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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for dmbx1a+dmbx1b

Z-value: 0.33

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Transcription factors associated with dmbx1a+dmbx1b

Gene Symbol Gene ID Gene Info
dmbx1b
ENSDARG00000002510 diencephalon/mesencephalon homeobox 1b
dmbx1a
ENSDARG00000009922 diencephalon/mesencephalon homeobox 1a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
dmbx1adr11_v1_chr2_-_10192459_101924870.232.3e-02Click!
dmbx1bdr11_v1_chr6_-_3573716_35737160.223.3e-02Click!

Activity profile of dmbx1a+dmbx1b motif

Sorted Z-values of dmbx1a+dmbx1b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_1805421 4.19 ENSDART00000173143
lrp1aa
low density lipoprotein receptor-related protein 1Aa
chr1_-_45177373 1.18 ENSDART00000143142
ENSDART00000034549
zgc:111983
zgc:111983
chr17_-_31058900 0.96 ENSDART00000134998
ENSDART00000104307
ENSDART00000172721
eml1
echinoderm microtubule associated protein like 1
chr10_+_6013076 0.83 ENSDART00000167613
ENSDART00000159216
hmgcs1
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr12_+_17042754 0.81 ENSDART00000066439
ch25h
cholesterol 25-hydroxylase
chr10_-_7988396 0.79 ENSDART00000141445
ENSDART00000024282
ewsr1a
EWS RNA-binding protein 1a
chr3_+_34919810 0.76 ENSDART00000055264
ca10b
carbonic anhydrase Xb
chr1_-_58064738 0.75 ENSDART00000073778
caspb
caspase b
chr4_-_4256300 0.74 ENSDART00000103319
ENSDART00000150279
cd9b
CD9 molecule b
chr17_-_16965809 0.67 ENSDART00000153697
nrxn3a
neurexin 3a
chr17_-_20979077 0.67 ENSDART00000006676
phyhipla
phytanoyl-CoA 2-hydroxylase interacting protein-like a
chr2_+_243778 0.65 ENSDART00000182262
CABZ01085887.1

chr12_+_31729075 0.63 ENSDART00000152973
RNF157
si:dkey-49c17.3
chr1_-_16507812 0.59 ENSDART00000169081
mtmr7b
myotubularin related protein 7b
chr11_-_29082429 0.55 ENSDART00000041443
igsf21a
immunoglobin superfamily, member 21a
chr23_-_3759692 0.52 ENSDART00000028885
hmga1a
high mobility group AT-hook 1a
chr23_-_545942 0.50 ENSDART00000105316
samhd1
SAM domain and HD domain 1
chr11_-_29082175 0.50 ENSDART00000123245
igsf21a
immunoglobin superfamily, member 21a
chr3_+_19914332 0.49 ENSDART00000078982
vat1
vesicle amine transport 1
chr21_-_3770636 0.46 ENSDART00000053596
scamp1
secretory carrier membrane protein 1
chr15_-_6976851 0.45 ENSDART00000158474
ENSDART00000168943
ENSDART00000169944
si:ch73-311h14.2
si:ch73-311h14.2
chr23_-_3759345 0.45 ENSDART00000132205
ENSDART00000137707
ENSDART00000189382
hmga1a
high mobility group AT-hook 1a
chr1_-_45920632 0.44 ENSDART00000140890
pnpla6
patatin-like phospholipase domain containing 6
chr10_+_24504464 0.43 ENSDART00000141387
mtus2a
microtubule associated tumor suppressor candidate 2a
chr3_-_28828242 0.43 ENSDART00000151445
si:ch211-76l23.4
si:ch211-76l23.4
chr2_-_38363017 0.41 ENSDART00000088026
prmt5
protein arginine methyltransferase 5
chr5_-_22602979 0.40 ENSDART00000146287
nono
non-POU domain containing, octamer-binding
chr6_+_22597362 0.39 ENSDART00000131242
cygb2
cytoglobin 2
chr2_+_44972720 0.39 ENSDART00000075146
alg3
asparagine-linked glycosylation 3 (alpha-1,3-mannosyltransferase)
chr21_-_28340977 0.39 ENSDART00000141629
nrxn2a
neurexin 2a
chr5_-_5243079 0.37 ENSDART00000130576
ENSDART00000164377
mvb12ba
multivesicular body subunit 12Ba
chr10_+_24504292 0.37 ENSDART00000090059
mtus2a
microtubule associated tumor suppressor candidate 2a
chr11_-_16215470 0.36 ENSDART00000185744
rab7
RAB7, member RAS oncogene family
chr3_+_15296824 0.35 ENSDART00000043801
cabp5b
calcium binding protein 5b
chr4_+_10721795 0.33 ENSDART00000136000
ENSDART00000067253
stab2
stabilin 2
chr5_-_22602780 0.32 ENSDART00000011699
nono
non-POU domain containing, octamer-binding
chr10_-_37075361 0.32 ENSDART00000132023
myo18aa
myosin XVIIIAa
chr8_+_14381272 0.32 ENSDART00000057642
acbd6
acyl-CoA binding domain containing 6
chr6_-_10320676 0.32 ENSDART00000151247
scn1lab
sodium channel, voltage-gated, type I like, alpha b
chr19_+_3140313 0.31 ENSDART00000125504
zgc:86598
zgc:86598
chr15_-_8191992 0.31 ENSDART00000155381
ENSDART00000190714
bach1a
BTB and CNC homology 1, basic leucine zipper transcription factor 1 a
chr23_+_45512825 0.30 ENSDART00000064846
prelid1b
PRELI domain containing 1b
chr7_+_38395197 0.30 ENSDART00000138669
cep89
centrosomal protein 89
chr17_+_10593398 0.30 ENSDART00000168897
ENSDART00000193989
ENSDART00000191664
ENSDART00000167188
mapkbp1
mitogen-activated protein kinase binding protein 1
chr20_-_31067306 0.29 ENSDART00000014163
fndc1
fibronectin type III domain containing 1
chr23_-_26652273 0.28 ENSDART00000112124
ENSDART00000111029
hspg2
heparan sulfate proteoglycan 2
chr13_-_35892243 0.27 ENSDART00000002750
ENSDART00000122810
ENSDART00000162399
tacc3
transforming, acidic coiled-coil containing protein 3
chr22_+_2709467 0.27 ENSDART00000141416
znf1171
zinc finger protein 1171
chr23_+_44644911 0.27 ENSDART00000140799
zgc:85858
zgc:85858
chr13_-_35892051 0.27 ENSDART00000145884
tacc3
transforming, acidic coiled-coil containing protein 3
chr5_-_8817841 0.26 ENSDART00000170921
fgf10b
fibroblast growth factor 10b
chr14_-_48939560 0.26 ENSDART00000021736
scocb
short coiled-coil protein b
chr12_+_31729498 0.26 ENSDART00000188546
ENSDART00000182562
ENSDART00000186147
RNF157
si:dkey-49c17.3
chr11_-_16215143 0.25 ENSDART00000027014
rab7
RAB7, member RAS oncogene family
chr18_-_10713230 0.25 ENSDART00000183646
rbm28
RNA binding motif protein 28
chr19_+_2631565 0.24 ENSDART00000171487
fam126a
family with sequence similarity 126, member A
chr19_+_24324967 0.23 ENSDART00000090081
sema4ab
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Ab
chr20_-_21672970 0.23 ENSDART00000133286
si:ch211-207i1.2
si:ch211-207i1.2
chr8_-_30424182 0.23 ENSDART00000099021
dock8
dedicator of cytokinesis 8
chr25_-_19068557 0.23 ENSDART00000184780
cacna2d4b
calcium channel, voltage-dependent, alpha 2/delta subunit 4b
chr16_+_16265850 0.22 ENSDART00000181265
setd2
SET domain containing 2
chr16_-_21692024 0.22 ENSDART00000123597
si:ch211-154o6.2
si:ch211-154o6.2
chr4_-_16628801 0.22 ENSDART00000040708
ENSDART00000064009
caprin2
caprin family member 2
chr5_+_69808763 0.21 ENSDART00000143482
fsd1l
fibronectin type III and SPRY domain containing 1-like
chr13_-_14269626 0.20 ENSDART00000079176
gfra4a
GDNF family receptor alpha 4a
chr16_+_48678655 0.20 ENSDART00000150156
tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr18_-_10713414 0.20 ENSDART00000034817
rbm28
RNA binding motif protein 28
chr1_+_35949269 0.20 ENSDART00000180628
BX276105.3

chr12_+_3848109 0.19 ENSDART00000144067
ENSDART00000192042
cabp5a
calcium binding protein 5a
chr8_+_46327350 0.19 ENSDART00000145618
si:dkey-75a21.2
si:dkey-75a21.2
chr18_-_21950751 0.18 ENSDART00000043452
tsnaxip1
translin-associated factor X interacting protein 1
chr23_-_27050083 0.18 ENSDART00000142324
ENSDART00000133249
ENSDART00000138751
ENSDART00000128718
zgc:66440
zgc:66440
chr20_-_9963713 0.17 ENSDART00000104234
gjd2b
gap junction protein delta 2b
chr13_+_1015749 0.16 ENSDART00000190982
prokr1b
prokineticin receptor 1b
chr15_+_45640906 0.15 ENSDART00000149361
ENSDART00000149079
sagb
S-antigen; retina and pineal gland (arrestin) b
chr13_-_31938512 0.15 ENSDART00000026726
ENSDART00000182666
diexf
digestive organ expansion factor homolog
chr3_-_15139293 0.14 ENSDART00000161213
ENSDART00000146053
fam173a
family with sequence similarity 173, member A
chr2_-_9744081 0.14 ENSDART00000097732
dvl3a
dishevelled segment polarity protein 3a
chr5_-_69180227 0.14 ENSDART00000154816
zgc:171967
zgc:171967
chr4_-_59152337 0.14 ENSDART00000156770
znf1149
zinc finger protein 1149
chr1_+_47585700 0.14 ENSDART00000153746
ENSDART00000084457
sh3pxd2aa
SH3 and PX domains 2Aa
chr19_-_30811161 0.13 ENSDART00000103524
myclb
MYCL proto-oncogene, bHLH transcription factor b
chr4_-_42039794 0.13 ENSDART00000110313
si:dkeyp-85d8.5
si:dkeyp-85d8.5
chr15_+_36156986 0.12 ENSDART00000059791
sst1.1
somatostatin 1, tandem duplicate 1
chr17_-_8656155 0.12 ENSDART00000148990
ctbp2a
C-terminal binding protein 2a
chr18_+_21951551 0.11 ENSDART00000146261
ranbp10
RAN binding protein 10
chr15_-_7337148 0.11 ENSDART00000182568
SLC7A1 (1 of many)
high affinity cationic amino acid transporter 1
chr4_+_76671012 0.11 ENSDART00000005585
ms4a17a.2
membrane-spanning 4-domains, subfamily A, member 17a.2
chr25_+_36411624 0.10 ENSDART00000124347
ankrd27
ankyrin repeat domain 27 (VPS9 domain)
chr5_-_30481263 0.10 ENSDART00000086734
phldb1a
pleckstrin homology-like domain, family B, member 1a
chr10_+_32104305 0.09 ENSDART00000099880
wnt11r
wingless-type MMTV integration site family, member 11, related
chr23_-_29553691 0.09 ENSDART00000053804
ube4b
ubiquitination factor E4B, UFD2 homolog (S. cerevisiae)
chr1_+_52560549 0.09 ENSDART00000167514
abca1a
ATP-binding cassette, sub-family A (ABC1), member 1A
chr4_-_18455480 0.09 ENSDART00000150221
sco2
SCO2 cytochrome c oxidase assembly protein
chr3_-_41995321 0.09 ENSDART00000192277
ttyh3a
tweety family member 3a
chr18_+_50525109 0.09 ENSDART00000098390
ubl7b
ubiquitin-like 7b (bone marrow stromal cell-derived)
chr14_-_3944017 0.09 ENSDART00000055817
si:ch73-49o8.1
si:ch73-49o8.1
chr9_-_21067971 0.09 ENSDART00000004333
tbx15
T-box 15
chr10_+_31244619 0.08 ENSDART00000145562
ENSDART00000184412
robo4
roundabout, axon guidance receptor, homolog 4 (Drosophila)
chr5_-_38107741 0.08 ENSDART00000156853
si:ch211-284e13.14
si:ch211-284e13.14
chr1_+_47091468 0.08 ENSDART00000036783
cryzl1
crystallin, zeta (quinone reductase)-like 1
chr13_+_1726953 0.08 ENSDART00000103004
zmp:0000000760
zmp:0000000760
chr7_-_35409027 0.07 ENSDART00000128334
lpcat2
lysophosphatidylcholine acyltransferase 2
chr6_-_39653972 0.07 ENSDART00000155859
larp4ab
La ribonucleoprotein domain family, member 4Ab
chr8_+_54263946 0.07 ENSDART00000193119
TMCC1 (1 of many)
transmembrane and coiled-coil domain family 1
chr4_+_73876128 0.07 ENSDART00000174225
CABZ01069022.1

chr7_-_72423666 0.06 ENSDART00000191214
rph3ab
rabphilin 3A homolog (mouse), b
chr7_+_18989241 0.06 ENSDART00000053213
zgc:194252
zgc:194252
chr4_-_56083825 0.06 ENSDART00000157710
znf986
zinc finger protein 986
chr10_-_27199135 0.06 ENSDART00000189511
ENSDART00000180314
auts2a
autism susceptibility candidate 2a
chr23_-_29553430 0.05 ENSDART00000157773
ENSDART00000126384
ube4b
ubiquitination factor E4B, UFD2 homolog (S. cerevisiae)
chr16_-_46578523 0.04 ENSDART00000131061
si:dkey-152b24.6
si:dkey-152b24.6
chr21_+_44773237 0.04 ENSDART00000084780
rnf121
ring finger protein 121
chr1_+_33383644 0.04 ENSDART00000187194
dhrsx
dehydrogenase/reductase (SDR family) X-linked
chr16_+_37876779 0.04 ENSDART00000140148
si:ch211-198c19.1
si:ch211-198c19.1
chr21_-_20342096 0.04 ENSDART00000065659
rbp4l
retinol binding protein 4, like
chr12_-_13081229 0.03 ENSDART00000152510
ENSDART00000126866
ccser2b
coiled-coil serine-rich protein 2b
chr23_+_25291891 0.02 ENSDART00000016248
pa2g4b
proliferation-associated 2G4, b
chr14_+_11909966 0.02 ENSDART00000171829
frmpd3
FERM and PDZ domain containing 3
chr15_-_8191841 0.01 ENSDART00000156663
bach1a
BTB and CNC homology 1, basic leucine zipper transcription factor 1 a
chr18_-_5103931 0.01 ENSDART00000188091
pdcd10a
programmed cell death 10a

Network of associatons between targets according to the STRING database.

First level regulatory network of dmbx1a+dmbx1b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0010142 farnesyl diphosphate biosynthetic process, mevalonate pathway(GO:0010142) isoprenoid biosynthetic process via mevalonate(GO:1902767)
0.2 0.8 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.2 0.5 GO:0016446 somatic diversification of immune receptors via somatic mutation(GO:0002566) somatic hypermutation of immunoglobulin genes(GO:0016446)
0.1 0.3 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.1 0.4 GO:0034969 histone arginine methylation(GO:0034969)
0.1 0.4 GO:0046755 virion assembly(GO:0019068) virus maturation(GO:0019075) multi-organism membrane organization(GO:0044803) viral budding(GO:0046755) multi-organism organelle organization(GO:1902590) multi-organism membrane budding(GO:1902592)
0.1 1.0 GO:0036368 cone photoresponse recovery(GO:0036368)
0.1 0.3 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)
0.1 0.2 GO:2000055 positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000055)
0.1 0.3 GO:0061033 lung growth(GO:0060437) secretion by lung epithelial cell involved in lung growth(GO:0061033)
0.0 0.2 GO:0002478 antigen processing and presentation of exogenous peptide antigen(GO:0002478) antigen processing and presentation of exogenous antigen(GO:0019884) antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
0.0 0.2 GO:0097198 histone H3-K36 trimethylation(GO:0097198)
0.0 0.3 GO:0061635 regulation of protein complex stability(GO:0061635)
0.0 1.0 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.1 GO:0010874 regulation of cholesterol efflux(GO:0010874)
0.0 0.1 GO:0001954 positive regulation of cell-matrix adhesion(GO:0001954)
0.0 4.2 GO:1901342 regulation of vasculature development(GO:1901342)
0.0 0.3 GO:0046470 phosphatidylcholine metabolic process(GO:0046470)
0.0 0.8 GO:0016126 sterol biosynthetic process(GO:0016126)
0.0 0.1 GO:0090177 establishment of planar polarity of embryonic epithelium(GO:0042249) establishment of planar polarity involved in neural tube closure(GO:0090177) regulation of establishment of planar polarity involved in neural tube closure(GO:0090178) planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.0 0.4 GO:0015671 oxygen transport(GO:0015671)
0.0 0.1 GO:0070073 clustering of voltage-gated calcium channels(GO:0070073)
0.0 0.8 GO:0036269 swimming behavior(GO:0036269)
0.0 0.5 GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0006919)
0.0 0.2 GO:0030431 sleep(GO:0030431)
0.0 0.2 GO:0046549 retinal cone cell development(GO:0046549)
0.0 0.0 GO:1903069 regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903069)
0.0 0.1 GO:0023058 desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) G-protein coupled receptor internalization(GO:0002031) negative adaptation of signaling pathway(GO:0022401) adaptation of signaling pathway(GO:0023058)
0.0 0.6 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.1 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.0 0.7 GO:0007338 single fertilization(GO:0007338)
0.0 0.2 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0061702 inflammasome complex(GO:0061702)
0.0 0.2 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.0 0.3 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 0.5 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.4 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.5 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.6 GO:0031970 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.0 0.2 GO:0005922 connexon complex(GO:0005922)
0.0 0.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 1.0 GO:0072686 mitotic spindle(GO:0072686)
0.0 0.2 GO:0005640 nuclear outer membrane(GO:0005640)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
0.1 0.4 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.1 0.8 GO:0000254 C-4 methylsterol oxidase activity(GO:0000254)
0.1 0.4 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.1 0.5 GO:0016793 dGTPase activity(GO:0008832) triphosphoric monoester hydrolase activity(GO:0016793)
0.1 0.8 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.1 0.4 GO:0098809 nitrite reductase activity(GO:0098809)
0.0 0.3 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.0 0.2 GO:0046977 peptide antigen-transporting ATPase activity(GO:0015433) peptide-transporting ATPase activity(GO:0015440) TAP binding(GO:0046977)
0.0 0.2 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.0 0.8 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.1 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.0 0.4 GO:0004622 lysophospholipase activity(GO:0004622)
0.0 0.6 GO:0004438 phosphatidylinositol-3-phosphatase activity(GO:0004438)
0.0 0.1 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.1 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012) phosphatidylcholine-translocating ATPase activity(GO:0090554) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.0 0.1 GO:0016176 superoxide-generating NADPH oxidase activity(GO:0016175) superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.1 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.0 0.2 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.3 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.3 GO:0042056 chemoattractant activity(GO:0042056)
0.0 0.3 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.1 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.8 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.5 PID AURORA A PATHWAY Aurora A signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS Genes involved in Synthesis of bile acids and bile salts
0.0 0.3 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.8 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.3 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.4 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein