 angioblast cell migration from lateral mesoderm to midline(GO:0035479)
0.3 1.2 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.3 5.4 GO:0019471 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471)
0.3 2.5 GO:1901998 toxin transport(GO:1901998)
0.3 1.1 GO:0019401 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
0.3 1.3 GO:0098529 neuromuscular junction development, skeletal muscle fiber(GO:0098529)
0.2 5.6 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.2 10.1 GO:0010906 regulation of glucose metabolic process(GO:0010906)
0.2 12.8 GO:0030834 regulation of actin filament depolymerization(GO:0030834) negative regulation of actin filament depolymerization(GO:0030835)
0.2 4.7 GO:0070570 regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.2 1.1 GO:0010159 specification of organ position(GO:0010159)
0.2 1.0 GO:0008592 regulation of Toll signaling pathway(GO:0008592)
0.2 2.2 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.2 1.5 GO:1902262 apoptotic process involved in patterning of blood vessels(GO:1902262)
0.2 2.5 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.2 8.0 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.2 2.8 GO:0071456 cellular response to hypoxia(GO:0071456)
0.2 8.5 GO:0000187 activation of MAPK activity(GO:0000187)
0.2 3.3 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.2 7.6 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.2 0.8 GO:1903251 multi-ciliated epithelial cell differentiation(GO:1903251)
0.2 0.6 GO:0048009 insulin-like growth factor receptor signaling pathway(GO:0048009)
0.1 4.5 GO:0006826 iron ion transport(GO:0006826)
0.1 1.0 GO:0050820 positive regulation of blood coagulation(GO:0030194) positive regulation of coagulation(GO:0050820) positive regulation of hemostasis(GO:1900048)
0.1 4.0 GO:0033627 cell adhesion mediated by integrin(GO:0033627)
0.1 5.7 GO:0032922 circadian regulation of gene expression(GO:0032922)
0.1 3.7 GO:0032506 cytokinetic process(GO:0032506)
0.1 2.4 GO:0070672 interleukin-15-mediated signaling pathway(GO:0035723) response to interleukin-15(GO:0070672) cellular response to interleukin-15(GO:0071350)
0.1 11.6 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.1 4.2 GO:0043277 apoptotic cell clearance(GO:0043277)
0.1 5.8 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.1 0.5 GO:0071962 establishment of mitotic sister chromatid cohesion(GO:0034087) mitotic sister chromatid cohesion, centromeric(GO:0071962)
0.1 0.6 GO:1901073 chitin biosynthetic process(GO:0006031) glucosamine-containing compound biosynthetic process(GO:1901073)
0.1 1.3 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 0.4 GO:0002312 B cell activation involved in immune response(GO:0002312) isotype switching(GO:0045190)
0.1 0.9 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.1 3.2 GO:0035118 embryonic pectoral fin morphogenesis(GO:0035118)
0.1 1.1 GO:0051601 exocyst localization(GO:0051601)
0.1 1.6 GO:0042752 regulation of circadian rhythm(GO:0042752)
0.1 1.6 GO:0045116 protein neddylation(GO:0045116) positive regulation of ubiquitin-protein transferase activity(GO:0051443)
0.1 3.5 GO:0060037 pharyngeal system development(GO:0060037)
0.1 1.1 GO:0030431 sleep(GO:0030431)
0.1 8.6 GO:0008045 motor neuron axon guidance(GO:0008045)
0.1 1.8 GO:0050926 regulation of positive chemotaxis(GO:0050926) positive regulation of positive chemotaxis(GO:0050927) induction of positive chemotaxis(GO:0050930)
0.1 2.8 GO:0010634 positive regulation of epithelial cell migration(GO:0010634)
0.1 1.0 GO:0051597 response to methylmercury(GO:0051597)
0.1 2.5 GO:0030500 regulation of bone mineralization(GO:0030500) regulation of biomineral tissue development(GO:0070167)
0.1 2.2 GO:0071907 determination of digestive tract left/right asymmetry(GO:0071907)
0.1 1.0 GO:0048512 rhythmic behavior(GO:0007622) circadian behavior(GO:0048512)
0.1 9.1 GO:0030239 myofibril assembly(GO:0030239)
0.1 6.0 GO:0015914 phospholipid transport(GO:0015914)
0.1 1.8 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.1 8.2 GO:0042742 defense response to bacterium(GO:0042742)
0.1 0.6 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365) aorta morphogenesis(GO:0035909) dorsal aorta morphogenesis(GO:0035912)
0.1 0.4 GO:0002260 lymphocyte homeostasis(GO:0002260)
0.1 0.8 GO:0060004 reflex(GO:0060004) vestibular reflex(GO:0060005)
0.1 3.8 GO:0045785 positive regulation of cell adhesion(GO:0045785)
0.1 1.1 GO:0030816 activation of adenylate cyclase activity(GO:0007190) positive regulation of cAMP metabolic process(GO:0030816) positive regulation of cAMP biosynthetic process(GO:0030819) positive regulation of adenylate cyclase activity(GO:0045762)
0.1 2.1 GO:0006828 manganese ion transport(GO:0006828)
0.1 1.9 GO:0001736 establishment of planar polarity(GO:0001736) establishment of tissue polarity(GO:0007164)
0.1 0.3 GO:0060350 endochondral bone morphogenesis(GO:0060350) cartilage development involved in endochondral bone morphogenesis(GO:0060351)
0.1 8.9 GO:0030178 negative regulation of Wnt signaling pathway(GO:0030178)
0.1 0.5 GO:0002363 CD4-positive, alpha-beta T cell differentiation involved in immune response(GO:0002294) T-helper cell lineage commitment(GO:0002295) T cell lineage commitment(GO:0002360) alpha-beta T cell lineage commitment(GO:0002363) acute-phase response(GO:0006953) T-helper cell differentiation(GO:0042093) positive T cell selection(GO:0043368) CD4-positive or CD8-positive, alpha-beta T cell lineage commitment(GO:0043369) CD4-positive, alpha-beta T cell lineage commitment(GO:0043373) T-helper 17 type immune response(GO:0072538) T-helper 17 cell differentiation(GO:0072539) T-helper 17 cell lineage commitment(GO:0072540)
0.1 2.1 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.1 4.7 GO:0050853 B cell receptor signaling pathway(GO:0050853)
0.1 1.4 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.1 2.8 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.1 1.5 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.1 2.6 GO:0050863 regulation of T cell activation(GO:0050863) regulation of leukocyte cell-cell adhesion(GO:1903037)
0.1 1.4 GO:0071594 B cell differentiation(GO:0030183) T cell differentiation in thymus(GO:0033077) thymocyte aggregation(GO:0071594)
0.1 1.6 GO:0060536 cartilage morphogenesis(GO:0060536)
0.1 2.1 GO:0000281 mitotic cytokinesis(GO:0000281)
0.1 4.1 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.1 4.3 GO:0031032 actomyosin structure organization(GO:0031032)
0.1 1.1 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.1 2.7 GO:0032465 regulation of cytokinesis(GO:0032465)
0.1 2.3 GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.1 2.3 GO:0007266 Rho protein signal transduction(GO:0007266)
0.1 8.1 GO:0016579 protein deubiquitination(GO:0016579)
0.1 17.2 GO:0030198 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.1 2.8 GO:0002224 toll-like receptor signaling pathway(GO:0002224)
0.1 4.8 GO:0045732 positive regulation of protein catabolic process(GO:0045732)
0.1 30.6 GO:0030036 actin cytoskeleton organization(GO:0030036)
0.1 0.4 GO:2000479 regulation of cAMP-dependent protein kinase activity(GO:2000479)
0.1 1.6 GO:0060914 heart formation(GO:0060914)
0.1 1.3 GO:0002377 immunoglobulin production(GO:0002377)
0.1 0.2 GO:0006844 acyl carnitine transport(GO:0006844)
0.0 1.4 GO:0051923 sulfation(GO:0051923)
0.0 1.0 GO:0009948 anterior/posterior axis specification(GO:0009948)
0.0 1.5 GO:2001056 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043280) positive regulation of cysteine-type endopeptidase activity(GO:2001056)
0.0 3.8 GO:0009617 response to bacterium(GO:0009617)
0.0 1.2 GO:0016525 negative regulation of angiogenesis(GO:0016525)
0.0 3.7 GO:0002040 sprouting angiogenesis(GO:0002040)
0.0 0.5 GO:0099560 synaptic membrane adhesion(GO:0099560)
0.0 0.3 GO:0090243 fibroblast growth factor receptor signaling pathway involved in somitogenesis(GO:0090243)
0.0 1.5 GO:0007050 cell cycle arrest(GO:0007050)
0.0 0.4 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 2.8 GO:0009880 embryonic pattern specification(GO:0009880)
0.0 1.3 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.0 1.0 GO:0006884 cell volume homeostasis(GO:0006884)
0.0 0.3 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.0 0.2 GO:0001887 selenium compound metabolic process(GO:0001887)
0.0 2.1 GO:0030318 melanocyte differentiation(GO:0030318)
0.0 0.6 GO:0043171 peptide catabolic process(GO:0043171)
0.0 3.4 GO:0007219 Notch signaling pathway(GO:0007219)
0.0 0.7 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198) serotonin receptor signaling pathway(GO:0007210)
0.0 2.8 GO:0006821 chloride transport(GO:0006821)
0.0 0.7 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.2 GO:0060324 face development(GO:0060324)
0.0 0.5 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 4.7 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.0 0.2 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.0 0.5 GO:0006306 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0 0.3 GO:0021592 fourth ventricle development(GO:0021592)
0.0 0.8 GO:0050432 catecholamine secretion(GO:0050432) regulation of catecholamine secretion(GO:0050433)
0.0 0.8 GO:0019432 triglyceride biosynthetic process(GO:0019432)
0.0 2.5 GO:0051216 cartilage development(GO:0051216)
0.0 0.0 GO:0010893 positive regulation of steroid biosynthetic process(GO:0010893) positive regulation of steroid metabolic process(GO:0045940)
0.0 0.7 GO:0030488 tRNA methylation(GO:0030488)
0.0 1.2 GO:0043065 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
0.0 0.9 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.0 0.2 GO:0002138 retinoic acid biosynthetic process(GO:0002138)
0.0 0.8 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.1 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0 0.1 GO:0002154 thyroid hormone mediated signaling pathway(GO:0002154)
0.0 0.9 GO:0007160 cell-matrix adhesion(GO:0007160)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 12.0 GO:0045095 keratin filament(GO:0045095)
1.0 5.0 GO:0043034 costamere(GO:0043034)
0.7 5.2 GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.7 14.0 GO:0031430 M band(GO:0031430)
0.6 3.8 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.6 2.5 GO:1990111 spermatoproteasome complex(GO:1990111)
0.6 26.5 GO:0031941 filamentous actin(GO:0031941)
0.4 2.0 GO:0034657 GID complex(GO:0034657)
0.3 1.7 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.3 4.7 GO:0005869 dynactin complex(GO:0005869)
0.3 11.5 GO:0005901 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.3 10.4 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.3 2.8 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.3 18.6 GO:0030018 Z disc(GO:0030018)
0.2 1.7 GO:0016012 sarcoglycan complex(GO:0016012)
0.2 18.6 GO:0042383 sarcolemma(GO:0042383)
0.2 14.8 GO:0005884 actin filament(GO:0005884)
0.2 24.1 GO:0016459 myosin complex(GO:0016459)
0.2 14.9 GO:0005581 collagen trimer(GO:0005581)
0.2 0.3 GO:0035253 ciliary rootlet(GO:0035253)
0.2 2.6 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.2 6.3 GO:0005758 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.1 6.2 GO:0008305 integrin complex(GO:0008305)
0.1 10.0 GO:0005814 centriole(GO:0005814)
0.1 0.6 GO:0005899 insulin receptor complex(GO:0005899)
0.1 8.5 GO:0030017 sarcomere(GO:0030017)
0.1 7.9 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.1 2.3 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.1 0.5 GO:0033165 interphotoreceptor matrix(GO:0033165)
0.1 9.7 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 0.5 GO:0030891 VCB complex(GO:0030891)
0.1 13.7 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 0.9 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 4.2 GO:0016592 mediator complex(GO:0016592)
0.1 20.5 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 0.6 GO:0030428 cell septum(GO:0030428)
0.1 0.7 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 0.3 GO:0031415 NatA complex(GO:0031415)
0.1 0.9 GO:0016363 nuclear matrix(GO:0016363)
0.1 3.2 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 2.8 GO:0030427 site of polarized growth(GO:0030427)
0.0 7.4 GO:0031012 extracellular matrix(GO:0031012)
0.0 0.6 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 49.9 GO:0005615 extracellular space(GO:0005615)
0.0 1.4 GO:0032432 actin filament bundle(GO:0032432)
0.0 1.1 GO:0000145 exocyst(GO:0000145)
0.0 0.7 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 2.8 GO:0005924 cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925)
0.0 2.7 GO:0000922 spindle pole(GO:0000922)
0.0 1.9 GO:0016342 catenin complex(GO:0016342)
0.0 1.5 GO:0005876 spindle microtubule(GO:0005876)
0.0 0.3 GO:0005688 U6 snRNP(GO:0005688)
0.0 2.8 GO:0005840 ribosome(GO:0005840)
0.0 0.5 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.4 GO:0097546 ciliary base(GO:0097546)
0.0 0.7 GO:1902711 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 0.6 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.3 GO:0045180 basal cortex(GO:0045180)
0.0 0.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 4.4 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 0.4 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.8 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.6 GO:0005128 erythropoietin receptor binding(GO:0005128)
1.8 5.3 GO:0008457 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
1.7 6.8 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
1.4 8.4 GO:0043914 NADPH:sulfur oxidoreductase activity(GO:0043914)
1.3 17.5 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
1.2 24.0 GO:0051393 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
1.1 9.0 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
1.0 6.1 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.9 7.6 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.9 26.2 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.9 5.6 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.9 6.3 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.9 6.3 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.8 3.8 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.6 6.8 GO:0031995 insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995)
0.6 1.7 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.5 1.6 GO:0048030 disaccharide binding(GO:0048030)
0.5 4.5 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.5 5.2 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.4 2.6 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.4 1.7 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.4 4.9 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.4 11.2 GO:0008307 structural constituent of muscle(GO:0008307)
0.4 8.6 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.4 1.6 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017) platelet-derived growth factor binding(GO:0048407)
