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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for e2f1_e2f7
Z-value: 1.43
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Transcription factors associated with e2f1_e2f7
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| e2f1 | dr11_v1_chr23_-_43486714_43486714 | 0.33 | 9.9e-04 | Click! |
| e2f7 | dr11_v1_chr4_-_2545310_2545345 | 0.25 | 1.7e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_+_14841685 Show fit | 12.06 |
ENSDART00000158291
ENSDART00000162039 |
stem-loop binding protein |
|
| chr19_-_47570672 Show fit | 11.51 |
ENSDART00000112155
|
ribonucleotide reductase M2 polypeptide |
|
| chr20_-_29498178 Show fit | 11.12 |
ENSDART00000152986
ENSDART00000027851 ENSDART00000152954 |
ribonucleotide reductase M2 polypeptide |
|
| chr24_-_35561672 Show fit | 10.94 |
ENSDART00000058564
|
minichromosome maintenance complex component 4 |
|
| chr7_+_24881680 Show fit | 10.84 |
ENSDART00000058843
|
kelch repeat-containing protein |
|
| chr7_+_24814866 Show fit | 10.73 |
ENSDART00000173581
|
si:ch211-226l4.6 |
|
| chr1_+_27690 Show fit | 9.37 |
ENSDART00000162928
|
embryonic ectoderm development |
|
| chr6_-_33916756 Show fit | 8.80 |
ENSDART00000137447
ENSDART00000138488 |
nuclear autoantigenic sperm protein (histone-binding) |
|
| chr13_-_35908275 Show fit | 8.57 |
ENSDART00000013961
|
MYCL proto-oncogene, bHLH transcription factor a |
|
| chr3_+_25999477 Show fit | 8.29 |
ENSDART00000024316
|
minichromosome maintenance complex component 5 |
Network of associatons between targets according to the STRING database.
First level regulatory network of e2f1_e2f7
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 28.0 | GO:0006260 | DNA replication(GO:0006260) |
| 2.5 | 27.8 | GO:0036388 | pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299) |
| 0.0 | 27.1 | GO:0006357 | regulation of transcription from RNA polymerase II promoter(GO:0006357) |
| 2.1 | 22.6 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 1.6 | 16.0 | GO:0044030 | regulation of DNA methylation(GO:0044030) |
| 4.0 | 15.9 | GO:0006335 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) |
| 0.2 | 13.5 | GO:0044744 | protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) single-organism nuclear import(GO:1902593) |
| 0.3 | 12.7 | GO:0006289 | nucleotide-excision repair(GO:0006289) |
| 1.7 | 12.1 | GO:0006398 | mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398) |
| 0.6 | 11.7 | GO:0006270 | DNA replication initiation(GO:0006270) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 80.7 | GO:0005634 | nucleus(GO:0005634) |
| 1.8 | 29.4 | GO:0042555 | MCM complex(GO:0042555) |
| 0.0 | 24.3 | GO:0005829 | cytosol(GO:0005829) |
| 0.0 | 18.9 | GO:0005654 | nucleoplasm(GO:0005654) |
| 3.3 | 13.4 | GO:0033186 | CAF-1 complex(GO:0033186) |
| 1.8 | 12.7 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.4 | 11.2 | GO:0043186 | P granule(GO:0043186) |
| 0.0 | 11.2 | GO:0005730 | nucleolus(GO:0005730) |
| 0.0 | 11.2 | GO:1990904 | ribonucleoprotein complex(GO:1990904) |
| 0.9 | 10.5 | GO:0005664 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.2 | 22.6 | GO:0004748 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 0.1 | 21.8 | GO:0042393 | histone binding(GO:0042393) |
| 1.0 | 17.3 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.0 | 16.6 | GO:0046983 | protein dimerization activity(GO:0046983) |
| 1.4 | 15.3 | GO:0043142 | single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116) single-stranded DNA-dependent ATPase activity(GO:0043142) |
| 0.4 | 14.6 | GO:0008094 | DNA-dependent ATPase activity(GO:0008094) |
| 0.3 | 13.3 | GO:0031491 | nucleosome binding(GO:0031491) |
| 0.5 | 12.3 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 0.1 | 12.1 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.1 | 9.6 | GO:0003724 | RNA helicase activity(GO:0003724) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 39.2 | PID E2F PATHWAY | E2F transcription factor network |
| 0.5 | 27.8 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.2 | 12.0 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 11.1 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.2 | 9.7 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.2 | 9.6 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.6 | 4.1 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.3 | 4.0 | PID ATR PATHWAY | ATR signaling pathway |
| 0.2 | 2.8 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.1 | 2.0 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 37.7 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 1.1 | 27.4 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 1.7 | 20.1 | REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 1.1 | 12.1 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| 1.3 | 12.0 | REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER | Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER |
| 0.9 | 11.7 | REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX | Genes involved in Activation of the pre-replicative complex |
| 0.8 | 10.6 | REACTOME TELOMERE MAINTENANCE | Genes involved in Telomere Maintenance |
| 0.2 | 9.3 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |
| 0.8 | 7.3 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 0.0 | 5.5 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |