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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for e2f1_e2f7

Z-value: 1.43

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Transcription factors associated with e2f1_e2f7

Gene Symbol Gene ID Gene Info
e2f1
ENSDARG00000103868 E2F transcription factor 1
e2f7
ENSDARG00000008986 E2F transcription factor 7

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
e2f1dr11_v1_chr23_-_43486714_434867140.339.9e-04Click!
e2f7dr11_v1_chr4_-_2545310_25453450.251.7e-02Click!

Activity profile of e2f1_e2f7 motif

Sorted Z-values of e2f1_e2f7 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_+_14841685 12.06 ENSDART00000158291
ENSDART00000162039
slbp
stem-loop binding protein
chr19_-_47570672 11.51 ENSDART00000112155
rrm2
ribonucleotide reductase M2 polypeptide
chr20_-_29498178 11.12 ENSDART00000152986
ENSDART00000027851
ENSDART00000152954
rrm2
ribonucleotide reductase M2 polypeptide
chr24_-_35561672 10.94 ENSDART00000058564
mcm4
minichromosome maintenance complex component 4
chr7_+_24881680 10.84 ENSDART00000058843
krcp
kelch repeat-containing protein
chr7_+_24814866 10.73 ENSDART00000173581
si:ch211-226l4.6
si:ch211-226l4.6
chr1_+_27690 9.37 ENSDART00000162928
eed
embryonic ectoderm development
chr6_-_33916756 8.80 ENSDART00000137447
ENSDART00000138488
nasp
nuclear autoantigenic sperm protein (histone-binding)
chr13_-_35908275 8.57 ENSDART00000013961
mycla
MYCL proto-oncogene, bHLH transcription factor a
chr3_+_25999477 8.29 ENSDART00000024316
mcm5
minichromosome maintenance complex component 5
chr13_+_8255106 8.27 ENSDART00000080465
hells
helicase, lymphoid specific
chr19_-_2582858 8.10 ENSDART00000113829
cdca7b
cell division cycle associated 7b
chr22_-_22301672 7.35 ENSDART00000111711
chaf1a
chromatin assembly factor 1, subunit A (p150)
chr19_+_627899 7.34 ENSDART00000148508
tert
telomerase reverse transcriptase
chr3_-_49514874 7.09 ENSDART00000167179
asf1ba
anti-silencing function 1Ba histone chaperone
chr13_-_86847 6.89 ENSDART00000158062
pole2
polymerase (DNA directed), epsilon 2
chr19_-_48391415 6.71 ENSDART00000170726
ENSDART00000169577
si:ch73-359m17.2
si:ch73-359m17.2
chr2_-_122154 6.14 ENSDART00000156248
ENSDART00000004071
znfl2a
zinc finger-like gene 2a
chr3_+_43086548 6.00 ENSDART00000163579
si:dkey-43p13.5
si:dkey-43p13.5
chr18_+_14277003 5.96 ENSDART00000006628
zgc:173742
zgc:173742
chr5_-_30535327 5.92 ENSDART00000040328
h2afx
H2A histone family, member X
chr13_-_35907768 5.88 ENSDART00000147522
mycla
MYCL proto-oncogene, bHLH transcription factor a
chr6_-_6976096 5.68 ENSDART00000151822
ENSDART00000039443
ENSDART00000177960
tuba8l4
tubulin, alpha 8 like 4
chr16_-_41990421 5.31 ENSDART00000055921
pycard
PYD and CARD domain containing
chr14_-_22015232 5.23 ENSDART00000137795
ssrp1a
structure specific recognition protein 1a
chr18_-_30499489 5.16 ENSDART00000033746
gins2
GINS complex subunit 2
chr20_+_13141408 5.13 ENSDART00000034098
dtl
denticleless E3 ubiquitin protein ligase homolog (Drosophila)
chr13_+_31402067 5.05 ENSDART00000019202
tdrd9
tudor domain containing 9
chr18_+_17020967 4.99 ENSDART00000189168
chtf8
CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
chr1_-_38170997 4.84 ENSDART00000142811
hmgb2a
high mobility group box 2a
chr8_+_52415603 4.72 ENSDART00000021604
ENSDART00000191424
gins4
GINS complex subunit 4 (Sld5 homolog)
chr9_-_2892250 4.64 ENSDART00000140695
cdca7a
cell division cycle associated 7a
chr18_+_17021391 4.43 ENSDART00000100160
chtf8
CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
chr11_+_1551603 4.40 ENSDART00000185383
ENSDART00000121489
ENSDART00000040577
mybl2b
v-myb avian myeloblastosis viral oncogene homolog-like 2b
chr12_+_46883785 4.38 ENSDART00000008312
fam53b
family with sequence similarity 53, member B
chr6_+_12968101 4.38 ENSDART00000013781
mcm6
minichromosome maintenance complex component 6
chr15_-_2640966 4.36 ENSDART00000063320
cldne
claudin e
chr13_+_48358467 4.35 ENSDART00000171080
ENSDART00000162531
msh6
mutS homolog 6 (E. coli)
chr8_+_29636431 4.33 ENSDART00000133047
smarcad1a
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 a
chr15_-_1484795 4.25 ENSDART00000129356
si:dkeyp-97b10.3
si:dkeyp-97b10.3
chr10_+_6884123 4.23 ENSDART00000149095
ENSDART00000148772
ENSDART00000149334
ddx4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
chr23_+_17839187 4.20 ENSDART00000104647
prim1
DNA primase subunit 1
chr16_-_4769877 4.02 ENSDART00000149421
ENSDART00000054078
rpa2
replication protein A2
chr19_+_41006975 4.01 ENSDART00000138555
ENSDART00000049842
casd1
CAS1 domain containing 1
chr5_-_67365750 3.94 ENSDART00000062359
unga
uracil DNA glycosylase a
chr9_-_746317 3.94 ENSDART00000129632
ENSDART00000130720
usp37
ubiquitin specific peptidase 37
chr8_+_29635968 3.89 ENSDART00000139029
ENSDART00000091409
smarcad1a
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 a
chr19_+_25465025 3.70 ENSDART00000018553
rpa3
replication protein A3
chr2_+_7106837 3.68 ENSDART00000138691
vcam1a
vascular cell adhesion molecule 1a
chr21_-_44731865 3.67 ENSDART00000013814
ammecr1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 homolog (human)
chr23_-_18057851 3.65 ENSDART00000173075
ENSDART00000173230
ENSDART00000173135
ENSDART00000173431
ENSDART00000173068
ENSDART00000172987
zgc:92287
zgc:92287
chr23_+_45025909 3.60 ENSDART00000188105
hmgb2b
high mobility group box 2b
chr1_-_59216197 3.59 ENSDART00000062426
lpar2b
lysophosphatidic acid receptor 2b
chr16_-_4770233 3.53 ENSDART00000193228
rpa2
replication protein A2
chr13_-_14929236 3.39 ENSDART00000020576
cdc25b
cell division cycle 25B
chr15_-_1485086 3.29 ENSDART00000191651
si:dkeyp-97b10.3
si:dkeyp-97b10.3
chr6_+_59854224 3.28 ENSDART00000083499
kdm6al
lysine (K)-specific demethylase 6A, like
chr19_+_48024457 3.28 ENSDART00000163823
kpnb1
karyopherin (importin) beta 1
chr20_+_33994580 3.28 ENSDART00000061729
si:dkey-97o5.1
si:dkey-97o5.1
chr22_+_24157807 3.24 ENSDART00000159165
b3galt2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr16_+_53252951 3.23 ENSDART00000126543
si:ch211-269k10.5
si:ch211-269k10.5
chr18_+_20226843 3.22 ENSDART00000100632
tle3a
transducin-like enhancer of split 3a
chr9_-_30555725 3.19 ENSDART00000079222
chaf1b
chromatin assembly factor 1, subunit B
chr14_-_16775158 3.13 ENSDART00000113711
ENSDART00000144781
ENSDART00000160411
mrnip
MRN complex interacting protein
chr24_+_26328787 3.02 ENSDART00000003884
mynn
myoneurin
chr1_+_49415281 2.99 ENSDART00000015007
taf5
TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr2_+_48074243 2.97 ENSDART00000056291
klf6b
Kruppel-like factor 6b
chr24_+_10413484 2.97 ENSDART00000111014
myca
MYC proto-oncogene, bHLH transcription factor a
chr21_+_30721733 2.88 ENSDART00000040443
zgc:110224
zgc:110224
chr11_-_3308569 2.86 ENSDART00000036581
cdk2
cyclin-dependent kinase 2
chr22_-_22301929 2.84 ENSDART00000142027
chaf1a
chromatin assembly factor 1, subunit A (p150)
chr21_-_25213616 2.76 ENSDART00000122513
rfc2
replication factor C (activator 1) 2
chr11_+_45153104 2.74 ENSDART00000159204
ENSDART00000177585
tk1
thymidine kinase 1, soluble
chr21_-_27413294 2.69 ENSDART00000131646
slc29a2
solute carrier family 29 (equilibrative nucleoside transporter), member 2
chr22_-_5655680 2.65 ENSDART00000159629
mcm2
minichromosome maintenance complex component 2
chr8_+_37749263 2.65 ENSDART00000108556
ENSDART00000147942
npm2a
nucleophosmin/nucleoplasmin, 2a
chr15_+_17406920 2.61 ENSDART00000081059
rps6kb1b
ribosomal protein S6 kinase b, polypeptide 1b
chr8_+_16407884 2.59 ENSDART00000133742
cdkn2c
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr3_-_16719244 2.58 ENSDART00000055859
pold1
polymerase (DNA directed), delta 1, catalytic subunit
chr1_+_11822 2.57 ENSDART00000166393
cep97
centrosomal protein 97
chr19_+_1873059 2.55 ENSDART00000145246
snrpd1
small nuclear ribonucleoprotein D1 polypeptide
chr15_+_43333121 2.52 ENSDART00000161011
zgc:85932
zgc:85932
chr12_+_41420355 2.50 ENSDART00000158811
epc1a
enhancer of polycomb homolog 1 (Drosophila) a
chr6_+_33931740 2.44 ENSDART00000130492
ENSDART00000151213
orc1
origin recognition complex, subunit 1
chr9_-_56232296 2.42 ENSDART00000149554
rpl31
ribosomal protein L31
chr25_+_31227747 2.42 ENSDART00000033872
tnni2a.1
troponin I type 2a (skeletal, fast), tandem duplicate 1
chr20_+_35438300 2.40 ENSDART00000102504
ENSDART00000153249
tdrd6
tudor domain containing 6
chr11_-_45434959 2.40 ENSDART00000173106
ENSDART00000172767
ENSDART00000172933
ENSDART00000172986
rfc4
replication factor C (activator 1) 4
chr12_+_17603528 2.37 ENSDART00000111565
pms2
PMS1 homolog 2, mismatch repair system component
chr7_+_55518519 2.36 ENSDART00000098476
ENSDART00000149915
cdt1
chromatin licensing and DNA replication factor 1
chr6_-_1762191 2.36 ENSDART00000167928
orc4
origin recognition complex, subunit 4
chr9_+_56232548 2.33 ENSDART00000099276
cnot11
CCR4-NOT transcription complex, subunit 11
chr17_-_49800869 2.33 ENSDART00000156264
col12a1a
collagen, type XII, alpha 1a
chr1_+_31573225 2.33 ENSDART00000075286
slc2a15b
solute carrier family 2 (facilitated glucose transporter), member 15b
chr3_-_12227359 2.32 ENSDART00000167356
tfap4
transcription factor AP-4 (activating enhancer binding protein 4)
chr24_+_26329018 2.30 ENSDART00000145752
mynn
myoneurin
chr8_-_2504714 2.28 ENSDART00000171559
rpl6
ribosomal protein L6
chr20_-_37933237 2.28 ENSDART00000142567
ENSDART00000036371
ENSDART00000061445
angel2
angel homolog 2 (Drosophila)
chr21_-_23017478 2.28 ENSDART00000024309
rb1
retinoblastoma 1
chr19_-_1947403 2.22 ENSDART00000113951
ENSDART00000151293
ENSDART00000134074
znrf2a
zinc and ring finger 2a
chr7_+_41812636 2.17 ENSDART00000174333
orc6
origin recognition complex, subunit 6
chr8_-_1219815 2.14 ENSDART00000016800
ENSDART00000149969
znf367
zinc finger protein 367
chr18_-_8380090 2.12 ENSDART00000141581
ENSDART00000081143
sephs1
selenophosphate synthetase 1
chr24_-_13349464 2.11 ENSDART00000134482
ENSDART00000139212
terf1
telomeric repeat binding factor (NIMA-interacting) 1
chr7_-_73843720 2.11 ENSDART00000111622
caap1
caspase activity and apoptosis inhibitor 1
chr18_-_7456378 2.10 ENSDART00000081459
pdp2
putative pyruvate dehydrogenase phosphatase isoenzyme 2
chr22_-_24992532 2.09 ENSDART00000102751
si:dkey-179j5.5
si:dkey-179j5.5
chr3_+_13603272 2.06 ENSDART00000185084
hspbp1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr3_-_7897305 2.05 ENSDART00000169757
ubn2b
ubinuclein 2b
chr3_+_57825938 2.05 ENSDART00000128815
cenpx
centromere protein X
chr13_+_28785814 2.04 ENSDART00000039028
nsmce4a
NSE4 homolog A, SMC5-SMC6 complex component
chr13_+_41022502 2.04 ENSDART00000026808
dkk1a
dickkopf WNT signaling pathway inhibitor 1a
chr19_+_1872794 2.04 ENSDART00000013217
snrpd1
small nuclear ribonucleoprotein D1 polypeptide
chr7_+_71586485 2.04 ENSDART00000165582
smchd1
structural maintenance of chromosomes flexible hinge domain containing 1
chr23_+_44236855 2.04 ENSDART00000130147
ENSDART00000051907
MEPCE
si:ch1073-157b13.1
chr22_-_38274188 2.01 ENSDART00000139420
ENSDART00000015117
elavl2
ELAV like neuron-specific RNA binding protein 2
chr4_+_13586455 2.01 ENSDART00000187230
tnpo3
transportin 3
chr17_-_11368662 1.99 ENSDART00000159061
ENSDART00000188694
ENSDART00000190932
si:ch211-185a18.2
si:ch211-185a18.2
chr20_-_33487729 1.97 ENSDART00000061843
smek1
SMEK homolog 1, suppressor of mek1 (Dictyostelium)
chr6_+_112579 1.95 ENSDART00000034505
ap1m2
adaptor-related protein complex 1, mu 2 subunit
chr8_-_49725430 1.94 ENSDART00000135675
gkap1
G kinase anchoring protein 1
chr25_+_8447565 1.94 ENSDART00000142090
fanci
Fanconi anemia, complementation group I
chr1_+_12196688 1.92 ENSDART00000143839
tdrd7a
tudor domain containing 7 a
chr1_+_14020445 1.92 ENSDART00000079716
hpf1
histone PARylation factor 1
chr2_-_45663945 1.91 ENSDART00000075080
prpf38b
pre-mRNA processing factor 38B
chr5_-_7712160 1.90 ENSDART00000168820
bmpr1ba
bone morphogenetic protein receptor, type IBa
chr24_+_11908480 1.90 ENSDART00000024224
fen1
flap structure-specific endonuclease 1
chr25_-_12824656 1.89 ENSDART00000171801
uba2
ubiquitin-like modifier activating enzyme 2
chr21_-_3422635 1.88 ENSDART00000150975
smad7
SMAD family member 7
chr25_+_32390794 1.88 ENSDART00000012600
galk2
galactokinase 2
chr23_+_20518504 1.88 ENSDART00000114246
adnpb
activity-dependent neuroprotector homeobox b
chr7_+_41812190 1.88 ENSDART00000113732
ENSDART00000174137
orc6
origin recognition complex, subunit 6
chr20_+_35445462 1.87 ENSDART00000124497
tdrd6
tudor domain containing 6
chr2_+_41926707 1.86 ENSDART00000023208
zgc:110183
zgc:110183
chr25_+_3549401 1.86 ENSDART00000166312
ccdc77
coiled-coil domain containing 77
chr1_+_24557414 1.85 ENSDART00000076519
dctpp1
dCTP pyrophosphatase 1
chr7_+_29080684 1.85 ENSDART00000173709
ENSDART00000173576
acd
ACD, shelterin complex subunit and telomerase recruitment factor
chr25_+_32496877 1.82 ENSDART00000132698
ctdspl2a
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2a
chr23_+_43177290 1.80 ENSDART00000193300
ENSDART00000186065
si:dkey-65j6.2
si:dkey-65j6.2
chr21_-_226071 1.80 ENSDART00000160667
nup54
nucleoporin 54
chr21_+_1647990 1.80 ENSDART00000148540
fech
ferrochelatase
chr13_+_42602406 1.79 ENSDART00000133388
ENSDART00000147996
mlh1
mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
chr5_+_41477526 1.79 ENSDART00000153567
pias2
protein inhibitor of activated STAT, 2
chr21_-_26483237 1.78 ENSDART00000169072
ENSDART00000147947
ankhd1
ankyrin repeat and KH domain containing 1
chr23_+_29358188 1.78 ENSDART00000189242
tardbpl
TAR DNA binding protein, like
chr8_-_53535262 1.78 ENSDART00000167839
ENSDART00000157521
actr8
ARP8 actin related protein 8 homolog
chr10_+_36650222 1.74 ENSDART00000126963
ucp3
uncoupling protein 3
chr6_-_42336987 1.72 ENSDART00000128777
ENSDART00000075601
fancd2
Fanconi anemia, complementation group D2
chr12_-_46985 1.68 ENSDART00000152327
wdr45b
WD repeat domain 45B
chr17_-_868004 1.68 ENSDART00000112803
wdr20a
WD repeat domain 20a
chr7_+_41812817 1.66 ENSDART00000174165
orc6
origin recognition complex, subunit 6
chr9_-_33081978 1.65 ENSDART00000100918
zgc:172053
zgc:172053
chr12_+_47446158 1.65 ENSDART00000152857
fmn2b
formin 2b
chr8_+_622640 1.62 ENSDART00000051774
spinb
spindlin b
chr13_-_25548733 1.61 ENSDART00000168099
ENSDART00000135788
ENSDART00000077655
mcmbp
minichromosome maintenance complex binding protein
chr23_-_36449111 1.61 ENSDART00000110478
zgc:174906
zgc:174906
chr12_-_24928497 1.60 ENSDART00000002465
msh2
mutS homolog 2 (E. coli)
chr5_-_67365006 1.60 ENSDART00000136116
unga
uracil DNA glycosylase a
chr5_+_20453874 1.60 ENSDART00000124545
ENSDART00000008402
sart3
squamous cell carcinoma antigen recognized by T cells 3
chr9_-_43644261 1.58 ENSDART00000023684
cwc22
CWC22 spliceosome-associated protein homolog (S. cerevisiae)
chr16_+_4770266 1.57 ENSDART00000038036
ube3d
ubiquitin protein ligase E3D
chr24_+_9693951 1.56 ENSDART00000082411
topbp1
DNA topoisomerase II binding protein 1
chr20_+_34770197 1.53 ENSDART00000018304
mcm3
minichromosome maintenance complex component 3
chr25_+_32496723 1.52 ENSDART00000087978
ctdspl2a
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2a
chr13_+_26703922 1.52 ENSDART00000020946
fancl
Fanconi anemia, complementation group L
chr3_-_45778123 1.52 ENSDART00000146211
h3f3b.1
H3 histone, family 3B.1
chr5_-_8096232 1.52 ENSDART00000158447
nipbla
nipped-B homolog a (Drosophila)
chr20_+_44582318 1.51 ENSDART00000149000
ENSDART00000149775
ENSDART00000085416
atad2b
ATPase family, AAA domain containing 2B
chr3_+_34988670 1.51 ENSDART00000011319
smarce1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
chr3_+_27027781 1.50 ENSDART00000065495
emp2
epithelial membrane protein 2
chr8_+_1118328 1.50 ENSDART00000081445
ubox5
U-box domain containing 5
chr8_+_54013199 1.49 ENSDART00000158497
CABZ01079663.1

chr15_-_26538989 1.49 ENSDART00000032880
rpa1
replication protein A1
chr4_+_38344 1.49 ENSDART00000170197
ENSDART00000175348
phtf2
putative homeodomain transcription factor 2
chr3_-_7897563 1.49 ENSDART00000185232
ubn2b
ubinuclein 2b
chr10_+_10728870 1.49 ENSDART00000109282
swi5
SWI5 homologous recombination repair protein
chr23_-_3758637 1.48 ENSDART00000131536
ENSDART00000139408
ENSDART00000137826
hmga1a
high mobility group AT-hook 1a
chr23_+_44078929 1.46 ENSDART00000102011
ENSDART00000189755
zgc:56304
zgc:56304
chr8_+_16408385 1.45 ENSDART00000177231
cdkn2c
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr6_-_9282080 1.45 ENSDART00000159506
ccdc14
coiled-coil domain containing 14
chr21_+_21743599 1.44 ENSDART00000101700
pold3
polymerase (DNA-directed), delta 3, accessory subunit
chr24_+_11908833 1.44 ENSDART00000178622
fen1
flap structure-specific endonuclease 1
chr1_+_11992 1.43 ENSDART00000161842
cep97
centrosomal protein 97
chr4_-_2380173 1.43 ENSDART00000177727
nap1l1
nucleosome assembly protein 1-like 1
chr10_-_7472323 1.41 ENSDART00000163702
ENSDART00000167054
ENSDART00000167706
nrg1
neuregulin 1
chr20_+_46427984 1.39 ENSDART00000060706
ENSDART00000143858
rad51
RAD51 recombinase
chr18_+_15271993 1.37 ENSDART00000099777
si:dkey-103i16.6
si:dkey-103i16.6
chr8_+_18545185 1.37 ENSDART00000191398
tab3
TGF-beta activated kinase 1/MAP3K7 binding protein 3
chr6_+_25213934 1.36 ENSDART00000163440
si:ch73-97h19.2
si:ch73-97h19.2
chr9_-_10068004 1.36 ENSDART00000011922
ENSDART00000162818
spopla
speckle-type POZ protein-like a
chr20_+_54349333 1.35 ENSDART00000132168
ENSDART00000147542
znf410
zinc finger protein 410
chr10_+_6010570 1.34 ENSDART00000190025
ENSDART00000163680
hmgcs1
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr23_-_18057553 1.33 ENSDART00000173102
ENSDART00000058742
zgc:92287
zgc:92287
chr16_-_12787029 1.30 ENSDART00000139916
foxj2
forkhead box J2
chr15_-_37589600 1.29 ENSDART00000154641
proser3
proline and serine rich 3
chr23_-_6722101 1.26 ENSDART00000157828
baz2a
bromodomain adjacent to zinc finger domain, 2A
chr16_+_54674556 1.25 ENSDART00000167040
pop1
POP1 homolog, ribonuclease P/MRP subunit
chr22_-_20419660 1.24 ENSDART00000105520
pias4a
protein inhibitor of activated STAT, 4a
chr19_-_2876321 1.24 ENSDART00000159253
exosc7
exosome component 7
chr8_+_18545539 1.24 ENSDART00000089274
tab3
TGF-beta activated kinase 1/MAP3K7 binding protein 3

Network of associatons between targets according to the STRING database.

First level regulatory network of e2f1_e2f7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 15.9 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
2.5 27.8 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
2.4 7.3 GO:0007571 age-dependent general metabolic decline(GO:0007571)
2.1 22.6 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
1.9 1.9 GO:0009211 pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211) pyrimidine deoxyribonucleotide metabolic process(GO:0009219)
1.8 5.4 GO:0016446 somatic diversification of immune receptors via somatic mutation(GO:0002566) pyrimidine dimer repair(GO:0006290) somatic hypermutation of immunoglobulin genes(GO:0016446)
1.7 12.1 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
1.6 16.0 GO:0044030 regulation of DNA methylation(GO:0044030)
1.4 9.9 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
1.1 4.2 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
1.0 4.0 GO:0006297 nucleotide-excision repair, DNA gap filling(GO:0006297)
1.0 9.8 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
1.0 6.8 GO:0007141 male meiosis I(GO:0007141)
0.9 2.8 GO:0043570 maintenance of DNA repeat elements(GO:0043570)
0.9 2.7 GO:0009120 deoxyribonucleoside metabolic process(GO:0009120) thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
0.8 3.4 GO:0009794 regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448)
0.8 6.9 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.7 8.2 GO:0000729 DNA double-strand break processing(GO:0000729)
0.6 1.9 GO:0051973 positive regulation of telomerase activity(GO:0051973)
0.6 1.8 GO:0036228 protein targeting to nuclear inner membrane(GO:0036228) protein localization to nuclear envelope(GO:0090435)
0.6 11.7 GO:0006270 DNA replication initiation(GO:0006270)
0.6 2.9 GO:0000012 single strand break repair(GO:0000012)
0.6 6.2 GO:0030719 P granule organization(GO:0030719)
0.6 3.3 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.5 1.6 GO:1903003 positive regulation of protein deubiquitination(GO:1903003)
0.5 2.1 GO:1904182 regulation of pyruvate dehydrogenase activity(GO:1904182) positive regulation of pyruvate dehydrogenase activity(GO:1904184)
0.5 1.5 GO:0001977 renal system process involved in regulation of blood volume(GO:0001977) renal system process involved in regulation of systemic arterial blood pressure(GO:0003071) regulation of glomerular filtration(GO:0003093)
0.5 1.4 GO:0060945 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171) Schwann cell migration(GO:0036135) cardiac neuron differentiation(GO:0060945) cardiac neuron development(GO:0060959)
0.4 2.7 GO:0015862 uridine transport(GO:0015862) pyrimidine nucleoside transport(GO:0015864)
0.4 1.3 GO:1902767 farnesyl diphosphate biosynthetic process, mevalonate pathway(GO:0010142) isoprenoid biosynthetic process via mevalonate(GO:1902767)
0.4 3.9 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.4 1.2 GO:0071042 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476) nuclear polyadenylation-dependent mRNA catabolic process(GO:0071042) polyadenylation-dependent mRNA catabolic process(GO:0071047)
0.4 1.2 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.4 10.3 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.4 1.9 GO:0060049 regulation of protein glycosylation(GO:0060049)
0.4 1.1 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371) positive regulation of endoplasmic reticulum tubular network organization(GO:1903373)
0.4 2.1 GO:0001887 selenium compound metabolic process(GO:0001887)
0.4 6.0 GO:0006265 DNA topological change(GO:0006265)
0.3 1.4 GO:0042148 strand invasion(GO:0042148)
0.3 1.7 GO:1990918 double-strand break repair involved in meiotic recombination(GO:1990918)
0.3 1.3 GO:0043968 histone H2A acetylation(GO:0043968)
0.3 12.7 GO:0006289 nucleotide-excision repair(GO:0006289)
0.3 3.2 GO:0061056 sclerotome development(GO:0061056)
0.3 1.2 GO:0031053 primary miRNA processing(GO:0031053)
0.3 2.3 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.3 0.8 GO:1900182 positive regulation of protein localization to nucleus(GO:1900182) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)
0.3 2.7 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.3 1.9 GO:0006012 galactose metabolic process(GO:0006012)
0.3 9.5 GO:0071427 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.3 0.8 GO:0050847 progesterone receptor signaling pathway(GO:0050847)
0.2 1.2 GO:0060339 negative regulation of type I interferon-mediated signaling pathway(GO:0060339)
0.2 3.2 GO:0030309 poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.2 1.1 GO:0010867 regulation of triglyceride biosynthetic process(GO:0010866) positive regulation of triglyceride biosynthetic process(GO:0010867)
0.2 5.4 GO:0045137 development of primary sexual characteristics(GO:0045137)
0.2 13.5 GO:0044744 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) single-organism nuclear import(GO:1902593)
0.2 1.7 GO:1990845 adaptive thermogenesis(GO:1990845)
0.2 28.0 GO:0006260 DNA replication(GO:0006260)
0.2 6.8 GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0006919)
0.2 0.8 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.2 1.5 GO:0003160 endocardium morphogenesis(GO:0003160)
0.1 1.0 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.1 4.6 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.1 3.7 GO:0043249 erythrocyte maturation(GO:0043249)
0.1 0.6 GO:0017185 peptidyl-lysine hydroxylation(GO:0017185)
0.1 0.7 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.1 10.4 GO:0006342 chromatin silencing(GO:0006342)
0.1 2.1 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.1 1.2 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.1 3.7 GO:0016925 protein sumoylation(GO:0016925)
0.1 2.9 GO:0010389 regulation of G2/M transition of mitotic cell cycle(GO:0010389)
0.1 4.6 GO:0048538 thymus development(GO:0048538)
0.1 3.1 GO:0006513 protein monoubiquitination(GO:0006513)
0.1 1.4 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.1 0.3 GO:0032469 endoplasmic reticulum calcium ion homeostasis(GO:0032469)
0.1 0.8 GO:0046070 dGTP catabolic process(GO:0006203) purine nucleoside triphosphate catabolic process(GO:0009146) purine deoxyribonucleoside triphosphate catabolic process(GO:0009217) dGTP metabolic process(GO:0046070)
0.1 2.3 GO:0070570 regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.1 6.0 GO:0048484 enteric nervous system development(GO:0048484)
0.1 2.0 GO:0070654 sensory epithelium regeneration(GO:0070654) epithelium regeneration(GO:1990399)
0.1 2.3 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.1 1.0 GO:0051898 negative regulation of protein kinase B signaling(GO:0051898)
0.1 0.5 GO:0034198 cellular response to amino acid starvation(GO:0034198)
0.1 0.6 GO:0097341 inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341)
0.1 4.4 GO:0070830 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.1 3.0 GO:0043966 histone H3 acetylation(GO:0043966)
0.1 0.4 GO:0045943 regulation of transcription from RNA polymerase I promoter(GO:0006356) positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.1 0.9 GO:0048041 cell-substrate adherens junction assembly(GO:0007045) focal adhesion assembly(GO:0048041) regulation of focal adhesion assembly(GO:0051893) regulation of cell-substrate junction assembly(GO:0090109)
0.1 0.3 GO:0006740 NADPH regeneration(GO:0006740)
0.1 7.1 GO:0006302 double-strand break repair(GO:0006302)
0.1 1.4 GO:0031397 negative regulation of protein ubiquitination(GO:0031397)
0.1 0.4 GO:1902804 negative regulation of neurotransmitter secretion(GO:0046929) response to cAMP(GO:0051591) cellular response to cAMP(GO:0071320) negative regulation of synaptic vesicle transport(GO:1902804) negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.1 0.9 GO:0043248 proteasome assembly(GO:0043248)
0.1 1.0 GO:0018216 peptidyl-arginine methylation(GO:0018216)
0.1 2.0 GO:0006310 DNA recombination(GO:0006310)
0.1 2.0 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.1 0.6 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.1 3.2 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.1 0.8 GO:0006298 mismatch repair(GO:0006298)
0.1 4.2 GO:0006334 nucleosome assembly(GO:0006334)
0.1 3.8 GO:0001946 lymphangiogenesis(GO:0001946)
0.1 0.2 GO:0002090 regulation of receptor internalization(GO:0002090)
0.1 0.5 GO:0046850 regulation of bone remodeling(GO:0046850)
0.1 1.1 GO:0072698 protein localization to microtubule cytoskeleton(GO:0072698)
0.1 0.3 GO:0031116 positive regulation of microtubule polymerization(GO:0031116)
0.1 9.0 GO:0008284 positive regulation of cell proliferation(GO:0008284)
0.0 1.0 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.8 GO:0016926 protein desumoylation(GO:0016926)
0.0 2.4 GO:0003009 skeletal muscle contraction(GO:0003009)
0.0 0.3 GO:0032204 regulation of telomere maintenance(GO:0032204)
0.0 0.9 GO:0097178 ruffle assembly(GO:0097178)
0.0 2.0 GO:0008643 carbohydrate transport(GO:0008643)
0.0 0.5 GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902254)
0.0 0.3 GO:0035188 hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.0 0.7 GO:1902807 negative regulation of cell cycle G1/S phase transition(GO:1902807) negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.0 1.0 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.0 2.4 GO:0006338 chromatin remodeling(GO:0006338)
0.0 0.8 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 2.0 GO:0006892 post-Golgi vesicle-mediated transport(GO:0006892)
0.0 2.3 GO:0031047 gene silencing by RNA(GO:0031047)
0.0 0.2 GO:0031063 regulation of histone deacetylation(GO:0031063)
0.0 0.2 GO:0098971 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937) anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)
0.0 0.3 GO:0046716 muscle cell cellular homeostasis(GO:0046716)
0.0 0.3 GO:0003315 heart rudiment formation(GO:0003315)
0.0 2.5 GO:0048916 posterior lateral line development(GO:0048916)
0.0 1.7 GO:0045010 actin nucleation(GO:0045010)
0.0 2.6 GO:0031929 TOR signaling(GO:0031929)
0.0 0.1 GO:0097037 heme export(GO:0097037)
0.0 0.3 GO:0002154 thyroid hormone mediated signaling pathway(GO:0002154)
0.0 1.9 GO:0071560 transforming growth factor beta receptor signaling pathway(GO:0007179) response to transforming growth factor beta(GO:0071559) cellular response to transforming growth factor beta stimulus(GO:0071560)
0.0 0.7 GO:0001649 osteoblast differentiation(GO:0001649) odontogenesis(GO:0042476)
0.0 0.8 GO:0030574 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.0 0.6 GO:0006695 cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
0.0 0.4 GO:0001539 cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285)
0.0 0.9 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.8 GO:0007093 mitotic cell cycle checkpoint(GO:0007093)
0.0 0.5 GO:0032402 melanosome transport(GO:0032402) pigment granule transport(GO:0051904)
0.0 1.6 GO:0006281 DNA repair(GO:0006281)
0.0 0.4 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.4 GO:0032543 mitochondrial translation(GO:0032543)
0.0 1.9 GO:0071772 BMP signaling pathway(GO:0030509) response to BMP(GO:0071772) cellular response to BMP stimulus(GO:0071773)
0.0 0.3 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.0 1.8 GO:0060047 heart contraction(GO:0060047)
0.0 1.2 GO:0016579 protein deubiquitination(GO:0016579)
0.0 27.1 GO:0006357 regulation of transcription from RNA polymerase II promoter(GO:0006357)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 13.4 GO:0033186 CAF-1 complex(GO:0033186)
3.1 9.4 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
2.4 7.3 GO:0000333 telomerase catalytic core complex(GO:0000333)
2.3 7.0 GO:0032301 MutSalpha complex(GO:0032301)
2.0 9.9 GO:0000811 GINS complex(GO:0000811)
1.8 29.4 GO:0042555 MCM complex(GO:0042555)
1.8 7.3 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
1.8 12.7 GO:0005662 DNA replication factor A complex(GO:0005662)
1.7 5.1 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
1.4 4.3 GO:0033391 chromatoid body(GO:0033391)
1.4 4.2 GO:1990077 primosome complex(GO:1990077)
1.3 5.3 GO:0061702 inflammasome complex(GO:0061702)
1.1 7.5 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.9 2.7 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.9 10.5 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.8 4.0 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.8 5.4 GO:0032300 mismatch repair complex(GO:0032300)
0.7 5.2 GO:0005663 DNA replication factor C complex(GO:0005663)
0.7 4.9 GO:0035101 FACT complex(GO:0035101)
0.7 8.6 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.7 4.6 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.5 3.2 GO:0030870 Mre11 complex(GO:0030870)
0.5 1.9 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.4 2.9 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.4 1.1 GO:0098826 endoplasmic reticulum tubular network membrane(GO:0098826)
0.4 11.2 GO:0043186 P granule(GO:0043186)
0.4 8.2 GO:0035861 site of double-strand break(GO:0035861)
0.3 3.6 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.3 1.2 GO:0005655 nucleolar ribonuclease P complex(GO:0005655)
0.3 2.0 GO:0071005 U2-type precatalytic spliceosome(GO:0071005)
0.3 1.3 GO:0033553 rDNA heterochromatin(GO:0033553)
0.2 1.1 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.2 4.5 GO:0000782 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783) nuclear chromosome, telomeric region(GO:0000784)
0.2 1.8 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.2 1.5 GO:0033061 DNA recombinase mediator complex(GO:0033061)
0.2 1.4 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.2 0.8 GO:0018444 translation release factor complex(GO:0018444)
0.1 3.0 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.1 2.7 GO:0044666 MLL3/4 complex(GO:0044666)
0.1 0.7 GO:0005879 axonemal microtubule(GO:0005879)
0.1 1.3 GO:0000812 Swr1 complex(GO:0000812)
0.1 0.5 GO:0070319 Golgi to plasma membrane transport vesicle(GO:0070319)
0.1 1.8 GO:0097346 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202) INO80-type complex(GO:0097346)
0.1 1.9 GO:0071011 precatalytic spliceosome(GO:0071011)
0.1 1.2 GO:0000176 nuclear exosome (RNase complex)(GO:0000176) cytoplasmic exosome (RNase complex)(GO:0000177)
0.1 2.3 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 1.9 GO:0005657 replication fork(GO:0005657)
0.1 1.6 GO:0015030 Cajal body(GO:0015030)
0.1 1.9 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 5.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 1.0 GO:0097431 mitotic spindle pole(GO:0097431)
0.1 0.7 GO:0000243 commitment complex(GO:0000243)
0.1 2.0 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 2.9 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 2.4 GO:0005861 troponin complex(GO:0005861)
0.1 0.9 GO:1990391 DNA repair complex(GO:1990391)
0.0 3.6 GO:0030173 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 0.3 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 1.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.9 GO:0005643 nuclear pore(GO:0005643)
0.0 11.2 GO:0005730 nucleolus(GO:0005730)
0.0 0.7 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 2.8 GO:0031965 nuclear membrane(GO:0031965)
0.0 0.6 GO:0036379 striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.0 0.4 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 3.8 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 2.3 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.9 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 1.0 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 2.7 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 18.9 GO:0005654 nucleoplasm(GO:0005654)
0.0 2.0 GO:0036064 ciliary basal body(GO:0036064)
0.0 11.2 GO:1990904 ribonucleoprotein complex(GO:1990904)
0.0 2.5 GO:0005884 actin filament(GO:0005884)
0.0 1.1 GO:0072686 mitotic spindle(GO:0072686)
0.0 24.3 GO:0005829 cytosol(GO:0005829)
0.0 80.7 GO:0005634 nucleus(GO:0005634)
0.0 1.1 GO:0005694 chromosome(GO:0005694)
0.0 0.2 GO:0005801 cis-Golgi network(GO:0005801)
0.0 1.8 GO:0005813 centrosome(GO:0005813)
0.0 4.1 GO:0000139 Golgi membrane(GO:0000139)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 22.6 GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
2.4 7.3 GO:0003721 telomerase RNA reverse transcriptase activity(GO:0003721)
2.3 7.0 GO:0032356 guanine/thymine mispair binding(GO:0032137) single base insertion or deletion binding(GO:0032138) single thymine insertion binding(GO:0032143) oxidized DNA binding(GO:0032356) oxidized purine DNA binding(GO:0032357) mismatch repair complex binding(GO:0032404) MutLalpha complex binding(GO:0032405)
2.2 6.5 GO:0043739 G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739)
1.5 6.0 GO:0070182 DNA polymerase binding(GO:0070182)
1.4 15.3 GO:0043142 single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116) single-stranded DNA-dependent ATPase activity(GO:0043142)
1.2 1.2 GO:0032135 DNA insertion or deletion binding(GO:0032135)
1.0 17.3 GO:0003688 DNA replication origin binding(GO:0003688)
0.9 2.8 GO:0071532 ankyrin repeat binding(GO:0071532)
0.6 4.2 GO:0030983 mismatched DNA binding(GO:0030983)
0.5 12.3 GO:0036002 pre-mRNA binding(GO:0036002)
0.5 2.1 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.5 5.2 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.5 3.3 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.5 1.9 GO:0019948 SUMO activating enzyme activity(GO:0019948)
0.5 1.4 GO:0000150 recombinase activity(GO:0000150)
0.5 6.0 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.4 1.3 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
0.4 4.4 GO:0030332 cyclin binding(GO:0030332)
0.4 1.7 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.4 2.0 GO:0039706 co-receptor binding(GO:0039706)
0.4 0.8 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.4 2.7 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.4 5.3 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.4 6.2 GO:0008301 DNA binding, bending(GO:0008301)
0.4 14.6 GO:0008094 DNA-dependent ATPase activity(GO:0008094)
0.3 1.0 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.3 0.9 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.3 1.9 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.3 4.0 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.3 2.7 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.3 13.3 GO:0031491 nucleosome binding(GO:0031491)
0.3 1.6 GO:0017070 U6 snRNA binding(GO:0017070)
0.3 3.6 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.3 4.0 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.2 4.2 GO:0061608 nuclear import signal receptor activity(GO:0061608)
0.2 8.1 GO:0003684 damaged DNA binding(GO:0003684)
0.2 3.0 GO:0061665 SUMO ligase activity(GO:0061665)
0.2 3.2 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.2 3.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.2 0.7 GO:0046964 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964)
0.2 2.6 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.2 1.5 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.2 2.1 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.2 0.6 GO:0070815 peptidyl-lysine 5-dioxygenase activity(GO:0070815)
0.2 1.5 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.2 4.2 GO:0034062 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.2 0.8 GO:0016793 dGTPase activity(GO:0008832) triphosphoric monoester hydrolase activity(GO:0016793)
0.2 1.9 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.2 1.1 GO:0035173 histone kinase activity(GO:0035173)
0.2 1.8 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.1 1.0 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 8.5 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 1.0 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.1 0.5 GO:0070513 death domain binding(GO:0070513)
0.1 1.2 GO:0035925 AU-rich element binding(GO:0017091) mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 12.1 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 1.2 GO:0005522 profilin binding(GO:0005522)
0.1 9.6 GO:0003724 RNA helicase activity(GO:0003724)
0.1 1.4 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.1 21.8 GO:0042393 histone binding(GO:0042393)
0.1 1.4 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 2.7 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.1 1.9 GO:0070411 I-SMAD binding(GO:0070411)
0.1 1.4 GO:0070403 NAD+ binding(GO:0070403)
0.1 0.6 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.1 5.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 2.0 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 2.5 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 2.3 GO:0070491 repressing transcription factor binding(GO:0070491)
0.1 0.3 GO:0016652 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.1 1.0 GO:0016274 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.1 1.8 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 2.3 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.1 0.9 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.8 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.0 1.4 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.9 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.0 0.8 GO:0017069 snRNA binding(GO:0017069)
0.0 1.8 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.1 GO:0016743 carboxyl- or carbamoyltransferase activity(GO:0016743)
0.0 4.2 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 1.0 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 1.0 GO:0016876 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 8.8 GO:0030246 carbohydrate binding(GO:0030246)
0.0 16.6 GO:0046983 protein dimerization activity(GO:0046983)
0.0 0.8 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 5.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.9 GO:0019213 deacetylase activity(GO:0019213)
0.0 0.6 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.8 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.2 GO:0070325 low-density lipoprotein particle receptor binding(GO:0050750) lipoprotein particle receptor binding(GO:0070325)
0.0 0.6 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 0.3 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.4 GO:0030515 snoRNA binding(GO:0030515)
0.0 1.4 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 1.1 GO:0042802 identical protein binding(GO:0042802)
0.0 0.7 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 3.9 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.0 0.1 GO:0015232 heme transporter activity(GO:0015232)
0.0 1.0 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 3.7 GO:0000989 transcription factor activity, transcription factor binding(GO:0000989) transcription cofactor activity(GO:0003712)
0.0 0.9 GO:0043130 ubiquitin binding(GO:0043130)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 4.1 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.5 27.8 PID FANCONI PATHWAY Fanconi anemia pathway
0.5 39.2 PID E2F PATHWAY E2F transcription factor network
0.3 4.0 PID ATR PATHWAY ATR signaling pathway
0.2 12.0 PID TELOMERASE PATHWAY Regulation of Telomerase
0.2 9.7 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 2.8 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.2 1.8 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.2 9.6 PID CMYB PATHWAY C-MYB transcription factor network
0.1 11.1 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 2.0 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 1.9 PID ALK1 PATHWAY ALK1 signaling events
0.1 0.8 ST G ALPHA S PATHWAY G alpha s Pathway
0.1 0.6 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.3 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 1.3 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.4 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 1.0 PID P53 REGULATION PATHWAY p53 pathway
0.0 0.5 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.7 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.2 PID REELIN PATHWAY Reelin signaling pathway
0.0 0.4 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 37.7 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
1.7 20.1 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
1.3 12.0 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
1.1 27.4 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
1.1 12.1 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
1.1 5.3 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
1.1 4.2 REACTOME POL SWITCHING Genes involved in Polymerase switching
0.9 11.7 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
0.8 7.3 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.8 10.6 REACTOME TELOMERE MAINTENANCE Genes involved in Telomere Maintenance
0.7 3.3 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.3 2.3 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.3 4.1 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.3 1.7 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.2 3.2 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.2 2.0 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.2 1.4 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.2 2.1 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.2 4.7 REACTOME G1 PHASE Genes involved in G1 Phase
0.2 2.9 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.2 9.3 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.1 2.5 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.1 1.9 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 1.8 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 1.5 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.1 1.5 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 1.2 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.1 1.2 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.1 0.8 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.1 2.0 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 3.0 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 5.5 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 1.0 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.4 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.3 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.8 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.4 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 1.7 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.0 0.9 REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.0 0.2 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 2.9 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 1.0 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events