0.4 8.0 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.4 3.3 GO:0005113 patched binding(GO:0005113)
0.4 1.8 GO:0042609 CD4 receptor binding(GO:0042609)
0.4 1.4 GO:0031005 filamin binding(GO:0031005)
0.3 2.8 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.3 10.5 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.3 6.4 GO:0003785 actin monomer binding(GO:0003785)
0.3 3.1 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.3 3.6 GO:0015101 organic cation transmembrane transporter activity(GO:0015101)
0.3 3.9 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.3 2.2 GO:0001130 bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding(GO:0001130) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)
0.3 5.4 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.3 5.2 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.3 1.0 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.3 2.5 GO:0016504 peptidase activator activity(GO:0016504)
0.2 0.7 GO:0046964 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964)
0.2 4.8 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.2 0.9 GO:0033857 inositol heptakisphosphate kinase activity(GO:0000829) diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.2 2.4 GO:0000828 inositol hexakisphosphate kinase activity(GO:0000828)
0.2 9.5 GO:0001786 phosphatidylserine binding(GO:0001786)
0.2 2.3 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.2 2.8 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.2 2.8 GO:0070403 NAD+ binding(GO:0070403)
0.2 1.6 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.2 8.0 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.2 2.1 GO:0005158 insulin receptor binding(GO:0005158)
0.2 2.6 GO:2001069 glycogen binding(GO:2001069)
0.2 1.4 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.1 6.9 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.1 21.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 1.0 GO:0015057 thrombin receptor activity(GO:0015057)
0.1 2.2 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 0.6 GO:0043560 insulin-activated receptor activity(GO:0005009) insulin receptor substrate binding(GO:0043560)
0.1 4.3 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.1 1.0 GO:0033613 activating transcription factor binding(GO:0033613)
0.1 2.2 GO:0048185 activin binding(GO:0048185)
0.1 2.4 GO:0042289 MHC class II protein binding(GO:0042289)
0.1 0.5 GO:0046592 polyamine oxidase activity(GO:0046592)
0.1 0.6 GO:0015172 L-glutamate transmembrane transporter activity(GO:0005313) acidic amino acid transmembrane transporter activity(GO:0015172)
0.1 1.0 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.1 0.9 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.1 1.8 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 34.7 GO:0051015 actin filament binding(GO:0051015)
0.1 0.9 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.1 1.7 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.1 1.5 GO:0048018 receptor activator activity(GO:0030546) receptor agonist activity(GO:0048018)
0.1 1.1 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 7.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 3.7 GO:0005109 frizzled binding(GO:0005109)
0.1 1.5 GO:0031386 protein tag(GO:0031386)
0.1 2.1 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 1.6 GO:0005080 protein kinase C binding(GO:0005080)
0.1 1.8 GO:0004875 complement receptor activity(GO:0004875)
0.1 8.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 9.3 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 1.6 GO:0097602 cullin family protein binding(GO:0097602)
0.1 0.9 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 4.0 GO:0005178 integrin binding(GO:0005178)
0.1 2.4 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 1.6 GO:0019894 kinesin binding(GO:0019894)
0.1 0.6 GO:0004100 chitin synthase activity(GO:0004100)
0.1 1.2 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.1 19.0 GO:0003779 actin binding(GO:0003779)
0.1 16.7 GO:0008234 cysteine-type peptidase activity(GO:0008234)
0.1 2.2 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.3 GO:1990756 protein binding, bridging involved in substrate recognition for ubiquitination(GO:1990756)
0.1 9.6 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.1 1.6 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 1.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.5 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.0 9.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.1 GO:0042923 neuropeptide binding(GO:0042923)
0.0 1.1 GO:0005112 Notch binding(GO:0005112)
0.0 2.2 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.5 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 1.3 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 3.1 GO:0008201 heparin binding(GO:0008201)
0.0 1.7 GO:0000049 tRNA binding(GO:0000049)
0.0 1.6 GO:0005272 sodium channel activity(GO:0005272)
0.0 6.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.8 GO:1902936 phosphatidylinositol bisphosphate binding(GO:1902936)
0.0 1.6 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 2.3 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.9 GO:0034062 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.0 1.3 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.7 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 9.4 GO:0003712 transcription factor activity, transcription factor binding(GO:0000989) transcription cofactor activity(GO:0003712)
0.0 10.1 GO:0046983 protein dimerization activity(GO:0046983)
0.0 2.8 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 0.7 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 0.6 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 14.2 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.2 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.1 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.0 0.2 GO:0005042 netrin receptor activity(GO:0005042)
0.0 1.3 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.1 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316)
0.0 0.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 16.6 NABA COLLAGENS Genes encoding collagen proteins
0.3 4.8 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.3 11.8 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.2 3.5 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.2 2.8 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.2 4.4 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.2 2.2 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.2 2.5 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.2 7.4 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.2 8.1 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 2.0 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.1 1.2 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 1.7 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.1 0.5 ST STAT3 PATHWAY STAT3 Pathway
0.1 4.2 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.1 2.5 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 1.5 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 0.6 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.1 1.0 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.5 PID RAS PATHWAY Regulation of Ras family activation
0.0 2.1 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 3.5 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.1 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.0 0.6 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.5 PID S1P S1P2 PATHWAY S1P2 pathway
0.0 1.3 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 3.1 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.4 PID ATM PATHWAY ATM pathway
0.0 0.6 PID AURORA B PATHWAY Aurora B signaling
0.0 0.2 PID NETRIN PATHWAY Netrin-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 21.2 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.8 2.5 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.5 3.4 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.4 5.7 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.4 2.4 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.3 16.6 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.3 2.8 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.2 8.0 REACTOME MYOGENESIS Genes involved in Myogenesis
0.2 2.5 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.2 0.7 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.2 4.5 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
0.2 2.8 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.2 2.4 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.1 2.7 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 2.3 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 1.0 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 1.7 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 1.0 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.1 0.7 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 1.2 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.1 1.5 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 1.0 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.1 7.5 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 0.5 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 4.3 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.5 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 1.0 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 5.0 REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION Genes involved in 3' -UTR-mediated translational regulation
0.0 0.7 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.7 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.7 REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.0 0.6 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.2 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis